Search Results - "Bhatia, Gurpreet S"

Enantioselective Formal Total Synthesis of the Antitumor Macrolide Bryostatin 7 by Manaviazar, Soraya, Frigerio, Mark, Bhatia, Gurpreet S, Hummersone, Marc G, Aliev, Abil E, Hale, Karl J

“…A new enantioselective synthesis of Masamune's AB fragment (1) for bryostatin 7 is described. Key steps in the new route include a Meerwein−Ponndorf−Verley…”
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Enantioselective synthesis of (3 R)- and (3 S)-piperazic acids. The comparative unimportance of DMPU mediated retro-hydrazination by Hale, Karl J, Cai, Jiaqiang, Delisser, Vern, Manaviazar, Soraya, Peak, S.Andrew, Bhatia, Gurpreet S, Collins, Timothy C, Jogiya, Neha

“…In response to a recent literature report by Decicco and Leathers (Ref. 13), the work of Hale, Delisser, and Manaviazar (1992) on the asymmetric synthesis of…”
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The neuroprotective action of JNK3 inhibitors based on the 6,7-dihydro-5H-pyrrolo[1,2-a]imidazole scaffold by GRACZYK, Piotr P, KHAN, Afzal, SMALES, Caroline, WHITFIELD, Jonathan, NEAME, Stephen J, SHAH, Bina, WILTON, Daniel, MORGAN, Louise, PATEL, Toshal, CHUNG, Raymond, DESMOND, Howard, STADDON, James M, BHATIA, Gurpreet S, SATO, Nobuaki, INOUE, Atsushi, PALMER, Vanessa, MEDLAND, Darren, NUMATA, Hirotoshi, OINUMA, Hitoshi, CATCHICK, Jacqueline, DUNNE, Angela, ELLIS, Moira

“…Imidazole-based structures of p38 inhibitors served as a starting point for the design of JNK3 inhibitors. Construction of a…”
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Synthesis of A83586C Analogs with Potent Anticancer and β-Catenin/ TCF4/Osteopontin Inhibitory Effects and Insights Into How A83586C Modulates E2Fs and pRb by Hale, Karl J, Manaviazar, Soraya, Lazarides, Linos, George, Jonathan, Walters, Marcus A, Cai, Jiaqiang, Delisser, Vern M, Bhatia, Gurpreet S, Peak, S. Andrew, Dalby, Stephen M, Lefranc, Amandine, Chen, Ying-Nan P, Wood, Alexander W, Crowe, Paul, Erwin, Pauline, El-Tanani, Mohamed

“…The synthesis of three potent new antitumor agents is described: the A83586C−citropeptin hybrid (1), the A83586C−GE3 hybrid (2), and l-Pro-A83586C (3)…”
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Control of Olefin Geometry in the Bryostatin B-Ring through Exploitation of a C 2-Symmetry Breaking Tactic and a Smith−Tietze Coupling Reaction by Hale, Karl J, Hummersone, Marc G, Bhatia, Gurpreet S

“…A completely stereocontrolled asymmetric synthesis of an advanced B-ring synthon for the bryostatin family of antitumor agents is reported. Noteworthy features…”
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A mild protocol for the deoxygenation of α-hydrogen-containing sulfoxides to the corresponding sulfides by Bhatia, Gurpreet S., Graczyk, Piotr P.

“…Graphic A mild method for the deoxygenation of α-hydrogen-containing sulfoxides to sulfides is reported. This synthetically useful and operationally simple…”
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The neuroprotective action of JNK3 inhibitors based on the 6,7-dihydro-5 H-pyrrolo[1,2- a]imidazole scaffold by Graczyk, Piotr P., Khan, Afzal, Bhatia, Gurpreet S., Palmer, Vanessa, Medland, Darren, Numata, Hirotoshi, Oinuma, Hitoshi, Catchick, Jacqueline, Dunne, Angela, Ellis, Moira, Smales, Caroline, Whitfield, Jonathan, Neame, Stephen J., Shah, Bina, Wilton, Daniel, Morgan, Louise, Patel, Toshal, Chung, Raymond, Desmond, Howard, Staddon, James M., Sato, Nobuaki, Inoue, Atsushi

“…The synthesis and neuroprotective properties of three representative enantiomeric pairs ( S)- 2 and ( R)- 2 are reported. Imidazole-based structures of p38…”
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Generation of near-enantiopure α-alkyl α-formyl α-hydroxy ketones/esters and their interception with ethoxycarbonylmethylenetriphenylphosphorane by Bhatia, Gurpreet S., Lowe, Richard F., Stoodley, Richard J.

“…Two protocols for the generation of the ( R)-enantiomers of α-alkyl α-formyl α-hydroxy ketones/esters in states of high enantiomeric purity are developed; the…”
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