Search Results - "Bickerdike, Michael J"

AT-0174, a novel dual IDO1/TDO2 enzyme inhibitor, synergises with temozolomide to improve survival in an orthotopic mouse model of glioblastoma by Bickerdike, Michael J, Nafia, Imane, Bessede, Alban, Chen, Cheng-Bang, Wangpaichitr, Medhi

“…Glioblastoma is an aggressive brain cancer, usually of unknown etiology, and with a very poor prognosis. Survival from diagnosis averages only 3 months if left…”
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Structure-Activity Relationships for the Anaesthetic and Analgaesic Properties of Aromatic Ring-Substituted Ketamine Esters by Dimitrov, Ivaylo V, Harvey, Martyn G, Voss, Logan J, Sleigh, James W, Bickerdike, Michael J, Denny, William A

“…A series of benzene ring substituted ketamine -alkyl esters were prepared from the corresponding substituted norketamines. Few of the latter have been reported…”
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Ketamine esters and amides as short-acting anaesthetics: Structure-activity relationships for the side-chain by Dimitrov, Ivaylo V., Harvey, Martyn G., Voss, Logan J., Sleigh, James W., Bickerdike, Michael J., Denny, William A.

“…[Display omitted] N-Aliphatic ester analogues of the non-opioid ketamine (1) retain effective anaesthetic/analgesic properties while minimising ketamine’s…”
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NNZ-2566: A Gly–Pro–Glu analogue with neuroprotective efficacy in a rat model of acute focal stroke by Bickerdike, Michael J, Thomas, Gregory B, Batchelor, David C, Sirimanne, Ernest S, Leong, Wing, Lin, Hai, Sieg, Frank, Wen, Jingyuan, Brimble, Margaret A, Harris, Paul W, Gluckman, Peter D

“…Abstract The N-terminal cleavage product of human insulin-like growth factor-1 (IGF-1) in the brain is the tripeptide molecule Glypromate® (Gly–Pro–Glu)…”
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5-HT2C receptor agonists as potential drugs for the treatment of obesity by Bickerdike, Michael J

“…An association between the brain serotonin (5-HT) system and feeding has been postulated since the 1970's but it has only been in recent years that the nature…”
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Pyrrolo(iso)quinoline derivatives as 5-HT2C receptor agonists by ADAMS, David R, BENTLEY, Jonathan M, MALCOLM, Craig S, MANSELL, Howard L, MISRA, Anil, QUIRK, Kathleen, ROFFEY, Jonathan R. A, VICKERS, Steven P, BENWELL, Karen R, BICKERDIKE, Michael J, BODKIN, Corinna D, CLIFFE, Ian A, DOURISH, Colin T, GEORGE, Ashley R, KENNETT, Guy A, KNIGHT, Antony R

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Striatal acetylcholine release correlates with behavioral sensitization in rats withdrawn from chronic amphetamine by Bickerdike, M J, Abercrombie, E D

“…Stimulant sensitization is defined as an enhancement of the behavioral response to drug after repeated drug exposure. We have examined the relation between the…”
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Enhanced acetylcholine release in striatum after chronic amphetamine is NMDA-dependent by Bickerdike, Michael J, Abercrombie, Elizabeth D

“…BEHAVIORAL sensitization to chronic amphetamine develops in parallel with an enhancement of amphetamine-stimulated efflux of acetylcholine (ACh) in striatum…”
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Pyrrolo(iso)quinoline derivatives as 5-HT(2C) receptor agonists by Adams, David R, Bentley, Jonathan M, Benwell, Karen R, Bickerdike, Michael J, Bodkin, Corinna D, Cliffe, Ian A, Dourish, Colin T, George, Ashley R, Kennett, Guy A, Knight, Antony R, Malcolm, Craig S, Mansell, Howard L, Misra, Anil, Quirk, Kathleen, Roffey, Jonathan R A, Vickers, Steven P

“…A series of 1-(1-pyrrolo(iso)quinolinyl)-2-propylamines was synthesised and evaluated as 5-HT(2C) receptor agonists for the treatment of obesity. The general…”
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Pyrrolo(iso)quinoline derivatives as 5-HT 2C receptor agonists by Adams, David R., Bentley, Jonathan M., Benwell, Karen R., Bickerdike, Michael J., Bodkin, Corinna D., Cliffe, Ian A., Dourish, Colin T., George, Ashley R., Kennett, Guy A., Knight, Antony R., Malcolm, Craig S., Mansell, Howard L., Misra, Anil, Quirk, Kathleen, Roffey, Jonathan R.A., Vickers, Steven P.

“…A series of 1-(1-pyrrolo(iso)quinolinyl)-2-propylamines was prepared and evaluated as 5-HT 2C receptor agonists for the treatment of obesity. A series of…”
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Striatal acetylcholine release correlates with behavioral sensitization in rats withdrawn from chronic amphetamine by Abercrombie, Elizabeth D., Bickerdike, Michael J.

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The influence of 5-hydroxytryptamine re-uptake blockade on CCK receptor antagonist effects in the rat elevated zero-maze by Bickerdike, M J, Marsden, C A, Dourish, C T, Fletcher, A

“…In this study, the elevated zero-maze model of anxiety was used to investigate CCK receptor antagonist effects on the behaviour of male Lister-hooded rats and…”
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