Search Results - "Beyer, P"

The PINK1-Parkin pathway promotes both mitophagy and selective respiratory chain turnover in vivo by Vincow, Evelyn S., Merrihew, Gennifer, Thomas, Ruth E., Shulman, Nicholas J., Beyer, Richard P., MacCoss, Michael J., Pallanck, Leo J.

“…The accumulation of damaged mitochondria has been proposed as a key factor in aging and the pathogenesis of many common agerelated diseases, including…”
Get full text

Spatial, temporal, and species variation in prevalence of influenza A viruses in wild migratory birds by Munster, Vincent J, Baas, Chantal, Lexmond, Pascal, Waldenström, Jonas, Wallensten, Anders, Fransson, Thord, Rimmelzwaan, Guus F, Beyer, Walter E P, Schutten, Martin, Olsen, Björn, Osterhaus, Albert D M E, Fouchier, Ron A M

“…Although extensive data exist on avian influenza in wild birds in North America, limited information is available from elsewhere, including Europe. Here,…”
Get full text

Transient rapamycin treatment can increase lifespan and healthspan in middle-aged mice by Bitto, Alessandro, Ito, Takashi K, Pineda, Victor V, LeTexier, Nicolas J, Huang, Heather Z, Sutlief, Elissa, Tung, Herman, Vizzini, Nicholas, Chen, Belle, Smith, Kaleb, Meza, Daniel, Yajima, Masanao, Beyer, Richard P, Kerr, Kathleen F, Davis, Daniel J, Gillespie, Catherine H, Snyder, Jessica M, Treuting, Piper M, Kaeberlein, Matt

“…The FDA approved drug rapamycin increases lifespan in rodents and delays age-related dysfunction in rodents and humans. Nevertheless, important questions…”
Get full text

Altered proteome turnover and remodeling by short‐term caloric restriction or rapamycin rejuvenate the aging heart by Dai, Dao‐Fu, Karunadharma, Pabalu P., Chiao, Ying A., Basisty, Nathan, Crispin, David, Hsieh, Edward J., Chen, Tony, Gu, Haiwei, Djukovic, Danijel, Raftery, Daniel, Beyer, Richard P., MacCoss, Michael J., Rabinovitch, Peter S.

“…Summary Chronic caloric restriction (CR) and rapamycin inhibit the mechanistic target of rapamycin (mTOR) signaling, thereby regulating metabolism and…”
Get full text

The Werner syndrome RECQ helicase targets G4 DNA in human cells to modulate transcription by Tang, Weiliang, Robles, Ana I, Beyer, Richard P, Gray, Lucas T, Nguyen, Giang H, Oshima, Junko, Maizels, Nancy, Harris, Curtis C, Monnat, Jr, Raymond J

“…The Werner syndrome (WS) is a prototypic adult Mendelian progeroid syndrome in which signs of premature aging are associated with genomic instability and an…”
Get full text

Rapamycin transiently induces mitochondrial remodeling to reprogram energy metabolism in old hearts by Chiao, Ying Ann, Kolwicz, Stephen C, Basisty, Nathan, Gagnidze, Arni, Zhang, Julia, Gu, Haiwei, Djukovic, Danijel, Beyer, Richard P, Raftery, Daniel, MacCoss, Michael, Tian, Rong, Rabinovitch, Peter S

“…Rapamycin, an inhibitor of mTOR signaling, has been shown to reverse diastolic dysfunction in old mice in 10 weeks, highlighting its therapeutic potential for…”
Get full text

Tbr1 regulates regional and laminar identity of postmitotic neurons in developing neocortex by Bedogni, Francesco, Hodge, Rebecca D., Elsen, Gina E., Nelson, Branden R., Daza, Ray A. M., Beyer, Richard P., Bammler, Theo K., Rubenstein, John L. R., Hevner, Robert F., Rakic, Pasko

“…Areas and layers of the cerebral cortex are specified by genetic programs that are initiated in progenitor cells and then, implemented in postmitotic neurons…”
Get full text

An anti-ANGPTL3/8 antibody decreases circulating triglycerides by binding to a LPL-inhibitory leucine zipper-like motif by Balasubramaniam, Deepa, Schroeder, Oliver, Russell, Anna M., Fitchett, Jonathan R., Austin, Aaron K., Beyer, Thomas P., Chen, Yan Q., Day, Jonathan W., Ehsani, Mariam, Heng, Aik Roy, Zhen, Eugene Y., Davies, Julian, Glaesner, Wolfgang, Jones, Bryan E., Siegel, Robert W., Qian, Yue-Wei, Konrad, Robert J.

“…Triglycerides (TG) are required for fatty acid transport and storage and are essential for human health. Angiopoietin-like-protein 8 (ANGPTL8) has previously…”
Get full text

Regulation of gene expression by the BLM helicase correlates with the presence of G-quadruplex DNA motifs by Nguyen, Giang Huong, Tang, Weiliang, Robles, Ana I., Beyer, Richard P., Gray, Lucas T., Welsh, Judith A., Schetter, Aaron J., Kumamoto, Kensuke, Wang, Xin Wei, Hickson, Ian D., Maizels, Nancy, Monnat, Raymond J., Harris, Curtis C.

“…Bloom syndrome is a rare autosomal recessive disorder characterized by genetic instability and cancer predisposition, and caused by mutations in the gene…”
Get full text

Age modifies respiratory complex I and protein homeostasis in a muscle type‐specific manner by Kruse, Shane E., Karunadharma, Pabalu P., Basisty, Nathan, Johnson, Richard, Beyer, Richard P., MacCoss, Michael J., Rabinovitch, Peter S., Marcinek, David J.

“…Summary Changes in mitochondrial function with age vary between different muscle types, and mechanisms underlying this variation remain poorly defined. We…”
Get full text

Coagulation Factor X Activates Innate Immunity to Human Species C Adenovirus by Doronin, Konstantin, Flatt, Justin W., Di Paolo, Nelson C., Khare, Reeti, Kalyuzhniy, Oleksandr, Acchione, Mauro, Sumida, John P., Ohto, Umeharu, Shimizu, Toshiyuki, Akashi-Takamura, Sachiko, Miyake, Kensuke, MacDonald, James W., Bammler, Theo M., Beyer, Richard P., Farin, Frederico M., Stewart, Phoebe L., Shayakhmetov, Dmitry M.

“…Although coagulation factors play a role in host defense for "living fossils" such as horseshoe crabs, the role of the coagulation system in immunity in higher…”
Get full text

Molecular Determinants of Adaptation of Highly Pathogenic Avian Influenza H7N7 Viruses to Efficient Replication in the Human Host by DE WIT, Emmie, MUNSTER, Vincent J, VAN RIEL, Debby, BEYER, Walter E. P, RIMMELZWAAN, Guus F, KUIKEN, Thijs, OSTERHAUS, Albert D. M. E, FOUCHIER, Ron A. M

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

Sequential Anti-PD1 Therapy Following Dendritic Cell Vaccination Improves Survival in a HER2 Mammary Carcinoma Model and Identifies a Critical Role for CD4 T Cells in Mediating the Response by Kodumudi, Krithika N, Ramamoorthi, Ganesan, Snyder, Colin, Basu, Amrita, Jia, Yongsheng, Awshah, Sabrina, Beyer, Amber P, Wiener, Doris, Lam, Lian, Zhang, Hongtao, Greene, Mark I, Costa, Ricardo L B, Czerniecki, Brian J

“…Patients with metastatic HER2 breast cancer (MBC) often become resistant to HER 2 targeted therapy and have recurrence of disease. The Panacea trial suggested…”
Get full text

Global proteomics and pathway analysis of pressure-overload-induced heart failure and its attenuation by mitochondrial-targeted peptides by Dai, Dao-Fu, Hsieh, Edward J, Chen, Tony, Menendez, Lorena G, Basisty, Nathan B, Tsai, Lauren, Beyer, Richard P, Crispin, David A, Shulman, Nicholas J, Szeto, Hazel H, Tian, Rong, MacCoss, Michael J, Rabinovitch, Peter S

“…We investigated the protective effects of mitochondrial-targeted antioxidant and protective peptides, Szeto-Schiller (SS) 31 and SS20, on cardiac function,…”
Get full text

Cochrane re-arranged: Support for policies to vaccinate elderly people against influenza by Beyer, Walter E.P, McElhaney, Janet, Smith, Derek J, Monto, Arnold S, Nguyen-Van-Tam, Jonathan S, Osterhaus, Albert D.M.E

“…Abstract The 2010 Cochrane review on efficacy, effectiveness and safety of influenza vaccination in the elderly by Jefferson et al. covering dozens of clinical…”
Get full text

Percutaneous Ablation of Hepatic Tumors Using Irreversible Electroporation: A Prospective Safety and Midterm Efficacy Study in 34 Patients by Niessen, Christoph, Dr Med, Beyer, Lukas P., Dr Med, Pregler, Benedikt, MD, Dollinger, Marco, Dr Med, Trabold, Benedikt, PD Dr, Schlitt, Hans J., Prof Dr, Jung, Ernst M., Prof Dr, Stroszczynski, Christian, Prof Dr, Wiggermann, Philipp, PD Dr

“…Abstract Purpose To evaluate the safety and efficacy of percutaneous irreversible electroporation (IRE) of primary and secondary liver cancer unsuitable for…”
Get full text

Irreversible Electroporation of Malignant Hepatic Tumors--Alterations in Venous Structures at Subacute Follow-Up and Evolution at Mid-Term Follow-Up by Dollinger, Marco, Müller-Wille, René, Zeman, Florian, Haimerl, Michael, Niessen, Christoph, Beyer, Lukas P, Lang, Sven A, Teufel, Andreas, Stroszczynski, Christian, Wiggermann, Philipp

“…To evaluate risk factors associated with alterations in venous structures adjacent to an ablation zone after percutaneous irreversible electroporation (IRE) of…”
Get full text

Evacetrapib is a novel, potent, and selective inhibitor of cholesteryl ester transfer protein that elevates HDL cholesterol without inducing aldosterone or increasing blood pressure by Cao, Guoqing, Beyer, Thomas P., Zhang, Youyan, Schmidt, Robert J., Chen, Yan Q., Cockerham, Sandra L., Zimmerman, Karen M., Karathanasis, Sotirios K., Cannady, Ellen A., Fields, Todd, Mantlo, Nathan B.

“…Cholesteryl ester transfer protein (CETP) catalyses the exchange of cholesteryl ester and triglyceride between HDL and apoB containing lipoprotein particles…”
Get full text

Regulation of liver regeneration and hepatocarcinogenesis by suppressor of cytokine signaling 3 by Riehle, Kimberly J, Campbell, Jean S, McMahan, Ryan S, Johnson, Melissa M, Beyer, Richard P, Bammler, Theo K, Fausto, Nelson

“…Suppressor of cytokine signaling 3 (SOCS3) down-regulates several signaling pathways in multiple cell types, and previous data suggest that SOCS3 may shut off…”
Get full text

Decreased Fibronectin Production Significantly Contributes to Dysregulated Repair of Asthmatic Epithelium by KICIC, Anthony, HALLSTRAND, Teal S, SUTANTO, Erika N, STEVENS, Paul T, KOBOR, Michael S, TAPLIN, Christopher, PARE, Peter D, BEYER, Richard P, STICK, Stephen M, KNIGHT, Darryl A

“…Damage to airway epithelium is followed by deposition of extracellular matrix (ECM) and migration of adjacent epithelial cells. We have shown that epithelial…”
Get full text