Search Results - "Biasin, Valentina"

Metformin induces lipogenic differentiation in myofibroblasts to reverse lung fibrosis by Kheirollahi, Vahid, Wasnick, Roxana M., Biasin, Valentina, Vazquez-Armendariz, Ana Ivonne, Chu, Xuran, Moiseenko, Alena, Weiss, Astrid, Wilhelm, Jochen, Zhang, Jin-San, Kwapiszewska, Grazyna, Herold, Susanne, Schermuly, Ralph T., Mari, Bernard, Li, Xiaokun, Seeger, Werner, Günther, Andreas, Bellusci, Saverio, El Agha, Elie

“…Idiopathic pulmonary fibrosis (IPF) is a fatal disease in which the intricate alveolar network of the lung is progressively replaced by fibrotic scars…”
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Human RECQ1 promotes restart of replication forks reversed by DNA topoisomerase I inhibition by Berti, Matteo, Ray Chaudhuri, Arnab, Thangavel, Saravanabhavan, Gomathinayagam, Shivasankari, Kenig, Sasa, Vujanovic, Marko, Odreman, Federico, Glatter, Timo, Graziano, Simona, Mendoza-Maldonado, Ramiro, Marino, Francesca, Lucic, Bojana, Biasin, Valentina, Gstaiger, Matthias, Aebersold, Ruedi, Sidorova, Julia M, Monnat, Raymond J, Lopes, Massimo, Vindigni, Alessandro

“…The cytotoxic effects of topoisomerase I inhibitors such as camptothecin can be modulated by replication fork reversal, in a process that requires…”
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Ectodomain shedding of CD99 within highly conserved regions is mediated by the metalloprotease meprin β and promotes transendothelial cell migration by Bedau, Tillmann, Peters, Florian, Prox, Johannes, Arnold, Philipp, Schmidt, Frederike, Finkernagel, Malin, Köllmann, Sandra, Wichert, Rielana, Otte, Anna, Ohler, Anke, Stirnberg, Marit, Lucius, Ralph, Koudelka, Tomas, Tholey, Andreas, Biasin, Valentina, Pietrzik, Claus U., Kwapiszewska, Grazyna, Becker-Pauly, Christoph

“…ABSTRACT The adhesion molecule CD99 is essential for the transendothelial migration of leukocytes. In this study, we used biochemical and cellular assays to…”
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CDK4/6 inhibition enhances pulmonary inflammatory infiltration in bleomycin-induced lung fibrosis by Birnhuber, Anna, Egemnazarov, Bakytbek, Biasin, Valentina, Bonyadi Rad, Ehsan, Wygrecka, Malgorzata, Olschewski, Horst, Kwapiszewska, Grazyna, Marsh, Leigh M

“…Inhibitors of cyclin-dependent kinases 4/6 (CDK4/6) block cell cycle progression and are commonly used for treatment of several forms of cancer. Due to their…”
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Fra2 Overexpression in Mice Leads to Non-allergic Asthma Development in an IL-13 Dependent Manner by Gungl, Anna, Biasin, Valentina, Wilhelm, Jochen, Olschewski, Andrea, Kwapiszewska, Grazyna, Marsh, Leigh M

“…Asthma is a complex chronic inflammatory disease characterised by airway inflammation, remodelling and hyperresponsiveness (AHR). Members of the AP-1…”
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Machine Learning Analysis of the Bleomycin Mouse Model Reveals the Compartmental and Temporal Inflammatory Pulmonary Fingerprint by Bordag, Natalie, Biasin, Valentina, Schnoegl, Diana, Valzano, Francesco, Jandl, Katharina, Nagy, Bence M., Sharma, Neha, Wygrecka, Malgorzata, Kwapiszewska, Grazyna, Marsh, Leigh M.

“…The bleomycin mouse model is the extensively used model to study pulmonary fibrosis; however, the inflammatory cell kinetics and their compartmentalization is…”
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Pirfenidone exacerbates Th2-driven vasculopathy in a mouse model of systemic sclerosis-associated interstitial lung disease by Birnhuber, Anna, Jandl, Katharina, Biasin, Valentina, Fließer, Elisabeth, Valzano, Francesco, Marsh, Leigh M., Krolczik, Christina, Olschewski, Andrea, Wilhelm, Jochen, Toller, Wolfgang, Heinemann, Akos, Olschewski, Horst, Wygrecka, Malgorzata, Kwapiszewska, Grazyna

“…Background Systemic sclerosis (SSc) is an autoimmune disease characterised by severe vasculopathy and fibrosis of various organs including the lung. Targeted…”
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IL-1 receptor blockade skews inflammation towards Th2 in a mouse model of systemic sclerosis by Birnhuber, Anna, Crnkovic, Slaven, Biasin, Valentina, Marsh, Leigh M, Odler, Balazs, Sahu-Osen, Anita, Stacher-Priehse, Elvira, Brcic, Luka, Schneider, Frank, Cikes, Nada, Ghanim, Bahil, Klepetko, Walter, Graninger, Winfried, Allanore, Yannick, Eferl, Robert, Olschewski, Andrea, Olschewski, Horst, Kwapiszewska, Grazyna

“…The interleukin (IL)-1 family of cytokines is strongly associated with systemic sclerosis (SSc) and pulmonary involvement, but the molecular mechanisms are…”
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Meprin β, a novel mediator of vascular remodelling underlying pulmonary hypertension by Biasin, Valentina, Marsh, Leigh M, Egemnazarov, Bakytbek, Wilhelm, Jochen, Ghanim, Bahil, Klepetko, Walter, Wygrecka, Malgorzata, Olschewski, Horst, Eferl, Robert, Olschewski, Andrea, Kwapiszewska, Grazyna

“…Vascular remodelling is a hallmark of pulmonary hypertension (PH) and is characterized by enhanced proliferation of pulmonary artery smooth muscle cells…”
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Endothelin-1 driven proliferation of pulmonary arterial smooth muscle cells is c-fos dependent by Biasin, Valentina, Chwalek, Karolina, Wilhelm, Jochen, Best, Johannes, Marsh, Leigh M., Ghanim, Bahil, Klepetko, Walter, Fink, Ludger, Schermuly, Ralph T., Weissmann, Norbert, Olschewski, Andrea, Kwapiszewska, Grazyna

“…Pulmonary hypertension (PH) is characterized by enhanced pulmonary artery smooth muscle cell (PASMC) proliferation leading to vascular remodeling. Although,…”
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Docking of Meprin α to Heparan Sulphate Protects the Endothelium from Inflammatory Cell Extravasation by Biasin, Valentina, Wygrecka, Malgorzata, Bärnthaler, Thomas, Jandl, Katharina, Jain, Pritesh P, Bálint, Zoltán, Kovacs, Gabor, Leitinger, Gerd, Kolb-Lenz, Dagmar, Kornmueller, Karin, Peters, Florian, Sinn, Katharina, Klepetko, Walter, Heinemann, Akos, Olschewski, Andrea, Becker-Pauly, Christoph, Kwapiszewska, Grazyna

“…Pulmonary arterial hypertension (PAH) is a rare disease characterized by increased pulmonary pressure and vascular remodelling as a consequence of smooth…”
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Pirfenidone exacerbates Th2-driven vasculopathy in a mouse model of SSc-ILD by Birnhuber, Anna, Jandl, Katharina, Biasin, Valentina, Fließer, Elisabeth, Valzano, Francesco, Marsh, Leigh M, Krolczik, Christina, Olschewski, Andrea, Wilhelm, Jochen, Toller, Wolfgang, Heinemann, Akos, Olschewski, Horst, Wygrecka, Malgorzata, Kwapiszewska, Grazyna

“…Systemic sclerosis (SSc) is an autoimmune disease characterised by severe vasculopathy and fibrosis of various organs including the lung. Targeted treatment…”
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Meprin [beta], a novel mediator of vascular remodelling underlying pulmonary hypertension by Biasin, Valentina, Marsh, Leigh M, Egemnazarov, Bakytbek, Wilhelm, Jochen, Ghanim, Bahil, Klepetko, Walter, Wygrecka, Malgorzata, Olschewski, Horst, Eferl, Robert, Olschewski, Andrea, Kwapiszewska, Grazyna

“…Vascular remodelling is a hallmark of pulmonary hypertension (PH) and is characterized by enhanced proliferation of pulmonary artery smooth muscle cells…”
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