Search Results - "Bhagat, Kavita"

Design, Synthesis, Antimicrobial Evaluation, and Molecular Modeling Studies of Novel Indolinedione–Coumarin Molecular Hybrids by Bhagat, Kavita, Bhagat, Jyoti, Gupta, Manish Kumar, Singh, Jatinder Vir, Gulati, Harmandeep Kaur, Singh, Atamjit, Kaur, Kamalpreet, Kaur, Gurinder, Sharma, Shally, Rana, Abhineet, Singh, Harbinder, Sharma, Sahil, Singh Bedi, Preet Mohinder

“…Keeping in view various pharmacological attributes of indole and coumarin derivatives, a new series of indolindione–coumarin molecular hybrids was rationally…”
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Design, synthesis and biological evaluation of novel indolinedione–coumarin hybrids as xanthine oxidase inhibitors by Gulati, Harmandeep Kaur, Bhagat, Kavita, Singh, Atamjit, Kumar, Nitish, Kaur, Arshmeet, Sharma, Akriti, Heer, Shilpa, Singh, Harbinder, Singh, Jatinder Vir, Bedi, Preet Mohinder S.

“…A library of indolinedione–coumarin hybrid molecules was rationally designed and synthesized against hyperuricemia. All of the synthesized hybrid molecules…”
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Most recent strategies targeting estrogen receptor alpha for the treatment of breast cancer by Kumar, Nitish, Gulati, Harmandeep Kaur, Sharma, Aakriti, Heer, Shilpa, Jassal, Anupmjot Kaur, Arora, Lovenish, Kaur, Simranpreet, Singh, Atamjit, Bhagat, Kavita, Kaur, Arshmeet, Singh, Harbinder, Singh, Jatinder Vir, Bedi, Preet Mohinder Singh

“…Breast cancer is the most prominent, frequently diagnosed and leading cause of death among women. Estrogen is an agonist of estrogen receptor alpha (ER-α),…”
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Thiazole-5-carboxylic acid derivatives as potent xanthine oxidase inhibitors: design, synthesis, in vitro evaluation, and molecular modeling studies by Kaur, Gurinder, Singh, Jatinder V., Gupta, Manish K., Bhagat, Kavita, Gulati, Harmandeep K., Singh, Atamjit, Bedi, Preet Mohinder S., Singh, Harbinder, Sharma, Sahil

“…A series of 22 compounds of thiazole-5-carboxylic acid derivatives was rationally designed and synthesized. All the compounds were characterized by using 1 H…”
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Rational approaches for the design of various GABA modulators and their clinical progression by Bhagat, Kavita, Singh, Jatinder V., Pagare, Piyusha P., Kumar, Nitish, Sharma, Anchal, Kaur, Gurinder, Kinarivala, Nihar, Gandu, Srinivasa, Singh, Harbinder, Sharma, Sahil, Bedi, Preet Mohinder S.

“…GABA (γ-amino butyric acid) is an important inhibitory neurotransmitter in the central nervous system. Attenuation of GABAergic neurotransmission plays an…”
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Phytoconstituents from ten natural herbs as potent inhibitors of main protease enzyme of SARS-COV-2: In silico study by Kumar, Nitish, Singh, Atamjit, Gulati, Harmandeep Kaur, Bhagat, Kavita, Kaur, Komalpreet, Kaur, Jaspreet, Dudhal, Shilpa, Duggal, Amit, Gulati, Puja, Singh, Harbinder, Singh, Jatinder Vir, Bedi, Preet Mohinder Singh

“…Lack of treatment of novel Coronavirus disease led to the search of specific antivirals that are capable to inhibit the replication of the virus. The plant…”
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Rational approaches, design strategies, structure activity relationship and mechanistic insights for therapeutic coumarin hybrids by Singh, Harbinder, Singh, Jatinder Vir, Bhagat, Kavita, Gulati, Harmandeep Kaur, Sanduja, Mohit, Kumar, Nitish, Kinarivala, Nihar, Sharma, Sahil

“…[Display omitted] •Rational approaches towards the design of pharmacologically active coumarin based hybrids.•Structure-activity relationships and mechanistic…”
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New coumarin-benzotriazole based hybrid molecules as inhibitors of acetylcholinesterase and amyloid aggregation by Singh, Atamjit, Sharma, Sahil, Arora, Saroj, Attri, Shivani, Kaur, Prabhjot, Kaur Gulati, Harmandeep, Bhagat, Kavita, Kumar, Nitish, Singh, Harbinder, Vir Singh, Jatinder, Mohinder Singh Bedi, Preet

“…[Display omitted] •Design and synthesis of new coumarin-benzotriazole based molecular hybrids.•Ellman’s method of evaluation demonstrated selective…”
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Novel series of triazole containing coumarin and isatin based hybrid molecules as acetylcholinesterase inhibitors by Bhagat, Kavita, Singh, Jatinder Vir, Sharma, Aakriti, Kaur, Arshmeet, Kumar, Nitish, Gulati, Harmandeep Kaur, Singh, Atamjit, Singh, Harbinder, Bedi, Preet Mohinder Singh

“…•Design and synthesis of Coumarin-triazole and Isatin-triazole hybrids.•Biological evaluation of synthesized hybrids against AChE by using Ellman's…”
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Triazole derivatives as potential xanthine oxidase inhibitors: Design, enzyme inhibition potential, and docking studies by Gulati, Harmandeep Kaur, Khanna, Aanchal, Kumar, Nitish, Sharma, Anchal, Rupali, Jyoti, Singh, Jatindervir, Bhagat, Kavita, Bedi, Preet Mohinder Singh

“…Considerable ingenuity has been shown in the recent years in the discovery of novel xanthine oxidase (XO) inhibitors that fall outside the purine scaffold. The…”
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Shikonin derivatives as potent xanthine oxidase inhibitors: in-vitro study by Kumar, Nitish, Rajput, Ankita, Kaur, Harmandeep, Sharma, Anchal, Bhagat, Kavita, Singh, Jatinder Vir, Arora, Saroj, Bedi, Preet Mohinder Singh

“…Induction of hypersensitivity reactions (may be fatal too) by specific XO inhibitors has led to development of new molecules that are efficacious and have…”
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Design, Synthesis, biological investigations and molecular interactions of triazole linked tacrine glycoconjugates as Acetylcholinesterase inhibitors with reduced hepatotoxicity by Kaur Gulati, Harmandeep, Choudhary, Sushil, Kumar, Nitish, Ahmed, Ajaz, Bhagat, Kavita, Vir Singh, Jatinder, Singh, Atamjit, Kumar, Ajay, Singh Bedi, Preet Mohinder, Singh, Harbinder, Mukherjee, Debaraj

“…[Display omitted] •Triazole linked tacrine glycoconjugates were synthesized as Acetylcholinesterase inhibitors.•In-silico hepatotoxicity was predicted via…”
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Discovery of potent inhibitors for M pro enzyme of SARS-COV2 by multi-stage in-silico screening of Alkannin/shikonin by Kumar, Nitish, Singh, Jatinder Vir, Bhagat, Kavita, Gulati, Harmandeep Kaur, Sharma, Anchal, Rani, Archana, Duggal, Amit, Gulati, Puja, Singh, Harbinder, Bedi, Preet Mohinder Singh, Kaur, Sarabjit

“…Novel coronavirus disease, a serious challenge for the healthcare system, has diverted all the researchers toward the exploration of potential targets,…”
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Monocarbonyl Curcumin-Based Molecular Hybrids as Potent Antibacterial Agents by Singh, Atamjit, Singh, Jatinder Vir, Rana, Abhineet, Bhagat, Kavita, Gulati, Harmandeep Kaur, Kumar, Raman, Salwan, Rajan, Bhagat, Kajal, Kaur, Gurinder, Singh, Navjot, Kumar, Randeep, Singh, Harbinder, Sharma, Sahil, Bedi, Preet Mohinder Singh

“…Keeping in view various pharmacological attributes of curcumin, coumarin, and isatin derivatives, triazole-tethered monocarbonyl curcumin–coumarin and…”
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Donepezil-Inspired Multitargeting Indanone Derivatives as Effective Anti-Alzheimer’s Agents by Singh, Jatinder Vir, Thakur, Shubham, Kumar, Nitish, Singh, Harjeet, Mithu, Venus Singh, Singh, Harpreet, Bhagat, Kavita, Gulati, Harmandeep Kaur, Sharma, Anchal, Singh, Harbinder, Sharma, Sahil, Bedi, Preet Mohinder Singh

“…In continuous efforts to develop anti-Alzheimer’s agents, we rationally designed and synthesized a series of multitargeting molecules by incorporating the…”
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Design, synthesis, and biological evaluation of isatin‐indole‐3‐carboxaldehyde hybrids as a new class of xanthine oxidase inhibitors by Singh, Atamjit, Heer, Shilpa, Kaur, Komalpreet, Gulati, Harmandeep K., Kumar, Nitish, Sharma, Anchal, Singh, Jatinder V., Bhagat, Kavita, Kaur, Gurinder, Kaur, Kirandeep, Singh, Harbinder, Chadha, Renu, Bedi, Preet M. S.

“…A novel series of triazole‐linked isatin‐indole‐3‐carboxaldehyde hybrids based on the febuxostat skeleton and its binding site interactions were rationally…”
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Discovery of potent inhibitors for Mpro enzyme of SARS-COV2 by multi-stage in-silico screening of Alkannin/shikonin by Kumar, Nitish, Singh, Jatinder Vir, Bhagat, Kavita, Gulati, Harmandeep Kaur, Sharma, Anchal, Rani, Archana, Duggal, Amit, Gulati, Puja, Singh, Harbinder, Preet Mohinder Singh Bedi, Kaur, Sarabjit

“…Novel coronavirus disease, a serious challenge for the healthcare system, has diverted all the researchers toward the exploration of potential targets,…”
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5,6-Benzoflavones as cholesterol esterase inhibitors: synthesis, biological evaluation and docking studiesElectronic supplementary information (ESI) available. See DOI: 10.1039/c7md00565bThis research article is dedicated to Dr. Sahil Sharma by Singh, Jatinder V, Kaur, Anumeet, Bhagat, Kavita, Gupta, Manish K, Singh, Manwinder, Singh, Harbinder, Bedi, Preet Mohinder S

“…In a continued effort to develop potent cholesterol esterase (CEase) inhibitors, a series of 5,6-benzoflavone derivatives was rationally designed and…”
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5,6-Benzoflavones as cholesterol esterase inhibitors: synthesis, biological evaluation and docking studies† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c7md00565b ‡ ‡This research article is dedicated to Dr. Sahil Sharma by Singh, Jatinder V., Kaur, Anumeet, Bhagat, Kavita, Gupta, Manish K., Singh, Manwinder, Singh, Harbinder, Bedi, Preet Mohinder S.

“…A library of forty 5,6-benzoflavone derivatives was synthesized and evaluated for their inhibitory potential against cholesterol esterase (CEase) enzyme. In a…”
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Microwave-assisted synthesis of 11-substituted-3,3-dimethyl-2,3,4,5,10,11-hexahydrodibenzo[b,e][1,4]diazepin-1-one derivatives catalysed by silica supported fluoroboric acid as potent antioxidant and anxiolytic agents by Bhagat, Kavita, Singh, Atamjit, Dhiman, Suruchi, Vir Singh, Jatinder, Kaur, Ramandeep, Kaur, Gurinder, Kaur Gulati, Harmandeep, Singh, Palwinder, Kumar, Raman, Salwan, Rajan, Bhagat, Kajal, Singh, Harbinder, Sharma, Sahil, Singh Bedi, Preet Mohinder

“…Keeping in view the successive attributes of benzodiazepines on the central nervous system, we have synthesized a novel series of benzodiazepine derivatives as…”
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