Search Results - "Bhute, Vijesh J."

BK virus infection and outcome following kidney transplantation in childhood by McCaffrey, James, Bhute, Vijesh J., Shenoy, Mohan

“…BK virus associated nephropathy (BKN) is an important cause of kidney allograft failure. In a cohort of paediatric kidney transplant recipients, we aimed to…”
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CAR-neutrophil mediated delivery of tumor-microenvironment responsive nanodrugs for glioblastoma chemo-immunotherapy by Chang, Yun, Cai, Xuechao, Syahirah, Ramizah, Yao, Yuxing, Xu, Yang, Jin, Gyuhyung, Bhute, Vijesh J., Torregrosa-Allen, Sandra, Elzey, Bennett D., Won, You-Yeon, Deng, Qing, Lian, Xiaojun Lance, Wang, Xiaoguang, Eniola-Adefeso, Omolola, Bao, Xiaoping

“…Glioblastoma (GBM) is one of the most aggressive and lethal solid tumors in human. While efficacious therapeutics, such as emerging chimeric antigen receptor…”
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CMV, EBV, JCV and BKV infection and outcome following kidney transplantation in children initiated on a corticosteroid-minimisation immunosuppressive regimen by McCaffrey, James, Bhute, Vijesh J., Shenoy, Mohan

“…Background Modern immunosuppressive regimens in paediatric kidney transplant recipients have contributed to improved long-term allograft survival, but at the…”
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A mutation in transmembrane protein 135 impairs lipid metabolism in mouse eyecups by Landowski, Michael, Bhute, Vijesh J., Takimoto, Tetsuya, Grindel, Samuel, Shahi, Pawan K., Pattnaik, Bikash R., Ikeda, Sakae, Ikeda, Akihiro

“…Aging is a significant factor in the development of age-related diseases but how aging disrupts cellular homeostasis to cause age-related retinal disease is…”
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Dynamic regulation of hypoxia-inducible factor-1α activity is essential for normal B cell development by Burrows, Natalie, Bashford-Rogers, Rachael J. M., Bhute, Vijesh J., Peñalver, Ana, Ferdinand, John R., Stewart, Benjamin J., Smith, Joscelin E. G., Deobagkar-Lele, Mukta, Giudice, Girolamo, Connor, Thomas M., Inaba, Akimichi, Bergamaschi, Laura, Smith, Sam, Tran, Maxine G. B., Petsalaki, Evangelia, Lyons, Paul A., Espeli, Marion, Huntly, Brian J. P., Smith, Kenneth G. C., Cornall, Richard J., Clatworthy, Menna R., Maxwell, Patrick H.

“…B lymphocyte development and selection are central to adaptive immunity and self-tolerance. These processes require B cell receptor (BCR) signaling and occur…”
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Local and systemic metabolic alterations in brain, plasma, and liver of rats in response to aging and ischemic stroke, as detected by nuclear magnetic resonance (NMR) spectroscopy by Wesley, Umadevi V., Bhute, Vijesh J., Hatcher, James F., Palecek, Sean P., Dempsey, Robert J.

“…Metabolic dysfunction impacts stroke incidence and outcome. However, the intricate association between altered metabolic program due to aging, and focal…”
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Metabolic alterations caused by the mutation and overexpression of the Tmem135 gene by Lee, Wei-Hua, Bhute, Vijesh J, Higuchi, Hitoshi, Ikeda, Sakae, Palecek, Sean P, Ikeda, Akihiro

“…Mitochondria are dynamic organelles that undergo fission and fusion. While they are essential for cellular metabolism, the effect of dysregulated mitochondrial…”
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The Poly (ADP-Ribose) Polymerase Inhibitor Veliparib and Radiation Cause Significant Cell Line Dependent Metabolic Changes in Breast Cancer Cells by Bhute, Vijesh J., Ma, Yan, Bao, Xiaoping, Palecek, Sean P.

“…Breast tumors are characterized into subtypes based on their surface marker expression, which affects their prognosis and treatment. Poly (ADP-ribose)…”
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Author Correction: Dynamic regulation of hypoxia-inducible factor-1α activity is essential for normal B cell development by Burrows, Natalie, Bashford-Rogers, Rachael J. M., Bhute, Vijesh J., Peñalver, Ana, Ferdinand, John R., Stewart, Benjamin J., Smith, Joscelin E. G., Deobagkar-Lele, Mukta, Giudice, Girolamo, Connor, Thomas M., Inaba, Akimichi, Bergamaschi, Laura, Smith, Sam, Tran, Maxine G. B., Petsalaki, Evangelia, Lyons, Paul A., Espeli, Marion, Huntly, Brian J. P., Smith, Kenneth G. C., Cornall, Richard J., Clatworthy, Menna R., Maxwell, Patrick H.

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Chemically-defined albumin-free differentiation of human pluripotent stem cells to endothelial progenitor cells by Bao, Xiaoping, Lian, Xiaojun, Dunn, Kaitlin K., Shi, Mengxuan, Han, Tianxiao, Qian, Tongcheng, Bhute, Vijesh J., Canfield, Scott G., Palecek, Sean P.

“…Human pluripotent stem cell (hPSC)-derived endothelial cells and their progenitors are important for vascular research and therapeutic revascularization. Here,…”
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Metabolomics Identifies Metabolic Markers of Maturation in Human Pluripotent Stem Cell-Derived Cardiomyocytes by Bhute, Vijesh J, Bao, Xiaoping, Dunn, Kaitlin K, Knutson, Kylie R, McCurry, Eric C, Jin, Gyuhyung, Lee, Wei-Hua, Lewis, Sarah, Ikeda, Akihiro, Palecek, Sean P

“…Cardiovascular disease is a leading cause of death worldwide. Human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs) hold immense clinical potential and…”
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Transmembrane protein 135 regulates lipid homeostasis through its role in peroxisomal DHA metabolism by Landowski, Michael, Bhute, Vijesh J., Grindel, Samuel, Haugstad, Zachary, Gyening, Yeboah K., Tytanic, Madison, Brush, Richard S., Moyer, Lucas J., Nelson, David W., Davis, Christopher R., Yen, Chi-Liang Eric, Ikeda, Sakae, Agbaga, Martin-Paul, Ikeda, Akihiro

“…Transmembrane protein 135 (TMEM135) is thought to participate in the cellular response to increased intracellular lipids yet no defined molecular function for…”
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Directed differentiation and long-term maintenance of epicardial cells derived from human pluripotent stem cells under fully defined conditions by Bao, Xiaoping, Lian, Xiaojun, Qian, Tongcheng, Bhute, Vijesh J, Han, Tianxiao, Palecek, Sean P

“…This protocol differentiates hPSCs into self-renewing epicardial cells by appropriate differentiation-stage-specific application of Gsk3 inhibitor, Wnt…”
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Moving to Timed Remote Assessments: The Impact of COVID-19 on Year End Exams in Chemical Engineering at Imperial College London by Bhute, Vijesh J, Campbell, James, Kogelbauer, Andreas, Shah, Umang V, Brechtelsbauer, Clemens

“…Summative year end assessments are a major component of student assessment at the Department of Chemical Engineering, Imperial College London. More than 600…”
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Building a kinetic Monte Carlo model with a chosen accuracy by Bhute, Vijesh J, Chatterjee, Abhijit

“…The kinetic Monte Carlo (KMC) method is a popular modeling approach for reaching large materials length and time scales. The KMC dynamics is erroneous when…”
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Metabolic responses induced by DNA damage and poly (ADP-ribose) polymerase (PARP) inhibition in MCF-7 cells by Bhute, Vijesh J., Palecek, Sean P.

“…Genomic instability is one of the hallmarks of cancer. Several chemotherapeutic drugs and radiotherapy induce DNA damage to prevent cancer cell replication…”
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Advances in Manufacturing Cardiomyocytes from Human Pluripotent Stem Cells by Floy, Martha E, Shabnam, Fathima, Simmons, Aaron D, Bhute, Vijesh J, Jin, Gyuhyung, Friedrich, Will A, Steinberg, Alexandra B, Palecek, Sean P

“…The emergence of human pluripotent stem cell (hPSC) technology over the past two decades has provided a source of normal and diseased human cells for a wide…”
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Mannose Binding Lectin Is Hydroxylated by Collagen Prolyl-4-hydroxylase and Inhibited by Some PHD Inhibitors by Bhute, Vijesh J, Harte, James, Houghton, Jack W, Maxwell, Patrick H

“…Mannose-binding lectin (MBL) is an important component of innate immune defense. MBL undergoes oligomerization to generate high mol weight (HMW) forms which…”
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Advances in applications of metabolomics in pluripotent stem cell research by Bhute, Vijesh J, Bao, Xiaoping, Palecek, Sean P

“…•Metabolism regulates stem cell fate by altering epigenetic markers.•Metabolite signatures can be used to characterize differences between cell…”
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Human pluripotent stem cell‐derived epicardial progenitors can differentiate to endocardial‐like endothelial cells by Bao, Xiaoping, Bhute, Vijesh J., Han, Tianxiao, Qian, Tongcheng, Lian, Xiaojun, Palecek, Sean P.

“…During heart development, epicardial progenitors contribute various cardiac lineages including smooth muscle cells, cardiac fibroblasts, and endothelial cells…”
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