Search Results - "Bhat, Krishna P L"

Mesenchymal Differentiation Mediated by NF-κB Promotes Radiation Resistance in Glioblastoma by Bhat, Krishna P.L., Balasubramaniyan, Veerakumar, Vaillant, Brian, Ezhilarasan, Ravesanker, Hummelink, Karlijn, Hollingsworth, Faith, Wani, Khalida, Heathcock, Lindsey, James, Johanna D., Goodman, Lindsey D., Conroy, Siobhan, Long, Lihong, Lelic, Nina, Wang, Suzhen, Gumin, Joy, Raj, Divya, Kodama, Yoshinori, Raghunathan, Aditya, Olar, Adriana, Joshi, Kaushal, Pelloski, Christopher E., Heimberger, Amy, Kim, Se Hoon, Cahill, Daniel P., Rao, Ganesh, Den Dunnen, Wilfred F.A., Boddeke, Hendrikus W.G.M., Phillips, Heidi S., Nakano, Ichiro, Lang, Frederick F., Colman, Howard, Sulman, Erik P., Aldape, Kenneth

“…Despite extensive study, few therapeutic targets have been identified for glioblastoma (GBM). Here we show that patient-derived glioma sphere cultures (GSCs)…”
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The Impact of the Tumor Microenvironment on the Properties of Glioma Stem-Like Cells by Audia, Alessandra, Conroy, Siobhan, Glass, Rainer, Bhat, Krishna P L

“…Glioblastoma is the most common and highly malignant primary brain tumor, and patients affected with this disease exhibit a uniformly dismal prognosis. Glioma…”
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Cell death in development, maintenance, and diseases of the nervous system by Mercau, Maria E., Patwa, Siraj, Bhat, Krishna P. L., Ghosh, Sourav, Rothlin, Carla V.

“…Cell death, be it of neurons or glial cells, marks the development of the nervous system. Albeit relatively less so than in tissues such as the gut, cell death…”
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FOXD1-ALDH1A3 Signaling Is a Determinant for the Self-Renewal and Tumorigenicity of Mesenchymal Glioma Stem Cells by Cheng, Peng, Wang, Jia, Waghmare, Indrayani, Sartini, Stefania, Coviello, Vito, Zhang, Zhuo, Kim, Sung-Hak, Mohyeldin, Ahmed, Pavlyukov, Marat S, Minata, Mutsuko, Valentim, Claudia L L, Chhipa, Rishi Raj, Bhat, Krishna P L, Dasgupta, Biplab, La Motta, Concettina, Kango-Singh, Madhuri, Nakano, Ichiro

“…Glioma stem-like cells (GSC) with tumor-initiating activity orchestrate the cellular hierarchy in glioblastoma and engender therapeutic resistance. Recent work…”
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The transcriptional coactivator TAZ regulates mesenchymal differentiation in malignant glioma by Bhat, Krishna P L, Salazar, Katrina L, Balasubramaniyan, Veerakumar, Wani, Khalida, Heathcock, Lindsey, Hollingsworth, Faith, James, Johanna D, Gumin, Joy, Diefes, Kristin L, Kim, Se Hoon, Turski, Alice, Azodi, Yasaman, Yang, Yuhui, Doucette, Tiffany, Colman, Howard, Sulman, Erik P, Lang, Frederick F, Rao, Ganesh, Copray, Sjef, Vaillant, Brian D, Aldape, Kenneth D

“…Recent molecular classification of glioblastoma (GBM) has shown that patients with a mesenchymal (MES) gene expression signature exhibit poor overall survival…”
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The dystroglycan receptor maintains glioma stem cells in the vascular niche by Day, Bryan W., Lathia, Justin D., Bruce, Zara C., D’Souza, Rochelle C. J., Baumgartner, Ulrich, Ensbey, Kathleen S., Lim, Yi Chieh, Stringer, Brett W., Akgül, Seçkin, Offenhäuser, Carolin, Li, Yuchen, Jamieson, Paul R., Smith, Fiona M., Jurd, Courtney L. R., Robertson, Thomas, Inglis, Po-Ling, Lwin, Zarnie, Jeffree, Rosalind L., Johns, Terrance G., Bhat, Krishna P. L., Rich, Jeremy N., Campbell, Kevin P., Boyd, Andrew W.

“…Glioblastomas (GBMs) are malignant central nervous system (CNS) neoplasms with a very poor prognosis. They display cellular hierarchies containing…”
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PDPN marks a subset of aggressive and radiation-resistant glioblastoma cells by Modrek, Aram S, Eskilsson, Eskil, Ezhilarasan, Ravesanker, Wang, Qianghu, Goodman, Lindsey D, Ding, Yingwen, Zhang, Ze-Yan, Bhat, Krishna P L, Le, Thanh-Thuy T, Barthel, Floris P, Tang, Ming, Yang, Jie, Long, Lihong, Gumin, Joy, Lang, Frederick F, Verhaak, Roel G W, Aldape, Kenneth D, Sulman, Erik P

“…Treatment-resistant glioma stem cells are thought to propagate and drive growth of malignant gliomas, but their markers and our ability to target them…”
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Evaluation of Estrogenic Activity of Plant Extracts for the Potential Treatment of Menopausal Symptoms by Liu, Jianghua, Burdette, Joanna E, Xu, Haiyan, Gu, Chungang, van Breemen, Richard B, Bhat, Krishna P. L, Booth, Nancy, Constantinou, Andreas I, Pezzuto, John M, Fong, Harry H. S, Farnsworth, Norman R, Bolton, Judy L

“…Eight botanical preparations that are commonly used for the treatment of menopausal symptoms were tested for estrogenic activity. Methanol extracts of red…”
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Aromatase Inhibitors from Broussonetia papyrifera by LEE, Dongho, BHAT, Krishna P. L., FONG, Harry H. S., FARNSWORTH, Norman R., PEZZUTO, John M., KINGHORN, A. Douglas

“…Bioassay-guided fractionation of an ethyl acetate-soluble extract from the whole plants of Broussonetia papyrifera, using an in vitro aromatase inhibition…”
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CDK4/6 inhibition is more active against the glioblastoma proneural subtype by Li, Ming, Xiao, Aizhen, Floyd, Desiree, Olmez, Inan, Lee, Jeongwu, Godlewski, Jakub, Bronisz, Agnieszka, Bhat, Krishna P L, Sulman, Erik P, Nakano, Ichiro, Purow, Benjamin

“…Glioblastoma (GBM) is the most common and lethal brain tumor. Gene expression profiling has classified GBM into distinct subtypes, including proneural,…”
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Tunneling Nanotubes Mediate Adaptation of Glioblastoma Cells to Temozolomide and Ionizing Radiation Treatment by Valdebenito, Silvana, Audia, Alessandra, Bhat, Krishna P.L., Okafo, George, Eugenin, Eliseo A.

“…Glioblastoma (GBM) is the most prevalent and aggressive tumor in the central nervous system. Surgical resection followed by concurrent radiotherapy (ionizing…”
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Myeloid cells coordinately induce glioma cell-intrinsic and cell-extrinsic pathways for chemoresistance via GP130 signaling by Cheng, Jiying, Li, Min, Motta, Edyta, Barci, Deivi, Song, Wangyang, Zhou, Ding, Li, Gen, Zhu, Sihan, Yang, Anru, Vaillant, Brian D., Imhof, Axel, Forné, Ignasi, Spiegl-Kreinecker, Sabine, Zhang, Nu, Katayama, Hiroshi, Bhat, Krishna P.L., Flüh, Charlotte, Kälin, Roland E., Glass, Rainer

“…The DNA damage response (DDR) and the blood-tumor barrier (BTB) restrict chemotherapeutic success for primary brain tumors like glioblastomas (GBMs)…”
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Not expecting the unexpected: diacylglycerol kinase alpha as a cancer target by Bhat, Krishna P L, Aldape, Kenneth

“…In this issue of Cancer Discovery, Dominguez and colleagues identify diacylglycerol kinase alpha (DGKα), an enzyme that converts the membrane lipid…”
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Trifolium pratense (red clover) exhibits estrogenic effects in vivo in ovariectomized Sprague-Dawley rats by Burdette, Joanna E, Liu, Jianghua, Lantvit, Dan, Lim, Eula, Booth, Nancy, Bhat, Krishna P L, Hedayat, Samad, Van Breemen, Richard B, Constantinou, Andreas I, Pezzuto, John M, Farnsworth, Norman R, Bolton, Judy L

“…Studies were conducted using an ovariectomized rat model to determine the estrogenic and antiestrogenic activity of Trifolium pratense L. (red clover)…”
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EGFR and EGFRvIII in Glioblastoma: Partners in Crime by Zadeh, Gelareh, Bhat, Krishna P.L., Aldape, Kenneth

“…EGFRvIII, a mutated form of EGFR, plays a prominent role in tumorigenesis, but the underlying mechanisms have remained elusive. In this issue of Cancer Cell,…”
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Induction of Atypical Ductal Hyperplasia in Mouse Mammary Gland Organ Culture by Mehta, Rajendra G., Bhat, Krishna P. L., Hawthorne, Michael E., Kopelovich, Levy, Mehta, Rajeshwari R., Christov, Konstantin, Kelloff, Gary J., Steele, Vernon E., Pezzuto, John M.

“…BRIEF COMMUNICATION Journal of the National Cancer Institute, Vol. 93, No. 14, July 18, 2001Table 1. Effect of modulators of estrogen function on…”
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Natural modulators of estrogen biosynthesis and function as chemopreventive agents by Bhat, Krishna P. L, Pezzuto, John M

“…There is clearly a need for novel breast cancer chemopreventive agents with enhanced potency and specificity with little or no side effects. To this end,…”
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IL-8 associates with a pro-angiogenic and mesenchymal subtype in glioblastoma by Conroy, Siobhan, Kruyt, Frank A E, Wagemakers, Michiel, Bhat, Krishna P L, den Dunnen, Wilfred F A

“…Glioblastoma (GBM) is a highly aggressive brain tumor characterized by a high rate of vascularization. However, therapeutic targeting of the vasculature…”
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Activity-Guided Isolation of Steroidal Alkaloid Antiestrogen-Binding Site Inhibitors from Pachysandra procumbens by Chang, Leng Chee, Bhat, Krishna P. L, Pisha, Emily, Kennelly, Edward J, Fong, Harry H. S, Pezzuto, John M, Kinghorn, A. Douglas

“…Four novel steroidal alkaloids, (+)−(20S)-20-(dimethylamino)-3-(3‘α-isopropyl)-lactam-5α-pregn-2-en-4-one (1),…”
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EZH2 Protects Glioma Stem Cells from Radiation-Induced Cell Death in a MELK/FOXM1-Dependent Manner by Kim, Sung-Hak, Joshi, Kaushal, Ezhilarasan, Ravesanker, Myers, Toshia R., Siu, Jason, Gu, Chunyu, Nakano-Okuno, Mariko, Taylor, David, Minata, Mutsuko, Sulman, Erik P., Lee, Jeongwu, Bhat, Krishna P.L., Salcini, Anna Elisabetta, Nakano, Ichiro

“…Glioblastoma (GBM)-derived tumorigenic stem-like cells (GSCs) may play a key role in therapy resistance. Previously, we reported that the mitotic kinase MELK…”
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