Search Results - "Bhatia, Harsharan S"
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Panoptic imaging of transparent mice reveals whole-body neuronal projections and skull–meninges connections
Published in Nature neuroscience (01-02-2019)“…Analysis of entire transparent rodent bodies after clearing could provide holistic biological information in health and disease, but reliable imaging and…”
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Anti-neuroinflammatory effects of Ginkgo biloba extract EGb761 in LPS-activated primary microglial cells
Published in Phytomedicine (Stuttgart) (15-05-2018)“…Neuroinflammation is a key factor of Alzheimer's disease (AD) and other neurodegenerative conditions. Microglia are the resident mononuclear immune cells of…”
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Alleviation of Microglial Activation Induced by p38 MAPK/MK2/PGE2 Axis by Capsaicin: Potential Involvement of other than TRPV1 Mechanism/s
Published in Scientific reports (08-03-2017)“…Exaggerated inflammatory responses in microglia represent one of the major risk factors for various central nervous system’s (CNS) associated pathologies…”
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Resveratrol potently reduces prostaglandin E2 production and free radical formation in lipopolysaccharide-activated primary rat microglia
Published in Journal of neuroinflammation (10-10-2007)“…Neuroinflammatory responses are triggered by diverse ethiologies and can provide either beneficial or harmful results. Microglial cells are the major cell type…”
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Pharmacological inhibition of Akt and downstream pathways modulates the expression of COX-2 and mPGES-1 in activated microglia
Published in Journal of neuroinflammation (03-01-2012)“…Microglia are considered a major target for modulating neuroinflammatory and neurodegenerative disease processes. Upon activation, microglia secrete…”
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Regulation of prostaglandin E2 synthase expression in activated primary rat microglia: Evidence for uncoupled regulation of mPGES-1 and COX-2
Published in Glia (01-06-2008)“…Prostaglandin E2 (PGE2) is among the most important mediators involved in neuroinflammatory processes. The final step of its synthesis is regulated by enzymes…”
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The anti-inflammatory effects of the 5-HT3 receptor antagonist tropisetron are mediated by the inhibition of p38 MAPK activation in primary human monocytes
Published in International immunopharmacology (01-08-2012)“…There is evidence from human and animal research that 5-hydroxytryptamine (5-HT) 3 receptor antagonists, particularly tropisetron, exert analgesic and…”
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Effects of diet and/or exercise in enhancing spinal cord sensorimotor learning
Published in PloS one (20-07-2012)“…Given that the spinal cord is capable of learning sensorimotor tasks and that dietary interventions can influence learning involving supraspinal centers, we…”
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Inflammatory and oxidative mechanisms potentiate bifenthrin-induced neurological alterations and anxiety-like behavior in adult rats
Published in Toxicology letters (15-09-2018)“…Graphical abstract summarizing the neurological alterations induced by BF. BF induces oxidative stress mediated inflammatory responses via the activation of…”
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Inhibition of neuroinflammation by thymoquinone requires activation of Nrf2/ARE signalling
Published in International immunopharmacology (01-07-2017)“…Thymoquinone is an antioxidant phytochemical that has been shown to inhibit neuroinflammation. However, little is known about the potential roles of…”
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Resveratrol inhibits prostaglandin formation in IL-1β-stimulated SK-N-SH neuronal cells
Published in Journal of neuroinflammation (14-09-2009)“…Resveratrol, a polyphenol present in grapes and red wine, has been studied due to its vast pharmacological activity. It has been demonstrated that resveratrol…”
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Rice bran derivatives alleviate microglia activation: possible involvement of MAPK pathway
Published in Journal of neuroinflammation (14-06-2016)“…Hyperactivation of microglia is considered to be a key hallmark of brain inflammation and plays a critical role in regulating neuroinflammatory events…”
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Silica Nanoparticles Induce Hepatotoxicity by Triggering Oxidative Damage, Apoptosis, and Bax-Bcl2 Signaling Pathway
Published in Biological trace element research (01-04-2022)“…The increase in the usage of silica nanoparticles (SiNPs) in the industrial and medical fields has raised concerns about their possible adverse effects on…”
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Anti-neuroinflammatory properties of synthetic cryptolepine in human neuroblastoma cells: Possible involvement of NF-κB and p38 MAPK inhibition
Published in European journal of medicinal chemistry (01-05-2013)“…Cryptolepis sanguinolenta and its bioactive alkaloid, cryptolepine have shown anti-inflammatory activity. However, the underlying mechanism of…”
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Mangiferin inhibits cyclooxygenase-2 expression and prostaglandin E2 production in activated rat microglial cells
Published in Archives of biochemistry and biophysics (15-09-2008)“…Mangiferin, a naturally occurring glucosylxanthone, has potent antioxidant and anti-inflammatory properties, as demonstrated in several reports. However, very…”
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Inhibition of Neuroinflammation in LPS-Activated Microglia by Cryptolepine
Published in Evidence-based complementary and alternative medicine (01-01-2013)“…Cryptolepine, an indoloquinoline alkaloid in Cryptolepis sanguinolenta, has anti-inflammatory property. In this study, we aimed to evaluate the effects of…”
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The anti-inflammatory effects of the 5-HT3 receptor antagonist tropisetron are mediated by the inhibition of p38 MAPK activation in primary human monocytes
Published in Brain, behavior, and immunity (15-02-2013)“…There is evidence from human and animal research that 5-hydroxytryptamine (5-HT) 3 receptor antagonists, particularly tropisetron, exert analgesic and…”
Get full text
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Ascorbic acid enhances the inhibitory effect of aspirin on neuronal cyclooxygenase-2-mediated prostaglandin E2 production
Published in Journal of neuroimmunology (01-05-2006)“…Inhibition of neuronal cyclooxygenase-2 (COX-2) and hence prostaglandin E2 (PGE2) synthesis by non-steroidal anti-inflammatory drugs has been suggested to…”
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P2-357: Effects of resveratrol on microglial inflammatory and phagocytic activity
Published in Alzheimer's & dementia (01-07-2008)Get full text
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