Pulmonary leptospirosis: an excellent response to bolus methylprednisolone

Background: This case series analyses the beneficial effect of methylprednisolone in pulmonary leptospirosis, which usually has an aggressive course and grave outcome. Methods: 30 patients of pulmonary leptospirosis were evaluated. The initial 13 patients did not receive corticosteroids while the re...

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Published in:	Postgraduate medical journal Vol. 82; no. 971; pp. 602 - 606
Main Authors:	Shenoy, V V, Nagar, V S, Chowdhury, A A, Bhalgat, P S, Juvale, N I
Format:	Journal Article
Language:	English
Published:	London The Fellowship of Postgraduate Medicine 01-09-2006 BMJ Oxford University Press BMJ Group
Subjects:	acute lung injury Adolescent Adult Bacterial diseases Biological and medical sciences corticosteroids Disease Dyspnea - microbiology Female Fever - microbiology General aspects Glucocorticoids - administration & dosage Hemoptysis - microbiology Hospitals Human bacterial diseases Humans Infectious diseases Infusions, Intravenous Leptospira Leptospirosis Leptospirosis - drug therapy Lung Diseases - drug therapy Male Medical sciences methylprednisolone Methylprednisolone - administration & dosage Miscellaneous Mortality Original pulmonary leptospirosis Respiratory distress syndrome Respiratory therapy Treatment Outcome Tropical diseases Ventilation Mumbai India Infection Leptospirosis Medicine Corticosteroid Bolus injection Steroid hormone Spirochaetosis Lung Bacteriosis Immunosuppressive agent Methylprednisolone
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Summary:	Background: This case series analyses the beneficial effect of methylprednisolone in pulmonary leptospirosis, which usually has an aggressive course and grave outcome. Methods: 30 patients of pulmonary leptospirosis were evaluated. The initial 13 patients did not receive corticosteroids while the remaining 17 all received bolus methylprednisolone one gram intravenously for three days followed by oral prednisolone 1 mg/kg for seven days, on the basis of occasional case reports of benefit in pulmonary leptospirosis. APACHE III and lung injury scores of similar severity were considered while comparing outcomes in those who received methylprednisolone with those who did not. Results: Dyspnoea and haemoptysis were the commonest symptoms in those with pulmonary manifestations. Overall mortality was 18% (3 of 17) in patients who received methylprednisolone, as compared with 62% (8 of 13 patients) in those who did not (p<0.02). In patients with established acute lung injury (ALI score >2.5), five of eight patients survived in the subgroup with corticosteroids (37% mortality) while only one of nine patients survived in the group that did not receive corticosteroids (89% mortality). Corticosteroids affected outcome only if given within the first 12 hours after the onset of pulmonary manifestations. Mortality seemed to correlate with the APACHE scores, and number of quadrants affected on chest radiographs, more than with blood gas pressures. Conclusions: Corticosteroids reduce mortality and change outcome significantly when used early in the management of pulmonary leptospirosis.
Bibliography:	href:postgradmedj-82-602.pdf Correspondence to:  Dr V S Nagar  4/29, Swastik, J J Hospital Campus, Byculla 400008, India; vidyaic@vsnl.net PMID:16954459 local:0820602 ark:/67375/NVC-7WSZPN7L-R istex:3ECBCF573DE9D6FED5D52CB3CD95F5283ADB4859 ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0032-5473 1469-0756
DOI:	10.1136/pgmj.2005.044255