Search Results - "Bi, Jianzhong"

Abnormality of m6A mRNA Methylation Is Involved in Alzheimer's Disease by Han, Min, Liu, Zhen, Xu, Yingying, Liu, Xiangtian, Wang, Dewei, Li, Fan, Wang, Yun, Bi, Jianzhong

“…Alzheimer's disease (AD), the most common form of dementia, is highly prevalent in older adults. The main clinical feature is the progressive decline of memory…”
Get full text

Exosomes Isolated From Human Umbilical Cord Mesenchymal Stem Cells Alleviate Neuroinflammation and Reduce Amyloid-Beta Deposition by Modulating Microglial Activation in Alzheimer’s Disease by Ding, Mao, Shen, Yang, Wang, Ping, Xie, Zhaohong, Xu, Shunliang, Zhu, ZhengYu, Wang, Yun, Lyu, Yongtao, Wang, Dewei, Xu, Linlin, Bi, JianZhong, Yang, Hui

“…Alzheimer’s disease (AD) is the most common neurodegenerative disease characterized by excessive accumulation of the amyloid-β peptide (Aβ) in the brain, which…”
Get full text

Systemic transplantation of human umbilical cord derived mesenchymal stem cells-educated T regulatory cells improved the impaired cognition in AβPPswe/PS1dE9 transgenic mice by Yang, Hongna, Yang, Hui, Xie, Zhaohong, Wei, Lifei, Bi, Jianzhong

“…Alzheimer's disease (AD) is one of most prevalent dementias, which is characterized by the deposition of extracellular amyloid-beta protein (Aβ) and the…”
Get full text

Hypermethylation of Mitochondrial Cytochrome b and Cytochrome c Oxidase II Genes with Decreased Mitochondrial DNA Copy Numbers in the APP/PS1 Transgenic Mouse Model of Alzheimer’s Disease by Xu, Yingying, Cheng, Ling, Sun, Jing, Li, Fan, Liu, Xiangtian, Wei, Yan, Han, Min, Zhu, Zhengyu, Bi, Jianzhong, Lai, Chao, Wang, Yun

“…Alzheimer’s disease (AD) is the most common cause of dementia. Increasing evidence shows that mitochondrial DNA (mtDNA) methylation plays an essential role in…”
Get full text

Altered mitochondrial DNA methylation and mitochondrial DNA copy number in an APP/PS1 transgenic mouse model of Alzheimer disease by Xu, YingYing, Xu, LinLin, Han, Min, Liu, XiangTian, Li, Fan, Zhou, XiaoYan, Wang, Yun, Bi, JianZhong

“…Alzheimer’s disease (AD) is a chronic neurodegenerative disease and mitochondrial impairment is a key feature of AD. The mitochondrial DNA (mtDNA) epigenetic…”
Get full text

Transplantation of IFN-γ Primed hUCMSCs Significantly Improved Outcomes of Experimental Autoimmune Encephalomyelitis in a Mouse Model by Zhou, Xiaoyan, Liu, Xiaoli, Liu, Li, Han, Chao, Xie, Zhaohong, Liu, Xiangtian, Xu, Yingying, Li, Fan, Bi, Jianzhong, Zheng, Chengyun

“…s The aim of this study was to investigate potential therapeutic effects of IFN-γ primed human umbilical cord mesenchymal stem cell (IFN-γ-hUCMSCs)…”
Get full text

Detection and significance of exosomal mRNA expression profiles in the cerebrospinal fluid of patients with meningeal carcinomatosis by Cheng, Peng, Feng, Feifei, Yang, Hui, Jin, Suqin, Lai, Chao, Wang, Yun, Bi, Jianzhong

“…Exosomes are cell-derived membrane vesicles with cargo that can be transported into receiver cells to exert their biological roles. Exosomal RNA signature…”
Get full text

Treadmill Exercise Decreases Aβ Deposition and Counteracts Cognitive Decline in APP/PS1 Mice, Possibly via Hippocampal Microglia Modifications by Zhang, Xianliang, He, Qiang, Huang, Tao, Zhao, Na, Liang, Fei, Xu, Bo, Chen, Xianghe, Li, Tuojian, Bi, Jianzhong

“…Recent studies have suggested that exercise may be beneficial for delaying or attenuating Alzheimer's disease (AD). However, the underlying mechanisms were not…”
Get full text

Effect of visual impairment on subjective cognitive decline in older adults: a cross-sectional study in China by Luo, Liyan, Jiang, Ning, Zheng, Xiaolei, Wang, Ping, Bi, Jianzhong, Xu, Feng, Xie, Zhaohong, Yang, Liping

“…ObjectivePeople with visual impairment have more functional limitations associated with subjective cognitive decline (SCD), and those with SCD are extremely…”
Get full text

A phase II randomized trial of sodium oligomannate in Alzheimer’s dementia by Wang, Tao, Kuang, Weihong, Chen, Wei, Xu, Wenwei, Zhang, Liming, Li, Yingjie, Li, Hailin, Peng, Ying, Chen, Yangmei, Wang, Baojun, Xiao, Jinsong, Li, Honghua, Yan, Chuanzhu, Du, Yifeng, Tang, Mouni, He, Zhiyi, Chen, Haibo, Li, Wei, Lin, Hong, Shi, Shugui, Bi, Jianzhong, Zhou, Huadong, Cheng, Yan, Gao, Xiaoping, Guan, Yihui, Huang, Qiu, Chen, Kewei, Xin, Xianliang, Ding, Jian, Geng, Meiyu, Xiao, Shifu

“…Abstract Background Sodium oligomannate (GV-971), a marine-derived oligosaccharide, is a novel agent that may improve cognition in AD patients. Methods The…”
Get full text

Orexin-A exacerbates Alzheimer’s disease by inducing mitochondrial impairment by Li, Maoyu, Meng, Yao, Chu, Bingcong, Shen, Yang, Xue, Xinhong, Song, Chaoyuan, Liu, Xiangtian, Ding, Mao, Cao, Xi, Wang, Ping, Xu, Shunliang, Bi, Jianzhong, Xie, Zhaohong

“…•Orexin-A aggravated cognitive deficit in APP/PS1 mice.•Orexin-A promoted Aβ accumulation in APP/PS1 mice.•Orexin-A aggravated mitochondrial impairment in…”
Get full text

Differential methylation of circRNA m6A in an APP/PS1 Alzheimer's disease mouse model by Zhang, Xiao, Yang, Suge, Han, Song, Sun, Yuan, Han, Min, Zheng, Xiaolei, Li, Fan, Wei, Yan, Wang, Yun, Bi, Jianzhong

“…Alzheimer's disease (AD) is a chronic neurological disease characterized by memory loss and progressive cognitive impairment. The characteristic AD pathologies…”
Get full text

Integrated investigation of DNA methylation, gene expression and immune cell population revealed immune cell infiltration associated with atherosclerotic plaque formation by Yin, Yihong, Xie, Zhaohong, Chen, Dong, Guo, Hao, Han, Min, Zhu, Zhengyu, Bi, Jianzhong

“…The clinical consequences of atherosclerosis are significant source of morbidity and mortality throughout the world, while the molecular mechanisms of the…”
Get full text

IRE1α-XBP1 Affects the Mitochondrial Function of Aβ25-35-Treated SH-SY5Y Cells by Regulating Mitochondria-Associated Endoplasmic Reticulum Membranes by Chu, Bingcong, Li, Maoyu, Cao, Xi, Li, Rulong, Jin, Suqin, Yang, Hui, Xu, Linlin, Wang, Ping, Bi, Jianzhong

“…Neurotoxicity induced by the amyloid beta (Aβ) peptide is one of the most important pathological mechanisms of Alzheimer's disease (AD). Activation of the…”
Get full text

IFN-γ-Primed hUCMSCs Significantly Reduced Inflammation via the Foxp3/ROR-γt/STAT3 Signaling Pathway in an Animal Model of Multiple Sclerosis by Ling, Xiao, Wang, Teng, Han, Chao, Wang, Pin, Liu, Xiaoli, Zheng, Chengyun, Bi, Jianzhong, Zhou, Xiaoyan

“…Our previous study showed that interferon gamma (IFN-γ) might enhance the immunosuppressive properties of mesenchymal stem cells (MSCs) by upregulating the…”
Get full text

Impact prediction of translocation of the mitochondrial outer membrane 70 as biomarker in Alzheimer's disease by Cao, Xi, Chen, Yanting, Sang, Xiaoyu, Xu, Shunliang, Xie, Zhaohong, Zhu, Zhengyu, Wang, Ping, Bi, Jianzhong, Xu, Linlin

“…Mitochondrial dysfunction plays a key role in the pathogenesis of Alzheimer's disease (AD). The translocase of the outer membrane (TOM) complex controls the…”
Get full text

Activation of Mitochondrial Unfolded Protein Response in SHSY5Y Expressing APP Cells and APP/PS1 Mice by Shen, Yang, Ding, Mao, Xie, Zhaohong, Liu, Xiangtian, Yang, Hui, Jin, Suqin, Xu, Shunliang, Zhu, Zhengyu, Wang, Yun, Wang, Dewei, Xu, Linlin, Zhou, Xiaoyan, Wang, Ping, Bi, Jianzhong

“…Alzheimer disease (AD) is the most common form of dementia. Amyloid β-peptide (Aβ) deposition is a major neuropathologic feature of AD. When unfolded or…”
Get full text

A Cross-Sectional Study on Mental Health Problems of Medical and Nonmedical Students in Shandong During the COVID-19 Epidemic Recovery Period by Zheng, Xiaolei, Guo, Yuji, Yang, Hui, Luo, Liyan, Ya, Bailiu, Xu, Hong, Xue, Zhiwei, Li, Qing, Shi, Jiale, Bi, Jianzhong, Ma, Wen, Wang, Ping

“…The coronavirus disease 2019 (COVID-19) pandemic has resulted in a plethora of psychological problems worldwide since its onset in December 2019. In the…”
Get full text

Long Non-coding RNAs in Pathogenesis of Neurodegenerative Diseases by Zhou, Shiyue, Yu, Xiao, Wang, Min, Meng, Yujie, Song, Dandan, Yang, Hui, Wang, Dewei, Bi, Jianzhong, Xu, Shunliang

“…Emerging evidence addresses the link between the aberrant epigenetic regulation of gene expression and numerous diseases including neurological disorders, such…”
Get full text

Low life satisfaction status among older people with and without an intimate partner: a nationwide cross‐sectional study in China by Luo, Liyan, Zheng, Xiaolei, Jiang, Ning, Xie, Zhaohong, Wang, Ping, Bi, Jianzhong, Lai, Chao, Yang, Liping

“…Background Focusing on older people with and without an intimate partner, this study aimed to evaluate the prevalence of low life satisfaction in both groups,…”
Get full text