Search Results - "Beyermann, Michael"
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Solid-phase peptide synthesis: from standard procedures to the synthesis of difficult sequences
Published in Nature protocols (01-12-2007)“…This protocol for solid-phase peptide synthesis (SPPS) is based on the widely used Fmoc/tBu strategy, activation of the carboxyl groups by aminium-derived…”
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Immobilization Reduces the Activity of Surface-Bound Cationic Antimicrobial Peptides with No Influence upon the Activity Spectrum
Published in Antimicrobial Agents and Chemotherapy (01-03-2009)“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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3
Wavelength-Selective Photoactivatable Protecting Groups for Thiols
Published in Journal of the American Chemical Society (25-11-2009)“…We developed and characterized efficient, remarkably water-soluble photolabile protecting groups for thiols based on 2-nitrobenzyl and (coumarin-4-yl)methyl…”
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Functional properties of cell-free expressed human endothelin A and endothelin B receptors in artificial membrane environments
Published in Biochimica et biophysica acta (01-09-2013)“…The human endothelin receptors are members of the rhodopsin class A of G-protein coupled receptors and key modulators of blood pressure regulation. Their…”
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Amyloid beta 42 peptide (Aβ42)-lowering compounds directly bind to Aβ and interfere with amyloid precursor protein (APP) transmembrane dimerization
Published in Proceedings of the National Academy of Sciences - PNAS (17-08-2010)“…Following ectodomain shedding by β-secretase, successive proteolytic cleavages within the transmembrane sequence (TMS) of the amyloid precursor protein (APP)…”
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modular toolkit to inhibit proline-rich motif–mediated protein–protein interactions
Published in Proceedings of the National Academy of Sciences - PNAS (21-04-2015)“…Significance Protein–protein interactions mediated by proline-rich motifs are involved in regulation of many important signaling cascades. Protein domains…”
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Synthesis of Biologically Active Peptide Nucleic Acid−Peptide Conjugates by Sortase-Mediated Ligation
Published in Journal of organic chemistry (11-05-2007)“…Sortase A is a transpeptidase that cleaves at a pentapeptide-motif and subsequently transfers the acyl component to a nucleophile containing N-terminal…”
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Photoswitchable Click Amino Acids: Light Control of Conformation and Bioactivity
Published in Chembiochem : a European journal of chemical biology (25-11-2011)“…Click the switch: By using a photoswitchable click amino acid (PSCaa) a light‐induced intramolecular thiol‐ene click reaction with a neighboring cysteine under…”
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Temporal sampling, resetting, and adaptation orchestrate gradient sensing in sperm
Published in The Journal of cell biology (17-09-2012)“…Sperm, navigating in a chemical gradient, are exposed to a periodic stream of chemoattractant molecules. The periodic stimulation entrains Ca(2+) oscillations…”
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Optimization of the antimicrobial activity of magainin peptides by modification of charge
Published in FEBS letters (20-07-2001)“…Investigation of magainin II amide analogs with cationic charges ranging between +3 and +7 showed that enhancement of the peptide charge up to a threshold…”
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A Peptidomimetic Tight Junction Modulator To Improve Regional Analgesia
Published in Molecular pharmaceutics (04-06-2012)“…The paracellular flux of solutes through tissue barriers is limited by transmembrane tight junction proteins. Within the family of tight junction proteins,…”
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Mass-Spectrometric Identification of a Novel Angiotensin Peptide in Human Plasma
Published in Arteriosclerosis, thrombosis, and vascular biology (01-02-2007)“…OBJECTIVE—Angiotensin peptides play a central role in cardiovascular physiology and pathology. Among these peptides, angiotensin II (Ang II) has been…”
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Defining a conformational consensus motif in cotransin-sensitive signal sequences: a proteomic and site-directed mutagenesis study
Published in PloS one (25-03-2015)“…The cyclodepsipeptide cotransin was described to inhibit the biosynthesis of a small subset of proteins by a signal sequence-discriminatory mechanism at the…”
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Depsipeptide Methodology for Solid-Phase Peptide Synthesis: Circumventing Side Reactions and Development of an Automated Technique via Depsidipeptide Units
Published in Journal of organic chemistry (04-08-2006)“…The depsipeptide technique is a recently developed method for peptide synthesis which is applicable to difficult sequences when the synthetic difficulty arises…”
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Intramolecular bridges formed by photoswitchable click amino acids
Published in Beilstein journal of organic chemistry (13-06-2012)“…Photoswitchable click amino acids (PSCaa) are amino acids bearing a side chain consisting of a photoswitchable unit elongated with a functional group that…”
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Compartmentalization of cAMP-dependent signaling by phosphodiesterase-4D is involved in the regulation of vasopressin-mediated water reabsorption in renal principal cells
Published in Journal of the American Society of Nephrology (2007)“…The cAMP/protein kinase A (PKA)-dependent insertion of water channel aquaporin-2 (AQP2)-bearing vesicles into the plasma membrane in renal collecting duct…”
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Modulation of G-protein coupled receptor sample quality by modified cell-free expression protocols: A case study of the human endothelin A receptor
Published in Journal of structural biology (01-10-2010)“…G-protein coupled receptors still represent one of the most challenging targets in membrane protein research. Here we present a strategic approach for the…”
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{7-[Bis(carboxymethyl)amino]coumarin-4-yl}methoxycarbonyl Derivatives for Photorelease of Carboxylic Acids, Alcohols/Phenols, Thioalcohols/Thiophenols, and Amines
Published in Chemistry : a European journal (08-02-2008)“…Light‐induced release of biomolecules from inactive precursor molecules represents a powerful method to study cellular processes with high temporal and spatial…”
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Binding of Antibacterial Magainin Peptides to Electrically Neutral Membranes: Thermodynamics and Structure
Published in Biochemistry (Easton) (10-08-1999)“…Magainins are positively charged amphiphatic peptides which permeabilize cell membranes and display antimicrobial activity. They are usually thought to bind…”
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The signal flow and motor response controling chemotaxis of sea urchin sperm
Published in Nature cell biology (01-02-2003)“…The signalling pathway and the behavioural strategy underlying chemotaxis of sperm are poorly understood. We have studied the cellular events and motor…”
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