Search Results - "Bhoola, Kanti D."

The relationship between clinical phenotype and kallikrein-kinin bioregulation in different forms of arthritis by Tan, Dino B A, Tedja, Chantalia, Kuster, Lukas, Raymond, Warren D, Harsanyi, Andreea, Chowalloor, Priya V, Misso, Neil L, Argawal, Shashi, Bhoola, Kanti D, Keen, Helen I

“…Patients with rheumatoid arthritis (RA) have shown increased levels of neutrophils generating kallikrein-kinin peptides in blood which are potent mediators of…”
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Kinin B1 receptor activation turns on exocytosis of matrix metalloprotease-9 and myeloperoxidase in human neutrophils: involvement of mitogen-activated protein kinase family by Ehrenfeld, Pamela, Matus, Carola E., Pavicic, Francisca, Toledo, Cesar, Nualart, Francisco, Gonzalez, Carlos B., Burgos, Rafael A., Bhoola, Kanti D., Figueroa, Carlos D.

“…Proinflammatory peptides known as kinins activate the human neutrophil and induce the release of its primary and tertiary granules. During neutrophil…”
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Expression of HER2 and bradykinin B1 receptors in precursor lesions of gallbladder carcinoma by Toledo, Cesar, Matus, Carola E, Barraza, Ximena, Arroyo, Pamela, Ehrenfeld, Pamela, Figueroa, Carlos D, Bhoola, Kanti D, Del Pozo, Maeva, Poblete, Maria T

“…AIM： To determine the expression of HER2 and bradykinin B1 receptors （B1R） in the two pathogenic models of gallbladder cancer： the metaplasia dysplasia carcino…”
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Activation of the human keratinocyte B1 bradykinin receptor induces expression and secretion of metalloproteases 2 and 9 by transactivation of epidermal growth factor receptor by Matus, Carola E., Ehrenfeld, Pamela, Pavicic, Francisca, González, Carlos B., Concha, Miguel, Bhoola, Kanti D., Burgos, Rafael A., Figueroa, Carlos D.

“…The B1 bradykinin receptor (BDKRB1) is a component of the kinin cascade localized in the human skin. Some of the effects produced by stimulation of BDKRB1…”
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Kinin receptors as targets for cancer therapy by Figueroa, Carlos D, Ehrenfeld, Pamela, Bhoola, Kanti D

“…Biological fluids of cancer patients contain increased levels of kinins. Activation of kinin B1 and B2 receptors expressed on cancer cells produce an increase…”
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GPER-1/GPR30 a novel estrogen receptor sited in the cell membrane: therapeutic coupling to breast cancer by Molina, Luis, Figueroa, Carlos D, Bhoola, Kanti D, Ehrenfeld, Pamela

“…Breast cancer is clinically classified as 'estrogen-positive' when at least 1% of cancer cells stain for the estrogen receptor alpha (ERα). However, recent…”
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Physiological concentrations of transforming growth factor β1 selectively inhibit human dendritic cell function by Fogel-Petrovic, Mirjana, Long, Julie A., Misso, Neil L., Foster, Paul S., Bhoola, Kanti D., Thompson, Philip J.

“…In this study the effects of different in vitro conditioning with transforming growth factor (TGF) β1 on human monocyte-derived DC maturation (hMo-DC) were…”
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Expression of kinin receptors on eosinophils: comparison of asthmatic patients and healthy subjects by Bertram, Cornelia M., Misso, Neil L., Fogel‐Petrovic, Mirjana, Figueroa, Carlos D., Foster, Paul S., Thompson, Philip J., Bhoola, Kanti D.

“…Eosinophils contribute to asthmatic airway inflammation by releasing cysteinyl leukotrienes (cysLT) and other inflammatory mediators, and bradykinin (BK)…”
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Kinin B1 Receptor Signaling in Skin Homeostasis and Wound Healing by Matus, Carola E, Bhoola, Kanti D, Figueroa, Carlos D

“…Kinins are proinflammatory peptides that are formed in the skin by the enzymatic action of tissue kallikrein (KLK1) on kininogens. Tissue kallikrein is…”
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Stimulated human neutrophils form biologically active kinin peptides from high and low molecular weight kininogens by Stuardo, Miguel, Gonzalez, Carlos B., Nualart, Francisco, Boric, Mauricio, Corthorn, Jenny, Bhoola, Kanti D., Figueroa, Carlos D.

“…Human neutrophils play a pivotal role in acute inflammation. However, their capacity to generate bioactive kinin peptides has not been established as yet. We…”
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Expression and function of retinoblastoma binding protein 6 (RBBP6) in human lung cancer by Motadi, Lesetja R, Bhoola, Kanti D, Dlamini, Zodwa

“…Highlights ► First study demonstrating the expression of RBBP6 in lung cancer. ► Functionally RBBP6 is a proliferative gene. ► RBBP6 expression appears to…”
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Discovery and therapeutic potential of kinin receptor antagonists by Whalley, Eric T, Figueroa, Carlos D, Gera, Lajos, Bhoola, Kanti D

“…Kinins are bioactive peptide hormones that exert biological effects by activating two types of G protein-coupled receptors namely, B(1) (B(1)R) and B(2)…”
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Expression and bioregulation of the kallikrein-related peptidases family in the human neutrophil by Lizama, Alejandro J, Andrade, Yessica, Colivoro, Patricio, Sarmiento, Jose, Matus, Carola E, Gonzalez, Carlos B, Bhoola, Kanti D, Ehrenfeld, Pamela, Figueroa, Carlos D

“…The family of kallikrein-related peptidases (KLKs) has been identified in a variety of immunolabeled human tissue sections, but no previous study has…”
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Effects of the Demethylating Agent, 5-Azacytidine, on Expression of the Kallikrein-Kinin Genes in Carcinoma Cells of the Lung and Pleura by Misso, Neil L., Wong, Joshua, Bhoola, Kanti D., Ng, Angeline, Aggarwal, Shashi, Sia, Yee Yen

“…Tissue kallikrein (KLK1) and plasma kallikrein (KLKB1) may regulate the growth and proliferation of tumours of the lung and pleura, through the generation of…”
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Expression of kinin B1 and B2 receptors in immature, monocyte-derived dendritic cells and bradykinin-mediated increase in intracellular Ca2+ and cell migration by Bertram, Cornelia M, Baltic, Svetlana, Misso, Neil L, Bhoola, Kanti D, Foster, Paul S, Thompson, Philip J, Fogel-Petrovic, Mirjana

“…The kinins, bradykinin (BK) and Lys‐des[Arg9]‐BK, are important inflammatory mediators that act via two specific G protein‐coupled kinins, B1 and B2 receptors…”
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Bioregulation of kallikrein-related peptidases 6, 10 and 11 by the kinin B₁ receptor in breast cancer cells by Ehrenfeld, Pamela, Manso, Lorella, Pavicic, María F, Matus, Carola E, Borquez, Carlos, Lizama, Alejandro, Sarmiento, José, Poblete, María T, Bhoola, Kanti D, Naran, Anupan, Figueroa, Carlos D

“…The sera of patients with breast cancer have higher levels of des[Arg(9)]bradykinin, a kinin B1 receptor (B1R) agonist, than that from healthy individuals…”
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Expression of tissue and plasma kallikreins and kinin B1 and B2 receptors in lung cancer by Chee, Jessica, Naran, Anupam, Misso, Neil L, Thompson, Philip J, Bhoola, Kanti D

“…Tissue kallikrein (hK1) and plasma kallikrein (PK, hKB1) are serine proteases that produce biologically active kinin peptides from endogenous kininogen…”
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Activation of kinin B1 receptor increases the release of metalloproteases-2 and -9 from both estrogen-sensitive and -insensitive breast cancer cells by Ehrenfeld, Pamela, Conejeros, Ivan, Pavicic, Maria F, Matus, Carola E, Gonzalez, Carlos B, Quest, Andrew F.G, Bhoola, Kanti D, Poblete, Maria T, Burgos, Rafael A, Figueroa, Carlos D

“…Abstract The kinin B1 receptor (B1 R) agonist Lys-des[Arg9 ]-bradykinin (LDBK) increases proliferation of estrogen-sensitive breast cancer cells by a process…”
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Immune responses in cancer by Adam, Jamila K, Odhav, Bharti, Bhoola, Kanti D

“…The complex of humoral factors and immune cells comprises two interleaved systems, innate and acquired. Immune cells scan the occurrence of any molecule that…”
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Kinin B1 receptor regulates interactions between neutrophils and endothelial cells by modulating the levels of Mac-1, LFA-1 and intercellular adhesion molecule-1 by Figueroa, Carlos D, Matus, Carola E, Pavicic, Francisca, Sarmiento, Jose, Hidalgo, Maria A, Burgos, Rafael A, Gonzalez, Carlos B, Bhoola, Kanti D, Ehrenfeld, Pamela

“…Kinins are pro-inflammatory peptides that mimic the cardinal features of inflammation. We examined the concept that expression levels of endothelial…”
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