Search Results - "Bezerra, Daniel P."

Overview of the therapeutic potential of piplartine (piperlongumine) by Bezerra, Daniel P., Pessoa, Claudia, de Moraes, Manoel O., Saker-Neto, Nicolau, Silveira, Edilberto R., Costa-Lotufo, Leticia V.

“…Piplartine (piperlongumine, 5,6-dihydro-1-[(2E)-1-oxo-3-(3,4,5-trimethoxyphenyl)-2-propenyl]-2(1H)-pyridinone) is a biologically active alkaloid/amide from…”
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Editorial: Reviews in molecular and cellular oncology by Bezerra, Daniel P, Ni, Jie, Chen, Maoshan

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Essential Oils: Chemistry and Pharmacological Activities by de Sousa, Damião P, Damasceno, Renan Oliveira S, Amorati, Riccardo, Elshabrawy, Hatem A, de Castro, Ricardo D, Bezerra, Daniel P, Nunes, Vitória Regina V, Gomes, Rebeca C, Lima, Tamires C

“…In this review, we provide an overview of the current understanding of the main mechanisms of pharmacological action of essential oils and their components in…”
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Emerging agents that target signaling pathways to eradicate colorectal cancer stem cells by Silva, Valdenizia R., Santos, Luciano de S., Dias, Rosane B., Quadros, Claudio A., Bezerra, Daniel P.

“…Colorectal cancer (CRC) represents the third most commonly diagnosed cancer and the second leading cause of cancer death worldwide. The modern concept of…”
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Editorial: Reviews in breast cancer: 2023 by Bezerra, Daniel P, Ni, Jie, Mohammed, Sulma I, De Miglio, Maria Rosaria

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Hedgehog components are overexpressed in a series of liver cancer cases by Sales, Caroline Brandi Schlaepfer, Dias, Rosane Borges, de Faro Valverde, Ludmila, Bomfim, Larissa M., Silva, Lais Almeida, de Carvalho, Nanashara C., Bastos, Jorge Luiz Andrade, Tilli, Tatiana Martins, Rocha, Gisele Vieira, Soares, Milena Botelho Pereira, de Freitas, Luiz Antonio Rodrigues, Gurgel Rocha, Clarissa A., Bezerra, Daniel P.

“…Liver cancers, including hepatocellular carcinoma (HCC), are the sixth most common cancer and the third leading cause of cancer-related death worldwide,…”
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Gouregine, an α -Gem-Dimethyltetradehydrocularine Alkaloid, and Other Aporphinoid Alkaloids from the Bark of Guatteria olivacea (Annonaceae) and Their In Vitro Cytotoxic Activities by Costa, Emmanoel V, Freitas, José Guilherme C, Manickchand, Steve Pereira, Araújo, Morgana de S, Silva, Valdenizia R, Santos, Luciano de S, Koolen, Hector Henrique Ferreira, Silva, Felipe M A da, Soares, Milena Botelho Pereira, Bezerra, Daniel P

“…R.E. Fries is an Amazonian species known as 'envira-bobó' and 'envira-fofa' and is common in the states of Amazonas, Acre, and Pará. Recently, the essential…”
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Ruthenium complex containing 1,3-thiazolidine-2-thione inhibits hepatic cancer stem cells by suppressing Akt/mTOR signalling and leading to apoptotic and autophagic cell death by Neves, Sara P., Bomfim, Larissa M., Kataura, Tetsushi, Carvalho, Sabrine G., Nogueira, Mateus L., Dias, Rosane B., Valverde, Ludmila de F., Gurgel Rocha, Clarissa A., Soares, Milena B.P., Silva, Monize M. da, Batista, Alzir A., Korolchuk, Viktor I., Bezerra, Daniel P.

“…Hepatic cancer is one of the main causes of cancer-related death worldwide. Cancer stem cells (CSCs) are a unique subset of cancer cells that promote tumour…”
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Emerging drugs targeting cellular redox homeostasis to eliminate acute myeloid leukemia stem cells by Costa, Rafaela G.A., Silva, Suellen L.R., Dias, Ingrid R.S.B., Oliveira, Maiara de S., Rodrigues, Ana Carolina B. da C., Dias, Rosane B., Bezerra, Daniel P.

“…Acute myeloid leukemia (AML) is a very heterogeneous group of disorders with large differences in the percentage of immature blasts that presently are…”
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Benzylated Dihydroflavones and Isoquinoline-Derived Alkaloids from the Bark of Diclinanona calycina (Annonaceae) and Their Cytotoxicities by Costa, Emmanoel V., Soares, Liviane do N., Chaar, Jamal da Silva, Silva, Valdenizia R., Santos, Luciano de S., Koolen, Hector H. F., Silva, Felipe M. A. da, Tavares, Josean F., Zengin, Gokhan, Soares, Milena B. P., Bezerra, Daniel P.

“…Diclinanona calycina R. E. Fries popularly known as “envira”, is a species of the Annonaceae family endemic to Brazil. In our ongoing search for bioactive…”
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In vitro and in vivo growth inhibition of human acute promyelocytic leukemia HL-60 cells by Guatteria megalophylla Diels (Annonaceae) leaf essential oil by Costa, Rafaela G.A., Anunciação, Talita A. da, Araujo, Morgana de S., Souza, César A., Dias, Rosane B., Sales, Caroline B.S., Rocha, Clarissa A.G., Soares, Milena B.P., Silva, Felipe M.A. da, Koolen, Hector H.F., Costa, Emmanoel V., Bezerra, Daniel P.

“…Guatteria megalophylla Diels (Annonaceae) is an 8−10 m tall tree that grows near streams and is widely spread throughout Colombian, Ecuadorian, Peruvian,…”
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A novel platinum complex containing a piplartine derivative exhibits enhanced cytotoxicity, causes oxidative stress and triggers apoptotic cell death by ERK/p38 pathway in human acute promyelocytic leukemia HL-60 cells by Oliveira, Maiara de S, Barbosa, Marília I F, de Souza, Thiago Belarmino, Moreira, Diogo R M, Martins, Felipe Terra, Villarreal, Wilmer, Machado, Rafael P, Doriguetto, Antônio Carlos, Soares, Milena B P, Bezerra, Daniel P

“…Piplartine (piperlongumine) is a plant-derived compound found in some Piper species that became a novel potential antineoplastic agent. In the present study,…”
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New ruthenium-xanthoxylin complex eliminates colorectal cancer stem cells by targeting the heat shock protein 90 chaperone by Santos, Luciano de S., Silva, Valdenizia R., de Castro, Maria V. L., Dias, Rosane B., Valverde, Ludmila de F., Rocha, Clarissa A. G., Soares, Milena B. P., Quadros, Claudio A., dos Santos, Edjane R., Oliveira, Regina M. M., Carlos, Rose M., Nogueira, Paulo C. L., Bezerra, Daniel P.

“…In this work, we describe a novel ruthenium-xanthoxylin complex, [Ru(phen) 2 (xant)](PF 6 ) (RXC), that can eliminate colorectal cancer (CRC) stem cells by…”
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Antitumour properties of the leaf essential oil of Xylopia frutescens Aubl. (Annonaceae) by Ferraz, Rosana P.C., Cardoso, Gabriella M.B., da Silva, Thanany B., Fontes, José Eraldo do N., Prata, Ana Paula do N., Carvalho, Adriana A., Moraes, Manoel O., Pessoa, Claudia, Costa, Emmanoel V., Bezerra, Daniel P.

“…•The essential oil contains (E)-caryophyllene as its major component.•The essential oil displays cytotoxicity to tumour cell lines.•The essential oil possesses…”
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Biological and physical approaches on the role of piplartine (piperlongumine) in cancer by Henrique, Tiago, Zanon, Caroline de F., Girol, Ana P., Stefanini, Ana Carolina Buzzo, Contessoto, Nayara S. de A., da Silveira, Nelson J. F., Bezerra, Daniel P., Silveira, Edilberto R., Barbosa-Filho, José M., Cornélio, Marinonio L., Oliani, Sonia M., Tajara, Eloiza H.

“…Chronic inflammation provides a favorable microenvironment for tumorigenesis, which opens opportunities for targeting cancer development and progression…”
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Antitumor Effect of the Essential Oil from the Leaves of Croton matourensis Aubl. (Euphorbiaceae) by Lima, Emilly J S P de, Alves, Rafaela G, D Elia, Gigliola M A, Anunciação, Talita A da, Silva, Valdenizia R, Santos, Luciano de S, Soares, Milena B P, Cardozo, Nállarett M D, Costa, Emmanoel V, Silva, Felipe M A da, Koolen, Hector H F, Bezerra, Daniel P

“…Aubl. (synonym Jabl.), popularly known as "orelha de burro", "maravuvuia", and/or "sangrad'água", is a medicinal plant used in Brazilian folk medicine as a…”
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Docking, synthesis and antiproliferative activity of N-acylhydrazone derivatives designed as combretastatin A4 analogues by do Amaral, Daniel Nascimento, Cavalcanti, Bruno C, Bezerra, Daniel P, Ferreira, Paulo Michel P, Castro, Rosane de Paula, Sabino, José Ricardo, Machado, Camila Maria Longo, Chammas, Roger, Pessoa, Claudia, Sant'Anna, Carlos M R, Barreiro, Eliezer J, Lima, Lídia Moreira

“…Cancer is the second most common cause of death in the USA. Among the known classes of anticancer agents, the microtubule-targeted antimitotic drugs are…”
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Duguetia pycnastera Sandwith (Annonaceae) Leaf Essential Oil Inhibits HepG2 Cell Growth In Vitro and In Vivo by Costa, Emmanoel V, de Souza, César A S, Galvão, Alexandre F C, Silva, Valdenizia R, Santos, Luciano de S, Dias, Rosane B, Rocha, Clarissa A Gurgel, Soares, Milena B P, da Silva, Felipe M A, Koolen, Hector H F, Bezerra, Daniel P

“…Duguetia pycnastera Sandwith (Annonaceae) is a tropical tree that can be found in the Guyanas, Bolivia, Venezuela, and Brazil. In Brazil, it is popularly known…”
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Antitumor Effect of Guatteria olivacea R. E. Fr. (Annonaceae) Leaf Essential Oil in Liver Cancer by Galvão, Alexandre F. C., Araújo, Morgana de S., Silva, Valdenizia R., Santos, Luciano de S., Dias, Rosane B., Rocha, Clarissa A. Gurgel, Soares, Milena B. P., Silva, Felipe M. A. da, Koolen, Hector H. F., Zengin, Gokhan, Costa, Emmanoel V., Bezerra, Daniel P.

“…Guatteria olivacea R. E. Fries (synonym Guatteria punctata (Aubl.) R.A. Howard) is a tree of 10–27 m tall popularly known as “envira-bobó”, “envira-fofa”,…”
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Essential Oils of Duguetia Species A. St. Hill (Annonaceae): Chemical Diversity and Pharmacological Potential by Santos, Albert C Dos, Nogueira, Mateus L, Oliveira, Felipe P de, Costa, Emmanoel V, Bezerra, Daniel P

“…A. St. Hill (Annonaceae) is recognized as one of the major genera with approximately 100 species, 67 of which are found in Brazil (29 of those are endemic)…”
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