Search Results - "Bharti, Sanjay"

Anti-cancer chalcones: Structural and molecular target perspectives by Mahapatra, Debarshi Kar, Bharti, Sanjay Kumar, Asati, Vivek

“…Chalcone or (E)-1,3-diphenyl-2-propene-1-one scaffold remained a fascination among researchers in the 21st century due to its simple chemistry, ease of…”
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Thiazolidine-2,4-diones as multi-targeted scaffold in medicinal chemistry: Potential anticancer agents by Asati, Vivek, Mahapatra, Debarshi Kar, Bharti, Sanjay K.

“…A variety of substituents on the thiazolidine-2,4-dione(TZD) nucleus have provided a wide spectrum of biological activities by the using of different mechanism…”
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Recent Advances in the Treatment and Management of Alzheimer's Disease: A Precision Medicine Perspective by Shukla, Deepali, Suryavanshi, Anjali, Bharti, Sanjay Kumar, Asati, Vivek, Mahapatra, Debarshi Kar

“…About 60% to 70% of people with dementia have Alzheimer's Disease (AD), a neurodegenerative illness. One reason for this disorder is the misfolding of…”
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PI3K/Akt/mTOR and Ras/Raf/MEK/ERK signaling pathways inhibitors as anticancer agents: Structural and pharmacological perspectives by Asati, Vivek, Mahapatra, Debarshi Kar, Bharti, Sanjay Kumar

“…The protein kinases regulate cellular functions such as transcription, translation, proliferation, growth and survival by the process of phosphorylation. Over…”
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Discovery of novel ALK2 inhibitors of pyrazolo-pyrimidines: A computational study by Asati, Vivek, Bharti, Sanjay K., Das, Ratnesh, Kashaw, Varsha, Kashaw, Sushil Kumar

“…ALK2 is a serine/threonine kinase, involved in different signaling pathways and associated with cell proliferation and differentiation. The present study…”
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A Long Noncoding RNA Regulates Sister Chromatid Cohesion by Marchese, Francesco P., Grossi, Elena, Marín-Béjar, Oskar, Bharti, Sanjay Kumar, Raimondi, Ivan, González, Jovanna, Martínez-Herrera, Dannys Jorge, Athie, Alejandro, Amadoz, Alicia, Brosh, Robert M., Huarte, Maite

“…Long noncoding RNAs (lncRNAs) are involved in diverse cellular processes through multiple mechanisms. Here, we describe a previously uncharacterized human…”
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Triggering PIK3CA Mutations in PI3K/Akt/mTOR Axis: Exploration of Newer Inhibitors and Rational Preventive Strategies by Asati, Vivek, Bharti, Sanjay K, Mahapatra, Debarshi Kar, Asati, Vikas, Budhwani, Ashok K

“…PIK3CA gene was found in generation of p110 alpha (p110α) protein through an instruction process. p110 alpha acts as a catalytic subunit of…”
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PIM kinase inhibitors: Structural and pharmacological perspectives by Asati, Vivek, Mahapatra, Debarshi Kar, Bharti, Sanjay Kumar

“…The PIM kinase, also known as serine/threonine kinase plays an important role in cancer biology and is found in three different isoforms namely PIM-1, PIM-2,…”
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Mutant B-Raf Kinase Inhibitors as Anticancer Agents by Asati, Vivek, Bharti, Sanjay K, Mahapatra, Debarshi K

“…The Ras/Raf/MEK/ERK signaling pathway involves various kinases in which each kinase is associated with one another through signals and regulates cell…”
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Chalcone Derivatives: Anti-inflammatory Potential and Molecular Targets Perspectives by Mahapatra, Debarshi Kar, Bharti, Sanjay Kumar, Asati, Vivek

“…Chalcone or (E)-1,3-diphenyl-2-propene-1-one scaffold has gained considerable scientific interest in medicinal chemistry owing to its simple chemistry, ease in…”
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K-Ras and its inhibitors towards personalized cancer treatment: Pharmacological and structural perspectives by Asati, Vivek, Mahapatra, Debarshi Kar, Bharti, Sanjay Kumar

“…The discovery of genetic, genomic and clinical biomarkers have revolutionized the treatment option in the form of personalized medicine which allows to…”
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Identification and Biochemical Characterization of a Novel Mutation in DDX11 Causing Warsaw Breakage Syndrome by Capo-Chichi, José-Mario, Bharti, Sanjay Kumar, Sommers, Joshua A., Yammine, Tony, Chouery, Eliane, Patry, Lysanne, Rouleau, Guy A., Samuels, Mark E., Hamdan, Fadi F., Michaud, Jacques L., Brosh Jr, Robert M., Mégarbane, André, Kibar, Zoha

“…ABSTRACT Mutations in the gene encoding the iron–sulfur‐containing DNA helicase DDX11 (ChlR1) were recently identified as a cause of a new recessive…”
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A genetic analysis of the functional interactions within Mycobacterium tuberculosis single-stranded DNA binding protein by Rex, Kervin, Bharti, Sanjay Kumar, Sah, Shivjee, Varshney, Umesh

“…Single-stranded DNA binding proteins (SSBs) are vital in all organisms. SSBs of Escherichia coli (EcoSSB) and Mycobacterium tuberculosis (MtuSSB) are…”
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3D-QSAR and Molecular Docking Studies on Oxadiazole Substituted Benzimidazole Derivatives: Validation of Experimental Inhibitory Potencies Towards COX-2 by Asati, Vivek, Ghode, Piyush, Bajaj, Shalini, Jain, Sanmati K, Bharti, Sanjay K

“…In past few decades, computational chemistry has seen significant advancements in design and development of novel therapeutics. Benzimidazole derivatives…”
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Getting Ready for the Dance: FANCJ Irons Out DNA Wrinkles by Bharti, Sanjay Kumar, Awate, Sanket, Banerjee, Taraswi, Brosh, Robert M

“…Mounting evidence indicates that alternate DNA structures, which deviate from normal double helical DNA, form in vivo and influence cellular processes such as…”
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DNA Sequences Proximal to Human Mitochondrial DNA Deletion Breakpoints Prevalent in Human Disease Form G-quadruplexes, a Class of DNA Structures Inefficiently Unwound by the Mitochondrial Replicative Twinkle Helicase by Bharti, Sanjay Kumar, Sommers, Joshua A., Zhou, Jun, Kaplan, Daniel L., Spelbrink, Johannes N., Mergny, Jean-Louis, Brosh, Robert M.

“…Mitochondrial DNA deletions are prominent in human genetic disorders, cancer, and aging. It is thought that stalling of the mitochondrial replication machinery…”
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Chimeras of Escherichia coli and Mycobacterium tuberculosis single-stranded DNA binding proteins: characterization and function in Escherichia coli by Bharti, Sanjay Kumar, Rex, Kervin, Sreedhar, Pujari, Krishnan, Neeraja, Varshney, Umesh

“…Single stranded DNA binding proteins (SSBs) are vital for the survival of organisms. Studies on SSBs from the prototype, Escherichia coli (EcoSSB) and, an…”
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Cockayne syndrome group A and B proteins converge on transcription-linked resolution of non-B DNA by Scheibye-Knudsen, Morten, Tseng, Anne, Jensen, Martin Borch, Scheibye-Alsing, Karsten, Fang, Evandro Fei, Iyama, Teruaki, Bharti, Sanjay Kumar, Marosi, Krisztina, Froetscher, Lynn, Kassahun, Henok, Eckley, David Mark, Maul, Robert W., Bastian, Paul, De, Supriyo, Ghosh, Soumita, Nilsen, Hilde, Goldberg, Ilya G., Mattson, Mark P., Wilson, David M., Brosh, Robert M., Gorospe, Myriam, Bohr, Vilhelm A.

“…Cockayne syndrome is a neurodegenerative accelerated aging disorder caused by mutations in the CSA or CSB genes. Although the pathogenesis of Cockayne syndrome…”
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Molecular functions and cellular roles of the ChlR1 (DDX11) helicase defective in the rare cohesinopathy Warsaw breakage syndrome by Bharti, Sanjay Kumar, Khan, Irfan, Banerjee, Taraswi, Sommers, Joshua A, Wu, Yuliang, Brosh, Robert M., Jr

“…In 2010, a new recessive cohesinopathy disorder, designated Warsaw breakage syndrome (WABS), was described. The individual with WABS displayed microcephaly,…”
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Synthesis, characterization, DNA cleavage and in vitro antimicrobial activities of copper(II) complexes of Schiff bases containing a 2,4-disubstituted thiazole by Bharti, Sanjay K., Patel, Saurabh K., Nath, Gopal, Tilak, Ragini, Singh, Sushil K.

“…Six Cu(II) complexes of Schiff base ligands of arylidene-2-(4-(4-bromo/methoxy-phenyl)thiazol-2-yl) hydrazines have been synthesized, characterized and…”
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