Search Results - "Bhandary, Lekhana"

Lipid tethering of breast tumor cells reduces cell aggregation during mammosphere formation by Bhandary, Lekhana, Bailey, Patrick C., Chang, Katarina T., Underwood, Karen F., Lee, Cornell J., Whipple, Rebecca A., Jewell, Christopher M., Ory, Eleanor, Thompson, Keyata N., Ju, Julia A., Mathias, Trevor M., Pratt, Stephen J. P., Vitolo, Michele I., Martin, Stuart S.

“…Mammosphere assays are widely used in vitro to identify prospective cancer-initiating stem cells that can propagate clonally to form spheres in free-floating…”
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The RUNX2 Transcription Factor Negatively Regulates SIRT6 Expression to Alter Glucose Metabolism in Breast Cancer Cells by Choe, Moran, Brusgard, Jessica L., Chumsri, Saranya, Bhandary, Lekhana, Zhao, Xianfeng Frank, Lu, Song, Goloubeva, Olga G., Polster, Brian M., Fiskum, Gary M., Girnun, Geoffrey D., Kim, Myoung Sook, Passaniti, Antonino

“…ABSTRACT Activation of genes promoting aerobic glycolysis and suppression of mitochondrial oxidative phosphorylation is one of the hallmarks of cancer. The…”
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Modulation of miR-204 Expression during Chondrogenesis by Dalle Carbonare, Luca, Bertacco, Jessica, Minoia, Arianna, Cominacini, Mattia, Bhandary, Lekhana, Elia, Rossella, Gambaro, Giovanni, Mottes, Monica, Valenti, Maria Teresa

“…RUNX2 and SOX9 are two pivotal transcriptional regulators of chondrogenesis. It has been demonstrated that RUNX2 and SOX9 physically interact; RUNX2…”
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Modulation of miR-146b Expression during Aging and the Impact of Physical Activity on Its Expression and Chondrogenic Progenitors by Dalle Carbonare, Luca, Minoia, Arianna, Braggio, Michele, Bertacco, Jessica, Piritore, Francesca Cristiana, Zouari, Sharazed, Vareschi, Anna, Elia, Rossella, Vedovi, Ermes, Scumà, Cristina, Carlucci, Matilde, Bhandary, Lekhana, Mottes, Monica, Romanelli, Maria Grazia, Valenti, Maria Teresa

“…The finding of molecules associated with aging is important for the prevention of chronic degenerative diseases and for longevity strategies. MicroRNAs…”
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Effects of a 4400 km ultra-cycling non-competitive race and related training on body composition and circulating progenitors differentiation by Valenti, Maria Teresa, Braggio, Michele, Minoia, Arianna, Dorelli, Gianluigi, Bertacco, Jessica, Bertoldo, Francesco, Cominacini, Mattia, De Simone, Tonia, Romanelli, Maria Grazia, Bhandary, Lekhana, Mottes, Monica, Dalle Carbonare, Luca

“…Abstract Background NorthCape4000 (NC4000) is the most participated ultra-endurance cycling race. Eight healthy male Caucasian amateur cyclists were evaluated:…”
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Effect of monocyte seeding density on dendritic cell generation in an automated perfusion-based culture system by Kozbial, Andrew, Bhandary, Lekhana, Murthy, Shashi K.

“…•Monocyte seeding density affects phenotype of generated immature DCs.•Immature DC phenotype affects extent of T cell proliferation.•MicroDEN successfully…”
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Molecular Pathways: New Signaling Considerations When Targeting Cytoskeletal Balance to Reduce Tumor Growth by Chakrabarti, Kristi R, Hessler, Lindsay, Bhandary, Lekhana, Martin, Stuart S

“…The dynamic balance between microtubule extension and actin contraction regulates mammalian cell shape, division, and motility, which has made the cytoskeleton…”
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Curcumin Targets Breast Cancer Stem-like Cells with Microtentacles That Persist in Mammospheres and Promote Reattachment by CHARPENTIER, Monica S, WHIPPLE, Rebecca A, VITOLO, Michele I, BOGGS, Amanda E, SLOVIC, Jana, THOMPSON, Keyata N, BHANDARY, Lekhana, MARTIN, Stuart S

“…Cancer stem-like cells (CSC) and circulating tumor cells (CTC) have related properties associated with distant metastasis, but the mechanisms through which…”
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Expression of FBXW11 in normal and disease‐associated osteogenic cells by Dalle Carbonare, Luca, Gomez Lira, Macarena, Minoia, Arianna, Bertacco, Jessica, Orsi, Silvia, Lauriola, Angela, Li Vigni, Veronica, Gandini, Alberto, Antoniazzi, Franco, Zipeto, Donato, Mottes, Monica, Bhandary, Lekhana, Guardavaccaro, Daniele, Valenti, Maria Teresa

“…The ubiquitin‐proteasome system (UPS) plays an important role in maintaining cellular homeostasis by degrading a multitude of key regulatory proteins. FBXW11,…”
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Automated generation of immature dendritic cells in a single-use system by Kozbial, Andrew, Bhandary, Lekhana, Collier, Bradley B., Eickhoff, Christopher S., Hoft, Daniel F., Murthy, Shashi K.

“…Dendritic cells (DCs) are an indispensable part of studying human responses that are important for protective immunity against cancer and infectious diseases…”
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Abstract LB-342: HDAC inhibition promotes tubulin-independent cancer cell migration by Hessler, Lindsay K., Boggs, Amanda E., Whipple, Rebecca A., Vitolo, Michele I., Chakrabarti, Kristi R., Bhandary, Lekhana, Thompson, Keyata N., Martin, Stuart S.

“…Abstract Breast cancer remains the most common cancer and second-leading cause of cancer-related death in women, with metastatic disease carrying a…”
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Rho-associated protein kinase inhibition promotes microtentacle formation in detached breast tumor cells through destabilization of the actin cortex by Bhandary, Lekhana

“…The presence of circulating tumor cells (CTCs) in blood predicts poor patient outcome and CTC frequency is correlated with a higher risk of metastasis. Recent…”
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Abstract 2161: Activation of the MAPK pathway in combination with PTEN loss leads to aggressive primary tumor formation by Thompson, Keyata N., Whipple, Rebecca A., Yoon, Jennifer R., Charpentier, Monica S., Boggs, Amanda E., Bhandary, Lekhana, Chakrabarti, Kristi R., Martin, Stuart S., Vitolo, Michele I.

“…Abstract Breast cancer is the most frequent malignancy in women, and although many breast cancers are curable via surgery, approximately one quarter maintain a…”
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ROCK inhibition promotes microtentacles that enhance reattachment of breast cancer cells by Bhandary, Lekhana, Whipple, Rebecca A, Vitolo, Michele I, Charpentier, Monica S, Boggs, Amanda E, Chakrabarti, Kristi R, Thompson, Keyata N, Martin, Stuart S

“…The presence of circulating tumor cells (CTCs) in blood predicts poor patient outcome and CTC frequency is correlated with higher risk of metastasis. Recently…”
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The combinatorial activation of the PI3K and Ras/MAPK pathways is sufficient for aggressive tumor formation, while individual pathway activation supports cell persistence by Thompson, Keyata N, Whipple, Rebecca A, Yoon, Jennifer R, Lipsky, Michael, Charpentier, Monica S, Boggs, Amanda E, Chakrabarti, Kristi R, Bhandary, Lekhana, Hessler, Lindsay K, Martin, Stuart S, Vitolo, Michele I

“…A high proportion of human tumors maintain activation of both the PI3K and Ras/MAPK pathways. In basal-like breast cancer (BBC), PTEN expression is…”
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Abstract 3160: ROCK inhibition promotes microtentacle formation and reattachment of breast cancer cells by Bhandary, Lekhana, Vitolo, Michele I., Bettes, Rebecca A., Charpentier, Monica S., Boggs, Amanda E., Slovic, Jana, Thompson, Keyata, Martin, Stuart S.

“…Abstract Circulating Tumor Cells (CTCs) predict poor patient outcome and increased CTC detection is correlated with higher risk of metastasis. The efficiency…”
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Pharmacologic regulation of AMPK in breast cancer affects cytoskeletal properties involved with microtentacle formation and re-attachment by Chakrabarti, Kristi R, Whipple, Rebecca A, Boggs, Amanda E, Hessler, Lindsay K, Bhandary, Lekhana, Vitolo, Michele I, Thompson, Keyata, Martin, Stuart S

“…The presence of tumor cells in the circulation is associated with a higher risk of metastasis in patients with breast cancer. Circulating breast tumor cells…”
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Analysis of microtubule growth dynamics arising from altered actin network structure and contractility in breast tumor cells by Ory, Eleanor C, Bhandary, Lekhana, Boggs, Amanda E, Chakrabarti, Kristi R, Parker, Joshua, Losert, Wolfgang, Martin, Stuart S

“…The periphery of epithelial cells is shaped by opposing cytoskeletal physical forces generated predominately by two dynamic force generating systems-growing…”
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Abstract 3772: The role of microtentacles in the metastatic potential of breast tumor stem cells by Charpentier, Monica S., Bettes, Rebecca A., Vitolo, Michele I., Boggs, Amanda E., Slovic, Jana, Thompson, Keyata, Bhandary, Lekhana, Yoon, Jennifer, Martin, Stuart S.

“…Abstract Breast cancer is the 2nd leading cause of cancer-related death among women; however, the majority of deaths arise as complications from metastasis,…”
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Abstract 276: Microtentacle stabilization during TGFβ-induced EMT as a new therapeutic target to reduce circulating tumor cell metastasis by Slovic, Jana, Vitolo, Michele I., Whipple, Rebbecca A., Boggs, Amanda E., Charpentier, Monica S., Bhandary, Lekhana, Thompson, Keyata, Martin, Stuart S.

“…Abstract Circulating tumor cells (CTCs) have been identified as a predictive factor of patient outcome and disease progression in breast cancer. Solid tumor…”
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