Search Results - "Bhamidipati, Somasekhar"

Regulation of bone homeostasis by MERTK and TYRO3 by Engelmann, Janik, Zarrer, Jennifer, Gensch, Victoria, Riecken, Kristoffer, Berenbrok, Nikolaus, Luu, The Vinh, Beitzen-Heineke, Antonia, Vargas-Delgado, Maria Elena, Pantel, Klaus, Bokemeyer, Carsten, Bhamidipati, Somasekhar, Darwish, Ihab S., Masuda, Esteban, Burstyn-Cohen, Tal, Alberto, Emily J., Ghosh, Sourav, Rothlin, Carla, Hesse, Eric, Taipaleenmäki, Hanna, Ben-Batalla, Isabel, Loges, Sonja

“…The fine equilibrium of bone homeostasis is maintained by bone-forming osteoblasts and bone-resorbing osteoclasts. Here, we show that TAM receptors MERTK and…”
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Metabolism of Fostamatinib, the Oral Methylene Phosphate Prodrug of the Spleen Tyrosine Kinase Inhibitor R406 in Humans: Contribution of Hepatic and Gut Bacterial Processes to the Overall Biotransformation by SWEENY, David J, WEIQUN LI, CLOUGH, Jeffrey, BHAMIDIPATI, Somasekhar, SINGH, Rajinder, PARK, Gary, BALUOM, Muhammad, GROSSBARD, Elliott, LAU, David T.-W

“…The metabolism of the spleen tyrosine kinase inhibitor…”
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R723, a selective JAK2 inhibitor, effectively treats JAK2V617F-induced murine myeloproliferative neoplasm by Shide, Kotaro, Kameda, Takuro, Markovtsov, Vadim, Shimoda, Haruko K., Tonkin, Elizabeth, Fang, Shuling, Liu, Chian, Gelman, Marina, Lang, Wayne, Romero, Jason, McLaughlin, John, Bhamidipati, Somasekhar, Clough, Jeffrey, Low, Caroline, Reitsma, Andrea, Siu, Stacey, Pine, Polly, Park, Gary, Torneros, Allan, Duan, Matt, Singh, Rajinder, Payan, Donald G., Matsunaga, Takuya, Hitoshi, Yasumichi, Shimoda, Kazuya

“…The activating mutations in JAK2 (including JAK2V617F) that have been described in patients with myeloproliferative neoplasms (MPNs) are linked directly to MPN…”
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Tuning the Reactivity of Nuclear Factor Erythroid 2‑Related Factor 2 (Nrf2) Activators for Optimal in Vivo Efficacy by Markovtsov, Vadim, Duncton, Matthew A. J., Bagos, Art, Yi, Sothy, Braselmann, Sylvia, Bhamidipati, Somasekhar, Darwish, Ihab S., Yu, Jiaxin, Owyang, Alexander M., Fernandez, Beth, Samant, Bhushan, Park, Gary, Masuda, Esteban S., Shaw, Simon J.

“…Dimethyl fumarate 1 is approved for the treatment of multiple sclerosis but is also associated with off-target activation of the niacin receptor. By using a…”
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Blockade of Mer By the Small Molecule Inhibitor R992 Inhibits Multiple Myeloma and Its Associated Bone Disease By Restoring the Perturbed Bone Homeostasis by Engelmann, Janik, Ben Batalla, Isabel, Taipaleenmäki, Hanna, Riecken, Kristoffer, Gensch, Victoria, Paesler, Sarina, Berenbrok, Nikolaus, Vargas, Maria Elena, Waizenegger, Jonas, Fehse, Boris, Pantel, Klaus, Darwish, Ihab S, Bhamidipati, Somasekhar, Masuda, Esteban, Bokemeyer, Carsten, Hesse, Eric, Loges, Sonja

“…Despite many therapeutic advances in recent years Multiple Myeloma (MM) still remains incurable in the majority of the patients. In addition, MM patients…”
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R970, A Selective Activator of Nrf2, is Efficacious in a Murine Model of Multiple Sclerosis by Owyang, Alexander, Masuda, Esteban S, Payan, Donald G, Park, Gary, Lau, David, Torneros, Allan, Pablo, Florentino San, Bhamidipati, Somasekhar, Singh, Rajinder, Duncton, Matthew A. J.

“…Abstract The transcription factor Nrf2 (nuclear factor erythroid-derived-2-like 2) is a key mediator of the anti-oxidant response. Nrf2 can be activated by…”
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Abstract 4869: Small molecule inhibitors of the anti-inflammatory TAM receptor MerTK by Holland, Sacha J., Owyang, Alex M., Yi, Sothy, Young, Chi, Braselmann, Sylvia, Frances, Roy, Bagos, Arthur, Tai, Ernest, Siu, Stacey, Park, Gary, Lau, David, Duan, Matt, Kolluri, Rao, Bhamidipati, Somasekhar, Darwish, Ihab, Duncton, Matthew, Singh, Rajinder, Masuda, Esteban, Payan, Donald G.

“…Abstract Introduction: MerTK, a TAM (Tyro3, Axl, MerTK) family RTK, is expressed on phagocytic myeloid and epithelial cells. Its normal function is to dampen…”
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Design, synthesis of diaminopyrimidine inhibitors targeting IgE- and IgG-mediated activation of Fc receptor signaling by Argade, Ankush, Bhamidipati, Somasekhar, Li, Hui, Sylvain, Catherine, Clough, Jeffrey, Carroll, David, Keim, Holger, Braselmann, Sylvia, Taylor, Vanessa, Zhao, Haoran, Herlaar, Ellen, Issakani, Sarkiz D., Wong, Brian R., Masuda, Esteban S., Payan, Donald G., Singh, Rajinder

“…[Display omitted] Using cultured human mast cells (CHMC) the optimization of 2,4-diaminopyrimidine compounds leading to 22, R406 is described. Compound 22 is a…”
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In vitro and in vivo characterization of small molecule inhibitors of the anti-inflammatory TAM receptor MerTK by Owyang, Alexander, Holland, Sacha, Yi, Sothy, Young, Chi, Braselmann, Sylvia, Frances, Roy, Bagos, Art, Tai, Ernie, Siu, Stacey, Park, Gary, Lau, David, Duan, Matt, Yu, Jiaxin, Ding, Pingyu, Kolluri, Rao, Bhamidipati, Somasekhar, Darwish, Ihab, Singh, Raj, Payan, Donald G, Masuda, Esteban S

“…Abstract MerTK, a TAM (Tyro3, Axl, MerTK) family RTK, is expressed on phagocytic cells. Its normal function is to dampen innate immune responses to…”
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Application of cultured human mast cells (CHMC) for the design and structure–activity relationship of IgE-mediated mast cell activation inhibitors by Argade, Ankush, Bhamidipati, Somasekhar, Li, Hui, Carroll, David, Clough, Jeffrey, Keim, Holger, Sylvain, Catherine, Rossi, Alexander B., Coquilla, Christina, Issakani, Sarkiz D., Masuda, Esteban S., Payan, Donald G., Singh, Rajinder

“…[Display omitted] Here we report the optimization of small molecule inhibitors of human mast cell degranulation via anti-IgE-mediated tryptase release…”
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Efficacy of R723, a Potent and Selective JAK2 Inhibitor, in JAK2V617F-Induced Murine MPD Model by Shide, Kotaro, Kameda, Takuro, Markovtsov, Vadim, Matsunaga, Takuya, Shimoda, Haruko, Hidaka, Tomonori, Katayose, Keiko, Kubuki, Yoko, Bhamidipati, Somasekhar, Park, Gary, Torneros, Allan, Duan, Matt, Hitoshi, Yasumichi, Shimoda, Kazuya

“…Abstract 3897 Poster Board III-833 The V617F mutation of JAK2 (JAK2-V617F) occurs at a high frequency in Philadelphia chromosome-negative myeloproliferative…”
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In Vitro and in Vivo Inhibition of JAK2 Signaling by Potent and Selective JAK2 Inhibitor by Markovtsov, Vadim, Tonkin, Elizabeth, Fang, Shuling, Liu, Chiang, Gelman, Marina, Lang, Wayne, Romero, Jason, McLaughlin, John, Bhamidipati, Somasekhar, Clough, Jeffrey, Singh, Rajinder, Low, Caroline, Reitsma, Andrea, Taylor, Vanessa, Siu, Stacey, Park, Gary, Sweeney, David, Pine, Polly, Torneros, Allan, Clemens, George, Duan, Matt, Daniel, Ruby, Payan, Donald, Holland, Sacha, Hitoshi, Yasumichi

“…Recent advances in understanding the role of JAK2 V617F mutation in Bcr-Abl negative myeloproliferative (MPD) diseases pathogenesis opened up a possibility to…”
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