Search Results - "Bezler, Valerie"

IRF4 downregulation improves sensitivity and endurance of CAR T cell functional capacities by Harrer, Dennis Christoph, Bezler, Valerie, Hartley, Jordan, Herr, Wolfgang, Abken, Hinrich

“…Chimeric antigen receptor (CAR) modified T cells can induce complete remissions in patients with advanced hematological malignancies. Nevertheless, the…”
Get full text

Automated manufacturing and characterization of clinical grade autologous CD20 CAR T cells for the treatment of patients with stage III/IV melanoma by Aleksandrova, Krasimira, Leise, Jana, Priesner, Christoph, Aktas, Murat, Apel, Michael, Assenmacher, Mario, Bürger, Iris, Richter, Anne, Altefrohne, Pia, Schubert, Christine, Holzinger, Astrid, Barden, Markus, Bezler, Valerie, von Bergwelt-Baildon, Michael, Borchmann, Peter, Goudeva, Lilia, Glienke, Wolfgang, Arseniev, Lubomir, Esser, Ruth, Abken, Hinrich, Koehl, Ulrike

“…Point-of-care (POC) manufacturing of chimeric antigen receptor (CAR) modified T cell has expanded rapidly over the last decade. In addition to the use of CD19…”
Get full text

CAR Triggered Release of Type-1 Interferon Limits CAR T-Cell Activities by an Artificial Negative Autocrine Loop by Harrer, Dennis Christoph, Schenkel, Charlotte, Bezler, Valerie, Kaljanac, Marcell, Hartley, Jordan, Barden, Markus, Pan, Hong, Holzinger, Astrid, Herr, Wolfgang, Abken, Hinrich

“…The advent of chimeric antigen receptor (CAR) T cells expedited the field of cancer immunotherapy enabling durable remissions in patients with refractory…”
Get full text

Magnetic CAR T cell purification using an anti-G4S linker antibody by Harrer, Dennis Christoph, Li, Sin-Syue, Kaljanac, Marcell, Bezler, Valerie, Barden, Markus, Pan, Hong, Herr, Wolfgang, Abken, Hinrich

“…Chimeric antigen receptor (CAR) redirected T cells are successfully employed in the combat against several hematological malignancies, however, are often…”
Get full text

Designed Ankyrin Repeat Protein (DARPin) to target chimeric antigen receptor (CAR)-redirected T cells towards CD4+ T cells to reduce the latent HIV+ cell reservoir by Patasic, Lea, Seifried, Janna, Bezler, Valerie, Kaljanac, Marcell, Schneider, Irene C., Schmitz, Heike, Tondera, Christiane, Hartmann, Jessica, Hombach, Andreas, Buchholz, Christian J., Abken, Hinrich, König, Renate, Cichutek, Klaus

“…Chimeric Antigen Receptor (CAR)-redirected T cells show great efficacy in the patient-specific therapy of hematologic malignancies. Here, we demonstrate that a…”
Get full text