Search Results - "Bibb, Mervyn J"

Regulation of secondary metabolism in streptomycetes by Bibb, Mervyn J

“…While the biological functions of most of the secondary metabolites made by streptomycetes are not known, it is inconceivable that they do not play an adaptive…”
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Heterologous expression of natural product biosynthetic gene clusters in Streptomyces coelicolor: from genome mining to manipulation of biosynthetic pathways by Gomez-Escribano, Juan Pablo, Bibb, Mervyn J

“…Heterologous gene expression is one of the main strategies used to access the full biosynthetic potential of actinomycetes, as well as to study the metabolic…”
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Understanding and manipulating antibiotic production in actinomycetes by Bibb, Mervyn J

“…Actinomycetes are prolific producers of natural products with a wide range of biological activities. Many of the compounds that they make (and derivatives…”
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Engineering Streptomyces coelicolor for heterologous expression of secondary metabolite gene clusters by Gomez-Escribano, Juan Pablo, Bibb, Mervyn J.

“…Summary We have constructed derivatives of Streptomyces coelicolor M145 as hosts for the heterologous expression of secondary metabolite gene clusters. To…”
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Next Generation Sequencing of Actinobacteria for the Discovery of Novel Natural Products by Gomez-Escribano, Juan Pablo, Alt, Silke, Bibb, Mervyn J

“…Like many fields of the biosciences, actinomycete natural products research has been revolutionised by next-generation DNA sequencing (NGS). Hundreds of new…”
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Discovery of unique lanthionine synthetases reveals new mechanistic and evolutionary insights by Goto, Yuki, Li, Bo, Claesen, Jan, Shi, Yanxiang, Bibb, Mervyn J, van der Donk, Wilfred A

“…Lantibiotic synthetases are remarkable biocatalysts generating conformationally constrained peptides with a variety of biological activities by repeatedly…”
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antibiotic planosporicin coordinates its own production in the actinomycete Planomonospora alba by Sherwood, Emma J, Bibb, Mervyn J

“…Planosporicin is a ribosomally synthesized, posttranslationally modified peptide lantibiotic produced by the actinomycete Planomonospora alba . It contains one…”
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Biosynthesis and Regulation of Grisemycin, a New Member of the Linaridin Family of Ribosomally Synthesized Peptides Produced by Streptomyces griseus IFO 13350 by CLAESEN, Jan, BIBB, Mervyn J

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Microbisporicin gene cluster reveals unusual features of lantibiotic biosynthesis in actinomycetes by Foulston, Lucy C., Bibb, Mervyn J., Demain, Arnold L.

“…Lantibiotics are ribosomally synthesized, posttranslationally modified peptide antibiotics. The biosynthetic gene cluster for microbisporicin, a potent…”
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Genome-wide analysis of the role of GlnR in Streptomyces venezuelae provides new insights into global nitrogen regulation in actinomycetes by Pullan, Steven T, Chandra, Govind, Bibb, Mervyn J, Merrick, Mike

“…GlnR is an atypical response regulator found in actinomycetes that modulates the transcription of genes in response to changes in nitrogen availability. We…”
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A mixed community of actinomycetes produce multiple antibiotics for the fungus farming ant Acromyrmex octospinosus by Barke, Jörg, Seipke, Ryan F, Grüschow, Sabine, Heavens, Darren, Drou, Nizar, Bibb, Mervyn J, Goss, Rebecca J M, Yu, Douglas W, Hutchings, Matthew I

“…Attine ants live in an intensely studied tripartite mutualism with the fungus Leucoagaricus gongylophorus, which provides food to the ants, and with…”
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Phage p1-derived artificial chromosomes facilitate heterologous expression of the FK506 gene cluster by Jones, Adam C, Gust, Bertolt, Kulik, Andreas, Heide, Lutz, Buttner, Mark J, Bibb, Mervyn J

“…We describe a procedure for the conjugative transfer of phage P1-derived Artificial Chromosome (PAC) library clones containing large natural product gene…”
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Cloning and Analysis of the Planosporicin Lantibiotic Biosynthetic Gene Cluster of Planomonospora alba by Sherwood, Emma J, Hesketh, Andrew R, Bibb, Mervyn J

“…The increasing prevalence of antibiotic resistance in bacterial pathogens has renewed focus on natural products with antimicrobial properties. Lantibiotics are…”
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system for the targeted amplification of bacterial gene clusters multiplies antibiotic yield in Streptomyces coelicolor by Murakami, Takeshi, Burian, Jan, Yanai, Koji, Bibb, Mervyn J, Thompson, Charles J

“…Gene clusters found in bacterial species classified as Streptomyces encode the majority of known antibiotics as well as many pharmaceutically active compounds…”
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Biosynthesis of the tunicamycin antibiotics proceeds via unique exo-glycal intermediates by Wyszynski, Filip J., Lee, Seung Seo, Yabe, Tomoaki, Wang, Hua, Gomez-Escribano, Juan Pablo, Bibb, Mervyn J., Lee, Soo Jae, Davies, Gideon J., Davis, Benjamin G.

“…The tunicamycins are archetypal nucleoside antibiotics targeting bacterial peptidoglycan biosynthesis and eukaryotic protein N -glycosylation. Understanding…”
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Synthetic RNA Silencing of Actinorhodin Biosynthesis in Streptomyces coelicolor A3(2) by Uguru, Gabriel C, Mondhe, Madhav, Goh, Shan, Hesketh, Andrew, Bibb, Mervyn J, Good, Liam, Stach, James E M

“…We demonstrate the first application of synthetic RNA gene silencers in Streptomyces coelicolor A3(2). Peptide nucleic acid and expressed antisense RNA…”
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Abyssomicin Biosynthesis: Formation of an Unusual Polyketide, Antibiotic-Feeding Studies and Genetic Analysis by Gottardi, Elvira M., Krawczyk, Joanna M., von Suchodoletz, Hanna, Schadt, Simone, Mühlenweg, Agnes, Uguru, Gabriel C., Pelzer, Stefan, Fiedler, Hans-Peter, Bibb, Mervyn J., Stach, James E. M., Süssmuth, Roderich D.

“…Small wonder: Atrop‐abyssomicin C is a small, yet complex spirotetronate (see scheme) that is active against Gram‐positive bacteria, such as MRSA. Feeding…”
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Manipulating and understanding antibiotic production in Streptomyces coelicolor A3(2) with decoy oligonucleotides by McArthur, Michael, Bibb, Mervyn J

“…We have adapted and extended the decoy oligonucleotide technique for use in prokaryotes. To identify cis-acting regulatory elements within a promoter, we…”
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Draft Genome Sequence of Streptomyces Strain S4, a Symbiont of the Leaf-Cutting Ant Acromyrmex octospinosus by SEIPKE, Ryan F, CROSSMAN, Lisa, DROU, Nizar, HEAVENS, Darren, BIBB, Mervyn J, CACCAMO, Mario, HUTCHINGS, Matthew I

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Genome Sequence of the Abyssomicin- and Proximicin-Producing Marine Actinomycete Verrucosispora maris AB-18-032 by ROH, Hanseong, UGURU, Gabriel C, STACH, James E. M, KO, Hyeok-Jin, KIM, Sujin, KIM, Byung-Yong, GOODFELLOW, Michael, BULL, Alan T, KYOUNG HEON KIM, BIBB, Mervyn J, CHOI, In-Geol

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