Search Results - "Bhat, Sushant"

The SARS-CoV-2 Spike protein has a broad tropism for mammalian ACE2 proteins by Conceicao, Carina, Thakur, Nazia, Human, Stacey, Kelly, James T, Logan, Leanne, Bialy, Dagmara, Bhat, Sushant, Stevenson-Leggett, Phoebe, Zagrajek, Adrian K, Hollinghurst, Philippa, Varga, Michal, Tsirigoti, Christina, Tully, Matthew, Chiu, Chris, Moffat, Katy, Silesian, Adrian Paul, Hammond, John A, Maier, Helena J, Bickerton, Erica, Shelton, Holly, Dietrich, Isabelle, Graham, Stephen C, Bailey, Dalan

“…SARS Coronavirus 2 (SARS-CoV-2) emerged in late 2019, leading to the Coronavirus Disease 2019 (COVID-19) pandemic that continues to cause significant global…”
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Risk assessment of the newly emerged H7N9 avian influenza viruses by Chang, Pengxiang, Sadeyen, Jean-Remy, Bhat, Sushant, Daines, Rebecca, Hussain, Altaf, Yilmaz, Huseyin, Iqbal, Munir

“…Since the first human case in 2013, H7N9 avian influenza viruses (AIVs) have caused more than 1500 human infections with a mortality rate of approximately 40%…”
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Evaluation of the immunogenicity of prime-boost vaccination with the replication-deficient viral vectored COVID-19 vaccine candidate ChAdOx1 nCoV-19 by Graham, Simon P., McLean, Rebecca K., Spencer, Alexandra J., Belij-Rammerstorfer, Sandra, Wright, Daniel, Ulaszewska, Marta, Edwards, Jane C., Hayes, Jack W. P., Martini, Veronica, Thakur, Nazia, Conceicao, Carina, Dietrich, Isabelle, Shelton, Holly, Waters, Ryan, Ludi, Anna, Wilsden, Ginette, Browning, Clare, Bialy, Dagmara, Bhat, Sushant, Stevenson-Leggett, Phoebe, Hollinghurst, Philippa, Gilbride, Ciaran, Pulido, David, Moffat, Katy, Sharpe, Hannah, Allen, Elizabeth, Mioulet, Valerie, Chiu, Chris, Newman, Joseph, Asfor, Amin S., Burman, Alison, Crossley, Sylvia, Huo, Jiandong, Owens, Raymond J., Carroll, Miles, Hammond, John A., Tchilian, Elma, Bailey, Dalan, Charleston, Bryan, Gilbert, Sarah C., Tuthill, Tobias J., Lambe, Teresa

“…Clinical development of the COVID-19 vaccine candidate ChAdOx1 nCoV-19, a replication-deficient simian adenoviral vector expressing the full-length SARS-CoV-2…”
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A ligation and restriction enzyme independent cloning technique: an alternative to conventional methods for cloning hard-to-clone gene segments in the influenza reverse genetics system by Bhat, Sushant, Bialy, Dagmara, Sealy, Joshua E, Sadeyen, Jean-Remy, Chang, Pengxiang, Iqbal, Munir

“…Reverse genetics is used in many laboratories around the world and enables the creation of tailor-made influenza viruses with a desired genotype or phenotype…”
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Evolution of Codon Usage Bias in Henipaviruses Is Governed by Natural Selection and Is Host-Specific by Kumar, Naveen, Kulkarni, Diwakar D, Lee, Benhur, Kaushik, Rahul, Bhatia, Sandeep, Sood, Richa, Pateriya, Atul Kumar, Bhat, Sushant, Singh, Vijendra Pal

“…Hendra virus (HeV) and Nipah virus (NiV) are among a group of emerging -borne paramyxoviruses that have crossed their species-barrier several times by…”
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Application of HDR-CRISPR/Cas9 and Erythrocyte Binding for Rapid Generation of Recombinant Turkey Herpesvirus-Vectored Avian Influenza Virus Vaccines by Chang, Pengxiang, Ameen, Faisal, Sealy, Joshua E, Sadeyen, Jean-Remy, Bhat, Sushant, Li, Yongqing, Iqbal, Munir

“…Avian influenza viruses (AIVs) are highly contagious and have caused huge economical loss to the poultry industry. AIV vaccines remain one of the most…”
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The Application of NHEJ-CRISPR/Cas9 and Cre-Lox System in the Generation of Bivalent Duck Enteritis Virus Vaccine against Avian Influenza Virus by Chang, Pengxiang, Yao, Yongxiu, Tang, Na, Sadeyen, Jean-Remy, Sealy, Joshua, Clements, Anabel, Bhat, Sushant, Munir, Muhammad, Bryant, Juliet E, Iqbal, Munir

“…Duck-targeted vaccines to protect against avian influenza are critically needed to aid in influenza disease control efforts in regions where ducks are endemic…”
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Highly pathogenic avian influenza H5N1 virus induces cytokine dysregulation with suppressed maturation of chicken monocyte-derived dendritic cells by Kalaiyarasu, Semmannan, Kumar, Manoj, Senthil Kumar, Dhanapal, Bhatia, Sandeep, Dash, Sandeep Kumar, Bhat, Sushant, Khetan, Rohit K., Nagarajan, Shanmugasundaram

“…ABSTRACT One of the major causes of death in highly pathogenic avian influenza virus (HPAIV) infection in chickens is acute induction of pro‐inflammatory…”
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Adsorptive mutation and N-linked glycosylation modulate influenza virus antigenicity and fitness by Sealy, Joshua E., Peacock, Thomas P., Sadeyen, Jean-Remy, Chang, Pengxiang, Everest, Holly J., Bhat, Sushant, Iqbal, Munir

“…Influenza viruses have an error-prone polymerase complex that facilitates a mutagenic environment. Antigenic mutants swiftly arise from this environment with…”
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Engineered Recombinant Single Chain Variable Fragment of Monoclonal Antibody Provides Protection to Chickens Infected with H9N2 Avian Influenza by Lukosaityte, Deimante, Sadeyen, Jean-Remy, Shrestha, Angita, Sealy, Joshua E, Bhat, Sushant, Chang, Pengxiang, Digard, Paul, Iqbal, Munir

“…Passive immunisation with neutralising antibodies can be a potent therapeutic strategy if used pre- or post-exposure to a variety of pathogens. Herein, we…”
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Recombinant A(H6N1)-H274Y avian influenza virus with dual drug resistance does not require permissive mutations to retain the replicative fitness in vitro and in ovo by Bialy, Dagmara, Richardson, Samuel, Chrzastek, Klaudia, Bhat, Sushant, Polo, Noemi, Freimanis, Graham, Iqbal, Munir, Shelton, Holly

“…The possible emergence of drug-resistant avian flu raises concerns over the limited effectiveness of currently approved antivirals (neuraminidase inhibitors -…”
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Immune Escape Adaptive Mutations in the H7N9 Avian Influenza Hemagglutinin Protein Increase Virus Replication Fitness and Decrease Pandemic Potential by Chang, Pengxiang, Sealy, Joshua E, Sadeyen, Jean-Remy, Bhat, Sushant, Lukosaityte, Deimante, Sun, Yipeng, Iqbal, Munir

“…H7N9 avian influenza viruses (AIVs) continue to evolve and remain a huge threat to human health and the poultry industry. Previously, serially passaging the…”
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Reverse genetics based H5N2 vaccine provides clinical protection against H5N1, H5N8 and H9N2 avian influenza infection in chickens by Panickan, Sivasankar, Bhatia, Sandeep, Bhat, Sushant, Bhandari, Nisha, Pateriya, Atul Kumar, Kalaiyarasu, Semmannan, Sood, Richa, Tripathi, Meghna

“…•rgH5N2 vaccine alone is protective against H5N1/H5N8 and reduced replication of H9N2 in chickens.•HA stalk is immunogenic in chicken.•HA stalk is not…”
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Coinfection of Chickens with H9N2 and H7N9 Avian Influenza Viruses Leads to Emergence of Reassortant H9N9 Virus with Increased Fitness for Poultry and a Zoonotic Potential by Bhat, Sushant, James, Joe, Sadeyen, Jean-Remy, Mahmood, Sahar, Everest, Holly J, Chang, Pengxiang, Walsh, Sarah K, Byrne, Alexander M P, Mollett, Benjamin, Lean, Fabian, Sealy, Joshua E, Shelton, Holly, Slomka, Marek J, Brookes, Sharon M, Iqbal, Munir

“…An H7N9 low-pathogenicity avian influenza virus (LPAIV) emerged in 2013 through genetic reassortment between H9N2 and other LPAIVs circulating in birds in…”
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The Origin of Internal Genes Contributes to the Replication and Transmission Fitness of H7N9 Avian Influenza Virus by James, Joe, Bhat, Sushant, Walsh, Sarah K, Karunarathna, Thusitha K, Sadeyen, Jean-Remy, Chang, Pengxiang, Sealy, Joshua E, Mahmood, Sahar, Mollett, Benjamin C, Slomka, Marek J, Brookes, Sharon M, Iqbal, Munir

“…H9N2 avian influenza viruses (AIVs) have donated internal gene segments during the emergence of zoonotic AIVs, including H7N9. We used reverse genetics to…”
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Antigenic Characterization of Human Monoclonal Antibodies for Therapeutic Use against H7N9 Avian Influenza Virus by Chang, Pengxiang, Lukosaityte, Deimante, Sealy, Joshua E, Rijal, Pramila, Sadeyen, Jean-Remy, Bhat, Sushant, Crossley, Sylvia, Daines, Rebecca, Huang, Kuan-Yin A, Townsend, Alain R, Iqbal, Munir

“…Since 2013, H7N9 avian influenza viruses (AIVs) have caused more than 1,500 human infections and the culling of millions of poultry. Despite large-scale…”
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Elevated level of pro inflammatory cytokine and chemokine expression in chicken bone marrow and monocyte derived dendritic cells following LPS induced maturation by Kalaiyarasu, Semmannan, Bhatia, Sandeep, Mishra, Niranjan, Sood, Richa, Kumar, Manoj, SenthilKumar, D., Bhat, Sushant, Dass Prakash, M

“…•Mature DCs showed significant up regulation of mRNA of surface markers.•iNOS and CXCLi2 mRNA expression is higher in mature DCs of both origin.•Mature DCs…”
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A two dose immunization with an inactivated reassortant H5N2 virus protects chickens against lethal challenge with homologous 2.3.2.1 clade and heterologous 2.2 clade highly pathogenic avian influenza H5N1 viruses by Bhat, Sushant, Sood, Richa, Shukla, Shweta, Khandia, Rekha, Pateriya, Atul Kumar, Kumar, Naveen, Singh, Vikas Kumar, Kalaiyarasu, Semmannan, Kumar, Manoj, Bhatia, Sandeep

“…•An inactivated H5N2 vaccine with HA from 2.3.2.1 clade H5N1 and NA from H9N2 was made.•The vaccine protected chickens against homologous clade 2.3.2.1 H5N1…”
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Identification and molecular characterization of H9N2 viruses carrying multiple mammalian adaptation markers in resident birds in central-western wetlands in India by Sood, Richa, Kumar, Naveen, Gokhe, Suresh S., Pateriya, Atul Kumar, Bhat, Sushant, Bhatia, Sandeep, Panickan, Sivasankar, Mishra, Anamika, Murugkar, H.V., Dixit, Roma, Shrivastava, Deepali, Singh, Pushpendra, Tripathi, Meghna, Singh, Vijendra Pal

“…We report here a targeted risk-based study to investigate the presence of influenza A viruses at the migratory-wild-domestic bird interface across the major…”
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Replicative fitness and transmission of G57 lineage and UDL01 like H9N2 viruses in chickens by Bhat, Sushant, Shelton, Holly, Sadeyen, Jean-Remy, Iqbal, Munir

“…The low pathogenic H9N2 influenza viruses are a threat to poultry as well as global public health due to their ability to reassort with other avian influenza…”
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