Search Results - "Bhat, Ratan V."

Fatty acid metabolism driven mitochondrial bioenergetics promotes advanced developmental phenotypes in human induced pluripotent stem cell derived cardiomyocytes by Ramachandra, Chrishan J.A., Mehta, Ashish, Wong, Philip, Ja, K.P. Myu Mai, Fritsche-Danielson, Regina, Bhat, Ratan V., Hausenloy, Derek J., Kovalik, Jean-Paul, Shim, Winston

“…Preferential utilization of fatty acids for ATP production represents an advanced metabolic phenotype in developing cardiomyocytes. We investigated whether…”
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Glycogen synthase kinase 3: a drug target for CNS therapies by Bhat, Ratan V., Budd Haeberlein, Samantha L., Avila, Jesús

“…Glycogen synthase kinase3 (GSK3) is emerging as a prominent drug target in the CNS. The most exciting of the possibilities of GSK3 lies within the treatment of…”
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A systematic investigation of the protein kinases involved in NMDA receptor-dependent LTD: evidence for a role of GSK-3 but not other serine/threonine kinases by Peineau, Stéphane, Nicolas, Céline S, Bortolotto, Zuner A, Bhat, Ratan V, Ryves, W Jonathan, Harwood, Adrian J, Dournaud, Pascal, Fitzjohn, Stephen M, Collingridge, Graham L

“…The signalling mechanisms involved in the induction of N-methyl-D-aspartate (NMDA) receptor-dependent long-term depression (LTD) in the hippocampus are poorly…”
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The Conundrum of GSK3 Inhibitors: Is it the Dawn of a New Beginning? by Bhat, Ratan V, Andersson, Ulf, Andersson, Shalini, Knerr, Laurent, Bauer, Udo, Sundgren-Andersson, Anna K

“…Spanning over three decades of extensive drug discovery research, the efforts to develop a potent and selective GSK3 inhibitor as a therapeutic for the…”
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Inhibiting cardiac myeloperoxidase alleviates the relaxation defect in hypertrophic cardiomyocytes by Ramachandra, Chrishan J A, Kp, Myu Mai Ja, Chua, Jasper, Hernandez-Resendiz, Sauri, Liehn, Elisa A, Knöll, Ralph, Gan, Li-Ming, Michaëlsson, Erik, Jonsson, Malin K B, Ryden-Markinhuhta, Katarina, Bhat, Ratan V, Fritsche-Danielson, Regina, Lin, Ying-Hsi, Sadayappan, Sakthivel, Tang, Hak Chiaw, Wong, Philip, Shim, Winston, Hausenloy, Derek J

“…Abstract Aims Hypertrophic cardiomyopathy (HCM) is characterized by cardiomyocyte hypertrophy and disarray, and myocardial stiffness due to interstitial…”
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AZD1080, a novel GSK3 inhibitor, rescues synaptic plasticity deficits in rodent brain and exhibits peripheral target engagement in humans by Georgievska, Biljana, Sandin, Johan, Doherty, James, Mörtberg, Anette, Neelissen, Jan, Andersson, Anita, Gruber, Susanne, Nilsson, Yvonne, Schött, Pär, Arvidsson, Per I., Hellberg, Sven, Osswald, Gunilla, Berg, Stefan, Fälting, Johanna, Bhat, Ratan V.

“…Abnormal tau phosphorylation resulting in detachment of tau from microtubules and aggregation are critical events in neuronal dysfunction, degeneration, and…”
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Novel small molecule inhibitors of caspase-3 block cellular and biochemical features of apoptosis by Scott, Clay W, Sobotka-Briner, Cindy, Wilkins, Deidre E, Jacobs, Robert T, Folmer, James J, Frazee, William J, Bhat, Ratan V, Ghanekar, Smita V, Aharony, David

“…Caspase-3 is an intracellular cysteine protease, activated as part of the apoptotic response to cell injury. Its interest as a therapeutic target has led many…”
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MEDI1814 selectively reduces free Aβ42 in cerebrospinal fluid of non‐clinical species and Alzheimer's disease patients by Lloyd, Christopher, Freskgård, Per‐Ola, Newton, Philip, Lowne, David, Nickson, Adrian, Bogstedt, Anna, Eketjäll, Susanna, Höglund, Kina, Gustavsson, Susanne, Welsh, Fraser, Chessell, Tharani, McFarlane, Mary, Bhat, Ratan V., Turner, Richard, Perkinton, Michael S., Santisteban Valencia, Zulma, Lindqvist, Eva, Pomfret, Michael, Dudley, Amanda D., Vaughan, Tristan J., Groves, Maria T., Natanegara, Fanni, Feng, Yingdong, Sims, John R., Proctor, Nicholas Kyle, Dage, Jeffrey L., Shering, Craig, Tan, Keith, Ostenfeld, Thor, Billinton, Andy, Chessell, Iain P.

“…INTRODUCTION Small molecules and antibodies are being developed to lower amyloid beta (Aβ) peptides. METHODS We describe MEDI1814, a fully human high‐affinity…”
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Thymosin Beta-4 Is Elevated in Women With Heart Failure With Preserved Ejection Fraction by Drum, Chester L, Tan, Warren K Y, Chan, Siew-Pang, Pakkiri, Leroy S, Chong, Jenny P C, Liew, Oi-Wah, Ng, Tze-Pin, Ling, Lieng-Hsi, Sim, David, Leong, Kui-Toh G, Yeo, Daniel P S, Ong, Hean-Yee, Jaufeerally, Fazlur, Wong, Raymond C C, Chai, Ping, Low, Adrian F, Davidsson, Pia, Liljeblad, Mathias, Söderling, Ann-Sofi, Gan, Li-Ming, Bhat, Ratan V, Purnamawati, Kristy, Lam, Carolyn S P, Richards, A Mark

“…Thymosin beta-4 (TB4) is an X-linked gene product with cardioprotective properties. Little is known about plasma concentration of TB4 in heart failure (HF),…”
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Molecular Characterization of an Aquaporin cDNA from Brain: Candidate Osmoreceptor and Regulator of Water Balance by Jung, Jin Sup, Bhat, Ratan V., Preston, Gregory M., Guggino, William B., Baraban, Jay M., Agre, Peter

“…The aquaporins transport water through membranes of numerous tissues, but the molecular mechanisms for sensing changes in extracellular osmolality and…”
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Association of Cardiomyopathy With MYBPC3 D389V and MYBPC3Δ25bpIntronic Deletion in South Asian Descendants by Viswanathan, Shiv Kumar, Puckelwartz, Megan J, Mehta, Ashish, Ramachandra, Chrishan J A, Jagadeesan, Aravindakshan, Fritsche-Danielson, Regina, Bhat, Ratan V, Wong, Philip, Kandoi, Sangeetha, Schwanekamp, Jennifer A, Kuffel, Gina, Pesce, Lorenzo L, Zilliox, Michael J, Durai, U Nalla B, Verma, Rama Shanker, Molokie, Robert E, Suresh, Domodhar P, Khoury, Philip R, Thomas, Annie, Sanagala, Thriveni, Tang, Hak Chiaw, Becker, Richard C, Knöll, Ralph, Shim, Winston, McNally, Elizabeth M, Sadayappan, Sakthivel

“…The genetic variant MYBPC3Δ25bp occurs in 4% of South Asian descendants, with an estimated 100 million carriers worldwide. MYBPC3 Δ25bp has been linked to…”
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Differential sensitivity to lithium's reversal of amphetamine-induced open-field activity in two inbred strains of mice by Gould, Thomas J, Keith, Rich A, Bhat, Ratan V

“…To determine whether genetic differences could contribute to the pharmacological sensitivity of lithium chloride (LiCl) to reverse amphetamine-associated…”
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Expression of the APC tumor suppressor protein in oligodendroglia by Bhat, Ratan V., Axt, Karen J., Fosnaugh, Jennifer S., Smith, Kelly J., Johnson, Karen A., Hill, David E., Kinzler, Kenneth W., Baraban, Jay M.

“…Mutations of the adenomatous polyposis coli (APC) tumor suppressor gene have been linked to familial polyposis, an inherited predisposition to colon cancer,…”
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Differential patterns of regional c-Fos induction in the rat brain by amphetamine and the novel wakefulness-promoting agent modafinil by Engber, Thomas M, Koury, Elizabeth J, Dennis, Shelley A, Miller, Matthew S, Contreras, Patricia C, Bhat, Ratan V

“…We examined the neuronal targets in the rat brain for the novel wakefulness-promoting agent modafinil and for amphetamine using c-Fos immunohistochemistry…”
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Activation of arc, a putative "effector" immediate early gene, by cocaine in rat brain by Fosnaugh, J S, Bhat, R V, Yamagata, K, Worley, P F, Baraban, J M

“…As immediate early genes (IEGs) are thought to play a critical role in mediating stimulus-induced neuronal plasticity, several laboratories have characterized…”
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Regulation and localization of tyrosine216 phosphorylation of glycogen synthase kinase-3β in cellular and animal models of neuronal degeneration by Bhat, Ratan V., Shanley, Jason, Correll, Maryann P., Fieles, William E., Keith, Richard A., Scott, Clay W., Lee, Chi-Ming

“…Inactivation of glycogen synthase kinase-3β (GSK3β) by S 9 phosphorylation is implicated in mechanisms of neuronal survival. Phosphorylation of a distinct…”
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Identification of insulin-like growth factor binding protein-2 as a biochemical surrogate marker for the in vivo effects of recombinant human insulin-like growth factor-1 in mice by Bhat, R V, Engber, T M, Zhu, Y, Miller, M S, Contreras, P C

“…Recent studies indicate that a daily s.c. injection of 1 mg/kg of recombinant human insulin-like growth factor-1 (rhIGF-1) for 17 days is efficacious in…”
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Activation of p38MAPK in Microglia After Ischemia by Walton, Kevin M., DiRocco, Richard, Bartlett, Becky A., Koury, Elizabeth, Marcy, Val Robert, Jarvis, Bruce, Schaefer, Erik M., Bhat, Ratan V.

“…: p38MAPK has been implicated in the regulation of proinflammatory cytokines and apoptosis in vitro. To understand its role in neurodegeneration, we determined…”
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Region‐Specific Targets of p42/p44MAPK Signaling in Rat Brain by Bhat, Ratan V., Engber, Thomas M., Finn, James P., Koury, Elizabeth J., Contreras, Patricia C., Miller, Matthew S., Dionne, Craig A., Walton, Kevin M.

“…: In vitro studies indicate that p42/p44MAPK phosphorylate both nuclear and cytoplasmic proteins. However, the functional targets of p42/p44MAPK activation in…”
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AZD 1080, a novel GSK 3 inhibitor, rescues synaptic plasticity deficits in rodent brain and exhibits peripheral target engagement in humans by Georgievska, Biljana, Sandin, Johan, Doherty, James, Mörtberg, Anette, Neelissen, Jan, Andersson, Anita, Gruber, Susanne, Nilsson, Yvonne, Schött, Pär, Arvidsson, Per I., Hellberg, Sven, Osswald, Gunilla, Berg, Stefan, Fälting, Johanna, Bhat, Ratan V.

“…Abstract Abnormal tau phosphorylation resulting in detachment of tau from microtubules and aggregation are critical events in neuronal dysfunction,…”
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