Search Results - "Bi, Mian"

Tau exacerbates excitotoxic brain damage in an animal model of stroke by Bi, Mian, Gladbach, Amadeus, van Eersel, Janet, Ittner, Arne, Przybyla, Magdalena, van Hummel, Annika, Chua, Sook Wern, van der Hoven, Julia, Lee, Wei S., Müller, Julius, Parmar, Jasneet, Jonquieres, Georg von, Stefen, Holly, Guccione, Ernesto, Fath, Thomas, Housley, Gary D., Klugmann, Matthias, Ke, Yazi D., Ittner, Lars M.

“…Neuronal excitotoxicity induced by aberrant excitation of glutamatergic receptors contributes to brain damage in stroke. Here we show that tau-deficient (tau…”
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Tau-targeted immunization impedes progression of neurofibrillary histopathology in aged P301L tau transgenic mice by Bi, Mian, Ittner, Arne, Ke, Yazi D, Götz, Jürgen, Ittner, Lars M

“…In Alzheimer's disease (AD) brains, the microtubule-associated protein tau and amyloid-β (Aβ) deposit as intracellular neurofibrillary tangles (NFTs) and…”
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Parkinsonism and impaired axonal transport in a mouse model of frontotemporal dementia by Ittner, Lars M, Fath, Thomas, Ke, Yazi D, Bi, Mian, van Eersel, Janet, Li, Kong M, Gunning, Peter, Götz, Jürgen

“…Frontotemporal dementia (FTD) is characterized by cognitive and behavioral changes and, in a significant subset of patients, Parkinsonism. Histopathologically,…”
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Short-term suppression of A315T mutant human TDP-43 expression improves functional deficits in a novel inducible transgenic mouse model of FTLD-TDP and ALS by Ke, Yazi D., van Hummel, Annika, Stevens, Claire H., Gladbach, Amadeus, Ippati, Stefania, Bi, Mian, Lee, Wei S., Krüger, Sarah, van der Hoven, Julia, Volkerling, Alexander, Bongers, Andre, Halliday, Glenda, Haass, Nikolas K., Kiernan, Matthew, Delerue, Fabien, Ittner, Lars M.

“…The nuclear transactive response DNA-binding protein 43 (TDP-43) undergoes relocalization to the cytoplasm with formation of cytoplasmic deposits in neurons in…”
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Cytoplasmic accumulation and aggregation of TDP-43 upon proteasome inhibition in cultured neurons by van Eersel, Janet, Ke, Yazi D, Gladbach, Amadeus, Bi, Mian, Götz, Jürgen, Kril, Jillian J, Ittner, Lars M

“…Amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD) are characterized by intraneuronal deposition of the nuclear TAR DNA-binding…”
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No Overt Deficits in Aged Tau-Deficient C57Bl/6.Mapttm1(EGFP)Kit GFP Knockin Mice by van Hummel, Annika, Bi, Mian, Ippati, Stefania, van der Hoven, Julia, Volkerling, Alexander, Lee, Wei S, Tan, Daniel C S, Bongers, Andre, Ittner, Arne, Ke, Yazi D, Ittner, Lars M

“…Several mouse lines with knockout of the tau-encoding MAPT gene have been reported in the past; they received recent attention due to reports that tau…”
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An unusual presentation of recurrent pneumonia by Cao, Christopher, MBBS, Bi, Mian, MBBS, Hendel, Nick, FRACS, Yan, Tristan D, Dr

“…Macroscopic pathological exam ination of the resected specimen showed a 10 mm calibre muscular vessel located along the inferior portion of the leftlower lobe,…”
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The importance of early immunotherapy in patients with faciobrachial dystonic seizures by Thompson, Julia, Bi, Mian, Murchison, Andrew G, Makuch, Mateusz, Bien, Christian G, Chu, Kon, Farooque, Pue, Gelfand, Jeffrey M, Geschwind, Michael D, Hirsch, Lawrence J, Somerville, Ernest, Lang, Bethan, Vincent, Angela, Leite, Maria I, Waters, Patrick, Irani, Sarosh R

“…Faciobrachial dystonic seizures (FBDS) are the first adult-onset autoantibody-mediated epilepsy. Thompson et al. describe 103 patients with FBDS, and show that…”
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Dendritic Function of Tau Mediates Amyloid-β Toxicity in Alzheimer's Disease Mouse Models by Ittner, Lars M., Ke, Yazi D., Delerue, Fabien, Bi, Mian, Gladbach, Amadeus, van Eersel, Janet, Wölfing, Heidrun, Chieng, Billy C., Christie, MacDonald J., Napier, Ian A., Eckert, Anne, Staufenbiel, Matthias, Hardeman, Edna, Götz, Jürgen

“…Alzheimer's disease (AD) is characterized by amyloid-β (Aβ) and tau deposition in brain. It has emerged that Aβ toxicity is tau dependent, although…”
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Site-specific phosphorylation of tau inhibits amyloid-β toxicity in Alzheimer's mice by Ittner, Arne, Chua, Sook Wern, Bertz, Josefine, Volkerling, Alexander, van der Hoven, Julia, Gladbach, Amadeus, Przybyla, Magdalena, Bi, Mian, van Hummel, Annika, Stevens, Claire H., Ippati, Stefania, Suh, Lisa S., Macmillan, Alexander, Sutherland, Greg, Kril, Julian J., Silva, Ana P. G., Mackay, Joel, Poljak, Anne, Delerue, Fabien, Ke, Yazi D., Ittner, Lars M.

“…Amyloid-β (Aβ) toxicity in Alzheimer's disease (AD) is considered to be mediated by phosphorylated tau protein. In contrast, we found that, at least in early…”
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Loss of LAMP5 interneurons drives neuronal network dysfunction in Alzheimer’s disease by Deng, Yuanyuan, Bi, Mian, Delerue, Fabien, Forrest, Shelley L., Chan, Gabriella, van der Hoven, Julia, van Hummel, Annika, Feiten, Astrid F., Lee, Seojin, Martinez-Valbuena, Ivan, Karl, Tim, Kovacs, Gabor G., Morahan, Grant, Ke, Yazi D., Ittner, Lars M.

“…In Alzheimer’s disease (AD), where amyloid-β (Aβ) and tau deposits in the brain, hyperexcitation of neuronal networks is an underlying disease mechanism, but…”
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Disinhibition-like behavior in a P301S mutant tau transgenic mouse model of frontotemporal dementia by Przybyla, Magdalena, Stevens, Claire H., van der Hoven, Julia, Harasta, Anne, Bi, Mian, Ittner, Arne, van Hummel, Annika, Hodges, John R., Piguet, Olivier, Karl, Tim, Kassiou, Michael, Housley, Gary D., Ke, Yazi D., Ittner, Lars M., van Eersel, Janet

“…•The amygdala is a major site of progressive tau pathology in P301S mutant tau-expressing TAU58/2 mice.•TAU58/2 mice present with early-onset…”
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ERK inhibition with PD184161 mitigates brain damage in a mouse model of stroke by Gladbach, Amadeus, van Eersel, Janet, Bi, Mian, Ke, Yazi D., Ittner, Lars M.

“…Ischemic stroke is a leading cause of death. It has previously been shown that blocking activation of extracellular signal-regulated kinase (ERK) with the MEK…”
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CNS cell type–specific gene profiling of P301S tau transgenic mice identifies genes dysregulated by progressive tau accumulation by Ke, Yazi D., Chan, Gabriella, Stefanoska, Kristie, Au, Carol, Bi, Mian, Müller, Julius, Przybyla, Magdalena, Feiten, Astrid, Prikas, Emmanuel, Halliday, Glenda M., Piguet, Olivier, Kiernan, Matthew C., Kassiou, Michael, Hodges, John R., Loy, Clement T., Mattick, John S., Ittner, Arne, Kril, Jillian J., Sutherland, Greg T., Ittner, Lars M.

“…The microtubule-associated protein tau undergoes aberrant modification resulting in insoluble brain deposits in various neurodegenerative diseases, including…”
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The Importance of Early Immunotherapy in patients with Faciobrachial Dystonic Seizures (P1.290) by Thompson, Julia, Bi, Mian, Makuch, Mateusz, Murchison, Andrew, Bien, Christian, Chu, Kon, Farooque, Pue, Gelfand, Jeffrey, Geschwind, Michael, Somerville, Ernest, Lang, Bethan, Vincent, Angela, Leite, M Isabel, Waters, Patrick, Irani, Sarosh

“…Abstract only…”
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Selective Spatiotemporal Vulnerability of Central Nervous System Neurons to Pathologic TAR DNA-Binding Protein 43 in Aged Transgenic Mice by van Hummel, Annika, Chan, Gabriella, van der Hoven, Julia, Morsch, Marco, Ippati, Stefania, Suh, Lisa, Bi, Mian, Asih, Prita R., Lee, Wei S., Butler, Troy A., Przybyla, Magdalena, Halliday, Glenda M., Piguet, Olivier, Kiernan, Matthew C., Chung, Roger S., Ittner, Lars M., Ke, Yazi D.

“…Amyotrophic lateral sclerosis (ALS) is a rapidly progressing and fatal disease characterized by muscular atrophy because of loss of upper and lower motor…”
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No Overt Deficits in Aged Tau-Deficient C57Bl/6.Mapt.sup.tm1 by van Hummel, Annika, Bi, Mian, Ippati, Stefania, van der Hoven, Julia, Volkerling, Alexander, Lee, Wei S, Tan, Daniel C. S, Bongers, Andre, Ittner, Arne, Ke, Yazi D, Ittner, Lars M

“…Several mouse lines with knockout of the tau-encoding MAPT gene have been reported in the past; they received recent attention due to reports that tau…”
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No Overt Deficits in Aged Tau-Deficient C57Bl/6.Mapt.sup.tm1Kit GFP Knockin Mice by van Hummel, Annika, Bi, Mian, Ippati, Stefania, van der Hoven, Julia, Volkerling, Alexander, Lee, Wei S, Tan, Daniel C. S, Bongers, Andre, Ittner, Arne, Ke, Yazi D, Ittner, Lars M

“…Several mouse lines with knockout of the tau-encoding MAPT gene have been reported in the past; they received recent attention due to reports that tau…”
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9 Early and late clinical features in 171 patients with LGI1-antibody encephalitis by Ramanathan, Sudarshini, Michael, Sophia, MacKrill, Samuel, Binks, Sophie, Rudnik, Jan, Anziska, Yaacov, Dinoto, Alessandro, Thouin, Anais, Dilwali, Sonam, Son, Hyoshin, Thompson, Julia, Bi, Mian, Hardy, Todd, Bleasel, Andrew, Reddel, Stephen W, Dale, Russell C, Johnson, Michael, Leite, Isabel, Maddison, Paul, Coebergh, Jan, Jacob, Saiju, Jacob, Anu, Lutteroti, Andreas, Pillas, Demetris, Finke, Carsten, Geschwind, Michael, Gelfand, Jeffrey, Lee, Soon-Tae, Irani, Sarosh R

“…ObjectivesLGI1-antibody encephalitis (LGI1-AbE) is a common form of autoimmune encephalitis. Despite almost universal responses to immunotherapy, patients can…”
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Site-specific phosphorylation of tau inhibits amyloid-[beta] toxicity in Alzheimer's mice by Ittner, Arne, Chua, Sook Wern, Bertz, Josefine, Volkerling, Alexander, van der Hoven, Julia, Gladbach, Amadeus, Przybyla, Magdalena, Bi, Mian, Annika van Hummel, Stevens, Claire H, Ippati, Stefania, Suh, Lisa S, Macmillan, Alexander, Sutherland, Greg, Kril, Jillian J, Silva, Ana P G, Mackay, Joel, Poljak, Anne, Delerue, Fabien, Ke, Yazi D, Ittner, Lars M

“…Alzheimer's disease presents with amyloid-β (Aβ) plaques and tau tangles. The prevailing idea in the field is that Aβ induces phosphorylation of tau, which in…”
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