Search Results - "Bhaskar, A. S."

Modulation of ROS/MAPK signaling pathways by okadaic acid leads to cell death via, mitochondrial mediated caspase-dependent mechanism by Ravindran, Jayaraj, Gupta, Nimesh, Agrawal, Mona, Bala Bhaskar, A. S, Lakshmana Rao, P. V

“…Okadaic acid (OA) is a specific and potent protein phosphatase inhibitor and tumor promoter. The present study establishes the role of reactive oxygen species…”
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Involvement of Mitogen-Activated Protein Kinase Pathway in T-2 Toxin-Induced Cell Cycle Alteration and Apoptosis in Human Neuroblastoma Cells by Agrawal, Mona, Bhaskar, A. S. B., Rao, P. V. Lakshmana

“…T-2 toxin is the most toxic trichothecene and a frequent contaminant in many agriculture products. Dietary ingestion represents the most common route of T-2…”
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Oxidative stress induction by T-2 toxin causes DNA damage and triggers apoptosis via caspase pathway in human cervical cancer cells by Chaudhari, Manjari, Jayaraj, R, Bhaskar, A.S.B, Lakshmana Rao, P.V

“…Abstract T-2 toxin is the most toxic trichothecene and both humans and animals suffer from several pathological conditions after consumption of foodstuffs…”
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T-2 toxin induced skin inflammation and cutaneous injury in mice by Agrawal, Mona, Yadav, Preeti, Lomash, Vinay, Bhaskar, A.S.B, Lakshmana Rao, P.V

“…Highlights ► T-2 toxin is the most toxic among the various Fusarium toxins. ► T-2 toxin induced dose and time dependent effect on skin inflammation and injury…”
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Differential effects of route of T‐2 toxin exposure on hepatic oxidative damage in mice by Chaudhary, Manjari, Bhaskar, A. S. B, Rao, P. V. Lakshmana

“…T‐2 toxin is the most toxic among mycotoxins and poses a potential health hazard for both humans and animals. At high doses, T‐2 toxin can cause shock‐like…”
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Hepatoprotective efficacy of certain flavonoids against microcystin induced toxicity in mice by Jayaraj, R, Deb, Utsab, Bhaskar, A.S.B, Prasad, G.B.K.S, Rao, P.V. Lakshmana

“…Toxic cyanobacteria (blue-green algae) water blooms have become a serious problem in several industrialized areas of the world. Microcystin-LR (MC-LR) is a…”
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Prophylactic efficacy of S-2(2-aminoethylamino)ethyl phenyl sulfide (DRDE-07) against sulfur mustard induced lung toxicity in mice by Kannan, G. M., Kumar, Pravin, Bhaskar, A. S. B., Pathak, U., Kumar, Deo, Nagar, D. P., Pant, S. C., Ganesan, K.

“…Objective: The present study was planned to investigate the prophylactic efficacy of S-2(2-aminoethylamino)ethyl phenyl sulfide (DRDE-07), against topically…”
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Will it rise or will it fall? Managing the complex effects of urbanization on base flow by Bhaskar, A. S., Beesley, L., Burns, M. J., Fletcher, T. D., Hamel, P., Oldham, C. E., Roy, A. H.

“…Sustaining natural levels of base flow is critical to maintaining ecological function as stream catchments are urbanized. Stream base flow responds variably to…”
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Hydrologic Signals and Surprises in U.S. Streamflow Records During Urbanization by Bhaskar, A. S., Hopkins, K. G., Smith, B. K., Stephens, T. A., Miller, A. J.

“…Urban development has been observed to lead to variable magnitudes of change for stormflow volume and directions of baseflow change across cities. This work…”
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Pulmonary protective efficacy of S-2[2-aminoethylamino] ethyl phenyl sulphide (DRDE-07) and its analogues against sulfur mustard induced toxicity in mice by Soni, A.K., Bhaskar, A.S.B., Pathak, U., Nagar, D.P., Gupta, A.K., Kannan, G.M.

“…•Dermal sulphur mustard (SM) exposure induces pulmonary oxidative stress and inflammation in mice.•SM exposure induces time dependent influx of inflammatory…”
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Characterization of Chikungunya virus infection in human neuroblastoma SH-SY5Y cells: Role of apoptosis in neuronal cell death by Dhanwani, R., Khan, M., Bhaskar, A.S.B., Singh, Rajpriya, Patro, I.K., Rao, P.V.L., Parida, M.M.

“…► We characterized Chikungunya virus infection in a transformed human neuroblastoma cell line. ► The neuronal cell death was mediated through caspase dependent…”
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Neutrophil mediated inflammatory lung damage following single Sub lethal inhalation exposure to plant protein toxin abrin in mice by Sant, Bhavana, Kumar, Pravin, Soni, A. K., Kannan, G. M., Nagar, D. P., Prasad, G. B. K. S., Bhaskar, A. S. B.

“…Abrin, a highly toxic plant protein found in the seeds of Abrus precatorius plant. To date, there is no antidote against abrin intoxication. Abrin is toxic by…”
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Comparative evaluation of antidotal efficacy of 2-PAM and HNK-102 oximes during inhalation of sarin vapor in Swiss albino mice by Swami, Devyani, Yadav, Ruchi, Bhaskar, A.S.B., Soni, A., Nagar, D.P., Acharya, J., Karade, H.N., Singh, K.P., Kumar, Pravin

“…Efficacy of two oximes treatments evaluated during inhalation of sarin vapor (LCt 50 , 755.9 mg/min/m 3 ) in simulated real scenario in vivo. Majority of mice…”
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Supersensitive detection of T-2 toxin by the in situ synthesized π-conjugated molecularly imprinted nanopatterns. An in situ investigation by surface plasmon resonance combined with electrochemistry by Gupta, Garima, Bhaskar, A.S.B., Tripathi, B.K., Pandey, P., Boopathi, M., Rao, P.V. Lakshmana, Singh, Beer, Vijayaraghavan, R.

“…A π-conjugated molecularly imprinted polymer (MIP) with nanopatterns for T-2 toxin (T-2) was prepared on SPR chip by in situ electropolymerization of…”
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Protective effects of certain pharmaceutical compounds against abrin induced cell death in Jurkat cell line by Saxena, Nandita, P.V.L., Rao, A.S.B., Bhaskar, Bhutia, Y.D.

“…Abrin is a plant glycoprotein toxin from the seeds of Abrus precatorius, and shares the structure and properties with ricin. Abrin is highly toxic, with an…”
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Transcriptomic profile of host response in mouse brain after exposure to plant toxin abrin by Bhaskar, A.S. Bala, Gupta, Nimesh, Rao, P.V. Lakshmana

“…Highlights ► Abrin toxin is a plant glycoprotein and a potent biological agent. ► We did whole genome microarray analysis of mouse brain after abrin exposure…”
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FRW Bulk Viscous Cosmology in Multi Dimensional Space-Time by Katore, S. D., Shaikh, A. Y., Kapse, D. V., Bhaskar, S. A.

“…The exact solutions of the field equations are obtained by using the gamma law equation of state p =( γ −1) ρ in which the parameter γ depends on scale factor …”
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Mechanism of ricin-induced apoptosis in human cervical cancer cells by Rao, P.V. Lakshmana, Jayaraj, R., Bhaskar, A.S.B., Kumar, Om, Bhattacharya, R., Saxena, Parag, Dash, P.K., Vijayaraghavan, R.

“…The mechanism of ricin-induced apoptosis in human cervical cancer cell line HeLa was studied. The present study demonstrated that ricin induces apoptosis of…”
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Abrin induced oxidative stress mediated DNA damage in human leukemic cells and its reversal by N-acetylcysteine by Bhaskar, A.S.B., Deb, Utsab, Kumar, Om, Lakshmana Rao, P.V.

“…Abrin is a plant glycoprotein toxin, classified as ribosome inactivating protein (RIP) due to its property of damaging ribosomes in an irreversible manner…”
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Toxicity assessment of indian marine cyanobacterial strains by BHASKAR, A. S. B, NIDHI, G, JAYARAJ, R, SUBRAMANIAN, G, LAKSHMANA RAO, P. V

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