Search Results - "Bhinder, Munir Ahmad"
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A Computational Approach to Modeling an Antagonistic Angiogenic VEGFR1-IL2 Fusion Protein for Cancer Therapy
Published in Bioinformatics and biology insights (2021)“…In cancer treatment, immunotherapy has great potential for improving the prognosis of patients with hematologic and solid malignancies. In this study, various…”
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The spectrum of novel ABCB11 gene variations in children with progressive familial intrahepatic cholestasis type 2 in Pakistani cohorts
Published in Scientific reports (14-08-2024)“…Progressive familial intrahepatic cholestasis (PFIC) is a rare childhood manifested disease associated with impaired bile secretion with severe pruritus yellow…”
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3
Association of MSX1 Gene Variants with Nonsyndromic Cleft Lip and/or Palate in the Pakistani Population
Published in The Cleft palate-craniofacial journal (01-11-2024)“…Objectives This study investigated the association of MSX1 gene variants rs3821949 and rs12532 with nonsyndromic cleft lip and/or palate (NSCL/P) in the…”
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4
Consanguinity: A blessing or menace at population level?
Published in Annals of human genetics (01-07-2019)“…Consanguinity has highly complex and multifaceted aspects with sociocultural as well as biological debates on its pros and cons. The biological upshot of…”
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5
Determination of expression profile of p53 gene in different grades of breast cancer tissues by real time PCR
Published in African health sciences (01-09-2020)“…Background: Pakistan has a high incidence of breast cancer in Asia, where annually 16,232 deaths are reported. There are many exogenous and endogenous risk…”
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PNPLA3 and TM6SF2 genetic variants and hepatic fibrosis and cirrhosis in Pakistani chronic hepatitis C patients: a genetic association study
Published in BMC gastroenterology (26-08-2022)“…Abstract Background The present study investigates if common missense functional variants p.I148M and p.E167K in PNPLA3 and TM6SF2 genes, respectively,…”
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Genetic analysis of fructose-1,6-bisphosphatase (FBPase) deficiency in nine consanguineous Pakistani families
Published in Journal of pediatric endocrinology & metabolism : JPEM (26-10-2017)“…Fructose-1,6-bisphosphatase (FBPase) deficiency is a rare inherited metabolic disorder characterized by recurrent episodes of hypoglycemia, ketosis and lactic…”
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Association study of CLDN14 variations in patients with kidney stones
Published in Open life sciences (28-02-2022)“…Claudin-14 protein plays an essential role in regulating calcium ions in the kidney and ear. Two phenotypes, hearing loss and kidney stones, were reportedly…”
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Identification of NS2B-NS3 Protease Inhibitors for Therapeutic Application in ZIKV Infection: A Pharmacophore-Based High-Throughput Virtual Screening and MD Simulations Approaches
Published in Vaccines (Basel) (05-01-2023)“…Zika virus (ZIKV) pandemic and its implication in congenital malformations and severe neurological disorders had created serious threats to global health. ZIKV…”
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A Putative Prophylactic Solution for COVID-19: Development of Novel Multiepitope Vaccine Candidate against SARS-COV-2 by Comprehensive Immunoinformatic and Molecular Modelling Approach
Published in Biology (Basel, Switzerland) (01-09-2020)“…The outbreak of 2019-novel coronavirus (SARS-CoV-2) that causes severe respiratory infection (COVID-19) has spread in China, and the World Health Organization…”
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11
Two novel variants in CYP1B1 gene: a major contributor of autosomal recessive primary congenital glaucoma with allelic heterogeneity in Pakistani patients
Published in International journal of ophthalmology (01-01-2019)“…To find the mutations associated with primary congenital glaucoma (PCG) in Pakistani consanguineous pedigrees. After getting informed consent, 11…”
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Identification of RdRp inhibitors against SARS-CoV-2 through E-pharmacophore-based virtual screening, molecular docking and MD simulations approaches
Published in International journal of biological macromolecules (15-05-2023)“…The outbreak of novel Coronavirus, an enduring pandemic declared by WHO, has consequences to an alarming ongoing public health menace which has already claimed…”
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13
Mapping of IDUA gene variants in Pakistani patients with mucopolysaccharidosis type 1
Published in Journal of pediatric endocrinology & metabolism : JPEM (26-11-2019)“…Background Mucopolysaccharidosis type 1 (MPS1) is a rare debilitating multisystem lysosomal disorder resulting due to the deficiency of α-L-iduronidase enzyme…”
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Association of Oral Submucous Fibrosis Risk with GSTM1 and GSTT1 Gene Polymorphisms
Published in Journal of the College of Physicians and Surgeons--Pakistan (01-03-2024)“…To determine the association of GSTM1 and GSTT1 polymorphisms with oral submucous fibrosis (OSF). A case-control study. Place and Duration of the Study:…”
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Association of Oral Submucous Fibrosis Risk with GSTM1 and GSTT1 Gene Polymorphisms
Published in Journal of the College of Physicians and Surgeons--Pakistan (01-03-2024)“…Objective: To determine the association of GSTM1 and GSTT1 polymorphisms with oral submucous fibrosis (OSF). Study Design: A case-control study. Place and…”
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Breeding performance and disease profile of six peafowl species in captivity at Jallo breeding center, Lahore
Published in Pure and applied biology (01-03-2019)“…Captive breeding is a process of raring the endangered species in man controlled environment like wild life parks, breeding centers and zoos. The present study…”
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Polymorphism of Interleukin-10 (IL-10, -1082 G/A) and Interleukin-28B (IL-28B, C/T) In Pediatric Acute Lymphoblastic Leukemia (ALL)
Published in Pakistan journal of pharmaceutical sciences (01-09-2019)“…We conducted genotypic analyses of interleukin-10 (IL-10) (-1082 G/A; GG, GA, AA) and interleukin-28B (CC, CT, TT) genes polymorphisms in acute lymphoblastic…”
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Computational screening of phytochemicals against survivin protein: A potent target for cancer
Published in Pakistan journal of pharmaceutical sciences (01-05-2019)“…Survivin (IAP proteins) is considered as a significant target for anticancer drug research owing to its upregulation in tumor cells to mediate resistance to…”
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SE33 locus as a reliable genetic marker for forensic DNA analysis systems
Published in Turkish journal of medical sciences (14-06-2018)“…Background/aim: Genetic variation, an authentic tool of individual discrimination, is being used for forensic investigations worldwide. A missing result for…”
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Computational screening of phytochemicals against survivin protein: A potent target for cancer
Published in Pakistan journal of pharmaceutical sciences (01-05-2019)“…Survivin (IAP proteins) is considered as a significant target for anticancer drug research owing to its upregulation in tumor cells to mediate resistance to…”
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