Search Results - "Bharathi, Sivakama S"

Sirtuin 5 Regulates Proximal Tubule Fatty Acid Oxidation to Protect against AKI by Chiba, Takuto, Peasley, Kevin D, Cargill, Kasey R, Maringer, Katherine V, Bharathi, Sivakama S, Mukherjee, Elina, Zhang, Yuxun, Holtz, Anja, Basisty, Nathan, Yagobian, Shiva D, Schilling, Birgit, Goetzman, Eric S, Sims-Lucas, Sunder

“…The primary site of damage during AKI, proximal tubular epithelial cells, are highly metabolically active, relying on fatty acids to meet their energy demands…”
Get full text

SIRT3 and SIRT5 regulate the enzyme activity and cardiolipin binding of very long-chain acyl-CoA dehydrogenase by Zhang, Yuxun, Bharathi, Sivakama S, Rardin, Matthew J, Uppala, Radha, Verdin, Eric, Gibson, Bradford W, Goetzman, Eric S

“…SIRT3 and SIRT5 have been shown to regulate mitochondrial fatty acid oxidation but the molecular mechanisms behind the regulation are lacking. Here, we…”
Get full text

Impaired mitochondrial medium-chain fatty acid oxidation drives periportal macrovesicular steatosis in sirtuin-5 knockout mice by Goetzman, Eric S., Bharathi, Sivakama S., Zhang, Yuxun, Zhao, Xue-Jun, Dobrowolski, Steven F., Peasley, Kevin, Sims-Lucas, Sunder, Monga, Satdarshan P.

“…Medium-chain triglycerides (MCT), containing C 8 –C 12 fatty acids, are used to treat several pediatric disorders and are widely consumed as a nutritional…”
Get full text

The fatty acid oxidation enzyme long-chain acyl-CoA dehydrogenase can be a source of mitochondrial hydrogen peroxide by Zhang, Yuxun, Bharathi, Sivakama S, Beck, Megan E, Goetzman, Eric S

“…Fatty acid oxidation (FAO)-driven H O has been shown to be a major source of oxidative stress in several tissues and disease states. Here, we established that…”
Get full text

Octanoate is differentially metabolized in liver and muscle and fails to rescue cardiomyopathy in CPT2 deficiency by Pereyra, Andrea S., Harris, Kate L., Soepriatna, Arvin H., Waterbury, Quin A., Bharathi, Sivakama S., Zhang, Yuxun, Fisher-Wellman, Kelsey H., Goergen, Craig J., Goetzman, Eric S., Ellis, Jessica M.

“…Long-chain fatty acid oxidation is frequently impaired in primary and systemic metabolic diseases affecting the heart; thus, therapeutically increasing…”
Get full text

GM3 synthase deficiency increases brain glucose metabolism in mice by Bharathi, Sivakama S., Zhang, Bob B., Paul, Eli, Zhang, Yuxun, Schmidt, Alexandra V., Fowler, Benjamin, Wu, Yijen, Tiemeyer, Michael, Inamori, Kei-ichiro, Inokuchi, Jin-ichi, Goetzman, Eric S.

“…GM3 synthase (GM3S) deficiency is a rare neurodevelopmental disorder caused by an inability to synthesize gangliosides, for which there is currently no…”
Get full text

Increased mortality from influenza infection in long-chain acyl-CoA dehydrogenase knockout mice by Shinde, Apurva, Luo, Jiadi, Bharathi, Sivakama S., Shi, Huifang, Beck, Megan E., McHugh, Kevin J., Alcorn, John F., Wang, Jieru, Goetzman, Eric S.

“…We previously showed that the mitochondrial fatty acid oxidation enzyme long-chain acyl-CoA dehydrogenase (LCAD) is expressed in alveolar type II pneumocytes…”
Get full text

Aspirin increases mitochondrial fatty acid oxidation by Uppala, Radha, Dudiak, Brianne, Beck, Megan E., Bharathi, Sivakama S., Zhang, Yuxun, Stolz, Donna B., Goetzman, Eric S.

“…The metabolic effects of salicylates are poorly understood. This study investigated the effects of aspirin on fatty acid oxidation. Aspirin increased…”
Get full text

Sirt2 Regulates Liver Metabolism in a Sex-Specific Manner by Schmidt, Alexandra V, Bharathi, Sivakama S, Solo, Keaton J, Bons, Joanna, Rose, Jacob P, Schilling, Birgit, Goetzman, Eric S

“…Sirtuin-2 (Sirt2), an NAD+-dependent lysine deacylase enzyme, has previously been implicated as a regulator of glucose metabolism, but the specific mechanisms…”
Get full text

Role of mitochondrial acyl-CoA dehydrogenases in the metabolism of dicarboxylic fatty acids by Bharathi, Sivakama S., Zhang, Yuxun, Gong, Zhenwei, Muzumdar, Radhika, Goetzman, Eric S.

“…Dicarboxylic fatty acids, taken as a nutritional supplement or produced endogenously via omega oxidation of monocarboxylic fatty acids, may have therapeutic…”
Get full text

Lysine desuccinylase SIRT5 binds to cardiolipin and regulates the electron transport chain by Zhang, Yuxun, Bharathi, Sivakama S., Rardin, Matthew J., Lu, Jie, Maringer, Katherine V., Sims-Lucas, Sunder, Prochownik, Edward V., Gibson, Bradford W., Goetzman, Eric S.

“…SIRT5 is a lysine desuccinylase known to regulate mitochondrial fatty acid oxidation and the urea cycle. Here, SIRT5 was observed to bind to cardiolipin via an…”
Get full text

Sirtuin 3 (SIRT3) Protein Regulates Long-chain Acyl-CoA Dehydrogenase by Deacetylating Conserved Lysines Near the Active Site by Bharathi, Sivakama S., Zhang, Yuxun, Mohsen, Al-Walid, Uppala, Radha, Balasubramani, Manimalha, Schreiber, Emanuel, Uechi, Guy, Beck, Megan E., Rardin, Matthew J., Vockley, Jerry, Verdin, Eric, Gibson, Bradford W., Hirschey, Matthew D., Goetzman, Eric S.

“…Long-chain acyl-CoA dehydrogenase (LCAD) is a key mitochondrial fatty acid oxidation enzyme. We previously demonstrated increased LCAD lysine acetylation in…”
Get full text

Dietary dicarboxylic acids provide a nonstorable alternative fat source that protects mice against obesity by Goetzman, Eric S, Zhang, Bob B, Zhang, Yuxun, Bharathi, Sivakama S, Bons, Joanna, Rose, Jacob, Shah, Samah, Solo, Keaton J, Schmidt, Alexandra V, Rao, Krithika S, Shiva, Sruti S, Pfister, Katherine E, Barbosa, Anne Silva, Sims-Lucas, Sunder, Dobrowolski, Steven F, Schilling, Birgit, Richert, Adam C, Mullet, Steven J, Gelhaus, Stacy L

“…Dicarboxylic fatty acids are generated in the liver and kidney in a minor pathway called fatty acid m-oxidation. The effects of consuming dicarboxylic fatty…”
Get full text

Sequential adaptive changes in a c-Myc-driven model of hepatocellular carcinoma by Dolezal, James M., Wang, Huabo, Kulkarni, Sucheta, Jackson, Laura, Lu, Jie, Ranganathan, Sarangarajan, Goetzman, Eric S., Bharathi, Sivakama S., Beezhold, Kevin, Byersdorfer, Craig A., Prochownik, Edward V.

“…Hepatocellular carcinoma (HCC) is a common cancer that frequently overexpresses the c-Myc (Myc) oncoprotein. Using a mouse model of Myc-induced HCC, we studied…”
Get full text

The common K333Q polymorphism in long-chain acyl-CoA dehydrogenase (LCAD) reduces enzyme stability and function by Beck, Megan E., Zhang, Yuxun, Bharathi, Sivakama S., Kosmider, Beata, Bahmed, Karim, Dahmer, Mary K., Nogee, Lawrence M., Goetzman, Eric S.

“…The fatty acid oxidation enzyme long-chain acyl-CoA dehydrogenase (LCAD) is expressed at high levels in human alveolar type II (ATII) cells in the lung. A…”
Get full text

Correction: Genetic Dissociation of Glycolysis and the TCA Cycle Affects Neither Normal nor Neoplastic Proliferation by Jackson, Laura E, Kulkarni, Sucheta, Wang, Huabo, Lu, Jie, Dolezal, James M, Bharathi, Sivakama S, Ranganathan, Sarangarajan, Patel, Mulchand S, Deshpande, Rahul, Alencastro, Frances, Wendell, Stacy G, Goetzman, Eric S, Duncan, Andrew W, Prochownik, Edward V

Get full text

Genetic Dissociation of Glycolysis and the TCA Cycle Affects Neither Normal nor Neoplastic Proliferation by Jackson, Laura E, Kulkarni, Sucheta, Wang, Huabo, Lu, Jie, Dolezal, James M, Bharathi, Sivakama S, Ranganathan, Sarangarajan, Patel, Mulchand S, Deshpande, Rahul, Alencastro, Frances, Wendell, Stacy G, Goetzman, Eric S, Duncan, Andrew W, Prochownik, Edward V

“…Rapidly proliferating cells increase glycolysis at the expense of oxidative phosphorylation (oxphos) to generate sufficient levels of glycolytic intermediates…”
Get full text

Long-chain Acyl-CoA Dehydrogenase Deficiency as a Cause of Pulmonary Surfactant Dysfunction by Goetzman, Eric S., Alcorn, John F., Bharathi, Sivakama S., Uppala, Radha, McHugh, Kevin J., Kosmider, Beata, Chen, Rimei, Zuo, Yi Y., Beck, Megan E., McKinney, Richard W., Skilling, Helen, Suhrie, Kristen R., Karunanidhi, Anuradha, Yeasted, Renita, Otsubo, Chikara, Ellis, Bryon, Tyurina, Yulia Y., Kagan, Valerian E., Mallampalli, Rama K., Vockley, Jerry

“…Long-chain acyl-CoA dehydrogenase (LCAD) is a mitochondrial fatty acid oxidation enzyme whose expression in humans is low or absent in organs known to utilize…”
Get full text

Dietary dicarboxylic acids provide a non-storable alternative fat source that protects mice against obesity by Goetzman, Eric S, Zhang, Bob B, Zhang, Yuxun, Bharathi, Sivakama S, Bons, Joanna, Rose, Jacob, Shah, Samah, Solo, Keaton J, Schmidt, Alexandra V, Richert, Adam C, Mullett, Steven J, Gelhaus, Stacy L, Rao, Krithika S, Shiva, Sruti S, Pfister, Katherine E, Silva Barbosa, Anne, Sims-Lucas, Sunder, Dobrowolski, Steven F, Schilling, Birgit

“…Dicarboxylic fatty acids are generated in the liver and kidney in a minor pathway called fatty acid ω-oxidation. The effects of consuming dicarboxylic fatty…”
Get full text

201: Beta oxidation of fatty acids in term human placentas by Mendez-Figueroa, Hector, Chien, Edward, Nesbitt, Nicole L, Bharathi, Sivakama S, Goetzman, Eric

Get full text