Search Results - "Bhadri, Vivek"

Opposing regulation of BIM and BCL2 controls glucocorticoid-induced apoptosis of pediatric acute lymphoblastic leukemia cells by Jing, Duohui, Bhadri, Vivek A., Beck, Dominik, Thoms, JulieA.I., Yakob, Nurul A., Wong, JasonW.H., Knezevic, Kathy, Pimanda, John E., Lock, Richard B.

“…Glucocorticoids are critical components of combination chemotherapy regimens in pediatric acute lymphoblastic leukemia (ALL). The proapoptotic BIM protein is…”
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High-dose chemotherapy for Ewing sarcoma and Rhabdomyosarcoma: A systematic review by the Australia and New Zealand sarcoma association clinical practice guidelines working party by Ramamurthy, Ashika, Connolly, Elizabeth A, Mar, Jasmine, Lewin, Jeremy, Bhadri, Vivek A, Phillips, Marianne B, Winstanley, Mark, Orme, Lisa M, Grimison, Peter, Connor, Joanna, Lazarakis, Smaro, Hong, Angela M, Omer, Natacha, Cayrol, Julie

“…•Systematic review to determine the role of high dose chemotherapy for Ewing Sarcoma and Rhabdomyosarcoma.•In Ewing sarcoma, the efficacy of high dose…”
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Zoledronic Acid Add-on Therapy for Standard-Risk Ewing Sarcoma Patients in the Ewing 2008R1 Trial by Koch, Raphael, Haveman, Lianne, Ladenstein, Ruth, Brichard, Benedicte, Jürgens, Heribert, Cyprova, Sona, van den Berg, Henk, Hassenpflug, Wolf, Raciborska, Anna, Ek, Torben, Baumhoer, Daniel, Egerer, Gerlinde, Kager, Leo, Renard, Marleen, Hauser, Peter, Burdach, Stefan, Bovee, Judith V M G, Hong, Angela M, Reichardt, Peter, Kruseova, Jarmila, Streitbürger, Arne, Kühne, Thomas, Kessler, Torsten, Bernkopf, Marie, Butterfaß-Bahloul, Trude, Dhooge, Catharina, Bauer, Sebastian, Kiss, János, Paulussen, Michael, Bonar, Fiona, Ranft, Andreas, Timmermann, Beate, Rascon, Jelena, Vieth, Volker, Kanerva, Jukka, Faldum, Andreas, Hartmann, Wolfgang, Hjorth, Lars, Bhadri, Vivek A, Metzler, Markus, Gelderblom, Hans, Dirksen, Uta

“…The phase III, open-label, prospective, multicenter, randomized Ewing 2008R1 trial (EudraCT2008-003658-13) was conducted in 12 countries to evaluate the effect…”
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Systemic treatments and outcomes in CIC-rearranged Sarcoma: A national multi-centre clinicopathological series and literature review by Connolly, Elizabeth A, Bhadri, Vivek A, Wake, Johnathon, Ingley, Katrina M, Lewin, Jeremy, Bae, Susie, Wong, Daniel D, Long, Anne P, Pryor, David, Thompson, Stephen R, Strach, Madeleine C, Grimison, Peter S, Mahar, Annabelle, Bonar, Fiona, Maclean, Fiona, Hong, Angela

“…CIC-rearranged sarcoma is a recently established, ultra-rare, molecularly defined sarcoma subtype. We aimed to further characterise clinical features of…”
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Epigenetic silencing of BIM in glucocorticoid poor-responsive pediatric acute lymphoblastic leukemia, and its reversal by histone deacetylase inhibition by Bachmann, Petra S., Piazza, Rocco G., Janes, Mary E., Wong, Nicholas C., Davies, Carwyn, Mogavero, Angela, Bhadri, Vivek A., Szymanska, Barbara, Geninson, Greta, Magistroni, Vera, Cazzaniga, Giovanni, Biondi, Andrea, Miranda-Saavedra, Diego, Göttgens, Berthold, Saffery, Richard, Craig, Jeffrey M., Marshall, Glenn M., Gambacorti-Passerini, Carlo, Pimanda, John E., Lock, Richard B.

“…Glucocorticoids play a critical role in the therapy of lymphoid malignancies, including pediatric acute lymphoblastic leukemia (ALL), although the mechanisms…”
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Mesenchymal chondrosarcoma: An Australian multi‐centre cohort study by Strach, Madeleine C., Grimison, Peter S., Hong, Angela, Boyle, Richard, Stalley, Paul, Karim, Rooshdiya, Connolly, Elizabeth A., Bae, Susie, Desai, Jayesh, Crowe, Philip, Singhal, Nimit, Bhadri, Vivek A.

“…Background Mesenchymal chondrosarcoma (MCS) is an ultra‐rare sarcoma that follows a more aggressive course than conventional chondrosarcoma. This study…”
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Glucocorticoid resistance in paediatric acute lymphoblastic leukaemia by Bhadri, Vivek A, Trahair, Toby N, Lock, Richard B

“…Glucocorticoids (GCs), such as prednisolone and dexamethasone, are key components in multi‐agent chemotherapy protocols used for the treatment of acute…”
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Evaluation of the NOD/SCID xenograft model for glucocorticoid-regulated gene expression in childhood B-cell precursor acute lymphoblastic leukemia by Bhadri, Vivek A, Cowley, Mark J, Kaplan, Warren, Trahair, Toby N, Lock, Richard B

“…Glucocorticoids such as prednisolone and dexamethasone are critical drugs used in multi-agent chemotherapy protocols used to treat acute lymphoblastic leukemia…”
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Extrapleural pneumonectomy for sarcoma: Outcomes of adult patients at a specialized center by Zhang, Betty Y., Wilson‐Smith, Ashley R., Connolly, Elizabeth A., Strach, Madeleine C., Ussher, Nathan, Yan, Tristan, Bhadri, Vivek A.

“…Background Extrapleural pneumonectomy (EPP) is a complex surgical procedure involving en‐bloc resection of the parietal and visceral pleura, lung, pericardium,…”
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Factors Influencing the Outcome of Patients with Primary Ewing Sarcoma of the Sacrum by Rechl, Victor, Ranft, Andreas, Bhadri, Vivek, Brichard, Benedicte, Collaud, Stephane, Cyprova, Sona, Eich, Hans, Ek, Torben, Gelderblom, Hans, Hardes, Jendrik, Haveman, Lianne M., Hartmann, Wolfgang, Hauser, Peter, Heesen, Philip, Jürgens, Heribert, Kanerva, Jukka, Kühne, Thomas, Raciborska, Anna, Rascon, Jelena, Streitbürger, Arne, Uhlenbruch, Yasmin, Timmermann, Beate, Kersting, Josephine, Pham, Minh Thanh, Dirksen, Uta

“…Background. Ewing sarcoma (EwS) is a rare and highly malignant bone tumor primarily affecting children, adolescents, and young adults. The pelvis, trunk, and…”
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Programmed cell death-1 blockade in recurrent disseminated Ewing sarcoma by McCaughan, Georgia J B, Fulham, Michael J, Mahar, Annabelle, Soper, Judy, Hong, Angela M, Stalley, Paul D, Tattersall, Martin H N, Bhadri, Vivek A

“…Ewing sarcoma (EWS) is a malignant tumour of bone and soft tissue, and although many patients are cured with conventional multimodal therapy, those with…”
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Stability of gene expression and epigenetic profiles highlights the utility of patient-derived paediatric acute lymphoblastic leukaemia xenografts for investigating molecular mechanisms of drug resistance by Wong, Nicholas C, Bhadri, Vivek A, Maksimovic, Jovana, Parkinson-Bates, Mandy, Ng, Jane, Craig, Jeff M, Saffery, Richard, Lock, Richard B

“…Patient-derived tumour xenografts are an attractive model for preclinical testing of anti-cancer drugs. Insights into tumour biology and biomarkers predictive…”
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PD‐1 blockade using pembrolizumab in adolescent and young adult patients with advanced bone and soft tissue sarcoma by Scheinberg, Tahlia, Lomax, Anna, Tattersall, Martin, Thomas, David, McCowage, Geoff, Sullivan, Michael, Karim, Rooshdiya, Luk, Peter P., Mahar, Annabelle, Bonar, Fiona, Bhadri, Vivek A.

“…Background Sarcomas represent 10%–15% of cancers in adolescent and young adult (AYA) patients, and survival for those with metastatic disease or relapse is…”
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Atypical Ewing sarcoma breakpoint region 1 fluorescence in-situ hybridization signal patterns in bone and soft tissue tumours: diagnostic experience with 135 cases by Vargas, A Cristina, Selinger, Christina I, Satgunaseelan, Laveniya, Cooper, Wendy A, Gupta, Ruta, Stalley, Paul, Brown, Wendy, Soper, Judy, Schatz, Julie, Boyle, Richard, Thomas, David M, Tattersall, Martin H N, Bhadri, Vivek A, Maclean, Fiona, Bonar, S Fiona, Scolyer, Richard A, Karim, Rooshdiya Z, McCarthy, Stanley W, Mahar, Annabelle, O'Toole, Sandra A

“…Aims Recurrent Ewing sarcoma breakpoint region 1 (EWSR1) gene rearrangements characterize a select group of bone and soft tissue tumours. In our routine…”
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Effect of Radiotherapy Dose on Outcome in Nonmetastatic Ewing Sarcoma by Kersting, Josephine, Ranft, Andreas, Bhadri, Vivek, Brichard, Bénédicte, Collaud, Stéphane, Cyprová, Sona, Eich, Hans, Ek, Torben, Gelderblom, Hans, Hardes, Jendrik, Haveman, Lianne, Hartmann, Wolfgang, Hauser, Peter, Heesen, Philip, Jürgens, Heribert, Kanerva, Jukka, Kühne, Thomas, Raciborska, Anna, Rascon, Jelena, Rechl, Victor, Streitbürger, Arne, Timmermann, Beate, Uhlenbruch, Yasmine, Dirksen, Uta

“…Radiation therapy (RT) is an integral part of Ewing sarcoma (EwS) therapy. The Ewing 2008 protocol recommended RT doses ranging from 45 to 54 Gy. However, some…”
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367 Pharmacokinetic and immunologic data from a phase I study of the click chemistry-based therapy SQ3370 in advanced solid tumors and soft-tissue sarcoma provides proof-of-concept for the CAPAC platform by Bhadri, Vivek, Subbiah, Vivek, Strauss, James, Chawla, Sant, Bui, Nam, Kwatra, Vineet, Weiss, Mia, Batty, Kathleen, Zakharian, Michael, Oneto, Jose Mejia, Srinivasan, Sangeetha, Yee, Nathan, Wilson, Rosalind, Wayne Saville, M, Guminski, Alexander

“…BackgroundConventional chemotherapeutics lack specificity for tumor tissue and usually have anarrow therapeutic index. SQ3370, a novel therapy that activates…”
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416 SQ3370–001 is a multi-center open-label phase I dose-escalation study to test a novel intratumoral and systemic approach to treat advanced solid tumors by Bhadri, Vivek, Bui, Nam, Guminski, Alexander, Oneto, Jose Mejia, Murthy, Ravi, Sankhala, Kamalesh, Wayne Saville, M, Srinivasan, Sangeetha, Steffner, Robert, Subbiah, Vivek, Wang, Ding, Yee, Nathan

“…BackgroundCancer immunotherapies have been very successful in recent times; however, they benefit only a subset of patients and have varying response rates…”
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Excellent response to dasatinib of childhood Philadelphia positive intracranial acute lymphoblastic leukaemia tumours by Bhadri, Vivek A., Satharasinghe, Keshan, Sugo, Ella, Barbaric, Draga, Trahair, Toby N.

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Variation in Toll-like receptor 9 gene modifies the risk of infection in children treated for acute lymphoblastic leukemia by Bhadri, Vivek A., Beckett, Sara M., Duncan, Catriona, Marshall, Glenn M., Ashton, Lesley J.

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Hepatocellular Carcinoma in Children with Alagille Syndrome by Bhadri, Vivek A, Stormon, Michael O, Arbuckle, Susan, Lam, Albert H, Gaskin, Kevin J, Shun, Albert

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