Search Results - "Bhamidipati, Ravi Kanth"

A small molecule inhibitor of Nicotinamide N-methyltransferase for the treatment of metabolic disorders by Kannt, Aimo, Rajagopal, Sridharan, Kadnur, Sanjay Venkatachalapathi, Suresh, Juluri, Bhamidipati, Ravi Kanth, Swaminathan, Srinivasan, Hallur, Mahanandeesha Siddappa, Kristam, Rajendra, Elvert, Ralf, Czech, Jörg, Pfenninger, Anja, Rudolph, Christine, Schreuder, Herman, Chandrasekar, Devaraj Venkatapura, Mane, Vishal Subhash, Birudukota, Swarnakumari, Shaik, Shama, Zope, Bharat Ravindra, Burri, Raghunadha Reddy, Anand, Niranjan Naranapura, Thakur, Manish Kumar, Singh, Manvi, Parveen, Reejuana, Kandan, Saravanan, Mullangi, Ramesh, Yura, Takeshi, Gosu, Ramachandraiah, Ruf, Sven, Dhakshinamoorthy, Saravanakumar

“…Nicotinamide N-methyltransferase (NNMT) is a cytosolic enzyme that catalyzes the transfer of a methyl group from the co-factor S-adenosyl-L-methionine (SAM)…”
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Novel nicotinamide analog as inhibitor of nicotinamide N-methyltransferase by Ruf, Sven, Hallur, Mahanandeesha Siddappa, Anchan, Nisha K., Swamy, Indu N., Murugesan, Karthikai Raj, Sarkar, Sayantani, Narasimhulu, Lokesh Kananti, Putta, V.P. Rama Kishore, Shaik, Shama, Chandrasekar, Devaraj Venkatapura, Mane, Vishal Subhash, Kadnur, Sanjay Venkatachalapathi, Suresh, Juluri, Bhamidipati, Ravi Kanth, Singh, Manvi, Burri, Raghunadha Reddy, Kristam, Rajendra, Schreuder, Herman, Czech, Joerg, Rudolph, Christine, Marker, Alexander, Langer, Thomas, Mullangi, Ramesh, Yura, Takeshi, Gosu, Ramachandraiah, Kannt, Aimo, Dhakshinamoorthy, Saravanakumar, Rajagopal, Sridharan

“…Compound 12 Human/mouse NNMT enzymatic inhibition (IC50): 0.58/4.5 µM. Inhibition of MNA in U2OS/3T3L1 cell based assay: 0.3/2.1 µM. Human/mouse metabolic…”
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Validated LC–MS-MS Method for Determination of SF0034 in Mice Plasma: Application to a Pharmacokinetic Study in Mice by Todmal, Umesh, Suresh, P. S., Zainuddin, Mohd, Kanth Bhamidipati, Ravi, Samanta, Swapan Kumar, Hallur, Gurulingappa, Rajagopal, Sridharan, Rajagopal, Sriram, Mullangi, Ramesh

“…Abstract A rapid and sensitive assay method has been developed and validated using liquid chromatography coupled to tandem mass spectrometry with electrospray…”
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Retrospective and Prospective Human Intravenous and Oral Pharmacokinetic Projection of Dipeptidyl peptidase-IV Inhibitors Using Simple Allometric Principles - Case Studies of ABT-279, ABT-341, Alogliptin, Carmegliptin, Sitagliptin and Vildagliptin by Gilibili, Ravindranath R, Bhamidipati, Ravi Kanth, Mullangi, Ramesh, Srinivas, Nuggehally R

“…The purpose of this exercise was to explore the utility of allometric scaling approach for the prediction of intravenous and oral pharmacokinetics of six…”
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Area under the curve predictions of dalbavancin, a new lipoglycopeptide agent, using the end of intravenous infusion concentration data point by regression analyses such as linear, log-linear and power models by Bhamidipati, Ravi Kanth, Syed, Muzeeb, Mullangi, Ramesh, Srinivas, Nuggehally

“…1. Dalbavancin, a lipoglycopeptide, is approved for treating gram-positive bacterial infections. Area under plasma concentration versus time curve (AUC inf )…”
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LC–MS/MS determination of tideglusib, a novel GSK-3β inhibitor in mice plasma and its application to a pharmacokinetic study in mice by Saini, Neeraj Kumar, Suresh, P.S., Lella, Mahalakhsmi, Bhamidipati, Ravi Kanth, Rajagopal, Sriram, Mullangi, Ramesh

“…[Display omitted] •First bioanalytical method being reported for quantification of tideglusib in mice plasma on LC–MS/MS.•Simple sample processing method and…”
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Preclinical assessment of ulixertinib, a novel ERK1/2 inhibitor by Balakrishna, Vinod Anera, Police, Anitha, Hiremath, Rakesh, Raj, Anusha, Sulochana, Suresh P, Chandrasekhar, Devaraj V, Mohd, Zainuddin, Bhamidipati, Ravi Kanth, Mullangi, Ramesh

“…Ulixertinib (BVD-523) is a novel and selective reversible inhibitor of ERK1/ERK2. In xenograft studies it inhibited tumor growth in BRAF-mutant melanoma and…”
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High‐throughput screening assay for the quantification of Cer d18:1/16:0, d18:1/24:0, d18:1/24:1, d18:1/18:0, d18:1/14:0, d18:1/20:0, and d18:1/22:0 in HepG2 cells using RapidFire mass spectrometry by Dittakavi, Sreekanth, Mahadevan, Lavanya, Chandrashekar, Devaraj V., Bhamidipati, Ravi Kanth, Suresh, Juluri, Dhakshinamoorthy, Saravanakumar, Li, Ziyu, Baerenz, Felix, Tennagels, Norbert, Mullangi, Ramesh

“…Ceramides are known to be involved in various biological processes with their physiological levels elevated in various disease conditions such as diabetes,…”
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Interspecies scaling of urinary excretory amounts of nine drugs belonging to different therapeutic areas with diverse chemical structures - accurate prediction of the human urinary excretory amounts by Bhamidipati, Ravi Kanth, Mullangi, Ramesh, Srinivas, Nuggehally R.

“…1. The human urinary excretory amounts of total drug (parent + metabolites) were predicted for nine drugs with diverse chemical structures using simple…”
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Cover Image by Dittakavi, Sreekanth, Mahadevan, Lavanya, Chandrashekar, Devaraj V., Bhamidipati, Ravi Kanth, Suresh, Juluri, Dhakshinamoorthy, Saravanakumar, Li, Ziyu, Baerenz, Felix, Tennagels, Norbert, Mullangi, Ramesh

“…The cover image is based on the Short Communication High throughput screening assay for quantification of Cer d18:1/16:0, d18:1/24:0, d18:1/24:1, d18:1/18:0,…”
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Cover Image by Dittakavi, Sreekanth, Mahadevan, Lavanya, Chandrashekar, Devaraj V., Bhamidipati, Ravi Kanth, Suresh, Juluri, Dhakshinamoorthy, Saravanakumar, Li, Ziyu, Baerenz, Felix, Tennagels, Norbert, Mullangi, Ramesh

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Prediction of Human Pharmacokinetics of Fomepizole from Preclinical Species Pharmacokinetics Based on Normalizing Time Course Profiles by Jairam, Ravi Kumar, Mallurwar, Sadanand Rangnathrao, Sulochana, Suresh P., Chandrasekhar, Devaraj V., Todmal, Umesh, Bhamidipati, Ravi Kanth, Richter, Wolfgang, Srinivas, Nuggehally R., Mullangi, Ramesh

“…Fomepizole is used as an antidote to treat methanol poisoning due to its selectivity towards alcohol dehydrogenase. In the present study, the goal is to…”
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Validation of an LC–MS/MS Method for Simultaneous Detection of Five Selective KCNQ Channel Openers: ICA-27243, ML-213, PF-05020182, SF-0034 and Flupirtine in Mice Plasma and its Application to a Pharmacokinetic Study in Mice by Todmal, Umesh, Sulochana, Suresh P., Zainuddin, Mohd, Bhamidipati, Ravi Kanth, Samanta, Swapan Kumar, Hallur, Gurulingappa, Rajagopal, Sridharan, Rajagopal, Sriram, Mullangi, Ramesh

“…A sensitive and rapid LC–MS/MS method was developed and validated for the simultaneous quantitation of five selective KCNQ channel openers, namely ICA-27243,…”
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Sensitive LC-MS/MS Method for the Simultaneous Determination of Bendamustine and its Active Metabolite, γ-Hydroxybendamustine in Small Volume Mice and Dog Plasma and its Application to a Pharmacokinetic Study in Mice and Dogs by Chandrashekar, Devaraj V, Suresh, Ponnayyan S, Kumar, Rajnish, Bhamidipati, Ravi Kanth, Mullangi, Ramesh, Richter, Wolfgang, Srinivas, Nuggehally R

“…A highly sensitive, specific and rapid LC-ESI-MS/MS method has been developed and validated for the simultaneous quantification of bendamustine (BM) and…”
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Development and validation of an RP-HPLC method for the quantitation of odanacatib in rat and human plasma and its application to a pharmacokinetic study by Police, Anitha, Gurav, Sandip, Dhiman, Vinay, Zainuddin, Mohd, Bhamidipati, Ravi kanth, Rajagopal, Sriram, Mullangi, Ramesh

“…A simple, specific, sensitive and reproducible high‐performance liquid chromatography (HPLC) assay method has been developed and validated for the estimation…”
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Prediction of Human Pharmacokinetics of Bendamustine from Preclinical Species Pharmacokinetics Based on Normalizing Time Course Profiles by Jairam, Ravi Kumar, Mallurwar, Sadanand Rangnathrao, Sulochana, Suresh P, Chandrasekar, Devaraj V, Bhamidipati, Ravi Kanth, Richter, Wolfgang, Srinivas, Nuggehally R, Mullangi, Ramesh

“…Bendamustine, an alkylating anticancer agent, is used to treat chronic lymphocytic leukemia by intravenous infusion alone or in combination. The work aimed to…”
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Prediction of Human Pharmacokinetics of Ulixertinib, a Novel ERK1/2 Inhibitor from Mice, Rats, and Dogs Pharmacokinetics by Suresh, Ponnayyan Sulochana, Jairam, Ravi Kumar, Chandrasekhar, Devaraj V., Vinod, Anera Balakrishna, Hiremath, Rakesh A., Raj, Anusha, Zainuddin, Mohd, Bhamidipati, Ravi Kanth, Mullangi, Ramesh

“…Background and Objectives Ulixertinib (BVD-523) is a novel and selective reversible inhibitor of ERK1/ERK2. The primary objectives of the study were to…”
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Validation of an LC–MS/MS method for simultaneous detection of four HDAC inhibitors – belinostat, panobinostat, rocilinostat and vorinostat in mouse plasma and its application to a mouse pharmacokinetic study by Giri, Kalpesh Kumar, Suresh, P. S., Saim, Syed Mohd, Zainuddin, Mohd, Bhamidipati, Ravi Kanth, Dewang, Purushottam, Hallur, Mahanandeesha S., Rajagopal, Sridharan, Rajagopal, Sriram, Mullangi, Ramesh

“…A sensitive and rapid LC–MS/MS method was developed and validated for the simultaneous quantitation of four HDAC inhibitors, namely belinostat (BST),…”
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LC‐ESI‐MS/MS determination of 4‐methylpyrazole in dog plasma and its application to a pharmacokinetic study in dogs by Chandrasekhar, Devaraj V., Suresh, Ponnayyan Sulochana, Dittakavi, Sreekanth, Hiremath, Rakesh A., Bhamidipati, Ravi Kanth, Richter, Wolfgang, Srinivas, Nuggehally R., Mullangi, Ramesh

“…A simple, specific, sensitive and rapid LC‐ESI‐MS/MS method has been developed and validated for the quantification of 4‐methylpyrazole in dog plasma using…”
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Sensitive method for the determination of rocilinostat in small volume mouse plasma by LC-MS/MS and its application to a pharmacokinetic study in mice by Gupta, Manish, Dixit, Abhishek, Devaraj, V. C., Zainuddin, Mohd, Bhamidipati, Ravi Kanth, Hallur, Mahanandeesha S., Dewang, Purushottam, Rajagopal, Sridharan, Rajagopal, Sriram, Mullangi, Ramesh

“…A highly sensitive, specific and rapid LC‐ESI‐MS/MS method has been developed and validated for the quantification of rocilinostat in small volume mouse plasma…”
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