Search Results - "Bianca Marmontel de Souza"
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The rs2304256 Polymorphism in TYK2 Gene Is Associated with Protection for Type 1 Diabetes Mellitus
Published in Diabetes & metabolism journal (30-11-2021)“…Background: Tyrosine kinase 2 (TYK2) is a candidate gene for type 1 diabetes mellitus (T1DM) since it plays an important role in regulating apoptotic and…”
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Association of TYK2 polymorphisms with autoimmune diseases: A comprehensive and updated systematic review with meta-analysis
Published in Genetics and molecular biology (01-01-2021)“…Autoimmune diseases are characterized by the loss of self-tolerance, leading to immune-mediated tissue destruction and chronic inflammation. Tyrosine kinase 2…”
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Polymorphisms of the UCP2 Gene Are Associated with Glomerular Filtration Rate in Type 2 Diabetic Patients and with Decreased UCP2 Gene Expression in Human Kidney
Published in PloS one (28-07-2015)“…Uncoupling protein 2 (UCP2) reduces production of reactive oxygen species (ROS) by mitochondria. ROS overproduction is one of the major contributors to the…”
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The rs2304256 Polymorphism in TYK2 Gene Is Associated with Protection for Type 1 Diabetes Mellitus
Published in Diabetes & metabolism journal (01-11-2021)“…Tyrosine kinase 2 (TYK2) is a candidate gene for type 1 diabetes mellitus (T1DM) since it plays an important role in regulating apoptotic and pro-inflammatory…”
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Mining the transcriptome of target tissues of autoimmune and degenerative pancreatic β-cell and brain diseases to discover therapies
Published in iScience (18-11-2022)“…Target tissues of autoimmune and degenerative diseases show signals of inflammation. We used publicly available RNA-seq data to study whether pancreatic…”
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866G/A and Ins/Del polymorphisms in the UCP2 gene and diabetic kidney disease: case-control study and meta-analysis
Published in Genetics and molecular biology (01-01-2020)“…Uncoupling protein 2 (UCP2) decreases reactive oxygen species (ROS). ROS overproduction is a key contributor to the pathogenesis of diabetic kidney disease…”
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Interferons are key cytokines acting on pancreatic islets in type 1 diabetes
Published in Diabetologia (01-05-2024)“…Aims/hypothesis The proinflammatory cytokines IFN-α, IFN-γ, IL-1β and TNF-α may contribute to innate and adaptive immune responses during insulitis in type 1…”
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The association of uncoupling proteins 1, 2, and 3 with weight loss variability after bariatric surgery: a systematic review
Published in Surgery for obesity and related diseases (01-11-2020)“…Bariatric surgery is currently the most effective treatment for patients with severe obesity. Uncoupling proteins (UCP) 1, 2, and 3 play key roles in the…”
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Blueberry Consumption and Changes in Obesity and Diabetes Mellitus Outcomes: A Systematic Review
Published in Metabolites (22-12-2022)“…Low-grade inflammation and oxidative stress are key mechanisms involved in obesity and related disorders. Polyphenols from blueberry (BB) and bilberries (BiB)…”
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MiR-30e-5p and MiR-15a-5p Expressions in Plasma and Urine of Type 1 Diabetic Patients With Diabetic Kidney Disease
Published in Frontiers in genetics (12-06-2019)“…Diabetic kidney disease (DKD) is a common microvascular complication that affects 40% of patients with diabetes mellitus (DM). Emerging evidence suggests a…”
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The A allele of the UCP2 -866G/A polymorphism changes UCP2 promoter activity in HUVECs treated with high glucose
Published in Molecular biology reports (01-10-2019)“…The mitochondrial uncoupling protein 2 (UCP2) decreases reactive oxygen species (ROS) formation by mitochondria. Our group previously showed that the UCP2…”
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The role of uncoupling protein 2 (UCP2) on the development of type 2 diabetes mellitus and its chronic complications
Published in Arquivos brasileiros de endocrinologia e metabologia (01-06-2011)“…It is well established that genetic factors play an important role in the development of type 2 diabetes mellitus (DM2) and its chronic complications, and that…”
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The rs2304256 Polymorphism in Gene Is Associated with Protection for Type 1 Diabetes Mellitus
Published in Diabetes & metabolism journal (01-11-2021)“…Background Tyrosine kinase 2 (TYK2) is a candidate gene for type 1 diabetes mellitus (T1DM) since it plays an important role in regulating apoptotic and…”
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Effect of co-culture of mesenchymal stem/stromal cells with pancreatic islets on viability and function outcomes: a systematic review and meta-analysis
Published in Islets (04-03-2017)“…The maintenance of viable and functional pancreatic islets is crucial for successful islet transplantation from brain-dead donors. To overcome islet quality…”
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Comparison of two techniques for evaluation of pancreatic islet viability: flow cytometry and FDA/PI staining
Published in Clinical and Biomedical Research (01-12-2021)“…Introduction: The success of islet transplantation for patients with unstable type 1 diabetes mellitus is dependent, in part, on the number of isolated islets…”
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Association of the UCP polymorphisms with susceptibility to obesity: case–control study and meta-analysis
Published in Molecular biology reports (01-08-2014)“…This paper describes a case–control study and a meta-analysis performed to evaluate if the following polymorphisms are associated with presence of obesity:…”
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A functional genomic approach to identify reference genes for human pancreatic beta cell real-time quantitative RT-PCR analysis
Published in Islets (04-07-2021)“…Exposure of human pancreatic beta cells to pro-inflammatory cytokines or metabolic stressors is used to model events related to type 1 and type 2 diabetes,…”
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866G/A and Ins/Del polymorphisms in the UCP2 gene and diabetic kidney disease: case-control study and meta-analysis
Published in Genetics and molecular biology (2020)“…Abstract Uncoupling protein 2 (UCP2) decreases reactive oxygen species (ROS). ROS overproduction is a key contributor to the pathogenesis of diabetic kidney…”
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Erratum to: Association of the UCP polymorphisms with susceptibility to obesity: case–control study and meta-analysis
Published in Molecular biology reports (01-09-2014)Get full text
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