Search Results - "Bialkowska, Agnieszka B."

Krüppel-like factors in mammalian stem cells and development by Bialkowska, Agnieszka B, Yang, Vincent W, Mallipattu, Sandeep K

“…Krüppel-like factors (KLFs) are a family of zinc-finger transcription factors that are found in many species. Recent studies have shown that KLFs play a…”
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Krüppel-like Factor 5, Increased in Pancreatic Ductal Adenocarcinoma, Promotes Proliferation, Acinar-to-Ductal Metaplasia, Pancreatic Intraepithelial Neoplasia, and Tumor Growth in Mice by He, Ping, Yang, Jong Won, Yang, Vincent W., Bialkowska, Agnieszka B.

“…Activating mutations in KRAS are detected in most pancreatic ductal adenocarcinomas (PDACs). Expression of an activated form of KRAS (KrasG12D) in pancreata of…”
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SP and KLF Transcription Factors in Digestive Physiology and Diseases by Kim, Chang-Kyung, He, Ping, Bialkowska, Agnieszka B, Yang, Vincent W

“…Specificity proteins (SPs) and Krüppel-like factors (KLFs) belong to the family of transcription factors that contain conserved zinc finger domains involved in…”
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KLF5 Is Induced by FOXO1 and Causes Oxidative Stress and Diabetic Cardiomyopathy by Kyriazis, Ioannis D., Hoffman, Matthew, Gaignebet, Lea, Lucchese, Anna Maria, Markopoulou, Eftychia, Palioura, Dimitra, Wang, Chao, Bannister, Thomas D., Christofidou-Solomidou, Melpo, Oka, Shin-ichi, Sadoshima, Junichi, Koch, Walter J., Goldberg, Ira J., Yang, Vincent W., Bialkowska, Agnieszka B., Kararigas, Georgios, Drosatos, Konstantinos

“…Diabetic cardiomyopathy (DbCM) is a major complication in type-1 diabetes, accompanied by altered cardiac energetics, impaired mitochondrial function, and…”
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SP and KLF Transcription Factors in Cancer Metabolism by Orzechowska-Licari, Emilia J., LaComb, Joseph F., Mojumdar, Aisharja, Bialkowska, Agnieszka B.

“…Tumor development and progression depend on reprogramming of signaling pathways that regulate cell metabolism. Alterations to various metabolic pathways such…”
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The Role of MicroRNAs in Pancreatitis Development and Progression by Patel, Hetvi R, Diaz Almanzar, Vanessa M, LaComb, Joseph F, Ju, Jingfang, Bialkowska, Agnieszka B

“…Pancreatitis (acute and chronic) is an inflammatory disease associated with significant morbidity, including a high rate of hospitalization and mortality…”
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The Role of Krüppel-like Factors in Pancreatic Physiology and Pathophysiology by Giarrizzo, Michael, LaComb, Joseph F, Bialkowska, Agnieszka B

“…Krüppel-like factors (KLFs) belong to the family of transcription factors with three highly conserved zinc finger domains in the C-terminus. They regulate…”
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Computational immunohistochemical mapping adds immune context to histological phenotypes in mouse models of colitis by Kobayashi, Soma, Sullivan, Christopher, Bialkowska, Agnieszka B., Saltz, Joel H., Yang, Vincent W.

“…Inflammatory bowel disease (IBD) is characterized by chronic, dysregulated inflammation in the gastrointestinal tract. The heterogeneity of IBD is reflected…”
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AUM302, a novel triple kinase PIM/PI3K/mTOR inhibitor, is a potent in vitro pancreatic cancer growth inhibitor by Ingle, Komala, LaComb, Joseph F, Graves, Lee M, Baines, Antonio T, Bialkowska, Agnieszka B

“…Pancreatic cancer is one of the leading causes of cancer deaths, with pancreatic ductal adenocarcinoma (PDAC) being the most common subtype. Advanced stage…”
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Murine Model for Colitis-Associated Cancer of the Colon by Snider, Ashley J, Bialkowska, Agnieszka B, Ghaleb, Amr M, Yang, Vincent W, Obeid, Lina M, Hannun, Yusuf A

“…Inflammatory bowel disease (IBD), including ulcerative colitis (UC) and Crohn's disease (CD), significantly increases the risk for development of colorectal…”
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Oncogenic KRAS Reduces Expression of FGF21 in Acinar Cells to Promote Pancreatic Tumorigenesis in Mice on a High-Fat Diet by Luo, Yongde, Yang, Yaying, Liu, Muyun, Wang, Dan, Wang, Feng, Bi, Yawei, Ji, Juntao, Li, Suyun, Liu, Yan, Chen, Rong, Huang, Haojie, Wang, Xiaojie, Swidnicka-Siergiejko, Agnieszka K., Janowitz, Tobias, Beyaz, Semir, Wang, Guoqiang, Xu, Sulan, Bialkowska, Agnieszka B., Luo, Catherine K., Pin, Christoph L., Liang, Guang, Lu, Xiongbin, Wu, Maoxin, Shroyer, Kenneth R., Wolff, Robert A., Plunkett, William, Ji, Baoan, Li, Zhaoshen, Li, Ellen, Li, Xiaokun, Yang, Vincent W., Logsdon, Craig D., Abbruzzese, James L., Lu, Weiqin

“…Obesity is a risk factor for pancreatic cancer. In mice, a high-fat diet (HFD) and expression of oncogenic KRAS lead to development of invasive pancreatic…”
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Activin A signaling stimulates neutrophil activation and macrophage migration in pancreatitis by Wiley, Mark B., Bauer, Jessica, Alvarez, Valentina, Mehrotra, Kunaal, Cheng, Wenxuan, Kolics, Zoe, Giarrizzo, Michael, Ingle, Komala, Bialkowska, Agnieszka B., Jung, Barbara

“…Acute Pancreatitis (AP) is associated with high mortality and current treatment options are limited to supportive care. We found that blockade of activin A…”
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Interplay among p21Waf1/Cip1, MUSASHI-1 and Krüppel-like factor 4 in activation of Bmi1-CreER reserve intestinal stem cells after gamma radiation-induced injury by Orzechowska, Emilia J., Katano, Takahito, Bialkowska, Agnieszka B., Yang, Vincent W.

“…Gamma radiation is a commonly used adjuvant treatment for abdominally localized cancer. Since its therapeutic potential is limited due to gastrointestinal (GI)…”
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5-FU-miR-15a Inhibits Activation of Pancreatic Stellate Cells by Reducing YAP1 and BCL-2 Levels In Vitro by Almanzar, Vanessa M Diaz, Shah, Kunal, LaComb, Joseph F, Mojumdar, Aisharja, Patel, Hetvi R, Cheung, Jacky, Tang, Meiyi, Ju, Jingfang, Bialkowska, Agnieszka B

“…Chronic pancreatitis is characterized by chronic inflammation and fibrosis, processes heightened by activated pancreatic stellate cells (PSCs). Recent…”
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Deep learning-based approach to the characterization and quantification of histopathology in mouse models of colitis by Kobayashi, Soma, Shieh, Jason, Ruiz de Sabando, Ainara, Kim, Julie, Liu, Yang, Zee, Sui Y, Prasanna, Prateek, Bialkowska, Agnieszka B, Saltz, Joel H, Yang, Vincent W

“…Inflammatory bowel disease (IBD) is a chronic immune-mediated disease of the gastrointestinal tract. While therapies exist, response can be limited within the…”
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Krüppel-Like Factor 15 Mediates Glucocorticoid-Induced Restoration of Podocyte Differentiation Markers by Mallipattu, Sandeep K, Guo, Yiqing, Revelo, Monica P, Roa-Peña, Lucia, Miller, Timothy, Ling, Jason, Shankland, Stuart J, Bialkowska, Agnieszka B, Ly, Victoria, Estrada, Chelsea, Jain, Mukesh K, Lu, Yuan, Ma'ayan, Avi, Mehrotra, Anita, Yacoub, Rabi, Nord, Edward P, Woroniecki, Robert P, Yang, Vincent W, He, John C

“…Podocyte injury is the inciting event in primary glomerulopathies, such as minimal change disease and primary FSGS, and glucocorticoids remain the initial and…”
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Acute postoperative pain and dorsal root ganglia transcriptomic signatures following total knee arthroplasty (TKA) in rats: An experimental study by Komatsu, David E, Uddin, Sardar M Z, Gordon, Chris, Kanjiya, Martha P, Bogdan, Diane, Achonu, Justice, DiBua, Adriana, Iftikhar, Hira, Ackermann, Amanda, Shah, Rohan J, Shieh, Jason, Bialkowska, Agnieszka B, Kaczocha, Martin

“…Total knee arthroplasty (TKA) is the final treatment option for patients with advanced knee osteoarthritis (OA). Unfortunately, TKA surgery is accompanied by…”
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The Role of Intestinal Stem Cells in Epithelial Regeneration Following Radiation-Induced Gut Injury by Kim, Chang-Kyung, Yang, Vincent W., Bialkowska, Agnieszka B.

“…Purpose of Review Intestinal epithelial cells show remarkable plasticity in regenerating the epithelium following radiation injury. In this review, we explore…”
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Notch Inhibits Expression of the Krüppel-Like Factor 4 Tumor Suppressor in the Intestinal Epithelium by Ghaleb, Amr M, Aggarwal, Gaurav, Bialkowska, Agnieszka B, Nandan, Mandayam O, Yang, Vincent W

“…The zinc finger-containing transcription factor, Krüppel-like factor 4 (KLF4), inhibits cell proliferation. An in vivo tumor-suppressive role for KLF4 is shown…”
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IQ Motif-Containing GTPase-Activating Protein 2 (IQGAP2) Is a Novel Regulator of Colonic Inflammation in Mice by Ghaleb, Amr M, Bialkowska, Agnieszka B, Snider, Ashley J, Gnatenko, Dmitri V, Hannun, Yusuf A, Yang, Vincent W, Schmidt, Valentina A

“…IQ motif-containing GTPase-activating protein 2 (IQGAP2) is a multidomain scaffolding protein that plays a role in cytoskeleton regulation by juxtaposing Rho…”
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