Search Results - "Bhandary, Binny"

Fatty Acid Synthase induced S6Kinase facilitates USP11-eIF4B complex formation for sustained oncogenic translation in DLBCL by Kapadia, Bandish, Nanaji, Nahid M., Bhalla, Kavita, Bhandary, Binny, Lapidus, Rena, Beheshti, Afshin, Evens, Andrew M., Gartenhaus, Ronald B.

“…Altered lipid metabolism and aberrant protein translation are strongly associated with cancerous outgrowth; however, the inter-regulation of these key…”
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SIRT3, a metabolic target linked to ataxia-telangiectasia mutated (ATM) gene deficiency in diffuse large B-cell lymphoma by Bhalla, Kavita, Jaber, Sausan, Reagan, Kayla, Hamburg, Arielle, Underwood, Karen F., Jhajharia, Aditya, Singh, Maninder, Bhandary, Binny, Bhat, Shambhu, Nanaji, Nahid M., Hisa, Ruching, McCracken, Carrie, Creasy, Heather Huot, Lapidus, Rena G., Kingsbury, Tami, Mayer, Dirk, Polster, Brian, Gartenhaus, Ronald B.

“…Inactivation of Ataxia-telangiectasia mutated (ATM) gene results in an increased risk to develop cancer. We show that ATM deficiency in diffuse large B-cell…”
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Role of caveolin-1 as a biomarker for radiation resistance and tumor aggression in lung cancer by Leiser, Dominic, Samanta, Santanu, Eley, John, Strauss, Josh, Creed, Michael, Kingsbury, Tami, Staats, Paul N, Bhandary, Binny, Chen, Minjie, Dukic, Tijana, Roy, Sanjit, Mahmood, Javed, Vujaskovic, Zeljko, Shukla, Hem D

“…Radiation therapy plays a major role in the treatment of lung cancer patients. However, cancer cells develop resistance to radiation. Tumor radioresistance is…”
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Venetoclax and pegcrisantaspase for complex karyotype acute myeloid leukemia by Emadi, Ashkan, Kapadia, Bandish, Bollino, Dominique, Bhandary, Binny, Baer, Maria R., Niyongere, Sandrine, Strovel, Erin T., Kaizer, Hannah, Chang, Elizabeth, Choi, Eun Yong, Ma, Xinrong, Tighe, Kayla M., Carter-Cooper, Brandon, Moses, Blake S., Civin, Curt I., Mahurkar, Anup, Shetty, Amol C., Gartenhaus, Ronald B., Kamangar, Farin, Lapidus, Rena G.

“…Complex karyotype acute myeloid leukemia (CK-AML) has a dismal outcome with current treatments, underscoring the need for new therapies. Here, we report…”
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Correction: Role of caveolin-1 as a biomarker for radiation resistance and tumor aggression in lung cancer by Leiser, Dominic, Samanta, Santanu, Strauss, Josh, Eley, John, Creed, Michael, Kingsbury, Tami, Staats, Paul N, Bhandary, Binny, Chen, Minjie, Dukic, Tijana, Roy, Sanjit, Mahmood, Javed, Vujaskovic, Zeljko, Shukla, Hem D

“…[This corrects the article DOI: 10.1371/journal.pone.0258951.]…”
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Pancreatic cancer derived 3D organoids as a clinical tool to evaluate the treatment response by Shukla, Hem D, Dukic, Tijana, Roy, Sanjit, Bhandary, Binny, Gerry, Andrew, Poirier, Yannick, Lamichhane, Narottam, Molitoris, Jason, Carrier, France, Banerjee, Aditi, Regine, William F, Polf, Jerimy C

“…Pancreatic cancer (PC) is the fourth leading cause of cancer death in both men and women. The standard of care for patients with locally advanced PC of…”
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SOX2 and OCT4 mediate radiation and drug resistance in pancreatic tumor organoids by Roy, Sanjit, Dukic, Tijana, Keepers, Zachery, Bhandary, Binny, Lamichhane, Narottam, Molitoris, Jason, Ko, Young H., Banerjee, Aditi, Shukla, Hem D.

“…Pancreatic cancer has a five-year survival rate of only 10%, mostly due to late diagnosis and limited treatment options. In patients with unresectable disease,…”
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Author Correction: Role of hypoxia in Diffuse Large B-cell Lymphoma: Metabolic repression and selective translation of HK2 facilitates development of DLBCL by Bhalla, Kavita, Jaber, Sausan, Nahid M., Nanaji, Underwood, Karen, Beheshti, Afshin, Landon, Ari, Bhandary, Binny, Bastian, Paul, Evens, Andrew M., Haley, John, Polster, Brian, Gartenhaus, Ronald B.

“…A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper…”
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Abstract PO-126: Loss of HIF1A decreases resistance to radiation and invasiveness in pancreatic ductal adenocarcinoma by Tu, Kevin J., Roy, Sanjit K., Bhandary, Binny, Sawant, Amit, Shukla, Hem D.

“…Abstract Pancreatic ductal adenocarcinoma (PDAC) is the fourth most lethal cancer in the United States with an estimated 60,430 new cases and 48,220 deaths in…”
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Abstract 4455: Fatty acid synthase-induced S6Kinase facilitates USP11-eIF4B complex formation for sustained oncogenic translation in DLBCL by Kapadia, Bandish, Nanaji, Nahid, Bhalla, Kavita, Bhandary, Binny, Lapidus, Rena, Beheshti, Afshin, Evens, Andrew, Gartenhaus, Ronald

“…Abstract Fatty acid synthase (FASN) and protein translational machinery are two emergent therapeutic targets for cancer treatment, but their mutual dependency…”
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Evidence for trade-offs in detoxification and chemosensation gene signatures in Plutella xylostella by Bautista, Ma Anita M, Bhandary, Binny, Wijeratne, Asela J, Michel, Andrew P, Hoy, Casey W, Mittapalli, Omprakash

“…BACKGROUND Detoxification genes have been associated with insecticide adaptation in the diamondback moth, Plutella xylostella. The link between chemosensation…”
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Translatome changes in acute myeloid leukemia cells post exposure to pegcrisantaspase and venetoclax by Kapadia, Bandish, Shetty, Amol C., Bollino, Dominique, Bhandary, Binny, Lapidus, Rena G., Mahmood, Kanwal, Mahurkar, Anup, Gartenhaus, Ronald B., Eckert, Richard L., Emadi, Ashkan

“…•Venetoclax–asparaginase combination induces dysregulation of protein translation.•Translation of five mRNAs were altered by venetoclax and asparaginase…”
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Abstract 1094: 3-Bromopyruvate reduces pancreatic tumor growth by damaging mitochondria and inhibiting glucose metabolism in both cell culture and mouse model by Roy, Sanjit, Dukic, Tijana, Bhandary, Binny, Molitoris, Jason, Ko, Young H, Shukla, Hem D

“…Abstract Pancreatic cancer (PC) is the deadly cancer in both men and women, with a one-year relative survival rate of 20%, and a five-year relative survival…”
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Role of hypoxia in Diffuse Large B-cell Lymphoma: Metabolic repression and selective translation of HK2 facilitates development of DLBCL by Bhalla, Kavita, Jaber, Sausan, Nahid M., Nanaji, Underwood, Karen, Beheshti, Afshin, Landon, Ari, Bhandary, Binny, Bastian, Paul, Evens, Andrew M., Haley, John, Polster, Brian, Gartenhaus, Ronald B.

“…Published molecular profiling studies in patients with lymphoma suggested the influence of hypoxia inducible factor-1 alpha (HIF1α) targets in prognosis of…”
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Effect of hyperthermia and proton beam radiation as a novel approach in chordoma cells death and its clinical implication to treat chordoma by Singh, Prerna, Eley, John, Saeed, Ali, Bhandary, Binny, Mahmood, Nayab, Chen, Minjie, Dukic, Tijana, Mossahebi, Sina, Rodrigues, Dario B., Mahmood, Javed, Vujaskovic, Zeljko, Shukla, Hem D.

“…Chordoma is a locally aggressive tumor that most commonly affects the base of the skull/clivus, cervical, and sacral spine. Conventional radiotherapy (RT),…”
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Abstract B086: Patient-derived pancreatic tumor organoids as a tool to evaluate cancer stem cell populations and their role in therapeutic resistance by Keepers, Zachery L, Roy, Sanjit, Ryan, William, Bhandary, Binny, Lamichhane, Narottam, Carrier, France, Iyer, Ramaswamy K, Molitoris, Jason K, Regine, William F, Shukla, Hem D

“…Abstract Introduction: Pancreatic ductal adenocarcinoma remains one of the most lethal forms of cancer with a five-year survival rate of less than 15%…”
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Abstract 884: Mechanistically-driven investigation of pegcrisantaspase combination therapy against acute myeloid leukemia by Kaizer, Hannah, Bhandary, Binny, Carter-Cooper, Brandon A., Choi, Eun Yong, Kapadia, Bandish, Chang, Elizabeth T., Lapidus, Rena G., Gartenhaus, Ronald B., Emadi, Ashkan

“…Abstract Introduction: Novel, more efficacious, and better tolerated therapy for acute myeloid leukemia (AML) is needed, as current treatment options result in…”
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Abstract 5243: 3-Bromopyruvate in combination with radiation inhibits pancreatic cancer growth by dismantling mitochondria and ATP generation in a preclinical mouse model by Roy, Sanjit K., Dukic, Tijana, Bhandary, Binny, Acharya, Aneesh, Tu, Kevin J., Ko, Young H., Shukla, Hem D.

“…Abstract 3-Bromopyruvate (3 BP) is a promising anticancer drug against pancreatic cancer. It exerts potent anticancer effects by inhibiting hexokinase II…”
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3-Bromopyruvate inhibits pancreatic tumor growth by stalling glycolysis, and dismantling mitochondria in a syngeneic mouse model by Roy, Sanjit, Dukic, Tijana, Bhandary, Binny, Tu, Kevin J, Molitoris, Jason, Ko, Young H, Shukla, Hem D

“…Pancreatic cancer (PC) is the fourth-most-deadly cancer in the United States with a 5-year survival rate of only 8%. The majority of patients with locally…”
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Therapeutic Efficacy of Variable Biological Effectiveness of Proton Therapy in U-CH2 and MUG-Chor1 Human Chordoma Cell Death by Singh, Prerna, Eley, John, Mahmood, Nayab, Bhandary, Binny, Dukic, Tijana, Tu, Kevin J., Polf, Jerimy, Lamichhane, Narottam, Mahmood, Javed, Vujaskovic, Zeljko, Shukla, Hem D.

“…Background: Chordoma is a cancer of spinal cord, skull base, and sacral area. Currently, the standard of care to treat chordoma is resection followed by…”
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