Search Results - "Bhatti, Balwinder"

Identification and pharmacological characterization of 3,6-diazabicyclo[3.1.1]heptane-3-carboxamides as novel ligands for the α4β2 and α6/α3β2β3 nicotinic acetylcholine receptors (nAChRs) by Strachan, Jon-Paul, Kombo, David C., Mazurov, Anatoly, Heemstra, Ronald, Bhatti, Balwinder S., Akireddy, Rao, Murthy, Srinivasa, Miao, Lan, Jett, John E., Speake, Jason, Bencherif, Merouane

“…We have synthesized a novel series of compounds, 3,6-diazabicyclo[3.1.1]heptane-3-carboxamides, targeting both the α4β2 and α6/α3β2β3 nAChRs. Members of the…”
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Discovery of 3‑(5-Chloro-2-furoyl)-3,7-diazabicyclo[3.3.0]octane (TC-6683, AZD1446), a Novel Highly Selective α4β2 Nicotinic Acetylcholine Receptor Agonist for the Treatment of Cognitive Disorders by Mazurov, Anatoly A, Miao, Lan, Bhatti, Balwinder S, Strachan, Jon-Paul, Akireddy, Srinivasa, Murthy, Srinivasa, Kombo, David, Xiao, Yun-de, Hammond, Philip, Zhang, Jenny, Hauser, Terry A, Jordan, Kristen G, Miller, Craig H, Speake, Jason D, Gatto, Gregory J, Yohannes, Daniel

“…Diversification of essential nicotinic cholinergic pharmacophoric elements, i.e., cationic center and hydrogen bond acceptor, resulted in the discovery of…”
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Diazaspirocyclic compounds as selective ligands for the α4β2 nicotinic acetylcholine receptor by Strachan, Jon-Paul, Farias, Jarrett J., Zhang, Jenny, Caldwell, William S., Bhatti, Balwinder S.

“…Diazaspirocyclic ligands have been synthesized in four steps as selective α4β2 nicotinic acetylcholine receptor antagonists. Structural assignment of…”
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Structure–Activity Studies of 7‑Heteroaryl-3-azabicyclo[3.3.1]non-6-enes: A Novel Class of Highly Potent Nicotinic Receptor Ligands by Breining, Scott R, Melvin, Matt, Bhatti, Balwinder S, Byrd, Gary D, Kiser, Melanie N, Hepler, Christopher D, Hooker, Dawn N, Zhang, Jenny, Reynolds, Leslie A, Benson, Lisa R, Fedorov, Nikolai B, Sidach, Serguei S, Mitchener, J. Pike, Lucero, Linda M, Lukas, Ronald J, Whiteaker, Paul, Yohannes, Daniel

“…The potential for nicotinic ligands with affinity for the α4β2 or α7 subtypes to treat such diverse diseases as nicotine addiction, neuropathic pain, and…”
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Synthesis of 2-(Pyridin-3-yl)-1-azabicyclo[3.2.2]nonane, 2-(Pyridin-3-yl)-1-azabicyclo[2.2.2]octane, and 2-(Pyridin-3-yl)-1-azabicyclo[3.2.1]octane, a Class of Potent Nicotinic Acetylcholine Receptor–Ligands by Bhatti, Balwinder S, Strachan, Jon-Paul, Breining, Scott R, Miller, Craig H, Tahiri, Persida, Crooks, Peter A, Deo, Niranjan, Day, Cynthia S, Caldwell, William S

“…In an attempt to generate nicotinic acetylcholine receptor (nAChR) ligands selective for the α4β2 and α7 subtype receptors we designed and synthesized…”
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Synthesis of Bicyclic Tertiary α-Amino Acids by Strachan, Jon-Paul, Whitaker, Regina C, Miller, Craig H, Bhatti, Balwinder S

“…Novel bicyclic α-amino acids, exo and endo-1-azabicyclo[2.2.1]heptane-2-carboxylic acid, 1-azabicyclo[2.2.1]heptane-7-carboxylic acid, and…”
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First Total Synthesis of (±)-3-Hydroxy-11-norcytisine: Structure Confirmation and Biological Characterization by Yohannes, Daniel, Hansen, Camilla P, Akireddy, Srinivasa Rao, Hauser, Terry A, Kiser, Melanie N, Gurnon, Nicholas J, Day, Cynthia S, Bhatti, Balwinder, Caldwell, William S

“…The first total synthesis of the natural product 3-hydroxy-11-norcytisine (1), structurally related to cytisine (2), a benchmark ligand at neuronal nicotinic…”
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The neuroprotective effect of 2-(3-pyridyl)-1-azabicyclo[3.2.2]nonane (TC-1698), a novel alpha7 ligand, is prevented through angiotensin II activation of a tyrosine phosphatase by Marrero, Mario B, Papke, Roger L, Bhatti, Balwinder S, Shaw, Seán, Bencherif, Merouane

“…We have recently provided evidence for nicotine-induced complex formation between the alpha7 nicotinic acetylcholine receptor (nAChR) and the…”
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A novel enantioselective synthesis of (S)-(−)- and (R)-(+)-nornicotine via alkylation of a chiral 2-hydroxy-3-pinanone ketimine template by Swango, Jason H., Bhatti, Balwinder S., Qureshi, Muhammad M., Crooks, Peter A.

“…An asymmetric synthesis of the optically pure isomers of the minor tobacco alkaloid and CNS nicotine metabolite, nornicotine, has been achieved with moderately…”
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