Search Results - "Bhatia, Manish"

Hyperoxaluria leads to dysbiosis and drives selective enrichment of oxalate metabolizing bacterial species in recurrent kidney stone endures by Suryavanshi, Mangesh V., Bhute, Shrikant S., Jadhav, Swapnil D., Bhatia, Manish S., Gune, Rahul P., Shouche, Yogesh S.

“…Hyperoxaluria due to endogenously synthesized and exogenously ingested oxalates is a leading cause of recurrent oxalate stone formations. Even though, humans…”
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Design of Multitarget Inhibitors as Tracheal Smooth Muscle Relaxants by Bhatia, Neela M, Bhatia, Manish S, Mohanty, Sibaprasad K, Parulekar, Rishikesh S, Joshi, Amruta V, Ashtekar, Snehal S

“…Asthma complications and adverse effects associated with steroidal therapy highlight the need for non-steroidal compounds intercepting asthmatic…”
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A Systematic Review on Chemical Actives from Plant Sources, Targets and Chemotherapy for Triple-Negative Breast Cancer by Varne, Aarti A., Bhatia, Manish S., Ashtek, Snehal S.

“…Triple-negative breast cancer (TNBC) accounts for 15 – 20% of all other types of cancer. Due to the lack of target-specific compounds against particular…”
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Experimental and chemoinformatics evaluation of some physicochemical properties of excipients influencing release kinetics of the acidic drug ibuprofen by Gaikwad, Vinod L., Bhatia, Manish S., Singhvi, Indrajeet

“…[Display omitted] •Molecular descriptors of polymeric structures were calculated.•Formulation properties were correlated with calculated descriptors.•This…”
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Development of lipoprotein-drug conjugates for targeted drug delivery by Bhatia, Manish S., Choudhari, Sujata P., Dhavale, Rakesh P., Gaikwad, Vinod L.

“…Tumour targeting approaches used in cancer chemotherapy offers prolonged, localized, and protected drug interaction with the diseased tissue with minimal side…”
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Development of leads targeting ER-α in breast cancer: An in silico exploration from natural domain by Ashtekar, Snehal S., Bhatia, Neela M., Bhatia, Manish S.

“…[Display omitted] •Computational approach for screening chemically diverse natural products targeting ER+ breast cancer.•Virtual screening, QSAR studies and…”
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Computational Modeling of Polymeric Physicochemical Properties for Formulation Development of a Drug Containing Basic Functionality by Gaikwad, Vinod L, Bhatia, Neela M, Singhvi, Indrajeet, Mahadik, Kakasaheb R, Bhatia, Manish S

“…In the present research, predictive models were developed by correlating polymeric properties with characteristics of a formulation containing a drug with…”
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Discovery of pyridoindole derivatives as potential inhibitors for phosphodiesterase 5A: in silico and in vivo studies by Mali, Dipak P., Gaikwad, Dinanath T., Bhatia, Manish S., Bhatia, Neela M.

“…The aim of this work was to synthesise derivatives from identified plant based pyridoindole lead scaffold, and to assess phosphodiesterase 5A inhibitory…”
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In silico evaluation of NO donor heterocyclic vasodilators as SARS-CoV-2 M pro protein inhibitor by Al-Sehemi, Abdullah G, Parulekar, Rishikesh S, Pannipara, Mehboobali, P P, Manzur Ali, Zubaidha, Pudukulathan K, Bhatia, Manish S, Mohanta, Tapan Kumar, Al-Harrasi, Ahmed

“…Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) which causes COVID-19 disease has been exponentially increasing throughout the world. The…”
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Identification and Investigation of Chalcone Derivatives as Calcium Channel Blockers: Pharmacophore Modeling, Docking Studies, In vitro Screening, and 3D-QSAR Analysis by Sherikar, Amol S, Bhatia, Manish S, Dhavale, Rakesh P

“…The chalcones were reported to have many biological activities by showing affinity towards many enzymatic targets. The effect of nitric oxide (NO) on calcium…”
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Exploration of Leads from Natural Domain Targeting HER2 in Breast Cancer: An In-Silico Approach by Ashtekar, Snehal S., Bhatia, Neela M., Bhatia, Manish S.

“…The human epidermal growth factor (HER2/neu) receptor protein target expression plays a vital role in the development of breast cancer and is increased in…”
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Quantitative structure property relationship modeling of excipient properties for prediction of formulation characteristics by Gaikwad, Vinod L., Bhatia, Neela M., Desai, Sujit A., Bhatia, Manish S.

“…•Corrected values of molecular descriptors for excipients structure were calculated.•These descriptor values were then correlated with formulation…”
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Dermatomyositis: Look beyond skin by Prasad, Karthik K, Bhatia, Manish S, Sirsath, Nagesh T

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In silico evaluation of NO donor heterocyclic vasodilators as SARS-CoV-2 Mpro protein inhibitor by Al-Sehemi, Abdullah G., Parulekar, Rishikesh S., Pannipara, Mehboobali, P P, Manzur Ali, Zubaidha, Pudukulathan K., Bhatia, Manish S., Mohanta, Tapan Kumar, Al-Harrasi, Ahmed

“…Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) which causes COVID-19 disease has been exponentially increasing throughout the world. The…”
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Quantitative Structure–Property Relationship Approach in Formulation Development: an Overview by Kulkarni, Ajit S., Kasabe, Amit J., Bhatia, Manish S., Bhatia, Neela M., Gaikwad, Vinod L.

“…Chemoinformatics is emerging as a new trend to set drug discovery which correlates the relationship between structure and biological functions. The main aim of…”
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Development of controlled release cellulose-pellets based multicore tablets by Gaikwad, Vinod L., Sharma, Seema N., Bhatia, Manish S., Mahadik, Kakasaheb R.

“…[Display omitted] •Granules based multicore tablets showed inferior quality attributes.•Therefore, quality by design approach was integrated for product…”
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ENGINEERED ATENOLOL-GLYCOCONJUGATES TO TARGET H9C2 CARDIOMYOCYTE CELL LINES by Kumbha, Smita Tukaram, Bhatia, Manish Sudesh, Patil, Shitalkumar Shivgonda

“…Background: One of the most important fields of biomedical engineering study nowadays is targeted drug delivery to specific cells. A drug's therapeutic…”
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Synthesis, Antimicrobial Evaluation and Molecular Docking of Some Potential 2,6-disubstituted 1H-Benzimidazoles; Non-Classical Antifolates by Harer, Sunil, Bhatia, Manish, Kawade, Vikram

“…Dihydrofolate reductase is one of the important enzymes for thymidylate and purine synthesis in micro-organisms. A large number of drugs have been designed to…”
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3D QSAR, pharmacophore indentification studies on series of 1-(2-ethoxyethyl)-1H-pyrazolo [4,3-d]pyrimidines as phosphodiesterase V inhibitors by Choudhari, Prafulla, Bhatia, Manish

“…In recent years phosphodiesterase V acts as an attractive target for cardiovascular drug design and QSAR techniques are helpful for the optimization of…”
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Proteasome inhibitors mechanism; source for design of newer therapeutic agents by Harer, Sunil L, Bhatia, Manish S, Bhatia, Neela M

“…The proteasome was first identified as a high MW protease complex that gets resolved into a series of low MW protein species upon denaturation. As the dominant…”
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