Search Results - "Bhal, Subhasmita"

Quinacrine and Curcumin in combination decreased the breast cancer angiogenesis by modulating ABCG2 via VEGF A by Nayak, Deepika, Paul, Subarno, Das, Chinmay, Bhal, Subhasmita, Kundu, Chanakya Nath

“…Cancer stem cells (CSCs) cause drug resistance in cancer due to its extensive drug efflux, DNA repair and self-renewal capability. ATP binding cassette…”
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In silico-guided discovery and in vitro validation of novel sugar-tethered lysinated carbon nanotubes for targeted drug delivery of doxorubicin by Thakur, Chanchal Kiran, Martins, Fábio G., Karthikeyan, Chandrabose, Bhal, Subhasmita, Kundu, Chanakya Nath, Moorthy, N. S. Hari Narayana, Sousa, Sérgio F.

“…Context Multiwalled carbon nanotubes (MWCNTs) functionalized with lysine via 1,3-dipolar cycloaddition and conjugated to galactose or mannose are potential…”
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Targeting crosstalk of signaling pathways in cancer stem cells: a promising approach for development of novel anti-cancer therapeutics by Bhal, Subhasmita, Kundu, Chanakya Nath

“…Wnt, Hedgehog (Hh), and Notch signaling pathways are the evolutionarily conserved signaling pathways that regulate the embryonic development and also play…”
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Resveratrol nanoparticles induce apoptosis in oral cancer stem cells by disrupting the interaction between β-catenin and GLI-1 through p53-independent activation of p21 by Bhal, Subhasmita, Das, Biswajit, Sinha, Saptarshi, Das, Chinmay, Acharya, Sushree Subhadra, Maji, Joydeb, Kundu, Chanakya Nath

“…Cancer stem cells (CSCs) are mainly responsible for tumorigenesis, chemoresistance, and cancer recurrence. CSCs growth and progression are regulated by…”
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Quinacrine inhibits HIF-1α/VEGF-A mediated angiogenesis by disrupting the interaction between cMET and ABCG2 in patient-derived breast cancer stem cells by Das, Biswajit, Dash, Somya Ranjan, Patel, Harun, Sinha, Saptarshi, Bhal, Subhasmita, Paul, Subarno, Das, Chinmay, Pradhan, Rajalaxmi, Ahmed, Iqrar, Goutam, Kunal, Kundu, Chanakya Nath

“…•cMET and ABCG2 interacts with each other under hypoxia.•Interaction between cMET and ABCG2 upregulates HIF-1α/VEGF-A axis.•VEGF-A binds to VEGFR2 and…”
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Talazoparib enhances the quinacrine-mediated apoptosis in patient-derived oral mucosa CSCs by inhibiting BER pathway through the modulation of GCN5 and P300 by Das, Chinmay, Dash, Somya Ranjan, Sinha, Saptarshi, Paul, Subarno, Das, Biswajit, Bhal, Subhasmita, Sethy, Chinmayee, Kundu, Chanakya Nath

“…The presence of cancer stem cells (CSCs) in the tumor microenvironment (TME) is majorly responsible for the development and recurrence of cancer. Earlier…”
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Organocatalyzed umpolung addition for synthesis of heterocyclic-fused arylidene-imidazolones as anticancer agents by Kumar, Gulshan, Das, Chinmay, Acharya, Ayan, Bhal, Subhasmita, Joshi, Mayank, Kundu, Chanakya Nath, Choudhury, Angshuman Roy, Guchhait, Sankar K.

“…[Display omitted] •“Nature-to-new” as a medicinal chemistry strategy.•Iterative Scaffold-hopping to identify new chemotype.•Organocatalysed Umpolung Chemistry…”
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Combination of Resveratrol and PARP inhibitor Olaparib efficiently deregulates homologous recombination repair pathway in breast cancer cells through inhibition of TIP60-mediated chromatin relaxation by Sinha, Saptarshi, Paul, Subarno, Acharya, Sushree Subhadra, Das, Chinmay, Dash, Somya Ranjan, Bhal, Subhasmita, Pradhan, Rajalaxmi, Das, Biswajit, Kundu, Chanakya Nath

“…Recently, we reported that a combination of a natural, bioactive compound Resveratrol (RES) and a PARP inhibitor Olaparib (OLA) deregulated the homologous…”
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Targeted Delivery of Doxorubicin to Breast Cancer Cells by Multiwalled Carbon Nanotubes Functionalized with Lysine via 1,3-Dipolar Cycloaddition and Conjugation with Sugar Moieties by Chanchal Kiran Thakur, Chandrabose Karthikeyan, Subhasmita Bhal, Chanakya Nath Kundu, Narayana Subbiah Hari Narayana Moorthy

“…Multiwalled carbon nanotubes (MWCNTs) have attracted considerable multidisciplinary interest and biomedical applications, such as drug delivery, because of…”
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