Search Results - "Bickers, David R"

Multiple molecular targets of resveratrol: Anti-carcinogenic mechanisms by Athar, Mohammad, Back, Jung Ho, Kopelovich, Levy, Bickers, David R., Kim, Arianna L.

“…Plant-derived polyphenolic compounds, such as the stilbene resveratrol ( trans-3,4′,5-trihydroxystilbene), have been identified as potent anti-cancer agents…”
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Sonic hedgehog signaling in Basal cell nevus syndrome by Athar, Mohammad, Li, Changzhao, Kim, Arianna L, Spiegelman, Vladimir S, Bickers, David R

“…The hedgehog (Hh) signaling pathway is considered to be a major signal transduction pathway during embryonic development, but it usually shuts down after…”
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Inhibition of the hedgehog pathway in patients with basal-cell nevus syndrome: final results from the multicentre, randomised, double-blind, placebo-controlled, phase 2 trial by Tang, Jean Y, MD, Ally, Mina S, MD, Chanana, Anita M, BS, Mackay-Wiggan, Julian M, MD, Aszterbaum, Michelle, MD, Lindgren, Joselyn A, MS, Ulerio, Grace, BA, Rezaee, Melika R, BA, Gildengorin, Ginny, PhD, Marji, Jackleen, MD, Clark, Charlotte, MD, Bickers, David R, Prof, Epstein, Ervin H, Dr

“…Summary Background Aberrant hedgehog signalling underlies the development of basal-cell carcinomas. We previously reported the interim analysis of a…”
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Advances in Prevention and Surveillance of Cutaneous Malignancies by Trager, Megan H., Queen, Dawn, Samie, Faramarz H., Carvajal, Richard D., Bickers, David R., Geskin, Larisa J.

“…Skin cancer affects 1 in 5 Americans, resulting in significant morbidity and mortality. Treatment costs and rates of skin cancer and melanoma continue to rise,…”
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Author Correction: Patched1 haploinsufficiency severely impacts intermediary metabolism in the skin of Ptch1+/−/ODC transgenic mice by Li, Changzhao, Mishra, Bharat, Kashyap, Mahendra, Weng, Zhiping, Andrabi, Shaida A., Mukhtar, Shahid M., Kim, Arianna L., Bickers, David R., Kopelovich, Levy, Athar, Mohammad

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Dioxin-induced chloracne - reconstructing the cellular and molecular mechanisms of a classic environmental disease by Panteleyev, Andrey A., Bickers, David R.

“…:  2,3,7,8‐Tetrachlorodibenzo‐p‐dioxin (TCDD) is among the most toxic pollutants known to date that serves as a prototype for a group of halogenated…”
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Resveratrol Targets Transforming Growth Factor-β2 Signaling to Block UV-Induced Tumor Progression by Kim, Kwang Ho, Back, Jung Ho, Zhu, Yucui, Arbesman, Josh, Athar, Mohammad, Kopelovich, Levy, Kim, Arianna L., Bickers, David R.

“…Resveratrol (RES) is a potent anti-cancer agent. We have previously reported that RES arrests the growth of invasive human A431 squamous cell carcinoma (SCC)…”
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Oxidative Stress in the Pathogenesis of Skin Disease by Bickers, David R., Athar, Mohammad

“…Skin is the largest body organ that serves as an important environmental interface providing a protective envelope that is crucial for homeostasis. On the…”
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Shh and p50/Bcl3 signaling crosstalk drives pathogenesis of BCCs in Gorlin syndrome by Chaudhary, Sandeep C, Tang, Xiuwei, Arumugam, Aadithya, Li, Changzhao, Srivastava, Ritesh K, Weng, Zhiping, Xu, Jianmin, Zhang, Xiao, Kim, Arianna L, McKay, Kristopher, Elmets, Craig A, Kopelovich, Levy, Bickers, David R, Athar, Mohammad

“…Nevoid basal cell carcinoma syndrome (NBCCS) is a rare autosomal dominant disorder that is due, in large measure, to aberrant Shh signaling driven by mutations…”
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Correction: Inhibition of p38 MAPK Signaling Augments Skin Tumorigenesis via NOX2 Driven ROS Generation by Liu, Liang, Rezvani, Hamid Reza, Back, Jung Ho, Hosseini, Mohsen, Tang, Xiuwei, Zhu, Yucui, Mahfouf, Walid, Raad, Houssam, Ragi, Grace, Athar, Mohammad, Kim, Arianna L, Bickers, David R

“…[This corrects the article DOI: 10.1371/journal.pone.0097245.]…”
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Role of p38 MAPK in UVB-Induced Inflammatory Responses in the Skin of SKH-1 Hairless Mice by Kim, Arianna L., Labasi, Jeffrey M., Zhu, Yucui, Tang, Xiuwei, McClure, Kim, Gabel, Christopher A., Athar, Mohammad, Bickers, David R.

“…The p38 mitogen-activated protein kinase (MAPK) signaling pathway is activated by numerous inflammatory mediators and environmental stresses. We assessed the…”
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Inhibition of smoothened signaling prevents ultraviolet B-induced basal cell carcinomas through regulation of Fas expression and apoptosis by ATHAR, Mohammad, CHENGXIN LI, BICKERS, David R, JINGWU XIE, XIUWEI TANG, SUMIN CHI, XIAOLI ZHANG, KIM, Arianna L, TYRING, Stephen K, KOPELOVICH, Levy, HEBERT, Jennifer, EPSTEIN, Ervin H

“…Abnormal activation of the hedgehog-signaling pathway is the pivotal abnormality driving the growth of basal cell carcinomas (BCCs), the most common type of…”
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Loss of hairless confers susceptibility to UVB-induced tumorigenesis via disruption of NF-kappaB signaling by Kim, Hyunmi, Casta, Alexandre, Tang, Xiuwei, Luke, Courtney T, Kim, Arianna L, Bickers, David R, Athar, Mohammad, Christiano, Angela M

“…In order to model squamous cell carcinoma development in vivo, researchers have long preferred hairless mouse models such as SKH-1 mice that have traditionally…”
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Cyclooxygenase-2 Expression in Murine and Human Nonmelanoma Skin Cancers: Implications for Therapeutic Approaches by An, Kathy P., Athar, Mohammad, Tang, Xiuwei, Katiyar, Santosh K., Russo, Justin, Beech, J., Aszterbaum, Michelle, Kopelovich, Levy, Epstein, Ervin H., Mukhtar, Hasan, Bickers, David R.

“…Inflammatory stimuli result in the production of cutaneous eicosanoids, which are known to contribute to the process of tumor promotion. Cyclooxygenase (COX),…”
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P-Glycoprotein (ABCB1) expression in human skin is mainly restricted to dermal components by Skazik, Claudia, Wenzel, Jörg, Marquardt, Yvonne, Kim, Arianna, Merk, Hans F., Bickers, David R., Baron, Jens M.

“…:  Several transport proteins are constitutively expressed in skin cells, but the putative role of the ABC transporter P‐glycoprotein (P‐gp) in human skin is…”
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Differential Expression of E Prostanoid Receptors in Murine and Human Non-Melanoma Skin Cancer by Lee, Juliette Lois, Kim, Arianna, Kopelovich, Levy, Bickers, David R., Athar, Mohammad

“…Enhanced prostaglandin production via upregulated cyclooxygenase-2 (COX-2) expression is a likely contributing factor in ultraviolet B (UVB)-induced…”
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Inhibiting the Hedgehog Pathway in Patients with the Basal-Cell Nevus Syndrome by Tang, Jean Y, Mackay-Wiggan, Julian M, Aszterbaum, Michelle, Yauch, Robert L, Lindgren, Joselyn, Chang, Kris, Coppola, Carol, Chanana, Anita M, Marji, Jackleen, Bickers, David R, Epstein, Ervin H

“…In a randomized, placebo-controlled trial, the hedgehog-pathway inhibitor vismodegib prevented the development of new basal-cell carcinomas in patients with…”
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Inhibition of p38 MAPK signaling augments skin tumorigenesis via NOX2 driven ROS generation by Liu, Liang, Rezvani, Hamid Reza, Back, Jung Ho, Hosseini, Mohsen, Tang, Xiuwei, Zhu, Yucui, Mahfouf, Walid, Raad, Houssam, Ragi, Grace, Athar, Mohammad, Kim, Arianna L, Bickers, David R

“…p38 mitogen-activated protein kinases (MAPKs) respond to a wide range of extracellular stimuli. While the inhibition of p38 signaling is implicated in the…”
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Fifty Years of Collaboration between the SID and ESDR: Two Societies and One Journal by Gallo, Richard L, Bickers, David R, Minnillo, Rebecca

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SOX9 Transcriptionally Regulates mTOR-Induced Proliferation of Basal Cell Carcinomas by Kim, Arianna L., Back, Jung Ho, Chaudhary, Sandeep C., Zhu, Yucui, Athar, Mohammad, Bickers, David R.

“…Currently available smoothened targeted therapies in patients with basal cell nevus syndrome are associated with substantial tumor recurrence and clinical…”
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