Search Results - "Bi, Xukun"
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Endoplasmic Reticulum Chaperone GRP78 Protects Heart From Ischemia/Reperfusion Injury Through Akt Activation
Published in Circulation research (25-05-2018)“…Restoration of coronary artery blood flow is the most effective means of ameliorating myocardial damage triggered by ischemic heart disease. However, coronary…”
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Integrated Control of Fatty Acid Metabolism in Heart Failure
Published in Metabolites (29-04-2023)“…Disrupted fatty acid metabolism is one of the most important metabolic features in heart failure. The heart obtains energy from fatty acids via oxidation…”
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Genetic Evidence for Causal Relationships between Plasma Eicosanoid Levels and Cardiovascular Disease
Published in Metabolites (23-05-2024)“…Cardiovascular diseases are the most common causes of mortality and disability worldwide. Eicosanoids are a group of bioactive metabolites that are mainly…”
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Dendritic cell-mediated chronic low-grade inflammation is regulated by the RAGE-TLR4-PKCβ1 signaling pathway in diabetic atherosclerosis
Published in Molecular medicine (Cambridge, Mass.) (21-01-2022)“…Abstract Background The unique mechanism of diabetic atherosclerosis has been a central research focus. Previous literature has reported that the inflammatory…”
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Characterization of ferroptosis-triggered pyroptotic signaling in heart failure
Published in Signal transduction and targeted therapy (25-09-2024)“…Pressure overload–induced cardiac hypertrophy is a common cause of heart failure (HF), and emerging evidence suggests that excessive oxidized lipids have a…”
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iPLA2β Contributes to ER Stress-Induced Apoptosis during Myocardial Ischemia/Reperfusion Injury
Published in Cells (Basel, Switzerland) (09-06-2021)“…Both calcium-independent phospholipase A2 beta (iPLA2β) and endoplasmic reticulum (ER) stress regulate important pathophysiological processes including…”
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The Rho kinase inhibitor, fasudil, ameliorates diabetes-induced cardiac dysfunction by improving calcium clearance and actin remodeling
Published in Journal of molecular medicine (Berlin, Germany) (01-02-2017)“…Previous study showed inhibition of RhoA and Rho kinase (ROCK) activity with fasudil could alleviate diabetes-induced cardiac dysfunction partially due to…”
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GRP78 (Glucose-Regulated Protein of 78 kDa) Promotes Cardiomyocyte Growth Through Activation of GATA4 (GATA-Binding Protein 4)
Published in Hypertension (Dallas, Tex. 1979) (01-02-2019)“…The heart manifests hypertrophic growth in response to elevation of afterload pressure. Cardiac myocyte growth involves new protein synthesis and membrane…”
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Resveratrol prevents endothelial progenitor cells from senescence and reduces the oxidative reaction via PPAR-γ/HO-1 pathways
Published in Molecular medicine reports (01-12-2016)“…Increasing evidence suggests endothelial progenitor cells (EPCs) improve neovascularization and endothelium regeneration. Resveratrol (RSV) is a natural…”
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Glucose-regulated protein 78 is essential for cardiac myocyte survival
Published in Cell death and differentiation (01-12-2018)“…Secretory and transmembrane proteins rely on proper function of the secretory pathway for folding, posttranslational modification, assembly, and secretion…”
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Activation of liver X receptor attenuates lysophosphatidylcholine‐induced IL‐8 expression in endothelial cells via the NF‐κB pathway and SUMOylation
Published in Journal of cellular and molecular medicine (01-12-2016)“…The liver X receptor (LXR) is a cholesterol‐sensing nuclear receptor that has an established function in lipid metabolism; however, its role in inflammation is…”
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Apelin Ameliorates High Glucose-Induced Downregulation of Connexin 43 via AMPK-Dependent Pathway in Neonatal Rat Cardiomyocytes
Published in Aging and disease (01-02-2018)“…Diabetes Mellitus is a common disorder, with increasing risk of cardiac arrhythmias. Studies have shown that altered connexin expression and gap junction…”
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Identification of differentially expressed genes in the endothelial precursor cells of patients with type 2 diabetes mellitus by bioinformatics analysis
Published in Experimental and therapeutic medicine (01-01-2020)“…Type 2 diabetes mellitus (DM) is a metabolic disease with worldwide prevalence that is associated with a decrease in the number and function of endothelial…”
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GW25-e4550 Activation of Liver X receptor attenuates OxLDL-induced endothelial inflammation during atherosclerosis
Published in Journal of the American College of Cardiology (21-10-2014)“…Oxidized low-density lipoprotein induced endothelial inflammation is the initial step during pathogenesis of atherosclerosis which trigger the expression of…”
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Thymosin β4 promotes glucose-impaired endothelial progenitor cell function via Akt/endothelial nitric oxide synthesis signaling pathway
Published in Experimental and therapeutic medicine (01-10-2018)“…Circulating endothelial progenitor cells (EPCs) are a subtype of hematopoietic stem cells, which can differentiate into endothelial cells and restore…”
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Thymosin [beta]4 promotes glucose-impaired endothelial progenitor cell function via Akt/endothelial nitric oxide synthesis signaling pathway
Published in Experimental and therapeutic medicine (01-10-2018)“…Circulating endothelial progenitor cells (EPCs) are a subtype of hematopoietic stem cells, which can differentiate into endothelial cells and restore…”
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NADPH oxidase activation played a critical role in the oxidative stress process in stable coronary artery disease
Published in American journal of translational research (01-01-2016)“…The study was designed to investigate the oxidative stress levels of endothelial progenitor cells (EPCs) in stable coronary artery disease (CAD) and to explore…”
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Thymosin [beta]4 promotes endothelial progenitor cell angiogenesis via a vascular endothelial growth factor-dependent mechanism
Published in Molecular medicine reports (01-08-2018)“…Endothelial progenitor cells (EPCs) are a promising cell source for tissue repair and regeneration, predominantly through angiogenesis promotion. Paracrine…”
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Stromal cell-derived factor-1α prevents endothelial progenitor cells senescence and enhances re-endothelialization of injured arteries via human telomerase reverse transcriptase
Published in Cell biology international (01-08-2015)“…Recent studies have suggested that endothelial progenitor subpopulation (EPCs) number and activity were associated with EPCs senescence. Our previous study had…”
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