Search Results - "Bialesova, Lucia"
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NTP42, a novel antagonist of the thromboxane receptor, attenuates experimentally induced pulmonary arterial hypertension
Published in BMC pulmonary medicine (06-04-2020)“…NTP42 is a novel antagonist of the thromboxane prostanoid receptor (TP), currently in development for the treatment of pulmonary arterial hypertension (PAH)…”
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Epigenetic Regulation of PLIN1 in Obese Women and its Relation to Lipolysis
Published in Scientific reports (31-08-2017)“…Increased adipocyte lipolysis links obesity to insulin resistance. The lipid droplet coating-protein Perilipin participates in regulation of lipolysis and is…”
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The thromboxane receptor antagonist NTP42 promotes beneficial adaptation and preserves cardiac function in experimental models of right heart overload
Published in Frontiers in cardiovascular medicine (14-12-2022)“…Pulmonary arterial hypertension (PAH) is a progressive disease characterized by increased pulmonary artery pressure leading to right ventricular (RV) failure…”
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Nuclear receptors - target molecules for isoflavones in cancer chemoprevention
Published in General physiology and biophysics (01-12-2013)“…Breast cancer is the most occurring type of cancer among women. In Slovakia, there are yearly diagnosed about 1900 new cases of this disease. Breast cancer…”
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mRNA expression pattern of retinoic acid and retinoid X nuclear receptor subtypes in human thyroid papillary carcinoma
Published in Oncology reports (01-11-2013)“…Retinoids have shown potential for the inhibition of tumour growth and progression. The objective of this study was to investigate retinoic acid nuclear…”
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Efficacy of the thromboxane receptor antagonist NTP42 alone, or in combination with sildenafil, in the sugen/hypoxia-induced model of pulmonary arterial hypertension
Published in European journal of pharmacology (15-12-2020)“…NTP42 is a novel antagonist of the thromboxane A2 receptor (TP) in development for the treatment of pulmonary arterial hypertension (PAH). Recent studies…”
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Adipocyte Expression of SLC19A1 Links DNA Hypermethylation to Adipose Tissue Inflammation and Insulin Resistance
Published in The journal of clinical endocrinology and metabolism (01-02-2018)“…Abstract Context Insulin resistance (IR) is promoted by a chronic low-grade inflammation in white adipose tissue (WAT). The latter might be regulated through…”
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Agonistic/antagonistic effects of selected isoflavones in AZ-AHR cell line
Published in Toxicology letters (10-09-2014)Get full text
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Epigenetic Regulation of PLIN 1 in Obese Women and its Relation to Lipolysis
Published in Scientific reports (31-08-2017)“…Increased adipocyte lipolysis links obesity to insulin resistance. The lipid droplet coating-protein Perilipin participates in regulation of lipolysis and is…”
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Agonistic effect of selected isoflavones on arylhydrocarbon receptor in a novel AZ-AhR transgenic gene reporter human cell line
Published in General physiology and biophysics (01-07-2015)“…The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that controls the expression of a diverse set of genes. Structurally diverse…”
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Estrogen receptor β2 induces proliferation and invasiveness of triple negative breast cancer cells: association with regulation of PHD3 and HIF-1α
Published in Oncotarget (29-09-2017)“…The two estrogen receptor (ER) subtypes, ERα and ERβ, belong to the nuclear receptor superfamily. The human ERβ variant ERβ2 is proposed to be expressed at…”
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The relationship between renal cell carcinoma and nuclear retinoid/rexinoid receptors
Published in Biomedical papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia (01-12-2013)“…Renal cell carcinoma (RCC) is a urologic malignancy with a steady rise in incidence and high mortality rate. Between 60 to 70% of patients with renal cell…”
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Effects of biologically active tributyl-/triphenyl-organometal ligands of retinoid X receptors in human breast cancer cell line
Published in Toxicology letters (10-09-2014)Get full text
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Expression mRNA pattern of retinoic acid and retinoid X nuclear receptor subtypes in thyroid carcinomas
Published in Thyroid research (05-04-2013)“…Doc number: A11…”
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