Search Results - "Bezdekova, Renata"

Limited efficacy of daratumumab in multiple myeloma with extramedullary disease by Jelinek, Tomas, Sevcikova, Tereza, Zihala, David, Popkova, Tereza, Kapustova, Veronika, Broskevicova, Lucie, Capkova, Lenka, Rihova, Lucie, Bezdekova, Renata, Sevcikova, Sabina, Zidlik, Vladimir, Havel, Martin, Plonkova, Hana, Jungova, Alexandra, Minarik, Jiri, Stork, Martin, Pour, Ludek, Pavlicek, Petr, Spicka, Ivan, Maisnar, Vladimir, Radocha, Jakub, Simicek, Michal, Hajek, Roman

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Dynamics of tumor‐specific cfDNA in response to therapy in multiple myeloma patients by Vrabel, David, Sedlarikova, Lenka, Besse, Lenka, Rihova, Lucie, Bezdekova, Renata, Almasi, Martina, Kubaczkova, Veronika, Brožová, Lucie, Jarkovsky, Jiri, Plonkova, Hana, Jelinek, Tomas, Sandecka, Viera, Stork, Martin, Pour, Ludek, Sevcikova, Sabina, Hajek, Roman

“…Objectives Progress in multiple myeloma treatment allows patients to achieve deeper responses, for which the assessment of minimal residual disease (MRD) is…”
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Selected Genetic Polymorphisms Associated with Hypoxia and Multidrug Resistance in Monoclonal Gammopathies Patients by Almasi, Martina, Besse, Lenka, Brozova, Lucie, Jarkovsky, Jiří, Bezdekova, Renata, Pour, Luděk, Minarik, Jiří, Kessler, Petr, Pavlíček, Petr, Roziakova, Lubica, Penka, Miroslav, Hájek, Roman, Vasku, Anna, Sevcikova, Sabina

“…Adaptive response to hypoxia is regulated by several mechanisms and transcription factors, including hypoxia-inducible factors (HIFs). Activation of HIF-1α is…”
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LncRNAs LY86-AS1 and VIM-AS1 Distinguish Plasma Cell Leukemia Patients from Multiple Myeloma Patients by Bútová, Romana, Vychytilová-Faltejsková, Petra, Gregorová, Jana, Radová, Lenka, Almáši, Martina, Bezděková, Renata, Brožová, Lucie, Jarkovský, Jiří, Knechtová, Zdeňka, Štork, Martin, Pour, Luděk, Ševčíková, Sabina

“…Long non-coding RNAs (lncRNAs) are functional RNAs longer than 200 nucleotides. Due to modern genomic techniques, the involvement of lncRNAs in tumorigenesis…”
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Mutation landscape of multiple myeloma measurable residual disease: identification of targets for precision medicine by Zátopková, Martina, Ševčíková, Tereza, Fanfani, Viola, Chyra, Zuzana, Říhová, Lucie, Bezděková, Renata, Žihala, David, Growková, Kateřina, Filipová, Jana, Černá, Lucie, Broskevičova, Lucie, Kryukov, Fedor, Minařík, Jiří, Smejkalová, Jana, Maisnar, Vladimír, Harvanová, Ĺubica, Pour, Luděk, Jungova, Alexandra, Popková, Tereza, Bago, Juli Rodriguez, Anilkumar Sithara, Anjana, Hrdinka, Matouš, Jelínek, Tomáš, Šimíček, Michal, Stracquadanio, Giovanni, Hájek, Roman

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Activity of aldehyde dehydrogenase in B‐cell and plasma cell subsets of monoclonal gammopathy patients and healthy donors by Všianská, Pavla, Bezděková, Renata, Kryukov, Fedor, Almáši, Martina, Pour, Luděk, Penka, Miroslav, Hájek, Roman, Říhová, Lucie

“…Background Aldehyde dehydrogenase (ALDH) is highly active in physiological stem cells as well as in tumor‐initiating cells of some malignancies including…”
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More Than 2% of Circulating Tumor Plasma Cells Defines Plasma Cell Leukemia-Like Multiple Myeloma by Jelinek, Tomas, Bezdekova, Renata, Zihala, David, Sevcikova, Tereza, Anilkumar Sithara, Anjana, Pospisilova, Lenka, Sevcikova, Sabina, Polackova, Petra, Stork, Martin, Knechtova, Zdenka, Venglar, Ondrej, Kapustova, Veronika, Popkova, Tereza, Muronova, Ludmila, Chyra, Zuzana, Hrdinka, Matous, Simicek, Michal, Garcés, Juan-Jose, Puig, Noemi, Cedena, Maria-Teresa, Jurczyszyn, Artur, Castillo, Jorge J, Penka, Miroslav, Radocha, Jakub, Mateos, Maria Victoria, San-Miguel, Jesús F, Paiva, Bruno, Pour, Ludek, Rihova, Lucie, Hajek, Roman

“…Primary plasma cell leukemia (PCL) is the most aggressive monoclonal gammopathy. It was formerly characterized by ≥ 20% circulating plasma cells (CTCs) until…”
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Necessity of flow cytometry assessment of circulating plasma cells and its connection with clinical characteristics of primary and secondary plasma cell leukaemia by Bezdekova, Renata, Jelinek, Tomas, Kralova, Romana, Stork, Martin, Polackova, Petra, Vsianska, Pavla, Brozova, Lucie, Jarkovsky, Jiri, Almasi, Martina, Boichuk, Ivanna, Knechtova, Zdenka, Penka, Miroslav, Pour, Ludek, Sevcikova, Sabina, Hajek, Roman, Rihova, Lucie

“…Summary Plasma cell leukaemia (PCL) is a rare and very aggressive plasma cell disorder. Preventing a dismal outcome of PCL requires early diagnosis with…”
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P-123: Extramedullary expansion of Myeloma plasma cells into CNS by Rihova, Lucie, Bezdekova, Renata, Polackova, Petra, Stork, Martin, Sandecka, Viera, Pour, Luděk, Sevcikova, Sabina

“…Multiple myeloma (MM) is characterised by a presence of clonal plasma cell (a-PC) which are usually localised in bone marrow (BM) as a heterogeneous…”
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P-075: Myeloid derived suppressor cells are not elevated in monoclonal gammopathies by Rihova, Lucie, Bilikova, Klara, Bezdekova, Renata, Polackova, Petra, Penka, Miroslav, Pour, Luděk, Sevcikova, Sabina

“…The immunologically tolerant microenvironment may support a development of malignant multiple myeloma (MM) from precancerous monoclonal gammopathy of…”
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Transcriptional profiling of circulating tumor cells in multiple myeloma: a new model to understand disease dissemination by Garcés, Juan-Jose, Simicek, Michal, Vicari, Marco, Brozova, Lucie, Burgos, Leire, Bezdekova, Renata, Alignani, Diego, Calasanz, Maria-Jose, Growkova, Katerina, Goicoechea, Ibai, Agirre, Xabier, Pour, Ludek, Prosper, Felipe, Rios, Rafael, Martinez-Lopez, Joaquin, Millacoy, Pamela, Palomera, Luis, Del Orbe, Rafael, Perez-Montaña, Albert, Garate, Sonia, Blanco, Laura, Lasa, Marta, Maiso, Patricia, Flores-Montero, Juan, Sanoja-Flores, Luzalba, Chyra, Zuzana, Vdovin, Alexander, Sevcikova, Tereza, Jelinek, Tomas, Botta, Cirino, El Omri, Halima, Keats, Jonathan, Orfao, Alberto, Hajek, Roman, San-Miguel, Jesus F., Paiva, Bruno

“…The reason why a few myeloma cells egress from the bone marrow (BM) into peripheral blood (PB) remains unknown. Here, we investigated molecular hallmarks of…”
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Deregulated expression of long non‐coding RNA UCA1 in multiple myeloma by Sedlarikova, Lenka, Gromesova, Barbora, Kubaczkova, Veronika, Radova, Lenka, Filipova, Jana, Jarkovsky, Jiri, Brozova, Lucie, Velichova, Roberta, Almasi, Martina, Penka, Miroslav, Bezdekova, Renata, Stork, Martin, Adam, Zdenek, Pour, Ludek, Krejci, Marta, Kuglík, Petr, Hajek, Roman, Sevcikova, Sabina

“…Objectives Long non‐coding RNAs (lncRNAs) are RNA transcripts longer than 200 nucleotides that are not translated into proteins. They are involved in…”
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Real-World Evidence on Prognostic Value of MRD in Multiple Myeloma Using Flow Cytometry by Muronova, Ludmila, Soucek, Ondrej, Zihala, David, Sevcikova, Tereza, Popkova, Tereza, Plonkova, Hana, Venglar, Ondrej, Pour, Ludek, Stork, Martin, Rihova, Lucie, Bezdekova, Renata, Minarik, Jiri, Látal, Vojtech, Novak, Martin, Jungova, Alexandra, Dekojova, Tereza, Straub, Jan, Spacek, Martin, Rezacova, Vladimira, Maisnar, Vladimir, Radocha, Jakub, Hajek, Roman, Jelinek, Tomas

“…Minimal residual disease (MRD) is one of the most important prognostic factors in multiple myeloma (MM) and a valid surrogate for progression-free survival…”
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Predicting Treatment Response of Multiple Myeloma Patients Using Tumor Specific cell-free DNA by Gregorova, Jana, Vrabel, David, Almasi, Martina, Bezdekova, Renata, Stork, Martin, Pour, Ludek, Hajek, Roman, Sevcikova, Sabina

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P-031: Importance of flow cytometry assessment of circulating plasma cells and its connection with clinical characteristics of primary and secondary plasma cell leukemia by Bezdekova, Renata, Jelinek, Tomas, Stork, Martin, Polackova, Petra, Brozova, Lucie, Almasi, Martina, Boichuk, Ivanna, Knechtova, Zdenka, Penka, Miroslav, Pour, Luděk, Sevcikova, Sabina, Rihova, Lucie

“…Plasma cell leukemia (PCL) is a rare and very aggressive plasma cell (PC) disorder characterized by the presence of circulating plasma cells (cPC) in…”
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P-077: Bone marrow microenvironment analysis of exosomal microRNAs in multiple myeloma, extramedullary disease and plasma cell leukemia by Gregorova, Jana, Vlachova, Monika, Radova, Lenka, Brozova, Lucie, Bezdekova, Renata, Rihova, Lucie, Almasi, Martina, Stork, Martin, Pour, Luděk, Minarik, Jiri, Hájek, Roman, Sevcikova, Sabina

“…Multiple myeloma (MM) is a heterogeneous plasma cell (PC) malignancy. These malignant PC are dependent on the bone marrow (BM) microenvironment. However, a…”
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Identification of Phenotype Profile Related to the Extramedullary Involvement in Multiple Myeloma Relapse by Rihova, Lucie, Vsianska, Pavla, Bezdekova, Renata, Adam, Zdenek, Penka, Miroslav, Jelinek, Tomas, Sevcikova, Sabina, Pour, Ludek, Hájek, Roman

“…Background: Multiple myeloma (MM) is characterised by proliferation of malignant plasma cells (PCs) usually in bone marrow (BM). The mechanisms of…”
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P-075 Real-world evidence on prognostic value of minimal residual disease in multiple myeloma: Czech experience by Jelinek, Tomas, Muronova, Ludmila, Zihala, David, Sevcikova, Tereza, Popkova, Tereza, Plonkova, Hana, Venglar, Ondrej, Pour, Ludek, Stork, Martin, Rihova, Lucie, Bezdekova, Renata, Minarik, Jiri, Novak, Martin, Jungova, Alexandra, Chena, David, Straub, Jan, Spacek, Martin, Rezacova, Vladimira, Soucek, Ondrej, Maisnar, Vladimir, Radocha, Jakub, Hájek, Roman

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Bone marrow lymphocytes reconstructive pattern in multiple myeloma patients after autologous transplant has no prognostic significance by Stork, Martin, Bezdekova, Renata, Kralova, Romana, Sandecka, Viera, Adam, Zdeněk, Krejci, Marta, Boichuk, Ivanna, Sevcikova, Sabina, Rihova, Lucie, Pour, Ludek

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Gene Expression Profile of Circulating Myeloma Cells Reveals CD44 and CD97 (ADGRE5) Overexpression by Sevcikova, Tereza, Kryukov, Fedor, Brozova, Lucie, Filipova, Jana, Kufova, Zuzana, Growkova, Katerina, Bezdekova, Renata, Nemec, Pavel, Rihova, Lucie, Jarkovsky, Jiri, Hajek, Roman

“…Introduction: Release of the aberrant plasma cells (PC) from the bone marrow (BM) and their presence in the peripheral blood (PB) is a maker of disease…”
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