Search Results - "Bharathi, E Vijaya"
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Synthesis and biological evaluation of 3,5-diaryl isoxazoline/isoxazole linked 2,3-dihydroquinazolinone hybrids as anticancer agents
Published in European journal of medicinal chemistry (01-02-2011)“…A series of new 3,5-diaryl isoxazoline/isoxazole linked 2,3-dihydro quinazolinone hybrids with different linker architectures have been designed and…”
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2
Eight months of integrated yoga, hydrotherapy and acupuncture on serum IgE levels and symptoms severity of a patient with chronic allergic rhinosinusitis: A case report
Published in Journal of bodywork and movement therapies (01-07-2024)“…A 27-year-old man with Allergic rhino sinusitis presented to our hospital in July 2020 with complaints of continuous sneezing, coughing while rising from bed…”
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3
Design, synthesis and biological evaluation of 3,5-diaryl-isoxazoline/isoxazole-pyrrolobenzodiazepine conjugates as potential anticancer agents
Published in European journal of medicinal chemistry (01-09-2010)“…A series of 3,5-diaryl-isoxazoline/isoxazole linked pyrrolo[2,1- c][1,4]benzodiazepine (PBD) conjugates were prepared. These conjugates showed potent…”
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4
Synthesis and apoptosis inducing ability of new anilino substituted pyrimidine sulfonamides as potential anticancer agents
Published in European journal of medicinal chemistry (01-12-2011)“…A series of anilino substituted pyrimidine sulfonamides were prepared and evaluated for their anticancer activity. These sulfonamides showed promising activity…”
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5
Quinazolinone linked pyrrolo[2,1- c][1,4]benzodiazepine (PBD) conjugates: Design, synthesis and biological evaluation as potential anticancer agents
Published in Bioorganic & medicinal chemistry (15-01-2010)“…A series of novel quinazolinone linked pyrrolobenzodiazepine (PBD) conjugates were synthesized. These compounds 4a– f and 5a– f were prepared in good yields by…”
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6
Discovery of 2-(1H-indol-5-ylamino)-6-(2,4-difluorophenylsulfonyl)-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one (7ao) as a potent selective inhibitor of Polo like kinase 2 (PLK2)
Published in Bioorganic & medicinal chemistry (15-02-2016)“…[Display omitted] Several families of protein kinases have been shown to play a critical role in the regulation of cell cycle progression, particularly…”
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Synthesis and biological evaluation of estradiol linked pyrrolo[2,1- c][1,4]benzodiazepine (PBD) conjugates as potential anticancer agents
Published in Bioorganic & medicinal chemistry (15-04-2011)“…A new class of estradiol-pyrrolobenzodiazepine conjugates have been prepared and evaluated for their anticancer activity. Further, some of the biological…”
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8
Synthesis, anticancer activity and apoptosis inducing ability of anthranilamide-PBD conjugates
Published in Bioorganic & medicinal chemistry letters (01-06-2010)“…A series of novel anthranilamide linked pyrrolo[2,1-c][1,4]benzodiazepine conjugates were prepared and evaluated for their anticancer activity. The effects of…”
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9
Synthesis and biological evaluation of anilino substituted pyrimidine linked pyrrolobenzodiazepines as potential anticancer agents
Published in Bioorganic & medicinal chemistry letters (01-09-2010)“…A series of new anilino substituted pyrimidine linked pyrrolo[2,1- c][1,4]benzodiazepine (PBD) conjugates were prepared and evaluated for their anticancer…”
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10
Synthesis and biological evaluation of diaryl ether linked DC-81 conjugates as potential antitumor agents
Published in Anti-cancer agents in medicinal chemistry (01-12-2013)“…A series of new diaryl ether linked pyrrolobenzodiazepine (PBD) conjugates (4a-i, 5a-i and 6a-f) was synthesized and evaluated for their anticancer activity…”
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11
Discovery of 8‑Cyclopentyl-2-[4-(4-methyl-piperazin-1-yl)-phenylamino]-7-oxo-7,8-dihydro-pyrido[2,3‑d]pyrimidine-6-carbonitrile (7x) as a Potent Inhibitor of Cyclin-Dependent Kinase 4 (CDK4) and AMPK-Related Kinase 5 (ARK5)
Published in Journal of medicinal chemistry (13-02-2014)“…The success of imatinib, a BCR-ABL inhibitor for the treatment of chronic myelogenous leukemia, has created a great impetus for the development of additional…”
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12
Synthesis of pyrrolo[2,1-c][1,4]benzodiazepines and their conjugates by azido reductive cyclization strategy as potential DNA-binding agents
Published in Bioorganic & medicinal chemistry letters (16-05-2005)“…[Display omitted] Synthesis of pyrrolo[2,1-c][1,4]benzodiazepines via azido reductive cyclization process employing FeCl3–NaI reagent system. This methodology…”
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13
Design, Synthesis, and Biological Evaluation of (E)‑N‑Aryl-2-arylethenesulfonamide Analogues as Potent and Orally Bioavailable Microtubule-Targeted Anticancer Agents
Published in Journal of medicinal chemistry (11-07-2013)“…A series of novel (E)-N-aryl-2-arylethenesulfonamides (6) were synthesized and evaluated for their anticancer activity. Some of the compounds in this series…”
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14
Synthesis of Imidazothiazole-Chalcone Derivatives as Anticancer and Apoptosis Inducing Agents
Published in ChemMedChem (08-11-2010)“…A new class of imidazo[2,1‐b]thiazole chalcone derivatives were synthesized and evaluated for their anticancer activity. These chalcone derivatives show…”
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15
Synthesis, anticancer activity and mitochondrial mediated apoptosis inducing ability of 2,5-diaryloxadiazole–pyrrolobenzodiazepine conjugates
Published in Bioorganic & medicinal chemistry (15-09-2010)“…New class of 2,5-diaryloxadiazole–pyrrolobenzodiazepine conjugates have been prepared and evaluated for their anticancer activity. Further, some of the…”
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16
Search for new and novel chemotherapeutics for the treatment of human malignancies
Published in Mini reviews in medicinal chemistry (01-05-2010)“…One of the hallmarks of cancer is the uncontrolled cell proliferation which causes more deaths among the human diseases throughout the globe. One in eight…”
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17
Base-free monosulfonylation of amines using tosyl or mesyl chloride in water
Published in Tetrahedron letters (07-01-2008)“…A mild and efficient procedure has been developed for the monosulfonylation of various amines using mesyl or tosyl chlorides in water at room temperature to…”
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18
Design, Synthesis and Biological Evaluation of (E)-N-Aryl-2-arylethene-sulfonamide Analogues as Potent and Orally Bioavailable Microtubule-targeted Anticancer Agents
Published in Journal of medicinal chemistry (25-06-2013)“…A series of novel (E)-N-aryl-2-arylethenesulfonamides (6) were synthesized and evaluated for their anticancer activity. Some of the compounds in this series…”
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