Synthesis of Metabolites and Related Substances of Rabeprazole, an Anti-Ulcerative Drug

Synthesis of Metabolites and Related Substances of Rabeprazole, an Anti-Ulcerative Drug

Rabeprazole sodium (Aciphex®) is a gastric proton pump inhibitor used for the prevention and treatment of gastric acid-related diseases. During the synthesis of bulk drug of rabeprazole sodium, we have observed metabolites rabeprazole sulfide and rabeprazole sulfone and related substances rabeprazol...

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Bibliographic Details
Published in:Synthetic communications Vol. 39; no. 2; pp. 278 - 290
Main Authors: Reddy, Ganta Madhusudhan, Mukkanti, Kaga, Bhaskar, Boluggodu Vijaya, Reddy, Padi Pratap
Format: Journal Article
Language:English
Published: Taylor & Francis Group 01-01-2009
Subjects:
Impurities
metabolites
rabeprazole Na
spectral characterization
synthesis
Online Access:Get full text
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Description
Summary:Rabeprazole sodium (Aciphex®) is a gastric proton pump inhibitor used for the prevention and treatment of gastric acid-related diseases. During the synthesis of bulk drug of rabeprazole sodium, we have observed metabolites rabeprazole sulfide and rabeprazole sulfone and related substances rabeprazole-N-oxide, rabeprazole sulfone-N-oxide, N-aralkyl rabeprazole, chloro rabeprazole, and methoxy rabeprazole as impurities in the drug substance. The present work describes the synthesis and characterization of these compounds.
ISSN:0039-7911
1532-2432
DOI:10.1080/00397910802372541