Search Results - "Bhagat, Govind"

Akt-Mediated Regulation of Autophagy and Tumorigenesis Through Beclin 1 Phosphorylation by Wang, Richard C., Wei, Yongjie, An, Zhenyi, Zou, Zhongju, Xiao, Guanghua, Bhagat, Govind, White, Michael, Reichelt, Julia, Levine, Beth

“…Aberrant signaling through the class I phosphatidylinositol 3-kinase (PI3K)—Akt axis is frequent in human cancer. Here, we show that Beclin 1, an essential…”
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Disruption of the beclin 1–BCL2 autophagy regulatory complex promotes longevity in mice by Fernández, Álvaro F., Sebti, Salwa, Wei, Yongjie, Zou, Zhongju, Shi, Mingjun, McMillan, Kathryn L., He, Congcong, Ting, Tabitha, Liu, Yang, Chiang, Wei-Chung, Marciano, Denise K., Schiattarella, Gabriele G., Bhagat, Govind, Moe, Orson W., Hu, Ming Chang, Levine, Beth

“…Autophagy increases the lifespan of model organisms; however, its role in promoting mammalian longevity is less well-established 1 , 2 . Here we report…”
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Analysis of the coding genome of diffuse large B-cell lymphoma by Pasqualucci, Laura, Dalla-Favera, Riccardo, Trifonov, Vladimir, Fabbri, Giulia, Ma, Jing, Rossi, Davide, Chiarenza, Annalisa, Wells, Victoria A, Grunn, Adina, Messina, Monica, Elliot, Oliver, Chan, Joseph, Bhagat, Govind, Chadburn, Amy, Gaidano, Gianluca, Mullighan, Charles G, Rabadan, Raul

“…Laura Pasqualucci and Riccardo Dalla-Favera and colleagues report exome sequencing and copy-number analyses of diffuse large B-cell lymphomas. Their analyses…”
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The DLEU2/ miR-15a/ 16-1 Cluster Controls B Cell Proliferation and Its Deletion Leads to Chronic Lymphocytic Leukemia by Klein, Ulf, Lia, Marie, Crespo, Marta, Siegel, Rachael, Shen, Qiong, Mo, Tongwei, Ambesi-Impiombato, Alberto, Califano, Andrea, Migliazza, Anna, Bhagat, Govind, Dalla-Favera, Riccardo

“…Chronic lymphocytic leukemia (CLL) is a malignancy of B cells of unknown etiology. Deletions of the chromosomal region 13q14 are commonly associated with CLL,…”
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Combined Genetic Inactivation of β2-Microglobulin and CD58 Reveals Frequent Escape from Immune Recognition in Diffuse Large B Cell Lymphoma by Challa-Malladi, Madhavi, Lieu, Yen K., Califano, Olivia, Holmes, Antony B., Bhagat, Govind, Murty, Vundavalli V., Dominguez-Sola, David, Pasqualucci, Laura, Dalla-Favera, Riccardo

“…We report that diffuse large B cell lymphoma (DLBCL) commonly fails to express cell-surface molecules necessary for the recognition of tumor cells by…”
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EGFR-Mediated Beclin 1 Phosphorylation in Autophagy Suppression, Tumor Progression, and Tumor Chemoresistance by Wei, Yongjie, Zou, Zhongju, Becker, Nils, Anderson, Matthew, Sumpter, Rhea, Xiao, Guanghua, Kinch, Lisa, Koduru, Prasad, Christudass, Christhunesa S., Veltri, Robert W., Grishin, Nick V., Peyton, Michael, Minna, John, Bhagat, Govind, Levine, Beth

“…Cell surface growth factor receptors couple environmental cues to the regulation of cytoplasmic homeostatic processes, including autophagy, and aberrant…”
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Durability related properties of cement composites containing thermoplastic aggregates – A review by Bhagat, Govind V., Savoikar, Purnanand P.

“…Plastic is a myriad of resource-efficient materials which provide an economical and fit-for-purpose alternative for all walks of life. However, the disposal of…”
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Lineage specification of human dendritic cells is marked by IRF8 expression in hematopoietic stem cells and multipotent progenitors by Lee, Jaeyop, Zhou, Yu Jerry, Ma, Wenji, Zhang, Wanwei, Aljoufi, Arafat, Luh, Thomas, Lucero, Kimberly, Liang, Deguang, Thomsen, Matthew, Bhagat, Govind, Shen, Yufeng, Liu, Kang

“…Liu and colleagues show that specification of the dendritic-cell lineage occurs in parallel with specification of the myeloid and lymphoid lineages in or…”
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Early-stage epigenetic modification during somatic cell reprogramming by Parp1 and Tet2 by Doege, Claudia A., Inoue, Keiichi, Yamashita, Toru, Rhee, David B., Travis, Skylar, Fujita, Ryousuke, Guarnieri, Paolo, Bhagat, Govind, Vanti, William B., Shih, Alan, Levine, Ross L., Nik, Sara, Chen, Emily I., Abeliovich, Asa

“…Parp1 and Tet2 mediate essential epigenetic remodelling events in an early phase of induced pluripotent stem cell reprogramming, thus directing subsequent…”
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Genetics of Follicular Lymphoma Transformation by Pasqualucci, Laura, Khiabanian, Hossein, Fangazio, Marco, Vasishtha, Mansi, Messina, Monica, Holmes, Antony B., Ouillette, Peter, Trifonov, Vladimir, Rossi, Davide, Tabbò, Fabrizio, Ponzoni, Maurilio, Chadburn, Amy, Murty, Vundavalli V., Bhagat, Govind, Gaidano, Gianluca, Inghirami, Giorgio, Malek, Sami N., Rabadan, Raul, Dalla-Favera, Riccardo

“…Follicular lymphoma (FL) is an indolent disease, but 30%–40% of cases undergo histologic transformation to an aggressive malignancy, typically represented by…”
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Bile Acid and Inflammation Activate Gastric Cardia Stem Cells in a Mouse Model of Barrett-Like Metaplasia by Quante, Michael, Bhagat, Govind, Abrams, Julian A., Marache, Frederic, Good, Pamela, Lee, Michele D., Lee, Yoomi, Friedman, Richard, Asfaha, Samuel, Dubeykovskaya, Zinaida, Mahmood, Umar, Figueiredo, Jose-Luiz, Kitajewski, Jan, Shawber, Carrie, Lightdale, Charles J., Rustgi, Anil K., Wang, Timothy C.

“…Esophageal adenocarcinoma (EAC) arises from Barrett esophagus (BE), intestinal-like columnar metaplasia linked to reflux esophagitis. In a transgenic mouse…”
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Villous atrophy and negative celiac serology: a diagnostic and therapeutic dilemma by DeGaetani, Marisa, Tennyson, Christina A, Lebwohl, Benjamin, Lewis, Suzanne K, Abu Daya, Hussein, Arguelles-Grande, Carolina, Bhagat, Govind, Green, Peter H R

“…Patients with villous atrophy (VA) and negative celiac disease (CD) serologies pose a diagnostic and therapeutic dilemma. When a definitive etiology for VA is…”
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Genetic basis of PD-L1 overexpression in diffuse large B-cell lymphomas by Georgiou, Konstantinos, Chen, Longyun, Berglund, Mattias, Ren, Weicheng, de Miranda, Noel F.C.C., Lisboa, Susana, Fangazio, Marco, Zhu, Shida, Hou, Yong, Wu, Kui, Fang, Wenfeng, Wang, Xianhuo, Meng, Bin, Zhang, Li, Zeng, Yixin, Bhagat, Govind, Nordenskjöld, Magnus, Sundström, Christer, Enblad, Gunilla, Dalla-Favera, Riccardo, Zhang, Huilai, Teixeira, Manuel R., Pasqualucci, Laura, Peng, Roujun, Pan-Hammarström, Qiang

“…Diffuse large B-cell lymphoma (DLBCL) is one of the most common and aggressive types of B-cell lymphoma. Deregulation of proto-oncogene expression after a…”
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microRNA-29a induces aberrant self-renewal capacity in hematopoietic progenitors, biased myeloid development, and acute myeloid leukemia by Han, Yoon-Chi, Park, Christopher Y, Bhagat, Govind, Zhang, Jinping, Wang, Yulei, Fan, Jian-Bing, Liu, Mofang, Zou, Yongrui, Weissman, Irving L, Gu, Hua

“…The function of microRNAs (miRNAs) in hematopoietic stem cells (HSCs), committed progenitors, and leukemia stem cells (LSCs) is poorly understood. We show that…”
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Genetic and phenotypic characterization of indolent T-cell lymphoproliferative disorders of the gastrointestinal tract by Soderquist, Craig R, Patel, Nupam, Murty, Vundavalli V, Betman, Shane, Aggarwal, Nidhi, Young, Ken H, Xerri, Luc, Leeman-Neill, Rebecca, Lewis, Suzanne K, Green, Peter H, Hsiao, Susan, Mansukhani, Mahesh M, Hsi, Eric D, de Leval, Laurence, Alobeid, Bachir, Bhagat, Govind

“…Indolent T-cell lymphoproliferative disorders of the gastrointestinal tract are rare clonal T-cell diseases that more commonly occur in the intestines and have…”
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Genetic mechanisms of HLA-I loss and immune escape in diffuse large B cell lymphoma by Fangazio, Marco, Ladewig, Erik, Gomez, Karen, Garcia-Ibanez, Laura, Kumar, Rahul, Teruya-Feldstein, Julie, Rossi, Davide, Filip, Ioan, Pan-Hammarström, Qiang, Inghirami, Giorgio, Boldorini, Renzo, Ott, German, Staiger, Annette M., Chapuy, Björn, Gaidano, Gianluca, Bhagat, Govind, Basso, Katia, Rabadan, Raul, Pasqualucci, Laura, Dalla-Favera, Riccardo

“…Fifty percent of diffuse large B cell lymphoma (DLBCL) cases lack cell-surface expression of the class I major histocompatibility complex (MHC-I), thus…”
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Histamine deficiency promotes inflammation-associated carcinogenesis through reduced myeloid maturation and accumulation of CD11b + Ly6G + immature myeloid cells by Asfaha, Samuel, Shykind, Benjamin, Friedman, Richard A, Bhagat, Govind, Wang, Timothy C, Diacovo, Thomas G, Park, Heuijoon, Falus, Andras, Yang, Xiang Dong, Ai, Walden, Jin, Guangchun

“…Histidine decarboxylase (Hdc) is required for the endogenous production of histamine, but its role in tumorigenesis is unclear. Yang et al . now report that…”
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Whole-genome sequencing identifies recurrent somatic NOTCH2 mutations in splenic marginal zone lymphoma by Kiel, Mark J, Velusamy, Thirunavukkarasu, Betz, Bryan L, Zhao, Lili, Weigelin, Helmut G, Chiang, Mark Y, Huebner-Chan, David R, Bailey, Nathanael G, Yang, David T, Bhagat, Govind, Miranda, Roberto N, Bahler, David W, Medeiros, L Jeffrey, Lim, Megan S, Elenitoba-Johnson, Kojo S J

“…Splenic marginal zone lymphoma (SMZL), the most common primary lymphoma of spleen, is poorly understood at the genetic level. In this study, using whole-genome…”
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Phenogenomic heterogeneity of post-transplant plasmablastic lymphomas by Leeman-Neill, Rebecca J, Soderquist, Craig R, Montanari, Francesca, Raciti, Patricia, Park, David, Radeski, Dejan, Mansukhani, Mahesh M, Murty, Vundavalli V, Hsiao, Susan, Alobeid, Bachir, Bhagat, Govind

“…Plasmablastic lymphoma (PBL) is a rare and clinically aggressive neoplasm that typically occurs in immunocompromised individuals, including those with HIV…”
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Immunophenotypic Spectrum and Genomic Landscape of Refractory Celiac Disease Type II by Soderquist, Craig R., Lewis, Suzanne K., Gru, Alejandro A., Vlad, George, Williams, Eli S., Hsiao, Susan, Mansukhani, Mahesh M., Park, David C., Bacchi, Carlos E., Alobeid, Bachir, Green, Peter H., Bhagat, Govind

“…Refractory celiac disease type II (RCD II), also referred to as “cryptic” enteropathy-associated T-cell lymphoma (EATL) or “intraepithelial T-cell lymphoma,”…”
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