Search Results - "Bianchi, B R"

Pharmacological characterization of recombinant human and rat P2X receptor subtypes by Bianchi, Bruce R, Lynch, Kevin J, Touma, Edward, Niforatos, Wende, Burgard, Edward C, Alexander, Karen M, Park, Helen S, Yu, Haixia, Metzger, Randy, Kowaluk, Elizabeth, Jarvis, Michael F, van Biesen, Tim

“…ATP functions as a fast neurotransmitter through the specific activation of a family of ligand-gated ion channels termed P2X receptors. In this report, six…”
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Novel CCK analogues and bombesin: a detailed analysis between phosphoinositide breakdown and high-dose inhibition of pancreatic enzyme secretion in three rodent species by Bianchi, B R, Miller, T R, Witte, D G, Lin, C W

“…Cholecystokinin octapeptide (26-33) (CCK-8) stimulates pancreatic amylase secretion in a biphasic manner. Amylase secretion is stimulated in a dose-dependent…”
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Characterization of cloned human dopamine D1 receptor-mediated calcium release in 293 cells by Lin, C W, Miller, T R, Witte, D G, Bianchi, B R, Stashko, M, Manelli, A M, Frail, D E

“…Dopamine (DA) D1 receptors are generally known to couple only to Gs and cAMP production. Recently, D1 receptors expressed in mouse Ltk- cells have been shown…”
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Pharmacological and mechanistic studies of cholecystokinin-facilitated [3H]dopamine efflux from rat nucleus accumbens by Vickroy, T W, Bianchi, B R

“…Cholecystokinin (CCK) is co-localized with dopamine (DA) in mesolimbic neurons of the CNS and appears to selectively regulate the output of this system. In an…”
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Characterization of two novel cholecystokinin tetrapeptide (30-33) analogues, A-71623 and A-70874, that exhibit high potency and selectivity for cholecystokinin-A receptors by Lin, C W, Shiosaki, K, Miller, T R, Witte, D G, Bianchi, B R, Wolfram, C A, Kopecka, H, Craig, R, Wagenaar, F, Nadzan, A M

“…Based on their relative affinities for cholecystokinin octapeptide (26-33) (CCK-8), cholecystokinin tetrapeptide (30-33) (CCK-4), desulfated CCK-8, and…”
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Cholecystokinin receptors: relationships among phosphoinositide breakdown, amylase release and receptor affinity in pancreas by Lin, C W, Bianchi, B R, Grant, D, Miller, T, Danaher, E A, Tufano, M D, Kopecka, H, Nadzan, A M

“…The gut hormone cholecystokinin (CCK) octapeptide stimulates the release of amylase from exocrine pancreas, a process believed to be the result of the…”
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Boc-CCK-4 derivatives containing side-chain ureas as potent and selective CCK-A receptor agonists by Shiosaki, Kazumi, Lin, Chun Wel, Kopecka, Hana, Tufano, Michael D, Bianchi, Bruce R, Miller, Thomas R, Witte, David G, Nadzan, Alex M

“…Novel Boc-CCK-4 derivatives were communicated recently as having high potency and selectivity for the CCK-A receptor (Shiosaki et al. J. Med. Chem. 1990, 33,…”
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A71378: a CCK agonist with high potency and selectivity for CCK-A receptors by Lin, C W, Holladay, M W, Witte, D G, Miller, T R, Wolfram, C A, Bianchi, B R, Bennett, M J, Nadzan, A M

“…Receptors for the brain and gut peptide cholecystokinin (CCK) have been classified into two classes, CCK-A and CCK-B. To date, peptide analogues with…”
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Tetrapeptide CCK-A Agonists: Effect of Backbone N-Methylations on in vitro and in vivo CCK Activity by Holladay, Mark W, Kopecka, Hana, Miller, Thomas R, Bednarz, Lisa, Nikkel, A. L, Bianchi, Bruce R, Witte, David G, Shiosaki, Kazumi, Lin, Chun Wel

“…N-Methylation of backbone amide bonds was conducted on a tetrapeptide that had been identified previously (Shiosaki, K.; et al. J. Med. Chem. 1991, 34,…”
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Evidence that type A CCK receptors facilitate dopamine efflux in rat brain by Vickroy, T W, Bianchi, B R, Kerwin, Jr, J F, Kopecka, H, Nadzan, A M

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Development of potent and selective CCK-A receptor agonists from Boc-CCK-4: tetrapeptides containing Lys(N.epsilon.)-amide residues by Shiosaki, Kazumi, Lin, Chun Wel, Kopecka, Hana, Craig, Richard A, Bianchi, Bruce R, Miller, Thomas R, Witte, David G, Stashko, Michael, Nadzan, Alex M

“…A series of Boc-CCK-4 derivatives represented by the general structure Boc-Trp-Lys(N epsilon-COR)-Asp-Phe-NH2, where R is an aromatic, heterocyclic, or…”
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CCK-A-Selective Tetrapeptides Containing Lys(N.epsilon.)-Amide Residues: Favorable in vivo and in vitro Effects of N-Methylation at the Aspartyl Residue by Bennett, Michael J, Nikkel, A. L, Bianchi, Bruce R, Miller, Thomas R, Bednarz, Lisa, Witte, David G, Stashko, Michael, Wang, Song Shung, Gore, Paul A

“…Previous structure-activity studies on a series of CCK-A selective tetrapeptide agonists, typified by A-71623 (Boc-Trp-Lys(CONH-Ph-o-Me)-Asp-(N-Me)Phe-NH2),…”
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Differential sensitivity of hypothalamic norepinephrine and striatal dopamine to catecholamine-depleting agents by Takimoto, G S, Stittsworth, Jr, J D, Bianchi, B R, Stephens, J K

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Persistent activation of the dopamine D1 receptor contributes to prolonged receptor desensitization: studies with A-77636 by Lin, C W, Bianchi, B R, Miller, T R, Stashko, M A, Wang, S S, Curzon, P, Bednarz, L, Asin, K E, Britton, D R

“…A-77636 is a dopamine (DA) D1 receptor-selective agonist that was previously shown to elicit beneficial responses in animal models of Parkinson's disease (PD)…”
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Both CCK-A and CCK-B/gastrin receptors mediate pepsinogen release in guinea pig gastric glands by Lin, C W, Bianchi, B R, Miller, T R, Witte, D G, Wolfram, C A

“…We evaluated the affinity of cholecystokinin octapeptide (CCK-8), gastrin, and subtype-selective CCK agonists for CCK/gastrin receptors and compared it with…”
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Human astrocytoma U138MG cells express predominantly type-A endothelin receptor by Wu-Wong, Jinshyun R, Chiou, William, Magnuson, Scott R, Bianchi, Bruce R, Lin, Chun Wel

“…Endothelin-1 (ET-1) binding to human astrocytoma U138MG cells was time-dependent, and bound [125I]ET-1 was difficult to dissociate. The Bmax and Kd values of…”
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Peripheral cholecystokinin type A receptors mediate oxytocin secretion in vivo by Miller, T R, Bianchi, B R, Witte, D G, Lin, C W

“…Cholecystokinin-octapeptide (CCK8) administered intraperitoneally (i.p.) in rats induces a rapid elevation in serum oxytocin (OT). The receptor subtype…”
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Novel Asp32-Replacement Tetrapeptide Analogs as Potent and Selective CCK-A Agonists by Elliott, Richard L, Kopecka, Hana, Tufano, Michael D, Shue, Youe-Kong, Gauri, Andre J, Lin, Chun-Wel, Bianchi, Bruce R, Miller, Thomas R, Witte, David G

“…A series of novel CCK tetrapeptide analogues of the general formula Boc-Trp-Lys(Tac)-N(R)-(CH2)nCON(R')Phe-NH2 (Tac = o-tolylaminocarbonyl), where R,R' = H or…”
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Species comparison and pharmacological characterization of human, monkey, rat, and mouse TRPA1 channels by Bianchi, Bruce R, Zhang, Xu-Feng, Reilly, Regina M, Kym, Philip R, Yao, Betty B, Chen, Jun

“…The transient receptor potential ankyrin-1 (TRPA1) channel has emerged as an attractive target for development of analgesic and anti-inflammatory drugs…”
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Tetrapeptide CCK agonists: structure-activity studies on modifications at the N-terminus by Elliott, Richard L, Kopecka, Hana, Bennett, Michael J, Shue, Youe Kong, Craig, Richard, Lin, Chun Wel, Bianchi, Bruce R, Miller, Thomas R, Witte, David G

“…We had reported earlier on a novel series of potent and selective tetrapeptide cholecystokinin-A (CCK-A) agonists of the general structure…”
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