Search Results - "Bhutto, Imran"

Understanding age-related macular degeneration (AMD): Relationships between the photoreceptor/retinal pigment epithelium/Bruch’s membrane/choriocapillaris complex by Bhutto, Imran, Lutty, Gerard

“…There is a mutualistic symbiotic relationship between the components of the photoreceptor/retinal pigment epithelium (RPE)/Bruch’s membrane…”
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Histopathological Insights Into Choroidal Vascular Loss in Clinically Documented Cases of Age-Related Macular Degeneration by Seddon, Johanna M, McLeod, D Scott, Bhutto, Imran A, Villalonga, Mercedes B, Silver, Rachel E, Wenick, Adam S, Edwards, Malia M, Lutty, Gerard A

“…Age-related macular degeneration (AMD) is a multifactorial disease with genetic and environmental factors contributing to risk. Histopathologic changes…”
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Relationship between RPE and Choriocapillaris in Age-Related Macular Degeneration by McLeod, D. Scott, Grebe, Rhonda, Bhutto, Imran, Merges, Carol, Baba, Takayuki, Lutty, Gerard A

“…The purpose of this study was to examine the relationships between choriocapillaris (CC) and retinal pigment epithelial changes in age-related macular…”
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Systemic dendrimer nanotherapies for targeted suppression of choroidal inflammation and neovascularization in age-related macular degeneration by Kambhampati, Siva P., Bhutto, Imran A., Wu, Tony, Ho, Katie, McLeod, D. Scott, Lutty, Gerard A., Kannan, Rangaramanujam M.

“…Inflammation and neovascularization are key pathological events in human age-related macular degeneration (AMD). Activated microglia/macrophages (mi/ma) and…”
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Choriocapillaris dropout in early age-related macular degeneration by Lutty, Gerard A., McLeod, D. Scott, Bhutto, Imran A., Edwards, Malia M., Seddon, Johanna M.

“…Loss of choriocapillaris (CC) in advanced age-related macular degeneration (AMD) is well documented but changes in early AMD have not been quantified…”
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Evolution of oxidative stress, inflammation and neovascularization in the choroid and retina in a subretinal lipid induced age-related macular degeneration model by Kim, Soo-Young, Kambhampati, Siva P., Bhutto, Imran A., McLeod, D. Scott, Lutty, Gerard A., Kannan, Rangaramanujam M.

“…Oxidative stress, inflammation and neovascularization are the key pathological events that are implicated in human age-related macular degeneration (AMD)…”
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Subretinal Glial Membranes in Eyes With Geographic Atrophy by Edwards, Malia M, McLeod, D Scott, Bhutto, Imran A, Grebe, Rhonda, Duffy, Maeve, Lutty, Gerard A

“…Müller cells create the external limiting membrane (ELM) by forming junctions with photoreceptor cells. This study evaluated the relationship between focal…”
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A Role for βA3/A1-Crystallin in Type 2 EMT of RPE Cells Occurring in Dry Age-Related Macular Degeneration by Ghosh, Sayan, Shang, Peng, Terasaki, Hiroto, Stepicheva, Nadezda, Hose, Stacey, Yazdankhah, Meysam, Weiss, Joseph, Sakamoto, Taiji, Bhutto, Imran A, Xia, Shuli, Zigler, Jr, J Samuel, Kannan, Ram, Qian, Jiang, Handa, James T, Sinha, Debasish

“…The RPE cells have a major role in the development of dry age-related macular degeneration (AMD). We present novel evidence that βA3/A1-crystallin, encoded by…”
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An Acute Injury Model for the Phenotypic Characteristics of Geographic Atrophy by Bhutto, Imran A, Ogura, Shuntaro, Baldeosingh, Rajkumar, McLeod, D Scott, Lutty, Gerard A, Edwards, Malia M

“…Geographic atrophy (GA) is the late stage of non-neovascular age-related macular degeneration. A lack of animal models for GA has hampered treatment efforts…”
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A role for mast cells in geographic atrophy by Ogura, Shuntaro, Baldeosingh, Rajkumar, Bhutto, Imran A., Kambhampati, Siva P., Scott McLeod, Donald, Edwards, Malia M., Rais, Rana, Schubert, William, Lutty, Gerard A.

“…Mast cells (MCs) are the initial responders of innate immunity and their degranulation contribute to various etiologies. While the abundance of MCs in the…”
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Pathologic vs. protective roles of hypoxia-inducible factor 1 in RPE and photoreceptors in wet vs. dry age-related macular degeneration by Babapoor-Farrokhran, Savalan, Qin, Yu, Flores-Bellver, Miguel, Niu, Yueqi, Bhutto, Imran A, Aparicio-Domingo, Silvia, Guo, Chuanyu, Rodrigues, Murilo, Domashevich, Timothy, Deshpande, Monika, Megarity, Haley, Chopde, Rakesh, Eberhart, Charles G, Canto-Soler, Valeria, Montaner, Silvia, Sodhi, Akrit

“…It has previously been reported that antioxidant vitamins can help reduce the risk of vision loss associated with progression to advanced age-related macular…”
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Visualization of choroidal vasculature in pigmented mouse eyes from experimental models of AMD by Bhutto, Imran A., McLeod, D. Scott, Thomson, Benjamin R., Lutty, Gerard A., Edwards, Malia M.

“…A variety of techniques exist to investigate retinal and choroidal vascular changes in experimental mouse models of human ocular diseases. While all have…”
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Increased choroidal mast cells and their degranulation in age-related macular degeneration by Bhutto, Imran A, McLeod, D Scott, Jing, Tian, Sunness, Janet S, Seddon, Johanna M, Lutty, Gerard A

“…Inflammation has been implicated in age-related macular degeneration (AMD). This study investigates the association of mast cells (MCs), a resident choroidal…”
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Vascular progenitors generated from tankyrase inhibitor-regulated naïve diabetic human iPSC potentiate efficient revascularization of ischemic retina by Park, Tea Soon, Zimmerlin, Ludovic, Evans-Moses, Rebecca, Thomas, Justin, Huo, Jeffrey S., Kanherkar, Riya, He, Alice, Ruzgar, Nensi, Grebe, Rhonda, Bhutto, Imran, Barbato, Michael, Koldobskiy, Michael A., Lutty, Gerard, Zambidis, Elias T.

“…Here, we report that the functionality of vascular progenitors (VP) generated from normal and disease-primed conventional human induced pluripotent stem cells…”
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Role of glia in optic nerve by Yazdankhah, Meysam, Shang, Peng, Ghosh, Sayan, Hose, Stacey, Liu, Haitao, Weiss, Joseph, Fitting, Christopher S., Bhutto, Imran A., Zigler, J. Samuel, Qian, Jiang, Sahel, José-Alain, Sinha, Debasish, Stepicheva, Nadezda A.

“…Glial cells are critically important for maintenance of neuronal activity in the central nervous system (CNS), including the optic nerve (ON). However, the ON…”
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Clinicopathologic Findings in Three Siblings With Geographic Atrophy by Edwards, Malia M, McLeod, D Scott, Shen, Mengxi, Grebe, Rhonda, Sunness, Janet S, Bhutto, Imran A, McDonnell, Erin, Pado, Alexandra M, Gregori, Giovanni, Rosenfeld, Philip J, Lutty, Gerard A

“…Age-related macular degeneration (AMD) is a leading cause of blindness among the elderly worldwide. Clinical imaging and histopathologic studies are crucial to…”
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Small-molecule–directed, efficient generation of retinal pigment epithelium from human pluripotent stem cells by Maruotti, Julien, Sripathi, Srinivas R., Bharti, Kapil, Fuller, John, Wahlin, Karl J., Ranganathan, Vinod, Sluch, Valentin M., Berlinicke, Cynthia A., Davis, Janine, Kim, Catherine, Zhao, Lijun, Wan, Jun, Qian, Jiang, Corneo, Barbara, Temple, Sally, Dubey, Ramin, Olenyuk, Bogdan Z., Bhutto, Imran, Lutty, Gerard A., Zack, Donald J.

“…Age-related macular degeneration (AMD) is associated with dysfunction and death of retinal pigment epithelial (RPE) cells. Cell-based approaches using RPE-like…”
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Idiopathic preretinal glia in aging and age-related macular degeneration by Edwards, Malia M., McLeod, D. Scott, Bhutto, Imran A., Villalonga, Mercedes B., Seddon, Johanna M., Lutty, Gerard A.

“…During analysis of glia in wholemount aged human retinas, frequent projections onto the vitreal surface of the inner limiting membrane (ILM) were noted. The…”
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VEGF Secreted by Hypoxic Müller Cells Induces MMP-2 Expression and Activity in Endothelial Cells to Promote Retinal Neovascularization in Proliferative Diabetic Retinopathy by RODRIGUES, Murilo, XIAOBAN XIN, SOLOMON, Sharon, LUTTY, Gerard, SEMENZA, Gregg L, MONTANER, Silvia, SODHI, Akrit, JEE, Kathleen, BABAPOOR-FARROKHRAN, Savalan, KASHIWABUCHI, Fabiana, TAO MA, BHUTTO, Imran, HASSAN, Syed Junaid, DAOUD, Yassine, BARANANO, David

“…In proliferative diabetic retinopathy (PDR), retinal ischemia promotes neovascularization (NV), which can lead to profound vision loss in diabetic patients…”
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Lysosomal-mediated waste clearance in retinal pigment epithelial cells is regulated by CRYBA1/βA3/A1-crystallin via V-ATPase-MTORC1 signaling by Valapala, Mallika, Wilson, Christine, Hose, Stacey, Bhutto, Imran A, Grebe, Rhonda, Dong, Aling, Greenbaum, Seth, Gu, Limin, Sengupta, Samhita, Cano, Marisol, Hackett, Sean, Xu, Guotong, Lutty, Gerard A, Dong, Lijin, Sergeev, Yuri, Handa, James T, Campochiaro, Peter, Wawrousek, Eric, Zigler, Jr, J Samuel, Sinha, Debasish

“…In phagocytic cells, including the retinal pigment epithelium (RPE), acidic compartments of the endolysosomal system are regulators of both phagocytosis and…”
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