Search Results - "Bezombes, C"

Study of the efficacy of novel bispecific antibodies targeting immune checkpoints in a 3D model of B non‐Hodgkin lymphoma by Gower, N., Gava, F., Rimailho, L., Faria, C., Gravelle, P., Perez‐Galan, P., Serrat, N., Bouquet, F., Fonseca, C., Herter, S., Codarri, L., McCord, R., Chiang, E., Morschhauser, F., Ysebaert, L., Laurent, C., Bezombes, C.

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TAyloring LYmphoma therapy with Immune Escape Signatures from 3D avatars of B‐cell NHL by Gava, F., Faria, C., Gravelle, P., Garcia‐Valero, J., Quelen, C., Serrat, N., Gower, N., Morschhauser, F., Fournié, J., Bouquet, F., Fonseca, C., Herter, S., Codarri, L., McCord, R., Chiang, E., Laurent, C., Perez‐Galan, P., Ysebaert, L., Bezombes, C.

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Involvement of the Syk-mTOR pathway in follicular lymphoma cell invasion and angiogenesis by Fruchon, S, Kheirallah, S, Al Saati, T, Ysebaert, L, Laurent, C, Leseux, L, Fournié, J J, Laurent, G, Bezombes, C

“…Follicular lymphoma (FL) is the second-most common non-Hodgkin's lymphoma. The disease affects the lymph nodes, and 50% of patients present with bone marrow…”
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Rituximab antiproliferative effect in B-lymphoma cells is associated with acid-sphingomyelinase activation in raft microdomains by Bezombes, Christine, Grazide, Solène, Garret, Céline, Fabre, Claire, Quillet-Mary, Anne, Müller, Sabina, Jaffrézou, Jean-Pierre, Laurent, Guy

“…Rituximab is a chimeric human immunoglobulin G1 (IgG1) anti-CD20 monoclonal antibody with significant activity against CD20+ malignant B cells. Rituximab is…”
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Anti-tumor activity of obinutuzumab and rituximab in a follicular lymphoma 3D model by Decaup, E, Jean, C, Laurent, C, Gravelle, P, Fruchon, S, Capilla, F, Marrot, A, Al Saati, T, Frenois, F-X, Laurent, G, Klein, C, Varoqueaux, N, Savina, A, Fournié, J-J, Bezombes, C

“…Follicular lymphomas (FLs) account for 35–40% of all adult lymphomas. Treatment typically involves chemotherapy combined with the anti-CD20 monoclonal antibody…”
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Daunorubicin‐induced apoptosis: triggering of ceramide generation through sphingomyelin hydrolysis by Jaffrézou, J. P., Levade, T., Bettaïeb, A., Andrieu, N., Bezombes, C., Maestre, N., Vermeersch, S., Rousse, A., Laurent, G.

“…The nature of the signaling pathway(s) which initiate drug‐triggered apoptosis remains largely unknown and is of fundamental importance in understanding cell…”
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The serine‐threonine kinase p90RSK is a new target of enzastaurin in follicular lymphoma cells by Kheirallah, S, Fruchon, S, Ysebaert, L, Blanc, A, Capilla, F, Marrot, A, AlSaati, T, Frenois, F X, Benhadji, K A, Fournié, J J, Laurent, G, Bezombes, C

“…Background and Purpose Follicular lymphoma is the second most common non‐Hodgkin's lymphoma and, despite the introduction of rituximab for its treatment, this…”
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PD‐1 IMMUNE CHECKPOINT BLOCKADE IMPROVES ANTI‐CD20 BASED IMMUNOTHERAPY IN FOLLICULAR LYMPHOMA by Rossi, C., Decaup, E., Gravelle, P., Tosolini, M., Franchini, D., Laurent, C., Bordenave, J., Ligat, L., Jean, C., Pont, F., Savina, A., Klein, C., Perez‐Galan, P., Poupot, M., Fournié, J., Bezombes, C.

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ANTI‐TUMOR ACTIVITY OF DARATUMUMAB, A NOVEL HUMAN ANTI CD38 MONOCLONAL ANTIBODY, IN IN VITRO AND IN VIVO MODELS OF B‐CELL NON‐HODGKIN LYMPHOMA by Pérez‐Galán, P., Vidal‐Crespo, A., Matas‐Céspedes, A., Rodriguez, V., Rossi, C., Roué, G., López‐Guillermo, A., Giné, E., Campo, E., Colomer, D., Wiestner, A., Bezombes, C., Balasubramanian, S., Chiu, C., Doshi, P.

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Nerve growth factor-induced protein kinase C stimulation contributes to TrkA-dependent inhibition of p75 neurotrophin receptor sphingolipid signaling by Plo, I., Bono, F., Bezombes, C., Alam, A., Bruno, A., Laurent, G.

“…Previous studies have established that reciprocal interactions between the low‐affinity p75 nerve growth factor (NGF) receptor (p75NTR) and the high‐affinity…”
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Lysosomal sphingomyelinase is not solicited for apoptosis signaling by Bezombes, Christine, Ségui, Bruno, Cuvillier, Olivier, Bruno, Alain P., Uro‐Coste, Emmanuelle, Gouazé, Valérie, Andrieu‐Abadie, Nathalie, Carpentier, Stéphane, Laurent, Guy, Salvayre, Robert, Jaffrézou, Jean‐Pierre, Levade, Thierry

“…ABSTRACT Stress‐induced activation of an acidic sphingomyelinase leading to generation of ceramide, an important lipid mediator, has been associated with…”
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Oxidative stress‐induced activation of Lyn recruits sphingomyelinase and is requisite for its stimulation by Ara‐C by Bezombes, Christine, Plo, Isabelle, Mas, Véronique Mansat-De, Quillet-Mary, Anne, Nègre-Salvayre, Anne, Laurent, Guy, Jaffrézou, Jean-Pierre

“…ABSTRACT Induction of apoptosis is considered to be the underlying mechanism that accounts for the efficiency of chemotherapeutic drugs. The identification of…”
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Syk-dependent mTOR activation in follicular lymphoma cells by Leseux, Ludivine, Hamdi, Safouane M., al Saati, Talal, Capilla, Florence, Recher, Christian, Laurent, Guy, Bezombes, Christine

“…The mammalian target of rapamycin (mTOR) is emerging as a promising target for antitumor therapy. However, the mechanism that contributes to its regulation in…”
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UV-C Light Induces Raft-associated Acid Sphingomyelinase and JNK Activation and Translocation Independently on a Nuclear Signal by Charruyer, Alexandra, Grazide, Solène, Bezombes, Christine, Müller, Sabina, Laurent, Guy, Jaffrézou, Jean-Pierre

“…The initiation of UV light-induced signaling in mammalian cells is largely considered to be subsequent to DNA damage. Several studies have also described…”
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Implication of radical oxygen species in ceramide generation, c-Jun N-terminal kinase activation and apoptosis induced by daunorubicin by Mansat-de Mas, V, Bezombes, C, Quillet-Mary, A, Bettaïeb, A, D'orgeix, A D, Laurent, G, Jaffrézou, J P

“…Anthracyclines such as daunorubicin (DNR) generate radical oxygen species (ROS), which account, at least in part, for their cytotoxic effect. We observed that…”
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Restoration of TNF-alpha-induced ceramide generation and apoptosis in resistant human leukemia KG1a cells by the P-glycoprotein blocker PSC833 by Bezombes, C, Maestre, N, Laurent, G, Levade, T, Bettaïeb, A, Jaffrézou, J P

“…Tumor necrosis factor (TNF-alpha) is a cytokine with antitumor activity against several cellular models. TNF-alpha-induced apoptosis seems to be mediated by a…”
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Ara‐C‐ and daunorubicin‐induced recruitment of Lyn in sphingomyelinase‐enriched membrane rafts by Grazide, Solène, Maestre, Nicolas, Veldman, Robert Jan, Bezombes, Christine, Maddens, Stéphane, Levade, Thierry, Laurent, Guy, Jaffrézou, Jean‐pierre

“…ABSTRACT Induction of apoptosis by DNA‐damaging agents such as 1‐β‐D‐arabinofuranosylcytosine (Ara‐C) includes the activation of Lyn protein tyrosine kinase…”
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Protein kinase Cζ mediated Raf-1/extracellular-regulated kinase activation by daunorubicin by Mas, Véronique Mansat-De, Hernandez, Hélène, Plo, Isabelle, Bezombes, Christine, Maestre, Nicolas, Quillet-Mary, Anne, Filomenko, Rodolphe, Demur, Cécile, Jaffrézou, Jean-Pierre, Laurent, Guy

“…In light of the emerging concept of a protective function of the mitogen-activated protein kinase (MAPK) pathway under stress conditions, we investigated the…”
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Positive feedback control of neutral sphingomyelinase activity by ceramide by Jaffrezou, Jean‐Pierre, Maestre, Nicolas, Mas‐Mansat, Veronique, Bezombes, Christine, Levade, Thierry, Laurent, Guy

“…ABSTRACT While ceramide has emerged as a potent signal transducer, inconsistencies in the kinetics of ceramide generation, or its absence, in response to…”
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Stress‐induced apoptosis is not mediated by endolysosomal ceramide by SéGUI, BRUNO, BEZOMBES, CHRISTINE, URO‐COSTE, EMMANUELLE, MEDIN, JEFFREY A., ANDRIEU‐ABADIE, NATHALIE, AUGé, NATHALIE, BROUCHET, ANNE, LAURENT, GUY, SALVAYRE, ROBERT, JAFFRéZOU, JEAN‐PIERRE, LEVADE, THIERRY

“…ABSTRACT A major lipid‐signaling pathway in mammalian cells implicates the generation of ceramide from the ubiquitous sphingolipid sphingomyelin (SM)…”
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