Search Results - "Bhathal, Prithi S."

STAT3-Driven Upregulation of TLR2 Promotes Gastric Tumorigenesis Independent of Tumor Inflammation by Tye, Hazel, Kennedy, Catherine L., Najdovska, Meri, McLeod, Louise, McCormack, William, Hughes, Norman, Dev, Anouk, Sievert, William, Ooi, Chia Huey, Ishikawa, Tomo-o, Oshima, Hiroko, Bhathal, Prithi S., Parker, Andrew E., Oshima, Masanobu, Tan, Patrick, Jenkins, Brendan J.

“…Gastric cancer (GC) is associated with chronic inflammation; however, the molecular mechanisms promoting tumorigenesis remain ill defined. Using a GC mouse…”
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Hyperactive gp130/STAT3‐driven gastric tumourigenesis promotes submucosal tertiary lymphoid structure development by Hill, David G., Yu, Liang, Gao, Hugh, Balic, Jesse J., West, Alison, Oshima, Hiroko, McLeod, Louise, Oshima, Masanobu, Gallimore, Awen, D'Costa, Kimberley, Bhathal, Prithi S., Sievert, William, Ferrero, Richard L., Jenkins, Brendan J., Jones, Gareth W.

“…Tertiary lymphoid structures (TLSs) display phenotypic and functional characteristics of secondary lymphoid organs, and often develop in tissues affected by…”
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Serine-Phosphorylated STAT3 Promotes Tumorigenesis via Modulation of RNA Polymerase Transcriptional Activity by Balic, Jesse J, Garama, Daniel J, Saad, Mohamed I, Yu, Liang, West, Alison C, West, Alice J, Livis, Thaleia, Bhathal, Prithi S, Gough, Daniel J, Jenkins, Brendan J

“…Deregulated activation of the latent oncogenic transcription factor STAT3 in many human epithelial malignancies, including gastric cancer, has invariably been…”
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Constitutive STAT3 Serine Phosphorylation Promotes Helicobacter-Mediated Gastric Disease by Balic, Jesse J., Saad, Mohamed I., Dawson, Ruby, West, Alice J., McLeod, Louise, West, Alison C., D'Costa, Kimberley, Deswaerte, Virginie, Dev, Anouk, Sievert, William, Gough, Daniel J., Bhathal, Prithi S., Ferrero, Richard L., Jenkins, Brendan J.

“…Gastric cancer is associated with chronic inflammation (gastritis) triggered by persistent Helicobacter pylori (H. pylori) infection. Elevated tyrosine…”
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Nonalcoholic Fatty Liver Disease: Predictors of Nonalcoholic Steatohepatitis and Liver Fibrosis in the Severely Obese by Dixon, John B., Bhathal, Prithi S., O'Brien, Paul E.

“…Background & Aims: Nonalcoholic fatty liver disease (NAFLD) is common in severely obese subjects and can progress to cirrhosis and liver failure. Predicting…”
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Stereological Analysis of Liver Biopsy Histology Sections as a Reference Standard for Validating Non-Invasive Liver Fat Fraction Measurements by MRI by St Pierre, Tim G, House, Michael J, Bangma, Sander J, Pang, Wenjie, Bathgate, Andrew, Gan, Eng K, Ayonrinde, Oyekoya T, Bhathal, Prithi S, Clouston, Andrew, Olynyk, John K, Adams, Leon A

“…Validation of non-invasive methods of liver fat quantification requires a reference standard. However, using standard histopathology assessment of liver…”
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Heterogeneity of fibrosis patterns in non-alcoholic fatty liver disease supports the presence of multiple fibrogenic pathways by Skoien, Richard, Richardson, Michelle M., Jonsson, Julie R., Powell, Elizabeth E., Brunt, Elizabeth M., Neuschwander-Tetri, Brent A., Bhathal, Prithi S., Dixon, John B., O'Brien, Paul E., Tilg, Herbert, Moschen, Alexander R., Baumann, Ulrich, Brown, Rachel M., Couper, Richard T., Manton, Nicholas D., Ee, Looi C., Weltman, Martin, Clouston, Andrew D.

“…Background Adult non‐alcoholic fatty liver disease (NAFLD) involves lobular necroinflammatory activity and fibrosis is typically centrilobular, whereas…”
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Diagnostic performance of a rapid magnetic resonance imaging method of measuring hepatic steatosis by House, Michael J, Gan, Eng K, Adams, Leon A, Ayonrinde, Oyekoya T, Bangma, Sander J, Bhathal, Prithi S, Olynyk, John K, St Pierre, Tim G

“…Hepatic steatosis is associated with an increased risk of developing serious liver disease and other clinical sequelae of the metabolic syndrome. However,…”
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The molecular pathogenesis of STAT3-driven gastric tumourigenesis in mice is independent of IL-17 by Kennedy, Catherine L, Najdovska, Meri, Jones, Gareth W, McLeod, Louise, Hughes, Norman R, Allison, Cody, Huey Ooi, Chia, Tan, Patrick, Ferrero, Richard L, Jones, Simon A, Dev, Anouk, Sievert, William, Bhathal, Prithi S, Jenkins, Brendan J

“…Chronic activation of the gastric mucosal adaptive immune response is a characteristic trait of gastric cancer. It has recently emerged that a new class of T…”
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Consensus recommendations for histological criteria of autoimmune hepatitis from the International AIH Pathology Group: Results of a workshop on AIH histology hosted by the European Reference Network on Hepatological Diseases and the European Society of Pathology by Lohse, Ansgar W., Sebode, Marcial, Bhathal, Prithi S., Clouston, Andrew D., Dienes, Hans P., Jain, Dhanpat, Gouw, Annette S. H., Guindi, Maha, Kakar, Sanjay, Kleiner, David E., Krech, Till, Lackner, Carolin, Longerich, Thomas, Saxena, Romil, Terracciano, Luigi, Washington, Kay, Weidemann, Sören, Hübscher, Stefan G., Tiniakos, Dina

“…Background & AimsDiagnostic histological criteria for autoimmune hepatitis (AIH) have not been clearly established. Previously published criteria focused…”
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Copper, copper‐binding protein and cytokeratin 7 in biliary disorders by Quaglia, Alberto, Bhathal, Prithi S

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Nonalcoholic fatty liver disease: Improvement in liver histological analysis with weight loss by Dixon, John B., Bhathal, Prithi S., Hughes, Norman R., O'Brien, Paul E.

“…The effect of significant weight loss on nonalcoholic fatty liver disease remains unclear. In this case series of 36 selected obese patients, we examined the…”
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STAT3 and STAT1 mediate IL-11-dependent and inflammation-associated gastric tumorigenesis in gp130 receptor mutant mice by Ernst, Matthias, Najdovska, Meri, Grail, Dianne, Lundgren-May, Therese, Buchert, Michael, Tye, Hazel, Matthews, Vance B, Armes, Jane, Bhathal, Prithi S, Hughes, Norman R, Marcusson, Eric G, Karras, James G, Na, Songqing, Sedgwick, Jonathon D, Hertzog, Paul J, Jenkins, Brendan J

“…Deregulated activation of STAT3 is frequently associated with many human hematological and epithelial malignancies, including gastric cancer. While exaggerated…”
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Innate Immune Molecule NLRC5 Protects Mice From Helicobacter-induced Formation of Gastric Lymphoid Tissue by Chonwerawong, Michelle, Ferrand, Jonathan, Chaudhry, Hassan Mohammad, Higgins, Chloe, Tran, Le Son, Lim, San Sui, Walker, Marjorie M., Bhathal, Prithi S., Dev, Anouk, Moore, Gregory T., Sievert, William, Jenkins, Brendan J., D’Elios, Mario M., Philpott, Dana J., Kufer, Thomas A., Ferrero, Richard L.

“…Helicobacter pylori induces strong inflammatory responses that are directed at clearing the infection, but if not controlled, these responses can be harmful to…”
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Progressive Fibrosis in Nonalcoholic Steatohepatitis: Association With Altered Regeneration and a Ductular Reaction by Richardson, Michelle M, Jonsson, Julie R, Powell, Elizabeth E, Brunt, Elizabeth M, Neuschwander–Tetri, Brent A, Bhathal, Prithi S, Dixon, John B, Weltman, Martin D, Tilg, Herbert, Moschen, Alexander R, Purdie, David M, Demetris, Anthony J, Clouston, Andrew D

“…Background & Aims: Portal fibrosis and linkage is a key feature of progressive disease in nonalcoholic steatohepatitis (NASH), but not simple steatosis. It is…”
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Weight loss and non-alcoholic fatty liver disease: falls in gamma-glutamyl transferase concentrations are associated with histologic improvement by Dixon, John B, Bhathal, Prithi S, O'Brien, Paul E

“…The ability for aminotransferase levels to track histological features of non-alcoholic fatty liver disease (NAFLD) with weight loss has not been examined. We…”
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Nucleotide oligomerization domain 1 enhances IFN-γ signaling in gastric epithelial cells during Helicobacter pylori infection and exacerbates disease severity by Allison, Cody C, Ferrand, Jonathan, McLeod, Louise, Hassan, Mohammad, Kaparakis-Liaskos, Maria, Grubman, Alexandra, Bhathal, Prithi S, Dev, Anouk, Sievert, William, Jenkins, Brendan J, Ferrero, Richard L

“…Virulent Helicobacter pylori strains that specifically activate signaling in epithelial cells via the innate immune molecule, nucleotide oligomerization domain…”
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Effects of Bariatric Surgery on Liver Function Tests in Patients with Nonalcoholic Fatty Liver Disease by Ooi, Geraldine J., Burton, Paul R., Doyle, Lisa, Wentworth, John M., Bhathal, Prithi S., Sikaris, Ken, Cowley, Michael A., Roberts, Stuart K., Kemp, William, Earnest, Arul, O’Brien, Paul E., Brown, Wendy A.

“…Objectives Nonalcoholic fatty liver disease (NAFLD) affects over 80% of obese patients and is fueled by the metabolic syndrome. Weight loss is strongly…”
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Modified thresholds for fibrosis risk scores in nonalcoholic fatty liver disease are necessary in the obese by Ooi, Geraldine J., Burton, Paul R., Doyle, Lisa, Wentworth, John M., Bhathal, Prithi S., Sikaris, Ken, Cowley, Michael A., Roberts, Stuart K., Kemp, William, O’Brien, Paul E., Brown, Wendy A.

“…Background Obesity and its related comorbidities are significant risk factors for nonalcoholic fatty liver disease (NAFLD). Liver fibrosis is the major…”
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Adenocarcinoma of gallbladder: an immunohistochemical profile and comparison with cholangiocarcinoma by Hughes, Norman Richard, Bhathal, Prithi S

“…Cholangiocarcinomas display intestinal and pyloric gland metaplasia-cell phenotypes. Those that arise in chronically inflamed (fluke infested) bile ducts more…”
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