Search Results - "Bhat, Shridhar"

Inhibition of eukaryotic translation elongation by cycloheximide and lactimidomycin by Liu, Jun O, Schneider-Poetsch, Tilman, Ju, Jianhua, Eyler, Daniel E, Dang, Yongjun, Bhat, Shridhar, Merrick, William C, Green, Rachel, Shen, Ben

“…Cycloheximide is a natural product that cell biologists have used for decades as a tool to arrest protein synthesis in eukaryotes. Biochemical data now refine…”
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XPB, a subunit of TFIIH, is a target of the natural product triptolide by Liu, Jun O, Titov, Denis V, Gilman, Benjamin, He, Qing-Li, Bhat, Shridhar, Low, Woon-Kai, Dang, Yongjun, Smeaton, Michael, Demain, Arnold L, Miller, Paul S, Kugel, Jennifer F, Goodrich, James A

“…Triptolide is a bioactive natural product isolated from plants used in traditional Chinese medicine. A target identification approach shows that triptolide…”
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Three‐Component Synthesis of 3‐(Arylsulfonyl)benzothiophenes Using Acetic Acid as a Quencher for Methyl Radical‐Mediated Side Reactions by Shridhar Bhat, Vighneshwar, Lee, Anna

“…A one‐pot, three‐component synthesis of 3‐(arylsulfonyl)benzothiophenes was developed. The reaction did not require any catalysts or additives. The desired…”
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Hydrazide Mimics for Protein Lysine Acylation To Assess Nucleosome Dynamics and Deubiquitinase Action by Bhat, Shridhar, Hwang, Yousang, Gibson, Matthew D, Morgan, Michael T, Taverna, Sean D, Zhao, Yingming, Wolberger, Cynthia, Poirier, Michael G, Cole, Philip A

“…A range of acyl-lysine (acyl-Lys) modifications on histones and other proteins have been mapped over the past decade but for most, their functional and…”
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Disulfiram Reactivates Latent HIV-1 in a Bcl-2-Transduced Primary CD4+ T Cell Model without Inducing Global T Cell Activation by SIFEI XING, BULLEN, Cynthia K, MARGOLIS, David M, SILICIANO, Janet D, SILICIANO, Robert F, SHROFF, Neeta S, LIANG SHAN, YANG, Hung-Chih, MANUCCI, Jordyn L, BHAT, Shridhar, HAO ZHANG, MARGOLICK, Joseph B, QUINN, Thomas C

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The HBV Drug Entecavir — Effects on HIV-1 Replication and Resistance by McMahon, Moira A, Jilek, Benjamin L, Brennan, Timothy P, Shen, Lin, Zhou, Yan, Wind-Rotolo, Megan, Xing, Sifei, Bhat, Shridhar, Hale, Braden, Hegarty, Robert, Chong, Curtis R, Liu, Jun O, Siliciano, Robert F, Thio, Chloe L

“…Entecavir is a new antiviral medication to treat hepatitis B virus (HBV) infection. Initial in vitro studies suggested it had no activity against human…”
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Inhibition of eukaryotic translation elongation by the antitumor natural product Mycalamide B by Dang, Yongjun, Schneider-Poetsch, Tilman, Eyler, Daniel E, Jewett, John C, Bhat, Shridhar, Rawal, Viresh H, Green, Rachel, Liu, Jun O

“…Mycalamide B (MycB) is a marine sponge-derived natural product with potent antitumor activity. Although it has been shown to inhibit protein synthesis, the…”
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Comorbid conditions responsible for the higher complications and poorer outcome in cardiac and vascular surgery: Time to reconsider hyperhomocysteinemia and its repercussions by Haridas, ArunKumar, Bhat, BharathiShridhar

“…Background: Plasma homocysteine is a perceived risk factor for the cardiovascular diseases. Many studies confirmed its remarkably high level with severity of…”
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Synthesis of antiproliferative flavones from calycopterin, major flavonoid of Calycopteris floribunda Lamk by Lewin, Guy, Shridhar, Narayan Bhat, Aubert, Geneviève, Thoret, Sylviane, Dubois, Joëlle, Cresteil, Thierry

“…Eighteen new analogues of the potent natural cytotoxic and antimitotic flavone 1 were synthesized from calycopterin 4. One of them, the 3′-amino analogue 5…”
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Novel glycosaminoglycan precursors as anti-amyloid agents, part III by Kisilevsky, Robert, Szarek, Walter A, Ancsin, John, Bhat, Shridhar, Li, Zhanjiang, Marone, Sandra

“…In vivo amyloids consist of two classes of constituents. The first is the disease-defining protein, e.g., amyloid beta (Abeta) in Alzheimer's disease (AD). The…”
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Short-Chain Aliphatic Polysulfonates Inhibit the Entry of Plasmodium into Red Blood Cells by KISILEVSKY, Robert, CRANDALL, Ian, SZAREK, Walter A, BHAT, Shridhar, TAN, Christopher, BOUDREAU, Lee, KAIN, Kevin C

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Rapamycin-inspired macrocycles with new target specificity by Guo, Zufeng, Hong, Sam Y., Wang, Jingxin, Rehan, Shahid, Liu, Wukun, Peng, Hanjing, Das, Manisha, Li, Wei, Bhat, Shridhar, Peiffer, Brandon, Ullman, Brett R., Tse, Chung-Ming, Tarmakova, Zlatina, Schiene-Fischer, Cordelia, Fischer, Gunter, Coe, Imogen, Paavilainen, Ville O., Sun, Zhaoli, Liu, Jun O.

“…Rapamycin and FK506 are macrocyclic natural products with an extraordinary mode of action, in which they form binary complexes with FK506-binding protein…”
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Macromolecular crowding induces compaction and DNA binding in the disordered N-terminal domain of hUNG2 by Rodriguez, Gaddiel, Orris, Benjamin, Majumdar, Ananya, Bhat, Shridhar, Stivers, James T.

“…[Display omitted] Many human DNA repair proteins have disordered domains at their N- or C-termini with poorly defined biological functions. We recently…”
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Guanine-containing ssDNA and RNA induce dimeric and tetrameric structural forms of SAMHD1 by Orris, Benjamin, Sung, Min Woo, Bhat, Shridhar, Xu, Yingrong, Huynh, Kevin W, Han, Seungil, Johnson, Darren C, Bosbach, Benedikt, Shields, David J, Stivers, James T

“…Abstract The dNTPase activity of tetrameric SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1 (SAMHD1) plays a critical role in…”
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Deoxyguanosine-Linked Bifunctional Inhibitor of SAMHD1 dNTPase Activity and Nucleic Acid Binding by Egleston, Matthew, Dong, Linghao, Howlader, A. Hasan, Bhat, Shridhar, Orris, Benjamin, Bianchet, Mario A., Greenberg, Marc M., Stivers, James T.

“…Sterile alpha motif histidine-aspartate domain protein 1 (SAMHD1) is a deoxynucleotide triphosphohydrolase that exists in monomeric, dimeric, and tetrameric…”
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Substituted oxines inhibit endothelial cell proliferation and angiogenesis by Bhat, Shridhar, Shim, Joong Sup, Zhang, Feiran, Chong, Curtis Robert, Liu, Jun O

“…Two substituted oxines, nitroxoline (5) and 5-chloroquinolin-8-yl phenylcarbamate (22), were identified as hits in a high-throughput screen aimed at finding…”
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Catalyst‐Free, One‐Pot, Three‐Component Synthesis of 3‐Arylsulfonylated Thioflavones by Bhat, Vighneshwar Shridhar, Lee, Anna

“…A one‐pot, three‐component synthesis of 3‐arylsulfonylated thioflavones has been developed. The reactions were carried out without using any catalysts or…”
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Direct C3 Carbamoylation of 2H‐Indazoles by Bhat, Vighneshwar Shridhar, Lee, Anna

“…We developed a novel method for direct C3 carbamoylation of 2H‐indazoles using oxamic acids as carbamoyl radical sources. In the presence of ammonium…”
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Inhibition of Angiogenesis by the Antifungal Drug Itraconazole by Chong, Curtis R, Xu, Jing, Lu, Jun, Bhat, Shridhar, Sullivan, David J, Liu, Jun O

“…Angiogenesis, the formation of new blood vessels, is implicated in a number of important human diseases, including cancer, diabetic retinopathy, and rheumatoid…”
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Structure-activity relationship study of itraconazole, a broad-range inhibitor of picornavirus replication that targets oxysterol-binding protein (OSBP) by Bauer, Lisa, Ferla, Salvatore, Head, Sarah A., Bhat, Shridhar, Pasunooti, Kalyan K., Shi, Wei Q., Albulescu, Lucian, Liu, Jun O., Brancale, Andrea, van Kuppeveld, Frank J.M., Strating, Jeroen R.P.M.

“…Itraconazole (ITZ) is a well-known, FDA-approved antifungal drug that is also in clinical trials for its anticancer activity. ITZ exerts its anticancer…”
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