Search Results - "Bhasin, Harshit"

Single-nucleus RNA sequencing in ischemic cardiomyopathy reveals common transcriptional profile underlying end-stage heart failure by Simonson, Bridget, Chaffin, Mark, Hill, Matthew C., Atwa, Ondine, Guedira, Yasmine, Bhasin, Harshit, Hall, Amelia W., Hayat, Sikander, Baumgart, Simon, Bedi, Kenneth C., Margulies, Kenneth B., Klattenhoff, Carla A., Ellinor, Patrick T.

“…Ischemic cardiomyopathy (ICM) is the leading cause of heart failure worldwide, yet the cellular and molecular signature of this disease is largely unclear…”
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Perinatal High Fat Diet Offspring Exhibit Blunted Reward Valuation in a Taste Reactivity Test by Hurley, Matthew, O'Brien, Shannon, Bhasin, Harshit, Sabir, Aliasgher, Tamashiro, Kellie, Moran, Timothy

“…Background: Children of obese parents are 1.7 times more likely to become obese themselves. In part, the mother's diet during pregnancy may contribute to the…”
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Timing matters: The contribution of running during different periods of the light/dark cycle to susceptibility to activity-based anorexia in rats by Aston, S. Andrew, Caffo, Brian S., Bhasin, Harshit, Moran, Timothy H., Tamashiro, Kellie L.

“…•Rats that are susceptible and resistant to weight loss during activity-based anorexia exhibit distinct running patterns.•Resistant animals allocate a higher…”
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Discovery of Orally Bioavailable and Brain-Penetrable Prodrugs of the Potent nSMase2 Inhibitor DPTIP by Pal, Arindom, Gori, Sadakatali, Yoo, Seung-wan, Thomas, Ajit G., Wu, Ying, Friedman, Jacob, Tenora, Lukáš, Bhasin, Harshit, Alt, Jesse, Haughey, Norman, Slusher, Barbara S., Rais, Rana

“…Extracellular vesicles (EVs) can carry pathological cargo and play an active role in disease progression. Neutral sphingomyelinase-2 (nSMase2) is a critical…”
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Activity-based anorexia in adolescent female rats causes changes in brain mitochondrial dynamics by Bhasin, Harshit, O'Brien, Shannon C., Cordner, Zachary A., Aston, S. Andrew, Tamashiro, Kellie L.K., Moran, Timothy H.

“…•Female Sprague Dawley rats that underwent the activity-based anorexia paradigm show disruptions in mitochondrial dynamics in various brain regions.•Most of…”
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Large-scale single-nuclei profiling identifies role for ATRNL1 in atrial fibrillation by Hill, Matthew C., Simonson, Bridget, Roselli, Carolina, Xiao, Ling, Herndon, Caroline N., Chaffin, Mark, Mantineo, Helene, Atwa, Ondine, Bhasin, Harshit, Guedira, Yasmine, Bedi, Kenneth C., Margulies, Kenneth B., Klattenhoff, Carla A., Tucker, Nathan R., Ellinor, Patrick T.

“…Atrial fibrillation (AF) is the most common sustained arrhythmia in humans, yet the molecular basis of AF remains incompletely understood. To determine the…”
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Adolescent female rats prone to the activity based anorexia (ABA) paradigm have altered hedonic responses and cortical astrocyte density compared to resistant animals by Hurley, Matthew M., Collica, Sarah C., Aston, S. Andrew, Wiles, Lucas J., Weiner, Raphael C., Biswas, Aditi, Bhasin, Harshit, Sabir, Aliasgher I., Goodman, Ethan J., Purbey, Ritika, Tamashiro, Kellie L.K., Moran, Timothy H.

“…Anhedonia, which in part involves the lack of pleasure in consuming palatable food, is a long-lasting symptom observed in patients both when acutely ill and…”
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Activity‐based anorexia disrupts systemic oxidative state and induces cortical mitochondrial fission in adolescent female rats by Hurley, Matthew M., Murlanova, Kateryna, Macias, Lindsey K., Sabir, Aliasgher I., O'Brien, Shannon C., Bhasin, Harshit, Tamashiro, Kellie L., Pletnikov, Mikhail V., Moran, Timothy H.

“…Objective Patients with Anorexia Nervosa (AN) display increased levels of oxidative stress that correlates with disease severity. Unfortunately, the biological…”
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