Search Results - "Bhalla, N."

Microtubule-targeted anticancer agents and apoptosis by Bhalla, Kapil N

“…Over the past decade, significant progress has been made in our understanding of the biology of microtubule (MT) assembly into the mitotic spindle during…”
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Highly effective combination of LSD1 (KDM1A) antagonist and pan-histone deacetylase inhibitor against human AML cells by Fiskus, W, Sharma, S, Shah, B, Portier, B P, Devaraj, S G T, Liu, K, Iyer, S P, Bearss, D, Bhalla, K N

“…The histone demethylase LSD1 (KDM1A) demethylates mono- and di-methylated (Me2) lysine (K) 4 on histone H3. High LSD1 expression blocks differentiation and…”
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Epigenetic and Chromatin Modifiers As Targeted Therapy of Hematologic Malignancies by BHALLA, Kapil N

“…Epigenetic regulation of gene expression is mediated through alterations in the DNA methylation status, covalent modifications of core nucleosomal histones,…”
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Novel BET protein proteolysis-targeting chimera exerts superior lethal activity than bromodomain inhibitor (BETi) against post-myeloproliferative neoplasm secondary (s) AML cells by Saenz, D T, Fiskus, W, Qian, Y, Manshouri, T, Rajapakshe, K, Raina, K, Coleman, K G, Crew, A P, Shen, A, Mill, C P, Sun, B, Qiu, P, Kadia, T M, Pemmaraju, N, DiNardo, C, Kim, M-S, Nowak, A J, Coarfa, C, Crews, C M, Verstovsek, S, Bhalla, K N

“…The PROTAC (proteolysis-targeting chimera) ARV-825 recruits bromodomain and extraterminal (BET) proteins to the E3 ubiquitin ligase cereblon, leading to…”
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Auranofin Induces Lethal Oxidative and Endoplasmic Reticulum Stress and Exerts Potent Preclinical Activity against Chronic Lymphocytic Leukemia by FISKUS, Warren, SABA, Nakhle, AUSTIN, Christopher P, MADDOCKS, Kami, BYRD, John, MELNICK, Ari, PENG HUANG, WIESTNER, Adrian, BHALLA, Kapil N, MIN SHEN, GHIAS, Mondana, JINYUN LIU, DAS GUPTA, Soumyasri, CHAUHAN, Lata, RAO, Rekha, GUNEWARDENA, Sumedha, SCHORNO, Kevin

“…Chronic lymphocytic leukemia (CLL) exhibits high remission rates after initial chemoimmunotherapy, but with relapses with treatment, refractory disease is the…”
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Leukemia stemness and co-occurring mutations drive resistance to IDH inhibitors in acute myeloid leukemia by Wang, Feng, Morita, Kiyomi, DiNardo, Courtney D., Furudate, Ken, Tanaka, Tomoyuki, Yan, Yuanqing, Patel, Keyur P., MacBeth, Kyle J., Wu, Bin, Liu, Guowen, Frattini, Mark, Matthews, Jairo A., Little, Latasha D., Gumbs, Curtis, Song, Xingzhi, Zhang, Jianhua, Thompson, Erika J., Kadia, Tapan M., Garcia-Manero, Guillermo, Jabbour, Elias, Ravandi, Farhad, Bhalla, Kapil N., Konopleva, Marina, Kantarjian, Hagop M., Andrew Futreal, P., Takahashi, Koichi

“…Allosteric inhibitors of mutant IDH1 or IDH2 induce terminal differentiation of the mutant leukemic blasts and provide durable clinical responses in…”
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Acetylated hsp70 and KAP1-mediated Vps34 SUMOylation is required for autophagosome creation in autophagy by Yang, Yonghua, Fiskus, Warren, Yong, Bao, Atadja, Peter, Takahashi, Yoshinori, Pandita, Tej K., Wang, Hong-Gang, Bhalla, Kapil N.

“…Autophagy is a stress-induced catabolic process in which cytoplasmic components, sequestered in double-membrane autophagic vesicles (AVs) or autophagosomes,…”
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BET protein proteolysis targeting chimera (PROTAC) exerts potent lethal activity against mantle cell lymphoma cells by Sun, B, Fiskus, W, Qian, Y, Rajapakshe, K, Raina, K, Coleman, K G, Crew, A P, Shen, A, Saenz, D T, Mill, C P, Nowak, A J, Jain, N, Zhang, L, Wang, M, Khoury, J D, Coarfa, C, Crews, C M, Bhalla, K N

“…Bromodomain extraterminal protein (BETP) inhibitors transcriptionally repress oncoproteins and nuclear factor-κB (NF-κB) target genes that undermines the…”
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Spatial transcriptomics landscape of lesions from non-communicable inflammatory skin diseases by Schäbitz, A., Hillig, C., Mubarak, M., Jargosch, M., Farnoud, A., Scala, E., Kurzen, N., Pilz, A. C., Bhalla, N., Thomas, J., Stahle, M., Biedermann, T., Schmidt-Weber, C. B., Theis, F., Garzorz-Stark, N., Eyerich, K., Menden, M. P., Eyerich, S.

“…Abundant heterogeneous immune cells infiltrate lesions in chronic inflammatory diseases and characterization of these cells is needed to distinguish…”
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RUNX1-targeted therapy for AML expressing somatic or germline mutation in RUNX1 by Mill, Christopher P., Fiskus, Warren, DiNardo, Courtney D., Qian, Yimin, Raina, Kanak, Rajapakshe, Kimal, Perera, Dimuthu, Coarfa, Cristian, Kadia, Tapan M., Khoury, Joseph D., Saenz, Dyana T., Saenz, David N., Illendula, Anuradha, Takahashi, Koichi, Kornblau, Steven M., Green, Michael R., Futreal, Andrew P., Bushweller, John H., Crews, Craig M., Bhalla, Kapil N.

“…RUNX1 transcription factor regulates normal and malignant hematopoiesis. Somatic or germline mutant RUNX1 (mtRUNX1) is associated with poorer outcome in acute…”
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BET protein bromodomain inhibitor-based combinations are highly active against post-myeloproliferative neoplasm secondary AML cells by Saenz, D T, Fiskus, W, Manshouri, T, Rajapakshe, K, Krieger, S, Sun, B, Mill, C P, DiNardo, C, Pemmaraju, N, Kadia, T, Parmar, S, Sharma, S, Coarfa, C, Qiu, P, Verstovsek, S, Bhalla, K N

“…Myeloproliferative neoplasms with myelofibrosis (MPN-MF) demonstrate constitutive activation of Janus kinase/signal transducer and activator of transcription…”
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Highly active combination of BRD4 antagonist and histone deacetylase inhibitor against human acute myelogenous leukemia cells by Fiskus, Warren, Sharma, Sunil, Qi, Jun, Valenta, John A, Schaub, Leasha J, Shah, Bhavin, Peth, Karissa, Portier, Bryce P, Rodriguez, Melissa, Devaraj, Santhana G T, Zhan, Ming, Sheng, Jianting, Iyer, Swaminathan P, Bradner, James E, Bhalla, Kapil N

“…The bromodomain and extra-terminal (BET) protein family members, including BRD4, bind to acetylated lysines on histones and regulate the expression of…”
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Phase II Study of Venetoclax Added to Cladribine Plus Low-Dose Cytarabine Alternating With 5-Azacitidine in Older Patients With Newly Diagnosed Acute Myeloid Leukemia by Kadia, Tapan M, Reville, Patrick K, Wang, Xuemei, Rausch, Caitlin R, Borthakur, Gautam, Pemmaraju, Naveen, Daver, Naval G, DiNardo, Courtney D, Sasaki, Koji, Issa, Ghayas C, Ohanian, Maro, Montalban-Bravo, Guillermo, Short, Nicholas J, Jain, Nitin, Ferrajoli, Alessandra, Bhalla, Kapil N, Jabbour, Elias, Takahashi, Koichi, Malla, Rashmi, Quagliato, Kelly, Kanagal-Shamanna, Rashmi, Popat, Uday R, Andreeff, Michael, Garcia-Manero, Guillermo, Konopleva, Marina Y, Ravandi, Farhad, Kantarjian, Hagop M

“…The combination of venetoclax and 5-azacitidine (5-AZA) for older or unfit patients with acute myeloid leukemia (AML) improves remission rates and survival…”
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Aptamer-based Field-Effect Biosensor for Tenofovir Detection by Aliakbarinodehi, N., Jolly, P., Bhalla, N., Miodek, A., De Micheli, G., Estrela, P., Carrara, S.

“…During medical treatment it is critical to maintain the circulatory concentration of drugs within their therapeutic range. A novel biosensor is presented in…”
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Synergistic activity of BET protein antagonist-based combinations in mantle cell lymphoma cells sensitive or resistant to ibrutinib by Sun, Baohua, Shah, Bhavin, Fiskus, Warren, Qi, Jun, Rajapakshe, Kimal, Coarfa, Cristian, Li, Li, Devaraj, Santhana G.T., Sharma, Sunil, Zhang, Liang, Wang, Michael L., Saenz, Dyana T., Krieger, Stephanie, Bradner, James E., Bhalla, Kapil N.

“…Mantle cell lymphoma (MCL) cells exhibit increased B-cell receptor and nuclear factor (NF)-κB activities. The bromodomain and extra-terminal (BET) protein…”
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Effective Menin inhibitor-based combinations against AML with MLL rearrangement or NPM1 mutation (NPM1c) by Fiskus, Warren, Boettcher, Steffen, Daver, Naval, Mill, Christopher P., Sasaki, Koji, Birdwell, Christine E., Davis, John A., Takahashi, Koichi, Kadia, Tapan M., DiNardo, Courtney D., Jin, Qi, Qi, Yuan, Su, Xiaoping, McGeehan, Gerard M., Khoury, Joseph D., Ebert, Benjamin L., Bhalla, Kapil N.

“…Treatment with Menin inhibitor (MI) disrupts the interaction between Menin and MLL1 or MLL1-fusion protein (FP), inhibits HOXA9/MEIS1, induces differentiation…”
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Automated reporter quantification in vivo: high-throughput screening method for reporter-based assays in zebrafish by Walker, Steven L, Ariga, Junko, Mathias, Jonathan R, Coothankandaswamy, Veena, Xie, Xiayang, Distel, Martin, Köster, Reinhard W, Parsons, Michael J, Bhalla, Kapil N, Saxena, Meera T, Mumm, Jeff S

“…Reporter-based assays underlie many high-throughput screening (HTS) platforms, but most are limited to in vitro applications. Here, we report a simple…”
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Dual PI3K/AKT/mTOR inhibitor BEZ235 synergistically enhances the activity of JAK2 inhibitor against cultured and primary human myeloproliferative neoplasm cells by Fiskus, Warren, Verstovsek, Srdan, Manshouri, Taghi, Smith, Jacqueline E, Peth, Karissa, Abhyankar, Sunil, McGuirk, Joseph, Bhalla, Kapil N

“…Hemopoietic progenitor cells (HPC) from myeloproliferative neoplasms (MPN) such as myelofibrosis commonly express mutant JAK2-V617F or other mutations that are…”
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Combination of pan-histone deacetylase inhibitor and autophagy inhibitor exerts superior efficacy against triple-negative human breast cancer cells by Rao, Rekha, Balusu, Ramesh, Fiskus, Warren, Mudunuru, Uma, Venkannagari, Sreedhar, Chauhan, Lata, Smith, Jacqueline E, Hembruff, Stacey L, Ha, Kyungsoo, Atadja, Peter, Bhalla, Kapil N

“…Histone deacetylase (HDAC) inhibitors (HDI) induce endoplasmic reticulum (ER) stress and apoptosis, while promoting autophagy, which promotes cancer cell…”
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EVI1 dysregulation: impact on biology and therapy of myeloid malignancies by Birdwell, Christine, Fiskus, Warren, Kadia, Tapan M., DiNardo, Courtney D., Mill, Christopher P., Bhalla, Kapil N.

“…Ecotropic viral integration site 1 ( Evi1 ) was discovered in 1988 as a common site of ecotropic viral integration resulting in myeloid malignancies in mice…”
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