Search Results - "Bible, K. C"

Efatutazone, an Oral PPAR-γ Agonist, in Combination With Paclitaxel in Anaplastic Thyroid Cancer: Results of a Multicenter Phase 1 Trial by Smallridge, R. C, Copland, J. A, Brose, M. S, Wadsworth, J. T, Houvras, Y, Menefee, M. E, Bible, K. C, Shah, M. H, Gramza, A. W, Klopper, J. P, Marlow, L. A, Heckman, M. G, Von Roemeling, R

“…Purpose: A phase 1 study was initiated to determine the safety, potential effectiveness, and maximal tolerated dose and recommended phase 2 dose of efatutazone…”
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The anticancer effects of chaetocin are independent of programmed cell death and hypoxia, and are associated with inhibition of endothelial cell proliferation by Isham, C R, Tibodeau, J D, Bossou, A R, Merchan, J R, Bible, K C

“…Background: We previously reported that chaetocin has potent and selective anti-myeloma activity attributable to reactive oxygen species (ROS) induction…”
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Cytotoxic synergy between flavopiridol (NSC 649890, L86-8275) and various antineoplastic agents : The importance of sequence of administration by BIBLE, K. C, KAUFMANN, S. H

“…Flavopiridol, the first potent cyclin-dependent kinase inhibitor to undergo clinical trials as an antineoplastic agent in the United States, has attracted…”
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Flavopiridol : A cytotoxic flavone that induces cell death in noncycling A549 human lung carcinoma cells by BIBLE, K. C, KAUFMANN, S. H

“…Flavopiridol (NSC 649890, L86-8275), a potent inhibitor of cyclin-dependent kinase 1/p34cdc2 phosphorylation and kinase activity, is currently undergoing Phase…”
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Loss of expression of a new member of the DNAJ protein family confers resistance to chemotherapeutic agents used in the treatment of ovarian cancer by SHRIDHAR, Viji, BIBLE, Keith C, STAUB, Julie, AVULA, Rajeswari, LEE, Yean Kit, KALLI, Kimberly, HUANG, Haojie, HARTMANN, Lynn C, KAUFMANN, Scott H, SMITH, David I

“…Differential display-PCR between ovarian tumor cell lines and short-term cultures of normal ovarian epithelial cell brushings was used to isolate a…”
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Flavopiridol binds to duplex DNA by BIBLE, K. C, BIBLE, R. H, KOTTKE, T. J, SVINGEN, P. A, KUN XU, PANG, Y.-P, HAJDU, E, KAUFMANN, S. H

“…Flavopiridol, the first potent cyclin-dependent kinase inhibitor to enter clinical trials, was recently found to be cytotoxic to noncycling cells. The present…”
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Effect of P-glycoprotein on flavopiridol sensitivity by BOERNER, S. A, TOURNE, M. E, KAUFMANN, S. H, BIBLE, K. C

“…Flavopiridol is the first potent inhibitor of cyclin-dependent kinases (CDKs) to enter clinical trials. Little is known about mechanisms of resistance to this…”
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Cyclosporine A alleviates severe anaemia associated with refractory large granular lymphocytic leukaemia and chronic natural killer cell lymphocytosis by Bible, K C, Tefferi, A

“…Large granular lymphocytic (LGL) leukaemia and chronic natural killer cell lymphocytosis (CNKL) are chronic indolent disorders often associated with…”
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Characterization of an Ovarian Carcinoma Cell Line Resistant to Cisplatin and Flavopiridol by Keith C. Bible, Scott A. Boerner, Kathryn Kirkland, Kari L. Anderl, Duane Bartelt, Jr, Phyllis A. Svingen, Timothy J. Kottke, Yean K. Lee, Steven Eckdahl, Paul G. Stalboerger, Robert B. Jenkins, Scott H. Kaufmann

“…Flavopiridol, the first inhibitor of cyclin-dependent kinases to enter clinical trials, has shown promising antineoplastic activity and is currently undergoing…”
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Antitumor Activity of VB-111, a Novel Antiangiogenic Virotherapeutic, in Thyroid Cancer Xenograft Mouse Models by Reddi, H V, Madde, P, Cohen, Y C, Bangio, L, Breitbart, E, Harats, D, Bible, K C, Eberhardt, N L

“…VB-111 is an engineered antiangiogenic adenovirus that expresses Fas-c in angiogenic blood vessels and has previously been shown to have significant antitumor…”
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The HER tyrosine kinase inhibitor CI1033 enhances cytotoxicity of 7-ethyl-10-hydroxycamptothecin and topotecan by inhibiting breast cancer resistance protein-mediated drug efflux by ERLICHMAN, Charles, BOERNER, Scott A, KAUFMANN, Scott H, HALLGREN, Christopher G, SPIEKER, Rebecca, WANG, Xiao-Yang, JAMES, C. David, SCHEFFER, George L, MALIEPAARD, Marc, ROSS, Douglas D, BIBLE, Keith C

“…Because the activities of HER family members are elevated and/or aberrant in a variety of human neoplasms, these cell surface receptors are receiving…”
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Acyl Tunichlorins: A New Class of Nickel Chlorins Isolated from the Caribbean Tunicate Trididemnum solidum by Sings, Heather L., Bible, Keith C., Rinehart, Kenneth L.

“…A new class of nickel-containing chlorins (acyl tunichlorins) has been isolated from the Caribbean tunicate Trididemnum solidum. The structures of 28 of these…”
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Лечение токсических побочных эффектов у пациентов с распространенным медуллярным раком щитовидной железы by Brose, M. S., Bible, K. C., Chow, L. Q. M., Gilbert, J., Grande, C., Worden, F., Haddad, R.

“…Большой прогресс в лечении распространенного медуллярного рака щитовидной железы за последние 5 лет достигнут благодаря одобрению 2 препаратов – вандетаниба и…”
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Tunichlorin: A Nickel Chlorin Isolated from the Caribbean Tunicate Trididemnum solidum by Bible, Keith C., Buytendorp, Mark, Zierath, Paul D., Rinehart, Kenneth L.

“…Tunichlorin, a blue-green pigment isolated from the Caribbean tunicate Trididemnum solidum, has been identified as nickel(II)…”
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Didemnins and Tunichlorin: Novel Natural Products from the Marine Tunicate Trididemnum solidum by Rinehart, Kenneth L, Kishore, Vimal, Bible, Keith C, Sakai, Ryuichi, Sullins, David W, Li, Kai-Ming

“…Didemnins A, B, and C, cyclic depsipeptides previously reported by our laboratory from the Caribbean tunicate Trididemnum solidum, have now been synthesized…”
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Characterization of caspase processing and activation in HL-60 cell cytosol under cell-free conditions. Nucleotide requirement and inhibitor profile by Mesner, Jr, P W, Bible, K C, Martins, L M, Kottke, T J, Srinivasula, S M, Svingen, P A, Chilcote, T J, Basi, G S, Tung, J S, Krajewski, S, Reed, J C, Alnemri, E S, Earnshaw, W C, Kaufmann, S H

“…The present studies compared caspase activation under cell-free conditions in vitro and in etoposide-treated HL-60 leukemia cells in situ. Immunoblotting…”
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Anaplastic Thyroid Cancer Patterns of Nodal Disease and Proposed Radiotherapy Target Volumes by Gao, R.W., Foote, R.L., Garces, Y., Ma, D.J., Neben-Wittich, M.A., Routman, D.M., Patel, S.H., Ko, S., McGee, L.A., Bible, K.C., Chintakuntlawar, A.V., Morris, J.C., Rivera, M., Abraha, F., Lester, S.C.

“…Radiotherapy (RT) plays an important role in locoregional control for anaplastic thyroid cancer (ATC). Due to its rarity, RT guidelines for ATC are lacking. In…”
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A One-Step Method for Protein Estimation in Biological Samples: Nitration of Tyrosine in Nitric Acid by Bible, Keith C., Boerner, Scott A., Kaufmann, Scott H.

“…A number of methods are commonly employed for the determination of protein in biological samples. Unfortunately, several compounds that are constituents of…”
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Effect of pazopanib on hair and skin hypopigmentation: A series of three patients by Sideras, K., Menefee, M. E., Burton, J. K., Ivy, S. P., Erlichman, C., Bible, K. C.

“…Abstract only…”
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Intensity-modulated radiation therapy combined with concurrent and adjuvant chemotherapy in anaplastic thyroid carcinoma: A single-institution study by Bible, K. C., Molina, J. R., Kasperbauer, J. C., Lloyd, R. V., McIver, B., Morris, J. C., Hay, I. D., Suman, V., Smallridge, R. C., Foote, R. L.

“…Abstract only…”
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