Serum and hair zinc levels in epileptic children taking valproic acid

Serum and hair zinc levels in epileptic children taking valproic acid

This study was performed to investigate the serum and hair zinc levels in patients epilepsy diagnoses who were intended to be put on valproic acid (VA) monotherapy and had never ingested antiepileptics before. A total of 16 patients having normal growth, development and nutrition was selected as Gro...

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Bibliographic Details
Published in:Biological trace element research Vol. 58; no. 1-2; pp. 117 - 125
Main Authors: Altunbaşak, S, Biatmakoui, F, Baytok, V, Hergüner, O, Burgut, H R, Kayrin, L
Format: Journal Article
Language:English
Published: United States Springer Nature B.V 01-07-1997
Subjects:
Adolescent
Anticonvulsants - therapeutic use
Child
Child, Preschool
Children & youth
Drug therapy
Epilepsy
Epilepsy - blood
Epilepsy - drug therapy
Epilepsy - metabolism
Female
Hair
Hair - chemistry
Humans
Infant
Male
Nutrient deficiency
Nutrition
Patients
Pharmacology
Respiratory tract
Serum
Valproic acid
Valproic Acid - therapeutic use
Zinc
Zinc - analysis
Zinc - blood
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Summary:This study was performed to investigate the serum and hair zinc levels in patients epilepsy diagnoses who were intended to be put on valproic acid (VA) monotherapy and had never ingested antiepileptics before. A total of 16 patients having normal growth, development and nutrition was selected as Group 1, and Group 2 was made up of 10 patients who had received VA monotherapy for 2 yrs or more and had normal growth, development, and nutrition characteristics. A control group (Group 3) was formed of 15 subjects who applied to the hospital for upper respiratory tract disorders. Serum and hair samples were taken for zinc assays from the Group 1 patients on the d 0, 15, 30, 45, 60, 75, and 180. Groups 2 and 3 were sampled only once, and zinc levels were determined. We found that both serum and hair zinc levels in Group 1 were higher than those of Group 2 and control group before the beginning of VA therapy, but they returned to normal during VA treatment. There was no zinc deficiency, and zinc replacement treatment may therefore be considered as unnecessary.
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ISSN:0163-4984
1559-0720
DOI:10.1007/bf02910672