Search Results - "Beyers, N."

Symptom screening rules to identify active pulmonary tuberculosis: Findings from the Zambian South African Tuberculosis and HIV/AIDS Reduction (ZAMSTAR) trial prevalence surveys by Claassens, M M, van Schalkwyk, C, Floyd, S, Ayles, H, Beyers, N

“…High tuberculosis (TB) burden countries should consider systematic screening among adults in the general population. We identified symptom screening rules to…”
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Obituary for Donald A. Enarson by Chiang, C.-Y., El Sony, A., Beyers, N., Fanning, A., Marks, G. B., Rieder, H. L., Billo, N. E.

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Improving rifampicin-resistant tuberculosis diagnosis using Xpert® MTB/RIF: modelling interventions and costs by Dunbar, R., Naidoo, P., Beyers, N., Langley, I.

“…SETTING: Cape Town, South Africa.OBJECTIVE: To model the diagnosis of rifampicin-resistant tuberculosis (RR-TB) and laboratory costs of smear/culture and…”
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High laboratory cost predicted per tuberculosis case diagnosed with increased case finding without a triage strategy by Dunbar, R., Naidoo, P., Beyers, N., Langley, I.

“…SETTING: Cape Town, South Africa.OBJECTIVE: To model the effects of increased case finding and triage strategies on laboratory costs per tuberculosis (TB) case…”
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Recently Evolved Sublineage of the Mycobacterium tuberculosis Beijing Strain Family Is Associated with an Increased Ability to Spread and Cause Disease by Hanekom, M, van der Spuy, G.D, Streicher, E, Ndabambi, S.L, McEvoy, C.R.E, Kidd, M, Beyers, N, Victor, T.C, van Helden, P.D, Warren, R.M

“…This study aimed to reconstruct the evolutionary history of Beijing strains of Mycobacterium tuberculosis and to test the hypothesis that evolution has…”
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Diagnostic and Management Challenges for Childhood Tuberculosis in the Era of HIV by Marais, B. J, Graham, S. M, Cotton, M. F, Beyers, N

“…The diagnosis and management of childhood tuberculosis (TB) pose substantial challenges in the era of the human immunodeficiency virus (HIV) epidemic. The…”
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Operational modelling: the mechanisms influencing TB diagnostic yield in an Xpert® MTB/RIF-based algorithm by Dunbar, R., Naidoo, P., Beyers, N., Langley, I.

“…SETTING: Cape Town, South Africa.OBJECTIVE: To compare the diagnostic yield for smear/culture and Xpert® MTB/RIF algorithms and to investigate the mechanisms…”
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Notification of relapse and other previously treated tuberculosis in the 52 health districts of South Africa by Marx, F. M., Cohen, T., Lombard, C., Hesseling, A. C., Dlamini, S. S., Beyers, N., Naidoo, P.

“…OBJECTIVE: To investigate the extent to which relapse and other previously treated tuberculosis (TB) contribute to the notified TB burden in South…”
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Bacille Calmette-Guérin Vaccine—Induced Disease in HIV-Infected and HIV-Uninfected Children by Hesseling, A. C., Rabie, H., Marais, B. J., Manders, M., Lips, M., Schaaf, H. S., Gie, R. P., Cotton, M. F., van Helden, P. D., Warren, R. M., Beyers, N.

“…Background. Bacille Calmette-Guérin (BCG)—a live, attenuated vaccine—is routinely given to neonates in settings where tuberculosis is endemic, irrespective of…”
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Disseminated bacille Calmette―Guérin disease in HIV-infected South African infants by HESSELING, A. C, JOHNSON, L. F, BEYERS, N, GODFREY-FAUSSETT, P, JASPAN, H, COTTON, M. F, WHITELAW, A, SCHAAF, H. S, FINE, Pem, ELEY, B. S, MARAIS, B. J, NUTTALL, J

“…To determine the population-based incidence of disseminated bacille Calmette-Guérin (BCG) disease in HIV-infected infants (aged <or= 1 year) in a setting with…”
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The natural history of childhood intra-thoracic tuberculosis: a critical review of literature from the pre-chemotherapy era [State of the Art] by MARAIS, B. J, GIE, R. P, SCHAAF, H. S, HESSELING, A. C, OBIHARA, C. C, STARKE, J. J, ENARSON, T. D. A, DONALD, P. R, BEYERS, N

“…The pre-chemotherapy literature documented the natural history of tuberculosis in childhood. These disease descriptions remain invaluable for guiding public…”
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Differential cytokine secretion and early treatment response in patients with pulmonary tuberculosis by Djoba Siawaya, J.F, Beyers, N, van Helden, P, Walzl, G

“…Biomarkers for treatment response would facilitate the testing of urgently needed new anti-tuberculous drugs. The present study investigated the profiles of 30…”
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Health care workers' gender bias in testing could contribute to missed tuberculosis among women in South Africa by Smith, A., Burger, R., Claassens, M., Ayles, H., Godfrey-Faussett, P., Beyers, N.

“…SETTING: Eight communities with high tuberculosis (TB) prevalence, Western Cape, South Africa.OBJECTIVE: To identify sex differences in TB health-seeking…”
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Comparing laboratory costs of smear/culture and Xpert® MTB/RIF-based tuberculosis diagnostic algorithms by Naidoo, P., Dunbar, R., du Toit, E., van Niekerk, M., Squire, S. B., Beyers, N., Madan, J.

“…SETTING: Cape Town, South Africa, where Xpert® MTB/RIF was introduced as a screening test for all presumptive tuberculosis (TB) cases.OBJECTIVE: To compare…”
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Optimizing Mycobacterial Culture in Smear-Negative, Human Immunodeficiency Virus-Infected Tuberculosis Cases by Ismail, N A, Said, H M, Pinini, Z, Omar, S V, Beyers, N, Naidoo, P

“…Tuberculosis (TB) is a significant public health problem and the diagnosis in human immunodeficiency virus (HIV)-infected individuals is challenging. The use…”
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Highly discordant T cell responses in individuals with recent exposure to household tuberculosis by Hesseling, A C, Mandalakas, A M, Kirchner, H L, Chegou, N N, Marais, B J, Stanley, K, Zhu, X, Black, G, Beyers, N, Walzl, G

“…There are limited data comparing interferon-gamma release assays (IGRAs) for the detection of Mycobacterium tuberculosis infection in highly endemic settings…”
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Tuberculosis cases missed in primary health care facilities: should we redefine case finding? by Claassens, M. M., Jacobs, E., Cyster, E., Jennings, K., James, A., Dunbar, R., Enarson, D. A., Borgdorff, M. W., Beyers, N.

“…SETTING: This study was conducted in Cape Town in two primary health care facilities in a sub-district with a high prevalence of bacteriologically confirmed…”
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Tuberculosis patients in primary care do not start treatment. What role do health system delays play? by Claassens, M. M., du Toit, E., Dunbar, R., Lombard, C., Enarson, D. A., Beyers, N., Borgdorff, M. W.

“…SETTING: Primary health care facilities in five provinces of South Africa.OBJECTIVE: To investigate the association between the proportion of sputum results…”
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Renal dysfunction by baseline CD4 cell count in a cohort of adults starting antiretroviral treatment regardless of CD4 count in the HIV Prevention Trials Network 071 [HPTN 071; Population Effect of Antiretroviral Therapy to Reduce HIV Transmission (PopART)] study in South Africa by Bock, P, Nel, K, Fatti, G, Sloot, R, Ford, N, Voget, J, Gunst, C, Grobbelaar, N, Louis, F, Floyd, S, Hayes, R, Ayles, H, Beyers, N, Fidler, S

“…Objectives Renal dysfunction is a significant cause of morbidity and mortality among HIV‐positive individuals. This study evaluated renal dysfunction in a…”
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Baseline sputum time to detection predicts month two culture conversion and relapse in non-HIV-infected patients by Hesseling, A C, Walzl, G, Enarson, D A, Carroll, N M, Duncan, K, Lukey, P T, Lombard, C, Donald, P R, Lawrence, K A, Gie, R P, van Helden, P D, Beyers, N

“…BACKGROUND: Few biomarkers are available to identify tuberculosis (TB) patients at risk of delayed sputum conversion and relapse.OBJECTIVES: To investigate…”
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