Search Results - "Bicanic, Tihana"
-
1
Liposomal Amphotericin B (AmBisome®): A Review of the Pharmacokinetics, Pharmacodynamics, Clinical Experience and Future Directions
Published in Drugs (New York, N.Y.) (01-03-2016)“…Liposomal amphotericin B (AmBisome ® ; LAmB) is a unique lipid formulation of amphotericin B. LAmB is a standard of care for a wide range of medically…”
Get full text
Journal Article -
2
Tackling the emerging threat of antifungal resistance to human health
Published in Nature reviews. Microbiology (01-09-2022)“…Invasive fungal infections pose an important threat to public health and are an under-recognized component of antimicrobial resistance, an emerging crisis…”
Get full text
Journal Article -
3
Drug Resistance and Novel Therapeutic Approaches in Invasive Candidiasis
Published in Frontiers in cellular and infection microbiology (14-12-2021)“…species are the leading cause of invasive fungal infections worldwide and are associated with acute mortality rates of ~50%. Mortality rates are further…”
Get full text
Journal Article -
4
Cryptococcus: from environmental saprophyte to global pathogen
Published in Nature reviews. Microbiology (01-02-2016)“…Key Points Cryptococcosis is a widespread opportunistic fungal infection of humans and other animals. Cryptococcus species that infect humans likely evolved as…”
Get full text
Journal Article -
5
The importance of antimicrobial resistance in medical mycology
Published in Nature communications (12-09-2022)“…Prior to the SARS-CoV-2 pandemic, antibiotic resistance was listed as the major global health care priority. Some analyses, including the O’Neill report, have…”
Get full text
Journal Article -
6
The Cryptococcus neoformans Titan cell is an inducible and regulated morphotype underlying pathogenesis
Published in PLoS pathogens (01-05-2018)“…Fungal cells change shape in response to environmental stimuli, and these morphogenic transitions drive pathogenesis and niche adaptation. For example,…”
Get full text
Journal Article -
7
Cerebrospinal fluid cytokine profiles predict risk of early mortality and immune reconstitution inflammatory syndrome in HIV-associated cryptococcal meningitis
Published in PLoS pathogens (01-04-2015)“…Understanding the host immune response during cryptococcal meningitis (CM) is of critical importance for the development of immunomodulatory therapies. We…”
Get full text
Journal Article -
8
Global guideline for the diagnosis and management of cryptococcosis: an initiative of the ECMM and ISHAM in cooperation with the ASM
Published in The Lancet infectious diseases (01-08-2024)“…Cryptococcosis is a major worldwide disseminated invasive fungal infection. Cryptococcosis, particularly in its most lethal manifestation of cryptococcal…”
Get full text
Journal Article -
9
Cryptococcal meningitis: improving access to essential antifungal medicines in resource-poor countries
Published in The Lancet infectious diseases (01-07-2013)“…Summary Cryptococcal meningitis is the leading cause of adult meningitis in sub-Saharan Africa, and contributes up to 20% of AIDS-related mortality in…”
Get full text
Journal Article -
10
Efficient phagocytosis and laccase activity affect the outcome of HIV-associated cryptococcosis
Published in The Journal of clinical investigation (01-05-2014)“…Cryptococcal meningitis (CM) is a leading cause of HIV-associated mortality globally. High fungal burden in cerebrospinal fluid (CSF) at diagnosis and poor…”
Get full text
Journal Article -
11
The Case for Adopting the "Species Complex" Nomenclature for the Etiologic Agents of Cryptococcosis
Published in mSphere (01-01-2017)“…Cryptococcosis is a potentially lethal disease of humans/animals caused by and . Distinction between the two species is based on phenotypic and genotypic…”
Get full text
Journal Article -
12
The impact of immunosuppressive therapy on secondary infections and antimicrobial use in COVID-19 inpatients: a retrospective cohort study
Published in BMC infectious diseases (17-11-2023)“…Immunosuppressive therapies have become a cornerstone of the management of severe COVID-19. The impact of these therapies on secondary infections and…”
Get full text
Journal Article -
13
Fluconazole Monotherapy Is a Suboptimal Option for Initial Treatment of Cryptococcal Meningitis Because of Emergence of Resistance
Published in mBio (03-12-2019)“…Cryptococcal meningitis is a lethal disease with few therapeutic options. Induction therapy with fluconazole has been consistently demonstrated to be…”
Get full text
Journal Article -
14
Combination Antifungal Therapy for Cryptococcal Meningitis
Published in The New England journal of medicine (27-06-2013)“…To the Editor: In the trial of combination therapy for cryptococcal meningitis in patients with human immunodeficiency virus infection, Day et al. (April 4…”
Get full text
Journal Article -
15
Genotypic Diversity Is Associated with Clinical Outcome and Phenotype in Cryptococcal Meningitis across Southern Africa
Published in PLoS neglected tropical diseases (25-06-2015)“…Cryptococcal meningitis is a major cause of mortality throughout the developing world, yet little is known about the genetic markers underlying Cryptococcal…”
Get full text
Journal Article -
16
Fungal Burden, Early Fungicidal Activity, and Outcome in Cryptococcal Meningitis in Antiretroviral-Naive or Antiretroviral-Experienced Patients Treated with Amphotericin B or Fluconazole
Published in Clinical infectious diseases (01-07-2007)“…In a prospective observational study of 54 patients with human immunodeficiency virus–associated cryptococcal meningitis, the early fungicidal activity of…”
Get full text
Journal Article -
17
THUR 134 Isolated CNS histoplasmosis in an immunocompetent patient
Published in Journal of neurology, neurosurgery and psychiatry (01-10-2018)“…A 26-year-old Bolivian man presented with a 3 year history of occipital headaches and bilateral papilloedema. MRI showed communicating hydrocephalus and…”
Get full text
Journal Article -
18
The Cryptococcus neoformans transcriptome at the site of human meningitis
Published in mBio (04-02-2014)“…Cryptococcus neoformans is the leading cause of fungal meningitis worldwide. Previous studies have characterized the cryptococcal transcriptome under various…”
Get full text
Journal Article -
19
Genomic Variation across a Clinical Cryptococcus Population Linked to Disease Outcome
Published in mBio (20-12-2022)“…Cryptococcus neoformans is the causative agent of cryptococcosis, a disease with poor patient outcomes that accounts for approximately 180,000 deaths each…”
Get full text
Journal Article -
20
A Population Genomics Approach to Assessing the Genetic Basis of Within-Host Microevolution Underlying Recurrent Cryptococcal Meningitis Infection
Published in G3 : genes - genomes - genetics (01-04-2017)“…Recurrence of meningitis due to after treatment causes substantial mortality in HIV/AIDS patients across sub-Saharan Africa. In order to determine whether…”
Get full text
Journal Article